The clock in our genes and in every cell of your body | Joseph Takahashi | TEDxSMU 2013

Ғылым және технология

Joseph S. Takahashi, Ph.D. is the Loyd B. Sands Distinguished Chair in Neuroscience, an Investigator of the Howard Hughes Medical Institute, and Chair of the Department of Neuroscience at the University of Texas Southwestern Medical Center in Dallas. His research interests are the molecular mechanism of circadian clocks, neuroscience, and the genetic basis of behavior. Dr. Takahashi pioneered the use of genetics in the mouse as a tool for discovery of genes underlying neurobiology and behavior. His awards include the Honma International Prize in Biological Rhythms Research in 1986, W. Alden Spencer Award in Neuroscience from Columbia University in 2001, Eduard Buchner Prize from German Society for Biochemistry and Molecular Biology in 2003 and Outstanding Scientific Achievement Award from the Sleep Research Society in 2012. He was elected a Fellow of the American Academy of Arts and Sciences in 2000, and a Member of the National Academy of Sciences in 2003. He was a co-founder of Hypnion, Inc., a biotech discovery company in Worcester, Mass., that investigated sleep/wake neurobiology and pharmaceuticals (now owned by Eli Lilly and Co.), and is a co-founder of ReSet Therapeutics, Inc., a biotech company that works on the role of clocks in metabolism.
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Пікірлер: 28

  • @marckdan2508
    @marckdan25083 жыл бұрын

    It's interesting how our biology is so closely tied to the natural rhythm of the earth; how all life is orchestrated by the 24hr period that makes up the full rotation of the earth around its own axis. We were, indeed, made FOR this planet, BY this planet, and made OF this planet. I have confidence alien life will not survive here. We've earned our right to exist on this rock. We've learnt to cope with the many microbial life forms that could otherwise threaten our existence. We've evolved (in symbiosis) WITH this rock, to survive & thrive here........Does it then not make all it all the more illogical that we continue to threaten, maim, and destroy this rock -- not for survival, but for greed that does nothing to prolong our transcient individual existences?

  • @aaronlaitner4343

    @aaronlaitner4343

    Жыл бұрын

    "We become what we behold. We shape our tools and then our tools shape us." - Marshall McLuhan

  • @albussd

    @albussd

    Жыл бұрын

    All of that is fine but I certainly would not say that we earned our right to exist on this rock. Too much entitlement is assumed with that statement.

  • @hosoiarchives4858
    @hosoiarchives48582 жыл бұрын

    4:05 internal biological clock 8:49 gene animation, “cell clock” 11:53 SCN 14:40 chimera

  • @Johanna-qf1yx
    @Johanna-qf1yx4 жыл бұрын

    Very well done

  • @sourbhrankawat8454
    @sourbhrankawat8454 Жыл бұрын

    I'm working in circadian biology field and I feel sad about Sir Takahashi he was close to getting the Nobel prize for his discoveries of clock mechanism in mice eventually the Nobel award was given to a fly chronobiologist.

  • @gregorymullins8873

    @gregorymullins8873

    7 ай бұрын

    where circadian biology intersects with tcm body clock theory is really really interesting

  • @shiks800

    @shiks800

    3 ай бұрын

    He should have been the winner. His work opened a lot doors in determining when we even dose drugs!

  • @youkyung-yi9857
    @youkyung-yi98578 жыл бұрын

    thank you. awesome work !

  • @dcscccc

    @dcscccc

    7 жыл бұрын

    hi. an interesting question: according to evolution fly and mosquito split off about 250 my ago. fly generation is about less than one month. so even if one generation mean only 1 new mutation we will need only 10^8 month to change his entire genome. or about less than 10^7 years. so fly and mosquito are suppose to be different in about their entire genomes from each other. far from reality.

  • @AlexWatts1992

    @AlexWatts1992

    6 жыл бұрын

    You are forgetting that any mutation may be covered by mating with a genetically dissimilar mate - an event that is MUCH more likely to occur than mating with a genetically similar individual

  • @forwardfamilyfarmer

    @forwardfamilyfarmer

    5 жыл бұрын

    My dear, most of the mutation is harmful. hence during natural selection, most of the mutation is discarded. and repair system is also repaired mutation.

  • @geofffeltham6363
    @geofffeltham63637 жыл бұрын

    Sell Human Centric and this was a fantastic presentation. I thought I knew a lot before but this elevated my knowledge to a new level.

  • @walterscott2286
    @walterscott22862 жыл бұрын

    Can't hear. Volume is too low to be able to follow comfortably.

  • @riteshmahajan5209
    @riteshmahajan52093 жыл бұрын

    just to hear the last four words, I watched this whole talk

  • @RoyalW1979
    @RoyalW19799 жыл бұрын

    Profound!

  • @vasantipunchoo3699
    @vasantipunchoo36994 жыл бұрын

    Volume low. Wish cd have the text to read

  • @jmahtab
    @jmahtab Жыл бұрын

    And then there was shift work.

  • @Acidoverwrite
    @Acidoverwrite4 жыл бұрын

    What type of Lights energy do we use to regenerate?

  • @Atravick
    @Atravick7 жыл бұрын

    So how do the master clock cells in the brain interact with all the other cells in our body?

  • @liutasx

    @liutasx

    6 жыл бұрын

    Through hormones released by brain parts connected to masterclock. Also organs have their own clock.

  • @XKong-wf5yt

    @XKong-wf5yt

    4 жыл бұрын

    By Hormones, feeding behaviors, temperature fluctuations . But this question still has no confirmed answer

  • @saxenaryan

    @saxenaryan

    2 жыл бұрын

    You can listen to Andrew huberman podcast he explores actionable protocols for these concepts

  • @willycat7445
    @willycat74456 жыл бұрын

    Volume so low

  • @susydyson1750

    @susydyson1750

    3 жыл бұрын

    try putting the volume yr phone up

  • @BijouBhaskarPadinjaraChira
    @BijouBhaskarPadinjaraChira Жыл бұрын

    🌸🌸🌸

  • @juanconeo
    @juanconeo4 жыл бұрын

    I'm the second mouse... Fml

  • @Medinalegend
    @Medinalegend4 жыл бұрын

    Arabic translate ?

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