Steady state concentration and dosage regimens - Lect 15 - Pharmacology

Lecture 15: Steady state concentration, dosage regimens, loading dose, continuous infusions, and maintenance dose. These are lectures I gave on pharmacology and pharmacokinetics at University of California - Irvine School of Medicine.
Give a thumbs up and leave a comment. More to come thanks.
View the rest of my pharmacology videos below:
(1) Pharmacokinetics & ADME: • Pharmacokinetics for S...
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: • Absorption of Drugs - ...
(3) Bioavailability: • Drug Bioavailability O...
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: • Distribution - Pharmac...
(5) Volume of Distribution: • Volume of Distribution...
------------------
DRUG METABOLISM Videos:
(6) First Pass Metabolism: • First Pass Metabolism ...
(7) Phase I Metabolism: • Phase I Metabolism - P...
(8) Phase II Metabolism: • Phase II Metabolism - ...
(9) First Order and Zero Order Kinetics: • First Order & Zero Ord...
(10) Drug Half-life: • Drug Half-life | An Ov...
(11) First-order elimination rate constant and half-life-details: • First Order Eliminatio...
------------------------------------------
DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: • Clearance and Rate of ...
(13) Renal Excretion of Drugs: • Renal Excretion of Dru...
(14) Ion Trapping: [Note Yet Posted]
(15) Dosage Regimens: • Steady state concentra...
---------------------------------------------------------------------
Factors That Affect Drug Metabolism:
(16) Enzyme Induction: • Enzyme Induction - Pha...
(17) Competitive Inhibition Overview: • Competitive Inhibition...
(18) Competitive Inhibition of Statins: • Competitive Inhibition...
(19) Acetaminophen toxicity (Clinical Correlate): • Acetaminophen or Tylen...
(20) Pharmacogenomics Overview: • Pharmacogenomics | Asi...
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
Help us caption & translate this video!

Пікірлер: 37

  • @janverendel8517
    @janverendel85174 жыл бұрын

    But where is lecture 14? I could not find it anywhere.

  • @zhannakonovalova
    @zhannakonovalova5 жыл бұрын

    So happy you posted again ! You are a great teacher, please continue!

  • @TonyCanones
    @TonyCanones5 жыл бұрын

    Thanks for posting again!!!

  • @KMartinMusic
    @KMartinMusic3 жыл бұрын

    This video was very helpful, thanks!

  • @Squishes_mama
    @Squishes_mama5 жыл бұрын

    These videos are FANTASTIC. Wonderfully helpful for my doctorate level pharmacology material!! Thank you so much!

  • @lachlanshepherd9652

    @lachlanshepherd9652

    2 жыл бұрын

    you all probably dont care at all but does someone know a trick to get back into an Instagram account..? I somehow lost the password. I would appreciate any help you can offer me!

  • @bryannova5655

    @bryannova5655

    2 жыл бұрын

    @Lachlan Shepherd Instablaster ;)

  • @lachlanshepherd9652

    @lachlanshepherd9652

    2 жыл бұрын

    @Bryan Nova I really appreciate your reply. I got to the site on google and im trying it out now. Looks like it's gonna take quite some time so I will reply here later with my results.

  • @lachlanshepherd9652

    @lachlanshepherd9652

    2 жыл бұрын

    @Bryan Nova It did the trick and I now got access to my account again. I'm so happy:D Thanks so much you saved my account!

  • @bryannova5655

    @bryannova5655

    2 жыл бұрын

    @Lachlan Shepherd You are welcome =)

  • @mbbslovers9572
    @mbbslovers95724 жыл бұрын

    I’m lucky person as i found ur channel, I subscribed 🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹

  • @bhargavi368
    @bhargavi3683 жыл бұрын

    Thank god!! Hurrah a new vedios... I really REALLY admire the way u teach... So CLEARLY, PRECISELY, INDEPTH CONCEPTS IN UNDERSTANDABLE WAY!!! This whole playlist is just PRICELESS GIFT THANK U FOR MAKING ME FALL IN LOVE WITH PHARM🙏🙏😂which I never felt it so for past 3 yrs... U are Awesome.. thank u for SHARING AND TEACHING US BY SPENDING UR VALUABLE TIME

  • @stefansabev2231
    @stefansabev22313 жыл бұрын

    For the MD ( maintenance dose ) , dont we neeed to take into account the time intervals in which the designated drug is given in order to calculate the dose rate ?

  • @poornimasharma6632
    @poornimasharma66325 жыл бұрын

    Well done...!

  • @ghaidaal-hashmi887
    @ghaidaal-hashmi8874 жыл бұрын

    Good bless you

  • @SixTough
    @SixTough5 жыл бұрын

    Thanks for a new vidjayo

  • @salam7905
    @salam79053 жыл бұрын

    very helpful thank you so much ^-^

  • @user-um1ns5rm2k
    @user-um1ns5rm2k4 жыл бұрын

    So nice 👍

  • @nuwanga88
    @nuwanga885 жыл бұрын

    Thank you for the video. It was great! One small question though. When calculating volume of distribution, aren't we suppose to take the volume or weight of fluid which is 60% of total body weight 60% of 80 = 48 kg or 48 L than the body weight itself?

  • @muskangarg4056

    @muskangarg4056

    3 жыл бұрын

    I think 60% of total body weight is total body water... Here they have already given Vd in the unit of L/kg so you just need the total body weight for calculating Vd

  • @shailivr2229
    @shailivr22292 жыл бұрын

    Is there even a video for ORAL dosage regimens (DIGOXIN) in particular; calculating steady state peaks and troughs and time to steady state. Using Ka (absorption RC) and K (elimination RC)? If not, someone please help me.

  • @DaRyteJuan
    @DaRyteJuan2 жыл бұрын

    With respect to fluoxetine, it has a half-life of 5-7 days and is therefore eliminated between 25 - 35 days after the last dose. From this video it would take 25 - 35 days to reach steady-state concentration. If the patient then starts taking 20 mg/day, does it take another 25 - 35 days to reach the next steady-state concentration? If not, what is the way of calculating that? Also, there’s inflammation that after steady-state with fluoxetine, because of the long half-life, then dosing can occur every third day.

  • @TMTeeandEmm-uc6si
    @TMTeeandEmm-uc6si9 ай бұрын

    Thank u doc ❤️❤️❤️❤️❤️

  • @DaRyteJuan
    @DaRyteJuan2 жыл бұрын

    With fluoxetine that has a half-life of 5 days, why does the patient take it every day? It would seem the patient is given more drug than s/he can eliminate and the the plasma concentration will just continue increasing with each daily dose. What am I not understanding?

  • @dharitridash2096
    @dharitridash20964 жыл бұрын

    Sir,can you please upload the lecture 14 on ion trapping..It's missing

  • @vladtyb9487

    @vladtyb9487

    4 жыл бұрын

    Winner of a video, I have been researching "preventative maintenance plan example" for a while now, and I think this has helped. Have you ever come across - Peanlivory Singular Predominance - (should be on google have a look ) ? It is a smashing one of a kind product for discovering how to learning how to start a successful handyman business without the normal expense. Ive heard some great things about it and my m8 got excellent results with it.

  • @mamyn82
    @mamyn824 жыл бұрын

    Steady state should be 94% after 4 half lives and 97% after 5 half lives

  • @zahidakhan1304
    @zahidakhan13044 жыл бұрын

    Sir , Loading dose is always given as Iv ? Nd what about Maintenance dose,it will also be given as IV always or can be given as orally?

  • @rezaayoubi9147

    @rezaayoubi9147

    4 жыл бұрын

    He said if IV is used we can use 1 as bioavailability, any route can be used but they have different bioavailability.

  • @nadiabaig4820
    @nadiabaig48204 жыл бұрын

    I've understood all your previous videos very well and they were very helpful. But this video I just don't understand as well. Please bring back the previous teacher.

  • @Deccer

    @Deccer

    4 жыл бұрын

    lol is the same person

  • @DrMalik8
    @DrMalik8 Жыл бұрын

    Sir make many more videos as you can

  • @David-xs7bi
    @David-xs7bi8 ай бұрын

    How come certain drugs can be loaded while others cannot

  • @31sabeenfatima98
    @31sabeenfatima984 жыл бұрын

    👏👏

  • @muhammadimrankhan952
    @muhammadimrankhan9524 жыл бұрын

    4.32 half lives are required to achieve 95% ss

  • @nombla1111
    @nombla11114 жыл бұрын

    I understand that you want future doctors to know that 4 - 5 half-lives are required to reach steady-state, but I want to know why. Every video that I watch says the same thing without any explanation and it is extremely frustrating because I'd like to get the big picture rather than memorizing an arbitrary number.

  • @nadiabaig4820

    @nadiabaig4820

    4 жыл бұрын

    nombla1111 yes yes and yes! I've been looking for a video like that I love learning conceptually