Pharmacodynamics: Mechanisms of Drug Action

Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target proteins to elicit a particular cellular response, and by extension a physiological effect? Let's take a closer look at this now!
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Пікірлер: 90

  • @hoooty87
    @hoooty87 Жыл бұрын

    I'm 35 years old, love science but never went to post secondary for anything scientific. This is my 4th series I've watched so far from Dave and want to watch and learn from all of them. Even things I know nothing about but still can learn even at 35.

  • @jakeblake8851

    @jakeblake8851

    Жыл бұрын

    I admire your inquisitive nature, it makes me feel guilty for leaning these because i have to lol

  • @Guidus125
    @Guidus1254 жыл бұрын

    Great video! But you mention that an antagonist leaves a receptor inactive, which is not entirely correct. An antagonist does not block the activity of the receptor but instead blocks the activity of another agonist, partial agonist or inverse agonist. An antagonist still allows 'constitutive' activity, meaning that a receptor still has baseline activity when an antagonist is bound (the baseline activity is equal to the activity the receptor would have if nothing were bound to it) Because of this, an antagonist can in some cases increase the activity of a receptor, for example when it antagonizes an inverse agonist (since inverse agonists reduce receptor activity even below its baseline activity)

  • @tcunero
    @tcunero4 жыл бұрын

    Pretty good overview. My job is to run bioassays on these types of drugs and these graphs are what I look at all day. Good explanation!

  • @tglong98
    @tglong983 жыл бұрын

    Just found your pharmacology lectures...great for my nursing class.Thanks so much.

  • @DrHongsPharmacyClassroom
    @DrHongsPharmacyClassroom4 жыл бұрын

    Hi Professor Dave! Your education video is very good! I am amazed at how you approach the Pharmacology topic. It is not an easy topic to explain even for full-time faculties at universities! Well done! Keep up the good work!

  • @sccm100
    @sccm1004 жыл бұрын

    I'm loving it these new biochemistry videos

  • @_snehaaha_
    @_snehaaha_2 жыл бұрын

    You are very clear and to the point which is exactly what I needed! Keep up the good work :')💕

  • @Asmaiq
    @Asmaiq2 жыл бұрын

    Thank you.. I share and utilize your lectures with my class...You did a wonderful job...

  • @yaayorke8980
    @yaayorke89803 жыл бұрын

    I really love and appreciate the way you lecture you make it easier to understand but please if you can slow down a little it will also do much

  • @sohayla.4
    @sohayla.4 Жыл бұрын

    You know dr Dave that I'm a Level 5 Mpharm degree student and I am using your videos to understand most of the topics, and I have been following you since I was in high school when I totally depended on your videos to understand calculus and chemistry, and I wish sir if you could expand your videos in pharmaceutical studies more to make it easier for pharmacy students

  • @JuanMUbeda
    @JuanMUbeda4 жыл бұрын

    Very clear explanation for those of us who are not familiar with the pharmacopoeia

  • @tasneembadier6790
    @tasneembadier67903 жыл бұрын

    I had a hard time understanding this topic, but after watching the video I discovered that the topic is easy. Thank you very much

  • @chipoart
    @chipoart Жыл бұрын

    I started studing degree in pharmacy and mr dave you have helped me many times without fail. thank you😊😊

  • @NurseJuliaEzeji
    @NurseJuliaEzeji2 жыл бұрын

    Just had this lecture today decided to run here for more tips! 🤗

  • @marutinandansingh3546
    @marutinandansingh35463 жыл бұрын

    Thanks for making video on pharmacology Please make more video on pharmacology and medicinal chemistry if you have time then only otherwise no need to worry just do your work accordingly

  • @lis2596
    @lis25962 жыл бұрын

    awesome! he really knows how to explain.

  • @raghadbarjas7257
    @raghadbarjas72572 жыл бұрын

    Very helpful thank you so much ☺️

  • @desireet3644
    @desireet36442 жыл бұрын

    Not sure if it’s the way he talks or the pictures in the presentation but it’s working for me 👍

  • @Jay-lq8ly
    @Jay-lq8ly Жыл бұрын

    Great video !! Thank you 😊

  • @Mariiiam
    @Mariiiam Жыл бұрын

    Continue the series please :)

  • @evelynjoh9239
    @evelynjoh92392 жыл бұрын

    am glad i found this video on time

  • @Ahmad38761
    @Ahmad38761 Жыл бұрын

    More than perfect!!! awesome. Thank you is not enough!!!!

  • @DocJoby
    @DocJoby3 жыл бұрын

    Great video.

  • @Yousefmmohammed
    @Yousefmmohammed4 жыл бұрын

    Can u please do a tutorial about cell adhesion molecules??

  • @noziphodube3956
    @noziphodube395610 ай бұрын

    Hie Professor Dave . Thank you so much❤.

  • @muallaun6509
    @muallaun65092 жыл бұрын

    Awesome ! Thank you...

  • @ronaldmukisa4897
    @ronaldmukisa48972 жыл бұрын

    Good tutorial

  • @mawada-ju6ux
    @mawada-ju6ux4 жыл бұрын

    thank you prof ✨✨🦋

  • @user-pv7wy6fc1r
    @user-pv7wy6fc1r9 ай бұрын

    thank you!!

  • @tariqhassan3046
    @tariqhassan30468 ай бұрын

    Thank you

  • @TITORIALAMHARIC2024
    @TITORIALAMHARIC20243 жыл бұрын

    nice one

  • @akshaygullapalli6500
    @akshaygullapalli65004 жыл бұрын

    Dave sir 🙏 your are awesome

  • @redgekagaoan9462
    @redgekagaoan94624 жыл бұрын

    Thanks bro

  • @ambersalt2355
    @ambersalt23552 жыл бұрын

    brilliant

  • @samuelserrykamara8648
    @samuelserrykamara86482 жыл бұрын

    Thank you very much but I want to know why stones don't enter the appendix

  • @user-riya9
    @user-riya93 жыл бұрын

    Love from India ❤️

  • @wararslaan6565
    @wararslaan65653 жыл бұрын

    Will you upload More vedios, Please

  • @gloriadaniels9320
    @gloriadaniels9320 Жыл бұрын

    I have a question..please answer me: why response is better correlated with drug exposure than with dose

  • @sipheliresanga916
    @sipheliresanga9162 жыл бұрын

    Nice

  • @graceusa3942
    @graceusa39423 жыл бұрын

    These are the best teaching. Where can I see more of your teaching about pharmacology. 😭

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    3 жыл бұрын

    check out my pharmacology playlist

  • @graceusa3942

    @graceusa3942

    3 жыл бұрын

    @@ProfessorDaveExplains Professor Dave, there are only five under your pharmacology playlist. I watched all of them. Do you have any other videos explaining drug classes? Thank you so much for your wonderful teachings. I love your explanation. They are the best on the youtube.

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    3 жыл бұрын

    I just hired a writer to expand the playlist, I'll be doing a ton more real soon!

  • @graceusa3942

    @graceusa3942

    3 жыл бұрын

    @@ProfessorDaveExplainsThank you so much, Professor Dave. I searched everywhere on youtube and found out your teachings are the best. I will be looking forward to seeing more from you. I am saluting to you.

  • @In0god0we0trust
    @In0god0we0trust3 жыл бұрын

    2:00 Oooh... I see. Facilitator drugs just activate natural cell physiology by introducing appropriate molecules, and the cells do the rest. It's kind of like CRISPR technology.

  • @kassandrachan5268
    @kassandrachan52684 жыл бұрын

    At 5:55, “covalent bonds are not necessarily required for binding to be irreversible” does that mean there are other bonds/interactions between the antagonist and receptor that can also be irreversible? If so, what are they?

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    i think even just electrostatic interactions, if numerous and strong enough, are sufficient to make binding irreversible

  • @cyh0422

    @cyh0422

    4 жыл бұрын

    Also, I think there are certain types of molecules that can interact with receptors to cause a change in the shape of the receptor, thus making the binding irreversible.

  • @MalakMalak-nl1zb

    @MalakMalak-nl1zb

    2 жыл бұрын

    @@ProfessorDaveExplains hi dr i need help

  • @ruhidyusifov5106
    @ruhidyusifov51062 жыл бұрын

    great

  • @celloivan
    @celloivan3 жыл бұрын

    We want moreeeeeee, pleaseeee

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    3 жыл бұрын

    don't worry it's coming soon!

  • @rubidelahoz8591
    @rubidelahoz85912 жыл бұрын

    So, efficacy is the ability of a drug to produce a more intense response, as its concentration is increased?

  • @veronaademaj1230
    @veronaademaj12303 жыл бұрын

    Can you write down the video what do you say, please? Because I don't know English very well and I want to translate it.

  • @tbac2432
    @tbac24324 жыл бұрын

    Professor I love all your videos. Yes some I scratch my head because I do not understand but I do go to your play list and start from the first one. But I have a question for you, How do you do the videos with out moving your hands? All I ever hear is all Italians always talk with their hands. I am kidding sir. I had to. My son was watching this video and said dad this professor is a fake Italian because he is not talking with his hand like you do.

  • @shmatan
    @shmatan4 жыл бұрын

    Do one of drugaddiction aswell

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    check my biopsychology series for that one!

  • @harrisonlubcke7998
    @harrisonlubcke79984 жыл бұрын

    nice song

  • @michaelpantopurba507
    @michaelpantopurba5079 ай бұрын

    Kesimpulan nya apa

  • @alreadymarked
    @alreadymarked4 жыл бұрын

    Professor Dave, I wonder what are your degrees?

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    BA chemistry, MA science education

  • @cutieaadi9599

    @cutieaadi9599

    Жыл бұрын

    Haha...so good man. I love your pedagogy!!

  • @silly2717
    @silly27174 жыл бұрын

    Can you please make a video on long divison please im in 4th grade and i rlly need help :(

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    i did that! check my mathematics playlist

  • @silly2717

    @silly2717

    4 жыл бұрын

    @@ProfessorDaveExplains oh ok thx

  • @jonatanabraham1859
    @jonatanabraham18594 жыл бұрын

    your hair is good

  • @Omprakash-fd2pc
    @Omprakash-fd2pc4 жыл бұрын

    Dave sir which country are you from??

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    USA

  • @cassa6474
    @cassa6474 Жыл бұрын

    someone please help I still dont understand, why would you only want to find 50% maximum effect wouldn't you want to find 100% maximum effect??

  • @kaustubhken
    @kaustubhken4 жыл бұрын

    Dear Sir please tell us how hydroxy chloroquine works against corona virus

  • @antyspi4466

    @antyspi4466

    4 жыл бұрын

    The problem is that nobody really knows if it does at all work against SARS-Cov-2. Hydroxychloroquine is used against malaria (not caused by a virus) and against autoimmune diseases. In vitro tests against SARS-Cov-2 indicated positive results, but the so far limited tests with actual patients yielded only mixed or non conclusive results (humans are after all not simple cell colonies in dishes). Further studies are currently under way. Hydroxychlorine can however have severe side effects.

  • @kaustubhken

    @kaustubhken

    4 жыл бұрын

    @@antyspi4466 india is forced to supply Hydroxychloroquine to US

  • @warlordofvideogameglitches

    @warlordofvideogameglitches

    4 жыл бұрын

    With many viruses that we have came across like yellow fever these viruses weren't effective with hydroxychloroquine. It's the reason why we require blind clinical trials with placebo to understand many of things about how it works against covid 19. But we can't do this in a slow pace because of a pandemic so some scientist are somewhat bending some rules to ensure that these drugs get to people on time. because if we did it the other way it might take 10 years for one drug or vaccine.

  • @drams8710
    @drams87104 жыл бұрын

    Do you post any video on membership..?

  • @kamogelotladi1187
    @kamogelotladi11875 ай бұрын

    how do you know everything

  • @skipinkoreaable

    @skipinkoreaable

    4 ай бұрын

    I am guessing that he was born smart, asked a lot of questions and studied very hard. Love him or hate him, he is legitimately very clever.

  • @maxruphio5515
    @maxruphio55153 жыл бұрын

    Ohhhh you cut your hair. U look good.

  • @ghitaderraz9101
    @ghitaderraz91014 жыл бұрын

    Professor Dave did u cancel these series?

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    no i'm planning more right now!

  • @jessavallespin
    @jessavallespin8 ай бұрын

    ❤❤❤

  • @thehandsomenipple3623
    @thehandsomenipple36233 жыл бұрын

    Super helpful for my internship running assays at a biotech firm. I’m gonna be needing to look at graphs like these all day, so I better fuckin understand em

  • @thehandsomenipple3623

    @thehandsomenipple3623

    3 жыл бұрын

    you never fucking fail me professor dave ur such a great guy for all subjects got me through physics and all sorts of other stuff i love ur astronomy playlist like i just love u man u have a good heart

  • @babarazamsucks
    @babarazamsucks4 жыл бұрын

    First!

  • @zeedan1412
    @zeedan14124 жыл бұрын

    First

  • @jonatanabraham1859
    @jonatanabraham18594 жыл бұрын

    second

  • @eaftadatasin4676
    @eaftadatasin46764 жыл бұрын

    i want to see your long hair again

  • @chittibabu6533
    @chittibabu65334 жыл бұрын

    I joined study buddy plan please give your gmail

  • @jonatanabraham1859
    @jonatanabraham18594 жыл бұрын

    your hair is good

  • @mryup6100

    @mryup6100

    4 жыл бұрын

    Sure is