Calculation of Steady state concentration on IV infusion
IV infusion can't bring the steady state concentration immediately and it requires at least 4.32 half-lives to achieve 95% of required Css. On the other hand, IV bolus administration can achieve steady state immediately but it can't be maintained as the drug is eliminated from the body. So, in order to achieve steady state immediately which is then maintained for the desired time period, a combination of IV bolus dose is given as loading dose along with IV infusion. For a particular drug, steady state concentration depends on the infusion rate and it can be calculated as the ratio of rate of infusion to clearance of the drug. Similarly, loading dose is the ratio of rate of infusion to elimination rate constant.
0:00 Introduction
0:07 Steady state concentration
2:40 Solution to Working example 1
5:05 Solution to Working example 2
7:13 Solution to Working example 3
9:53 Calculation of loading dose
Пікірлер: 31
How i missed ur channel, it's really heaven
you are simply heaven sent! Thank you so much.
One of the good example for clinical pharmacokinetics exercise
very clear and well articulated. Keep the good work
I can't thank u enough..thank u soo much sir 🙏
Thankyou so much sir very clearly you explained
8:20 Could sir please explain how we got 3.32 relative 90% , though I know how we got the 95's and 99's%
Great job
Very clear explanation.... can you please share a video on how to make a template for NCA calculation?
Thanks Piece of cake
3:43 Hi, shouldn't we divide 10 by 60 since we are moving from minutes to hours, giving us 0.1666666667 hr?
@kartikmittal8138
Жыл бұрын
It's not like changing unit of min to hr , instead its changing rate like how much clearance is there in 1 min? so for 60 min we have to multiply it by 60 hence 1 hr.
Thnx,Sir
Good job👏.
@egpat
11 ай бұрын
Thank you!
Sir if time required to acheive steady state depends on elimination half life then why we give loading dose to acheive steady state rapidly how it is possible?
Do all drugs need to achieve the steady state concentration after 4-5 half life in order to see the therapeutic effect ? Doesn't ibuprofen produce its effect from a single dose without 4-5 half life ?
@egpat
4 жыл бұрын
Therapeutic effect is not related with steady state concentration where the former is observed whenever the drug level in the blood raises above minimum effective concentration. But steady state is level of drug in the blood which is constant for certain duration during which we introduce the drug. It can be achieved by either IV infusion or multiple oral doses.
Sir do lecture video on how to maintain steady concentration, what is loading dose ,maintance of dose , compartment models??
@egpat
4 жыл бұрын
Sure
Sir, would you please explain what is narrow therapeutic index clearly
@leenaghaeb4747
3 жыл бұрын
It's when a drug leads to serious adverse reactions. such as chemotherapy/cancer drugs their therapeutic index is very small. the wider the therapeutic index, the less toxic events for the patient
Very helpful! thank you
@egpat
3 жыл бұрын
Glad it was helpful! Thanks for watching
How cl =ke×vd can you ecplain or tell the source
Drug concentration = boomg to be given IV each 8 houre · Ty₂ = 6 hours, vd = 0.75 W/he. Cone at steady state 35mg, what is the infusion rate to be given Per hour to reach stready state Conc.
@vigneshwaranravichandran9563
3 жыл бұрын
Please answer for this question
so can Cmax of an IV bolus be called as the steady state plasma concentration of that drug?
@egpat
4 жыл бұрын
Steady state can't be achieved by single administration such as IV bolus or single oral administration. In both of these Cmax can be achieved but it is not maintained for significant amount of time due to elimination. Steady state can be achieved only by either continuous IV infusion or multiple oral administration where rate of input it equal to rate of output.
Can I email you??