Glad you pointed out food sources which far outway the amount provided by expensive supplements.

i have concluded tht u can given anything to mice and they will live longer.

@Sonia-zq9ek

2 жыл бұрын

LOL 😂

@TheChristopherBlake1

2 жыл бұрын

LOL 😂 LOL 😆 LOL 😝 EXCEPT, D-Con of course.

@asdnetwork4268

Жыл бұрын

Give them water. Boom, live longer. Give them food. Boom, live longer, give them Gameboy advance, boom live longer.

@chriswright2483

Жыл бұрын

Lol 😂!

@wmp3346

Жыл бұрын

Very scientific 🧪

Weight lifting trigger autophagy too without fasting

Thanks for providing this info!

Great info, thank you!

Great video and excellent use of language. Too many of the healthspan videos bury you by going round in circles with brain numbing advanced microbiology terminology. You have a great skill with language and simplfying the language. Thank you & keep it up. John Hancock

@LanceHitchings

3 жыл бұрын

Thanks

@sncnutrition7118

8 ай бұрын

​@@LanceHitchingsGreat video. Would love to know your thoughts on this article. Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study. It's on Pub Med Central. I personally had great results on 10mg of Spermidine 3cHcl by doublewood. I did just order the one u recommended in this video.

Great video. Thanks.

There is one animal product that is high in spermidine. Wikipedia says wheat germ has 243 mg per kg. Coming in second is aged cheese (at least one year) has 199 mg per kg. Soy beans come in at 128 mg, while mushrooms have 89 mg. Costco sells a cheap three year aged Vermont Cheddar. That is more palatable than wheat germ, or soy beans. Of course, mushrooms are palatable too, with fewer calories and fat. But you need twice the volume of aged cheddar to get the same spermidine.

@cizcalodiablopanzon

Жыл бұрын

I don't know how much spermidime i am getting but I add one tablespoon of wheat germ and half a spoon of wheat germ cold press oil to my morning shake

@62halee

4 күн бұрын

Wheat germ is delicious in milk.

My goodness found you, excellent

Excellent, informative video, presented well, as usual. Thanks

@LanceHitchings

3 жыл бұрын

Thanks again!

I've been trying to convince my wife of this for a long time.

You said that autophagy creates additional "energy" in our cells but autophagy recycles cellular components (proteins). Energy is supplied by the blood from the liver and consumes the body fat to do so. Mitochondria are rejuvenated by autophagy and become more efficient and thus may become more energetic.

I just want to note that on the spermidine life product that you're pitching, the ingredient label doesn't even use the word Spermadine, it's most active ingredient is declared as 800 mg of wheat germ extract, sure enough, wheat germ extract does indeed have spermidine in it, but there is no indication of how much spermAdine is actually in each dose. Inshort 800mg of wheat germ extract does not equal 800 mg of spermidine. Also, It would be nice to know how much spermidine is effective in starting autophagy.

@johnjallen

Жыл бұрын

You can buy wheat germ from the store and eat it by the spoonful. Very cheap and easy.

@karlfillmore57

Жыл бұрын

@@johnjallen Yep. Sprinkle a couple of tablespoons full on your salad and use plenty of olive oil for bio-absorption.

Thanx alot 🙏😌There are more to consider than just diet & fasting mental health.. Avoiding Toxic ppl..

@Viv8ldi

Жыл бұрын

Would u donate me some natural spermidine?

Aged cheese also has a lot of Spermidine, like Cheddar or Blue cheese.

Just a correction. Autophagy is not latin. It is Greek :-)

@LanceHitchings

3 жыл бұрын

Good to know. Thanks.

@ThaUnseenTruth

3 жыл бұрын

@@LanceHitchings “Elevated levels of polyamines have been associated with breast, colon, lung, prostate, and skin cancers,” www.ncbi.nlm.nih.gov/pmc/articles/PMC4027058/ “The polyamines spermine, spermidine, and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties. Dietary polyamines have important implications in human health. [...] “The antioxidant and anti-inflammatory effects described for polyamines can play an important role in the prevention of chronic conditions such as cardiovascular diseases and diabetes. On the other hand, cancer is associated with high levels of polyamines, brought about by an alteration in their homeostasis.” www.frontiersin.org/articles/10.3389/fnut.2019.00108/full

I have taken Spermidine for short while and i have better mental clarity. Thanks for the info!

@ahsanriazkhan3068

2 жыл бұрын

Desit help to verse gry hair

@hamid237

2 жыл бұрын

@@ahsanriazkhan3068 Actually it has helped with hair regrowing a little bit. It has to be taken for a long time to see all the benefits.

Love the video! Thoughtful and informative. Thanks :)

Love your content

@LanceHitchings

2 жыл бұрын

Thanks.

@erwinrogers9470

2 жыл бұрын

@@LanceHitchings Absolutely

What do u think about grape seed extract?

Fasting + Spermidine works. 16/8 approach + Spermidine before bed (1mg to 3mg)

@Viv8ldi

Жыл бұрын

Does 16/8 mean 8 hours of fast? Like during sleep? Do u have to take spermidine while u are fasting?

Thats important information

im going to be taking spermidine at night when I just begin my intermittent fast, I think it will work more naturally that way and I was thinking the same thing about rapamycin! Maybe if you're taking spermidine your rapamycin intake would not need to be so frequent and taking rapamycin on one of the days you take spermidine would make sense. Maybe once a month or every other month rapamycin.

@JoeMama-ud5eh

6 ай бұрын

How did get rapamycin?

Trehalose also increases autophagy. I welcome your comment.

Hi Lance Nice video. I can take spermidine with NMN? thanks

Any thoughts on prepared HuShuWu ?

Excellent video.. Don't want to be petty.. But please note that autophagy is a Greek word:The term 'autophagy' comes from the Greek words 'phagy' meaning eat, and 'auto' meaning self

@LanceHitchings

2 жыл бұрын

No problem. I love it when people point out something that I've gotten wrong. How else will I learn?

Sadly , currently, commercial spermidine comes from wheat germ oil, which usually contains Gluten. Not for Coeliacs (Gluten allergy) like me.. Does anyone know of a product where spermidine is isolated from other sources?

What about lkm512 probiotic which induce endogenous spermidine production ?

Спасибо

So could it be said that aciding of the body causes aging in general?

When is the best time to take spermidine? Without or with food? :) Thanks

I take Ultra Spermidine 700 mg . Can you take spermidine with NMN?

the evidence - particularly the pre-clinical one - is fascinating. But it seems to me that a normal diet will provide all the spermidine I need (and for $95 I can buy a lot of good food).

@michaelharrison9340

3 жыл бұрын

"normal" doesn't mean the Standard American Diet of course

@giannibravo347

2 жыл бұрын

@@michaelharrison9340 thats a lot of special miracle mushrooms :)

We don't need one more course. We need current research to stay up to date.

@LanceHitchings

3 жыл бұрын

I was unaware that there are currently ANY courses available on longevity. Links, please.

What about daily dosage

"And what about fasting while taking spermidine"? Anything new on this? Spermidine and fasting seems like a good combination. I take wheat germ extract as a source for spermidine to induce autophagy. Does anyone know if the extract would break a fast if taken during a fast?

@Viv8ldi

Жыл бұрын

Ofcourse all the good and interesting questions and those that might change something will not be answered sadly

@cococgb5389

Жыл бұрын

I would think anything that needs digestion would break a fast

Hello...with regard to autophagy. It is proposed that senolytics be applied intermittently for maximum/safe effect. Spermidine, as part of diet would be taken continuously....how do you reconcile this?

@LanceHitchings

2 жыл бұрын

As I understand it, spermidine is not a senolytic. It does impact senescence because autophagy makes cells more healthy and less likely to become senescent in the first place. I guess I don't see the conflict.

@bshul10

2 жыл бұрын

@@LanceHitchings Thank you....got my definitions straight...senolytics destroy senescent (non functioning) cells....autophagy agents cleans out waste products from functioning cells.

@bshul10

2 жыл бұрын

hello, I think we should be careful with spermidine supplementation for at least two reasons. Spermidine effects cardiac potassium ion channels in the direction of promoting atrial fibrillation. Additionally spermidine is competitive for the activity of DAO which increases histamine exposure. i have the references.

@kimcantswim174

2 жыл бұрын

@@bshul10 So it isn't safe?

I started eating aged Gouda cheese because it was supposed to have spermidine in it. Have no idea if it is causing autophagy. But it greatly improved things in the bedroom if you know what I mean. Who knows if there was some other compound in aged Gouda but I would say give it a try if you are over 40.

@LanceHitchings

3 жыл бұрын

Great tip, thanks

@lotzen8524

3 жыл бұрын

Take Minimum 12 months aged Cheddar not Gouda

@ManageDeMaia

2 жыл бұрын

Gouda has a lot of mk-4. That should have some effects on testosterone.

@mikelance7175

2 жыл бұрын

@Admiral Nelson I thought eating too much dairy cause cancer is it called the China study or something

@melinakoufalis281

Жыл бұрын

I just had gouda tonight lol

Memo: there is a connection between autophagy and learning memory

Every Spermidine supplement, that I have found, seems to be derived from wheat germ. I have steered clear so far, because I have celiac disease and I doubt that they are GF. Agmatine Sulfate is a precursor to Spermidine. I take this supplement in my preworkout. Do you know how effective this would be in increasing Spermidine and do you know if Spermidine is GF?

@timh-c7186

3 жыл бұрын

"spermidineLIFE® includes approximately 1.3mg of gluten per daily dose. Please consult with your physician to determine if spermidineLIFE® fits within a gluten-sensitive diet."

@scottmiller2591

3 жыл бұрын

Ditto if you are on keto.

@Scottlp2

2 жыл бұрын

Supersmart spermadine (amazon has it) sells spermamdine from rice extract

@rdance3

2 жыл бұрын

@@Scottlp2 Thanks!

@marlenecampbell5439

Жыл бұрын

I seen one on Amazon made from rice in a black jar. Also double wood makes one that is chemical not made from wheat.

If spermidine activates autophagy, can you eat regularly?

I went to their website and chatted wit the rep. She stated that this is not a fast acting supplement and requires a build up to work. wow! imagine activating autophagy 24/7 instead of just sometimes. If this is true, this is a really bad idea.

@LanceHitchings

3 жыл бұрын

Not as bad as never activating autophagy. Most people have so many nutrients from constant over-eating that they never activate autophagy. And I don't think that you can activate autophagy 24/7. But that's my opinion, not scientific fact.

@tomwoodall1463

3 жыл бұрын

@@LanceHitchings yes, but there are other ways to only sometimes activate autophagy. Doing it all the time is not a good idea. According to the rep I spoke with, this activates it all the time..

Many of us use broccoli seed sprouts for the Sulphoraphane (spelling?) Content. Are you aware of broccoli seed sprouts being a good source of spermidine as well?

@Libertas_P77

3 жыл бұрын

They are not especially high in spermidine. The highest natural food source by a long way is wheat germ. A few teaspoons a day is what I have added to my diet.

autophagy is a totally greek word, not latin. Αυτοφαγία (autophagia) means as you said self-eating.

@LanceHitchings

Жыл бұрын

Yep, misspoke.

I am sceptical that enough spermidine could be dosed in the few milligrams that are contained in spermidine supplements. And, the amount of food you would need to eat to get a therapeutic dose would obviate the benefits of fasting. I believe that larger amounts (therefore cheaper) would work better on an intermittent fasting schedule. But, really, it's way too expensive.

Watched this

Tiny correction, autophagy is Greek, not Latin.

Is all spermidine created equal?

But I like fasting.

Some say that spermadine trihydrochloride is toxic, but some companies use it, and I haven't seen good studies proving that it is harmful. If anybody has any, please post.

@LanceHitchings

2 жыл бұрын

That's interesting, I hadn't heard that. If you learn more, let me know.

@birage9885

2 жыл бұрын

@@LanceHitchings Will do, and if you find out more, please make a video. If it is safe, it is far cheaper. DoubleWoods has that in their spermadine supplement, and they say it is safe.

Blue Stilton cheese has spermidine? Another video says that.

Bro why r u asking us for info? We're here to get info from u 😭

@LanceHitchings

2 жыл бұрын

Because this is a community. I don't know it all, not nearly, and I'm always learning something new by reading the comments on this channel.

Rapamycin/Rapamyacin? Unsure on what it is called/how it is pronounced…? Getting my spermidine from aged cheese :-)

@lotzen8524

3 жыл бұрын

Aged Cheddar (Minimum 12 months) or better Wheat germ

@iblisthemage

3 жыл бұрын

@@lotzen8524 aye :-). I have a cheese box in the fridge, I get about 70-100g a day of Cheddar, Pamadano, Harvarti, etc, all aged at least 12 months. I eat low (no) carb due to prediabetes, so no wheat germs for me. Also, I really like my cheese 😎

Memo: it can be created by tissue or bacteria

Skip to 1:30

Memo: autophagy=selfeating

Does anyone know who this guy is?

@jonduringer5848

3 жыл бұрын

A friend of mine (IRL) for a few years.

@LanceHitchings

3 жыл бұрын

Thanks, Jon!

@scottpreston5074

2 жыл бұрын

Someone worth listening to.

Memo: spermedine is a polyamine

According to Dr. Greger the best, cheapest source is Wheat Germ. I will never argue with him!

@LanceHitchings

7 ай бұрын

Yeah, but you'd have to eat so much wheat germ to do any good that your caloric load would be through the roof.

@radic888

6 ай бұрын

Actually, on Dr Greger's list of spermadine sources, wheatgerm is not on the top of that list.

@danluther1741

6 ай бұрын

@@LanceHitchings Interesting. According to the National Institutes of Health (NIH) Wheatgerm is an excellent source.

I like the way you explain things in such a straightforward manner, repeating the important bits but I gave up all drugs to avoid the vivisection and torture of innocent animals and yet I find there is just as much torture of creatures that would normally be our pets justified in research of supplements! It is horrific and a unacceptable. If we just ate the way our grandparents did and stopped relying on the pharmaceutical industrial complex we would be healthy and not torturing adorable little sentient beings to make up for our lazy addicted food habits. So sad! The number of animals being tortured in the name of a renamed virus and vitamin D3 deficiency is heartbreaking and nobody should accept injections based on such appalling cruelty. I buy supplements that Are not tested on animals but what is the point if they rely on research based on unscientific unnecessary animal cruelty. ? When human beings manage to destroy themselves completely with their greed and gluttony, the planet will be a much better place, peace on Earth will be reinstated without humans. We do not have to be like this, there is still time to change But change does not come with mandated injections! Thank you Namaste 🙏

@forgodsolovedtheworld3389

Жыл бұрын

Jesus Christ will bring peace to the earth when He comes to rule what's left of it and humanity after the Great Tribulation. His rule will be just and fair and He will restore the planet to its previous glory after the end of His glorious 1000year Millennium reign. Seek the Lord whilst He can still be found...

No wonder my gf looks so young!

Well if u hate to fast and the pain that comes with it maybe u dont deserve to live longer? No pain no gain baby

Just buy aged cheddar. Much tastier and cheaper than supplements.

@LanceHitchings

Жыл бұрын

True, but the amount of cheese you'd have to eat to get a therapeutic dose would be rediculous.

hi can you post a link here teaching how to use these overly contrived head movements when conveying ideas ? thx

@duncano74

3 жыл бұрын

bet you're fun at parties

@jayhillz3705

3 жыл бұрын

😝

🤔😂🤔😂🤔😂

Autophagy is Greek not Latin.

fisetin from strawberries

Are you kidding?? Never heard 24 hours for autophagy. Starts at 18 is the common belief.

@radic888

6 ай бұрын

Actually, he's right about the 24 hrs.

Anybody ever tell you you remind them of Louis CK?

I get mine from 'swallowing' :)

@dianeditonno3569

Жыл бұрын

Supercal333. I can see why you hide your identity.

@mattbarnett6156

Жыл бұрын

Someone had to say it.

Look we all know everyone is curious about spermadine because it has the word Sperm in it ...

I like your videos but I think they can be a lot shorter, you repeat a lot of stuff and could speak faster or have faster cuts.

@tomlwallace

3 жыл бұрын

I think the depth and length are just right

@radic888

6 ай бұрын

I'm guessing you're a GenZ.

Blue Stilton cheese has spermidine? Another video says that.