SIRT6, FUCOIDAN & LONGEVITY: Will Activating SIRT6 Extend Your Life? [2021]

Ғылым және технология

SIRT6 & FUCOIDAN: In today's video, we examine the new paper that just came out on activating SIRT6 and the supplement extracted from seaweed that activates it.
We'll do a quick review of what sirtuins are and how they function before jumping into the new paper that was published last month on SIRT6. Prof. Haim Cohen and his team extended the lifespan of both male and female mice by as much as 27% (or over 30%, depending on who you believe). Then, after discussing the activation of sirtuin 6, we'll talk about Prof. Vera Gorbunova and a new supplement that she has discovered which she claims will do just that...activate SIRT6!
Prof. Cohen's study has galvanized the longevity community, so join us as we take a deep dive into this innovative new intervention.
Chapters & Timestamps:
00:00 Intro
02:21 Sirtuin In The News
04:08 Sirtuins: What Are They & How Do They Function?
10:00 SIRT6 Extends Lifespans In Mice
14:38 Activators Of SIRT6
17:01 Fucoidan & DoNotAge
**************************************************************
LInks to studies in this video:
www.nature.com/articles/s4146...
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/28355...
pubmed.ncbi.nlm.nih.gov/33308...
pubmed.ncbi.nlm.nih.gov/33934...
pubmed.ncbi.nlm.nih.gov/33684...
**************************************************************
SOCIAL MEDIA LINKS:
Facebook: / lancehitchings
Instagram: / lancehitchings
Twitter: / lancehitchings
**************************************************************
AFFILIATE LINKS:
Discount code for DoNotAge: LANCE
Product Links for DoNotAge:
SIRT6Activator: donotage.org/products/sirtuin...
Annual Subscription: donotage.org/subscribe/
Products : donotage.org/products/
Discount code for Alive By Science: LANCE10
Product Links: alivebyscience.com/all-produc...
Discount Code for Perfect Amino: HITCH10
PerfectAmino Drink Powder link: affiliates.bodyhealth.com/idev...
PerfectAmino Tablets link: affiliates.bodyhealth.com/idev...

Пікірлер: 204

  • @LanceHitchings
    @LanceHitchings3 жыл бұрын

    OK, I looked into this further. Fucoidan is not the name of a specific chemical substance, but rather the name for a class of substances. There are several different types of fucoidan, each with different molecular structure and different properties. Fucoidan refers to a type of polysaccharide that contains substantial percentages of L-fucose and sulfate ester group, but can also contain other monsaccharides, including mannose, galactose, glucose, xylose, etc. plus other compounds like uronic acids, acetyl groups and proteins. What type of fuciodan a compound is can depend on the type of seaweed that is was extracted from and the method of extraction, to name a few. Check out this page for a small selection of the different types of fucoidan: www.zenmony.com/types-of-fucoidan-f-u-l-g-ga-a27/ So, there are many different types of fucoidan, each with it's own distinct properties. In light of this, it's not too difficult to see why it can be so hard to find fucoidan that can activate SIRT6. Hope this helps.

  • @MarmaladeINFP

    @MarmaladeINFP

    2 жыл бұрын

    Thanks for the info. I watched this video when it first came out. And I've been curious about the Do Not Age product. But I haven't tried it. I keep hoping to hear more info about SIRT 6 activators, specifically in humans.

  • @drosphiliamelanogaster3755

    @drosphiliamelanogaster3755

    Жыл бұрын

    Have you seen EndoCalyx TM? It has been used in research papers. I'm not sure if it has been able to be standardized.

  • @peterdavila3045
    @peterdavila3045 Жыл бұрын

    Great video, thank you. I just ordered the Sirt6 Activator. I currently take Pure Apigenin, Fisetin and CA-AKG. I also take Metformin, even though I do not have Diabetes. I'm 2 months from my 68th birthday. I'm in great health and I have lots of energy. I go to the gym 5 days a week and do weights and aerobics exercising for about 2 hours each day. I love life. Live long enough to live forever!

  • @ConnieWobbles

    @ConnieWobbles

    Жыл бұрын

    No NMN?

  • @peterdavila3045

    @peterdavila3045

    Жыл бұрын

    @@ConnieWobbles Not currently in the budget.

  • @ConnieWobbles

    @ConnieWobbles

    Жыл бұрын

    @@peterdavila3045 I do sympathise as I'm in the same boat. I'm on a low income myself and struggling to afford these longevity supplements, but personally I think NMN is one of the most important. I suppose exercising will help boost NAD levels and maybe taking some dried parsley to keep your cd38 levels down could also help.

  • @Noegzit

    @Noegzit

    9 ай бұрын

    Not sure if metformin is really so great. I don't remember where exactly I saw that but apparently the effect on healthy subjects longevity is null and the study showing metformin increases longevity on diabetic subjects has some flaws. Metformin could also be detrimental: each drug has its side effects. And metformin should be avoided on days you have a workout, 5 days a week in your case. I you assume metformin could help by reducing blood glucose (by limiting glucose production in the liver) maybe you could replace metformin by a low-carb diet and/or a 1 or 2 days fast every now and then.

  • @peterdavila3045

    @peterdavila3045

    9 ай бұрын

    @@Noegzit I just got the results of my epigenetic age test. Epigenome at 57. Chronological 68.

  • @franklanham6936
    @franklanham69363 жыл бұрын

    CONGRATULATIONS Lance! I think your decision to create a longevity course and charge for it in order to support your work on KZread is brilliant. Your current videos bring all the detail of the complex chemistry and biology of longevity down to a level of understanding better than anyone else on KZread. I know it takes a lot of time and work to do that, and I’m glad to support you in your ongoing efforts. This will, no doubt, be a win-win for everyone. You get support and your audience gets a pre-digested source of understanding and information for the ongoing longevity research and the resulting practical capabilities being produced in this complex field. Here are two aspects of the course that I personally would like to see. First, I would really like to have the course content available in some “printed” form in addition to or instead of video. The amount of information involved and its complexity are very large, and just having a video to watch in order for me to mentally capture everything is not adequate. If only video content were presented, I’d have to spend a large amount of time taking notes and creating complex diagrams that I could use for study and review to ensure that I can confidently reason about what I should be doing to extend my own longevity. Ideally, the course would be presented both in video and in a printed format, such as PDF. If that were done, we students could view the video first to get the big ideas involved, and then study the text and diagrams to cement the details in our heads. Second, a hybrid of one-time purchase and a subscription model of pricing might work well. A person could buy the course to get the first version. The course would have to be updated occasionally, maybe on a quarterly basis, in order to keep up with the rapidly evolving field. So a person could either re-buy the course at full price whenever they think it’s worth doing, or they could subscribe to updates after they have purchased the full course so they could have lower cost access to the updates on a continuous basis. And if you really want to confuse everyone, you could also create two tiers of the course - one lower cost tier of video-only, and a higher cost tier of video and printed material. I’m not trying to tell you how to run your course, Lance; I’m just casting my vote for course features I’d like to see. However you do it, I’m sure it will be a major contribution to the many people who don’t have PhDs in this field but still want to understand it in order to extend their lifespan and healthspan. Thanks so much for doing this!

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    Thanks, Frank. You have no idea how gratifying it is to hear your type of comment. I really wasn't sure how well such a course would be accepted by this community. FYI, I'm planning on including in the course a number of PDFs that would contain additional information. For example, rather than list all of the supplements that I take in the video, which would be boring to listen to, I'd list them in a PDF. I'd also provide PDFs of any charts or diagrams that I use in the video. But I could also include a PDF of the script, perhaps broken down into bullet points for easier reference. With regard to your second tip, I was planning on making the course be available to anyone who signed up for it for life, including regular updates as more information becomes available. But I might like your idea better. I'm really looking for feedback from this community, I want to course to be what they want. I'll probably offer the first edition of the course at a discounted price, on the condition that everyone give me feedback regarding what else they'd like to see in the course, and then that revised edition will be version 1.0. Thanks for the feedback!!!

  • @stephenconnors6848
    @stephenconnors68483 жыл бұрын

    Great. As a newbie, there's a lot more I don't know than what I do know. Paying you for your knowledge saves me time and eliminates the wasted efforts. I look forward to it.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    I assume you're referring to my announcement about my online course. It'll have the most important info in one place, arranged in a flow that will be easy to follow and understand. Might come out in a couple of months.

  • @stephenconnors6848

    @stephenconnors6848

    3 жыл бұрын

    @@LanceHitchings Awesome

  • @manuelojeda9144
    @manuelojeda91443 жыл бұрын

    You're doing a great job.

  • @starryfolks
    @starryfolks2 жыл бұрын

    Great job sir. Truly inspirational. Probably the coolest thing to do at that age. I just turned 20. Any advice would be wondrous, although this KZread channel is more than enough...hope it grows virally.

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    Thanks. I hope so, too!

  • @danno1800
    @danno18002 жыл бұрын

    Great job getting her information! Much appreciated…

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    You're very welcome, indeed.

  • @Mrstevebro56
    @Mrstevebro563 жыл бұрын

    The work you are doing is wonderful. Your course will be a great value. Sign me up.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    Awesome, thank you! I let you know once I get closer to publication.

  • @davidvesco9101
    @davidvesco9101 Жыл бұрын

    Great lecture excellent information I will follow your podcasts Thank you

  • @LanceHitchings

    @LanceHitchings

    Жыл бұрын

    Welcome!

  • @anngraves6917
    @anngraves69173 жыл бұрын

    Great video Lance.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    Thanks

  • @glennthorn367
    @glennthorn3673 жыл бұрын

    I have been taking this supplement from ,DO NOT AGE, I have noticed a big increase apatite over the past 3 weeks and lots of energy

  • @happyfriend703

    @happyfriend703

    3 жыл бұрын

    make a video ,keep us updated somehow

  • @LeslieAlysonLawrence

    @LeslieAlysonLawrence

    3 жыл бұрын

    I started taking SupaFuco fucoidan chewable tablets from Tasmania and this has also increased my energy and appetite. If it’s a fucoidan that doesn’t activate my Sirt6, I have no idea, but it’s given me a lot of energy and costs way less than the DoNotAge product, which I can’t afford.

  • @glennthorn367

    @glennthorn367

    3 жыл бұрын

    Good Thinking

  • @johnbielenda7336

    @johnbielenda7336

    2 жыл бұрын

    @@LeslieAlysonLawrence I will give it try, thanks.

  • @oibal60
    @oibal60Ай бұрын

    Thanks again.

  • @tomlwallace
    @tomlwallace3 жыл бұрын

    Once again, if a function is good for you, you can probably activate it fasting. Thanks for this video!

  • @petermalmgren1207

    @petermalmgren1207

    2 жыл бұрын

    Good comment : thanks

  • @petermalmgren1207

    @petermalmgren1207

    2 жыл бұрын

    I need to know if resveratrol turns on mtor and can we build muscle in a different pathway

  • @olyav5819
    @olyav58193 жыл бұрын

    Thanks for your video. I would be interested to learn more about your course.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    I'll probably be putting up a video about the course in the next month or so. The course itself won't be ready for about 2 or 3 months.

  • @trankhang1308
    @trankhang13082 жыл бұрын

    I ' m come form vn. Thanks Lance..!!

  • @siselintl
    @siselintl2 жыл бұрын

    Awesome information, thanks for the hard work and research you put into all your videos, Lance! We have a video in which we talked about fucoidan's activation of sirtuins and some other health aspects of fucoidan, as well. Would love to hear your feedback. Thanks!

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    Watched the video and enjoyed it. Left a comment. Thanks.

  • @petermalmgren1207

    @petermalmgren1207

    2 жыл бұрын

    We actually need to know how our exercise effects sirt 6

  • @edisonclaro5363
    @edisonclaro53633 жыл бұрын

    please send more informations about your course. I will do . you are a very honest man.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    It'll be at least 2 or 3 months before I have anything, but as soon as I do, I'll let you know. Thanks for the encouragement.

  • @petermalmgren1207

    @petermalmgren1207

    2 жыл бұрын

    Lancer is the top

  • @shy-guy5544
    @shy-guy55443 жыл бұрын

    Excellent explanation of sirtuins, in particular, SIRT6. Thanks

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    You are welcome!

  • @Pluvo2for1
    @Pluvo2for13 жыл бұрын

    I wish I could afford it too Lance! Anyway the sirt info was nicely detailed thank you. I can see what Brad has given up on reservatrol as it seems to only activate sirt1.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    My pleasure.

  • @MyLongevityExperiment

    @MyLongevityExperiment

    3 жыл бұрын

    and it promotes hormesis

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    @@MyLongevityExperiment Hi, Vince! Yes, it does.

  • @reforesters
    @reforesters2 жыл бұрын

    Great video and I appreciate your pinned comment. Anyhow, there is one little piece of info missing: which type of fucoidan is the type that works? Any ideas, or is this unknown by everybody except those in Prof Gorbunova's lab?

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    Probably. I sure don't know, at any rate.

  • @simonmojarad4806
    @simonmojarad48063 жыл бұрын

    Hi Lance. Thanks for the work. Please provide a Patreon or other contribution link. Thanks!

  • @erwinrogers9470
    @erwinrogers94702 жыл бұрын

    Wow 🔥

  • @zeropain9319
    @zeropain93193 жыл бұрын

    Great video lance. I've watched some of the other peoples videos and I was confused as well. And it seems like there is still some confusion remaining. I'm suspecting the researchers are now influenced by $$$ and might be making some less conservative claims. Thanks for sorting through all of this and boiling it down to 20mins. It must have taken you a long time! I'm going to wait a few more months for more coherent results. One question. If NMN activates all Sirtuins, why bother with Fucoidan? Or is it that NMN only activates the de-acetilysation part of SIRT6?

  • @paulwolf3302

    @paulwolf3302

    3 жыл бұрын

    Fuciodan is dirt cheap. This company is pretending to have a special kind of fucoidan. That's BS.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    See my pinned comment.

  • @rmondave
    @rmondave Жыл бұрын

    Any human studies yet defined, and/or done for how well SIRT6 works on humans?

  • @manuelojeda9144
    @manuelojeda91443 жыл бұрын

    My life time is INVESTED in my PIANO. I LIKE YOUR INFO TO ESTEND MY LIFESPAN.

  • @manuelojeda9144

    @manuelojeda9144

    3 жыл бұрын

    Extend

  • @crafter2u
    @crafter2u10 ай бұрын

    problem is i live in the Philippines and if i order from do not age the cost ends up tripling

  • @christopherellis2663
    @christopherellis26632 жыл бұрын

    SIR2in, 1-6 Mine must be working well. Began going to the gym for the first time in 40 years. Seems easier than before. Fucoitin?

  • @AnnAnn-il2lk
    @AnnAnn-il2lk Жыл бұрын

    Where can u order this product

  • @ealeisa1
    @ealeisa13 жыл бұрын

    Hi Lance, is there a requirement to take a NAD+ supplement along with this Sirt6Activator ? Thanks

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    No, there's not. But it makes sense to me. However, depending on your age, there are different strategies to use to make sure that you NAD+ levels are on target. I'm becoming less and less convinced that NMN or NR is the answer most of the time. See this video: kzread.info/dash/bejne/ep1_tsN8gcS2Z5s.html

  • @ratherrapid
    @ratherrapid3 жыл бұрын

    are we to take Ms. Gorbunova at her word or is there some evidence out there that Fucoidan supports Sit 6?

  • @paulwolf3302

    @paulwolf3302

    3 жыл бұрын

    You have to take her word that she has a special kind of fuciodan, even though she doesn't explain why her fuciodan is different from the fuciodan you can buy by the kilogram.

  • @albardo08

    @albardo08

    2 жыл бұрын

    No human evidence at all. She is paid handsomely by the company that sells the product.

  • @Always-xl9db

    @Always-xl9db

    Жыл бұрын

    We have to take her word, yes, despite it’s evident that her “special” fucodian did not have any anti-aging effect on her, specifically….like, at all 😅

  • @chris-lk4ml
    @chris-lk4ml2 жыл бұрын

    Great video for learning. I am like you, searching in sites for studens of pharmacy, biology and so on. I am reading books for students, and ... Ill have a look on your offer. By the way, Im in contact with do not age too, because I havnt an answer on my questions jet. They offered me a phone call which is really nice! Maybe I will try their product.

  • @rodgerknight9646
    @rodgerknight96463 жыл бұрын

    Hi Lance: Thank-you for your work on this video - would you mind sharing the discount code for the DONOTAGE product -

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    LANCE

  • @luckssj
    @luckssj2 жыл бұрын

    1st what is your code and 2nd what other products are available to use for SIRT6

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    My code is "LANCE". I not aware of any other products that can activate SIRT6.

  • @libertysong1
    @libertysong1 Жыл бұрын

    Resveratrol activates SIRT6 does it not? The french paradox & subsequent investigation into said "paradox", lead researchers to the polyphenol RSV.

  • @user-ts4gw2dx8f
    @user-ts4gw2dx8fАй бұрын

    Anthocyandin(iirc) is the best SIRT6 activator by like 13x. Found in dark berries, elderberries have highest concentration. Even at 13x the next best, it is tiny on the grand scale. Some might say a fools errand.

  • @mathewdani5474
    @mathewdani54744 ай бұрын

    There are many molecules considered giving longevity. Like taurine, metformine, glysine, nac, creatine, resveratrol,nmn, ca akg etc. All these can be swallowed together or should maintain a distance minimum time between each molecule

  • @LanceHitchings

    @LanceHitchings

    4 ай бұрын

    IMO, it's more important that you take the fat soluble ones with a meal. Other than that, I'd simply follow instructions.

  • @michaelhason5310
    @michaelhason5310 Жыл бұрын

    One problem I can point out, alpha ketoglutarate was suppose to increase lifespan by mildly suppressing ATP generation!

  • @davidchung1697

    @davidchung1697

    Жыл бұрын

    But it is supposed to activate the genes that promote three of the four Yamanaka factors - at least that is what David Sinclair indicated.

  • @hobbyfarmer1452
    @hobbyfarmer14522 жыл бұрын

    I am taking Okinawa Fucoidan made by Japanese company Kanehide Bio.

  • @AnnAnn-il2lk

    @AnnAnn-il2lk

    Жыл бұрын

    Is that a good fucoidan

  • @popeyeseamaster87
    @popeyeseamaster873 жыл бұрын

    The discount code?

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    The discount code is LANCE. It's in the description, along with the product link.

  • @popeyeseamaster87

    @popeyeseamaster87

    3 жыл бұрын

    @@LanceHitchings cheers

  • @antoniomarti3322
    @antoniomarti3322 Жыл бұрын

    Evidentemente la extensión del 27 % en varones es sobre la vida media esperada que, en este sexo, es menor a la de mujeres. En cuanto a éstas, el 15 % de extensión o ganancia se daba sobre una esperanza de vida media superior a la de los varones. Cuando después habla de una extensión del 11 % para varones y un 15 % para mujeres ya no habla de vida media esperada sino de longevidad máxima o vida máxima conseguida sobre cada sexo.

  • @JonnyLWarren1
    @JonnyLWarren12 жыл бұрын

    to live longer do you have to take this stuff for the rest of your life

  • @doncoady1911
    @doncoady19113 жыл бұрын

    Elderberry

  • @SolarReannex

    @SolarReannex

    3 жыл бұрын

    why?

  • @kattypan3293
    @kattypan3293 Жыл бұрын

    i guess the seaweed that japanese and korean people eat is not better than the special fucoidan

  • @lucky2653
    @lucky26532 жыл бұрын

    I think the Do Not Age Sirt6 activator may be a total scam. Somebody needs to do a third party test to see if it activates Sirt6. When the people making it and selling it are the same ones testing it there's a potential for fraud. There needs to be third party testing for this product and so far as I know there isn't any.

  • @albardo08

    @albardo08

    2 жыл бұрын

    Good point. The supplement is insanely expensive and there is zero human evidence that it will activate SIRT-6 to the extent claimed for it. All studies have involved rodents and much of what works for rodents doesn't produce the same effects in humans.I think any sensible and intelligent person would not be lured by the claims made about this expensive product without first viewing some human evidence to show it works as advertised. The scientist pushing this product is paid by the company that sells it, so is not exactly an unbiased source!

  • @richardplantan4375

    @richardplantan4375

    Жыл бұрын

    Agreed. Especially when it is going to cost someone over$4,000 a year. Part of the high cost is due to the constant testing of each batch to make sure it works.

  • @Always-xl9db

    @Always-xl9db

    Жыл бұрын

    I agree as well, as any sensible person would. There is absolutely no proof it works in humans and that fishy “selection” process…they test it how exactly? Do Not Age CEO talking about it in interview - he sound so uneducated, he has no idea what he is selling but def enjoys the revenue I reckon.

  • @MichaelEdwardWright1

    @MichaelEdwardWright1

    Жыл бұрын

    Leading edge products done by leading edge teams must start somewhere with the categorization of seaweeds know to be beneficial. There is little profit in vitamins, minerals, botanicals until they are synthesized and commoditized or made into a pharmaceutical. A large number of supplements for sale are ineffective.

  • @houseoflongevity

    @houseoflongevity

    Жыл бұрын

    Do Not Age sends a sample of every batch of their products out for purity testing. If the molecule they are selling is the same molecule used in the studies are the same, then where is the scam? If Do Not Age was a scam, they would have a lot more products available, like blends and multivitamins, etc.

  • @joemoya9743
    @joemoya97433 жыл бұрын

    Hmmm... LANCE Discount code didn't change the price.... when I tried to order. {shrugs shoulders}

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    Hmmm. I'll have to check on that. Thanks for letting me know.

  • @scottk1525
    @scottk15252 жыл бұрын

    "I'm not sponsored by Do Not Age because I want to keep this channel unbiased..." "...but I am an affiliate."

  • @albardo08

    @albardo08

    2 жыл бұрын

    LOL!

  • @charlessavoie2367
    @charlessavoie23678 ай бұрын

    Its the old trick, say that only your offering is good while others will not work. Whatever fucoidan I am "led" to buy, will work for me. No shake down artists please.

  • @LanceHitchings

    @LanceHitchings

    8 ай бұрын

    Well, there's a new player in the field of developing therapies based around SIRT6. I'll be doing a new video on this tech in the next couple of weeks. Watch for it.

  • @charlessavoie2367

    @charlessavoie2367

    2 ай бұрын

    @@LanceHitchings listening

  • @rmondave
    @rmondave Жыл бұрын

    Hi Lance, I like your presentations. Please add to your information presented which (natural food) sources provide TMG. For example there is no reason for people like me who eat a steady amount of Wheat Germ, Beets, Spinach, Quinoa, to fork over $100 for TMG supplements, which I would venture to hypothesize are not nearly as bio available and surely not as broadly nutritious as the natural sources as follows: Here’s the amount of TMG found in a 3.5-ounce (100-gram) serving of several foods (24Trusted Source, 25Trusted Source, 26Trusted Source): Wheat bran: 1,339 mg Wheat germ: 1,241 mg Spinach: 600-645 mg Quinoa: 390 mg Beets: 114-297 mg Shrimp: 219 mg Wheat bread: 201 mg Keep in mind that several factors impact the amount of TMG found in foods. For example, certain cooking methods, particularly boiling, significantly decrease the TMG content .

  • @BiblicalLongevity

    @BiblicalLongevity

    Жыл бұрын

    I’m not sure where you’re seeing TMG costing so much, but Prohealth has 100g of TMG powder for under $14 after tax. That’s 14 cents a day for 1g of pure TMG. You’ll pay way more than that from food sources. You won’t get 1g of TMG for 14 cents anywhere else

  • @paulkiesow7588
    @paulkiesow75882 жыл бұрын

    Hello Lance, I seem to be the only person using cyanidin as a SIRT6 activator-via ribosylation, as well. Have been taking 200mg daily for two months. Fucoidan can occasionally work at 'cross-purposes' methinks, yet cyanidin is potent and rarely an inhibitor. Thoughts please.

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    Interesting. Apparently, cyanidin DOES activate SIRT6, and it apparently does it better than fucoidan. I think I'll start taking cyanidin, so that makes two of us. 😀

  • @paulkiesow7588

    @paulkiesow7588

    2 жыл бұрын

    Lance, Good to hear from you. So now we are 'two' taking cyanidin. . . . Before you commence, be advised of a possible reason why it hasn't yet been commercialized: cyanidin is one of the most aggressively staining substances I've encountered, which could possibly alarm some folks. If you would like more information on titration/dosages, perhaps we will communicate privately.

  • @Always-xl9db

    @Always-xl9db

    Жыл бұрын

    Paul, do you have any update about taking cyanidin? I would really like to know mire about your protocol, thank you!

  • @paulkiesow7588

    @paulkiesow7588

    Жыл бұрын

    I've been taking it for eight months. My Twitter page deals with my SIRT6 use and more, but the cyanidin does seem to be working, even though saying that something is working is tricky in the absence of any health issues at age 70. As for an immediate sensation associated with it, none. Cyanidin is incredibly staining and have had a couple of messes to clear up. It literally stains stainless steel so can see why selling it retail might be problematic. If I didn't know it won't irrevocably turn your body purple, I’d be afraid to take it. One other thing: the activator fucoidan can also inhibit SIRT6 when taken at higher dosages, but I understand this is not an issue with cyanidin. Let me know. . . .

  • @Always-xl9db

    @Always-xl9db

    Жыл бұрын

    Thank you, followed u on Twitter and reading through now…where do u get cyanidin 3-O-galactoside? I would really luv to see your full supplement stack, would u mind sharing?. Have you been taking Metformin for diabetes or anti-aging/both? 20 years is a long time…. I only have access to Berberine at this point….this is so interesting, about cyanidin, I have no concerns about staining whatsoever.I wonder if you did epigenetic age test or blood marker one. Appreciate all the information that you can share!

  • @wraylynsmith9614
    @wraylynsmith961411 ай бұрын

    Just change the shape of the distribution, Lance. Move the middle more than the right tail for instance.

  • @FXDUBOIS
    @FXDUBOIS2 жыл бұрын

    Don't be stupid, everybody! The seaweed extracts in question cost almost nothing and are not patentable: in just a few months, the competing companies will have had the time to formulate exactly the same fucoidan extract for much less: which is why they want you are subscribing now for a year, at shockingly expensive prices, because they are the only ones on the market, but they know it can't last long... Nonetheless I really consider their brand is a very good one, especially for thieur apigenin at a very competitive price... Anyway, Thanks and thumb up, Lance, for the excellent review !

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    I agree, DoNotAge is a great brand, which is why I doubt they're trying to scam us with their fucoidan supplement. Fucoidan isn't just one type of seaweed, it's a family of seaweed and as I understand it, not all fucoidan seaweeds produce the sirtuin activator. Which is why they have to test many different samples, which is why it's so expensive. That's my take anyway.

  • @investigativereports1622

    @investigativereports1622

    2 жыл бұрын

    @@LanceHitchings EXACTLY.

  • @SL-bu6qj

    @SL-bu6qj

    2 жыл бұрын

    any updates to this? The cost is still quite high.

  • @Always-xl9db

    @Always-xl9db

    Жыл бұрын

    There is a clear conflict of interest because ppl “testing” it and “selling” are the same. And their testing methods never disclosed. This is just so shady, reading description section for that product on their website just made me cringe.

  • @herveduchemin2139
    @herveduchemin2139 Жыл бұрын

    So what they're selling for that price is Fucus Vesiculosus. Can't you just take bladderwrack which is extremely high in it? On top of that, if you combine the bladderwrack with sea moss and burdock root and you get all of the minerals the body needs? Dr. Sebi used to talk about Fucus decades ago for extending longevity.

  • @lightbeingpontifex
    @lightbeingpontifex2 жыл бұрын

    most fucoidan blocks sirtuin 6 what the,,,,,

  • @LanceHitchings

    @LanceHitchings

    2 жыл бұрын

    See my pinned comment.

  • @123Goldhunter11
    @123Goldhunter113 жыл бұрын

    In capitalism the cure to high prices is......................high prices. I remember when quercetin cost a fortune - like spermedin does now.

  • @AnnAnn-il2lk
    @AnnAnn-il2lk Жыл бұрын

    Have anyone tried this product

  • @williamperkowski9025
    @williamperkowski90253 жыл бұрын

    median lifespan is how long most of the mice live. Max lifespan is how long the oldest mouse lives. If most mice live 48 months, then 30% increase is (48 x .3). If Max is 58 months then max is 58 x it's percentage increase. Thus max lifespan could still be higher than median lifespan notwithstanding the fact that median increased by a greater percentage value.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    Yeah, but I don't see how the median lifespan can exceed the maximal lifespan.

  • @williamperkowski9025

    @williamperkowski9025

    3 жыл бұрын

    @@LanceHitchings median is the average so it's always less than the max.

  • @williamperkowski9025

    @williamperkowski9025

    3 жыл бұрын

    @@LanceHitchings the median lifespan was extended 27 percent, the male max lifespan was extended 11 percent. If the median was 48 months, then it increased by about 14 to 15 months. If the max male was 58 months then it increased by about 6 months. The max male is still older than the median.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    @@williamperkowski9025 Now I get it. Thanks.

  • @stanislawpalka9015
    @stanislawpalka9015 Жыл бұрын

    11:25 Wrong!.. "Now that just doesn't make any sense to me...". This is possible because life span is variable and are people which life very shortly. So SIRT6 helps peoples live longer. But helps only for mouses which liver shorter than medium.

  • @cedrickkevinnanini9219
    @cedrickkevinnanini92193 жыл бұрын

    im pretty interested in a course that will give me the understanding about longevity and apply them to be commercially be produced cheaply. best regards from the philipines

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    Thanks, I'll let you know as soon as I have something.

  • @ArticBlueFox96
    @ArticBlueFox963 жыл бұрын

    I don't know why none of these organizations have genetically engineered foods to produce significant amounts of the ideal form of anti-aging compounds, like fucoidan.

  • @KenOtwell

    @KenOtwell

    3 жыл бұрын

    It's early days yet - give them time. This is bleeding edge work.

  • @lubnahabeeb
    @lubnahabeeb Жыл бұрын

    I bought the starter package including SIRT6 from the this company 8 or 9 months ago and I didn’t notice any positive difference. I get headaches and itching every time I take it and it has a fish smell. Did I receive a bad patch? Did anyone experience something similar?

  • @LanceHitchings

    @LanceHitchings

    Жыл бұрын

    I've been using SIRT6 Activator for about 6 months and I've noticed no fishy smell nor do I get headaches or itching. But that's just me, everyone is different. But my batches of the product do not smell fishy. I'd contact DoNotAge and let them know. I've found them to be very responsive.

  • @lubnahabeeb

    @lubnahabeeb

    Жыл бұрын

    @@LanceHitchings Thanks for clarifying 🌹 I will email them

  • @james575730

    @james575730

    Жыл бұрын

    ​@@LanceHitchings do you have a video reviewing your experience with this supplement?

  • @henryquenin6580
    @henryquenin658010 ай бұрын

    I've read that the most powerful sirt6 activator of all is a substance called cyanidin found in such things as the brightly-colored skins of berries like elderberry, blackberry, cranberry, blueberry. Being pretty ignorant about this area, I don't know if those sources of cyanidin would affect the deacetylation or the ribosylation function. May I please ask you for your opinion on the possible sirt6 benefits of taking extracts of these natural flavonoids above and whether they might have the same benefits as fucoidan if taken in large enough quantities?

  • @margaretsmith9637
    @margaretsmith9637 Жыл бұрын

    Once they find the kind of seaweed that has the right activation why don’t they take that seaweed and grow it?

  • @paulcohen6727
    @paulcohen6727 Жыл бұрын

    No disrespect intended Lance, but 'sigh,' more pills and potions? Isn't there a way where you can accomplish the same thing at home through exercise and diet or some kind of lifestyle intervention instead of expensive nostrums which as some of the comments indicate, have the potential for severe gastrointestinal distress and who knows what else?

  • @paulwolf3302
    @paulwolf33023 жыл бұрын

    Some fuciodan activates SIRT6, and other fuciodan supresses it, even though it's the same exact chemical. OK.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    As I understand it, it's not the fucoidan, it's the seaweed that it's derived from.

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    ​ @Paul Wolf See my pinned comment.

  • @MG-lz2nq
    @MG-lz2nq Жыл бұрын

    I took two capsules of Do Not Age Sirt 6 Activator and afterwards was taken to rhe hospital emergency. Got terrible stomach cramps that needed to treated with an infusion. They asked me what I had taken, I told them about the product. They never heard of it - of course. I am sure the cramps came.from the capsules. I never had pain like that before in my whole life. I won't take any of these capsules ever again. Even though, they were damn expensive.

  • @james575730

    @james575730

    Жыл бұрын

    Are you allergic to seaweed? Did you tell do not age about this?

  • @MG-lz2nq

    @MG-lz2nq

    Жыл бұрын

    @@james575730 Normally I'm not allergic to seaweed. I eat all kinds of seaweed regularly. Nothing happens. No I did not tell DoNotAge about it yet. Not sure whether I should do it. I consider it as an experiment. So the product might work quite well for many people, and I was in the unlucky posution that my body did not like it.

  • @ravern1000
    @ravern10003 жыл бұрын

    Personly I do not believe they are the only ones that sell the specific fucoidan that works,sounds like a money tree, considering it is a very cheap substance .

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    See my pinned comment.

  • @dlbdlb3919
    @dlbdlb39192 жыл бұрын

    Lance your face age is not showing results

  • @zacknow
    @zacknow3 жыл бұрын

    Too rich for me as well

  • @LanceHitchings

    @LanceHitchings

    3 жыл бұрын

    I hear ya!

  • @4Nanook
    @4Nanook Жыл бұрын

    Instead of spending $1,100 / year you can buy 120 capsules off of Amazon for $25. Nice scam you've got going there.

  • @naoumhalamoutis1960
    @naoumhalamoutis1960 Жыл бұрын

    You're misleading. You do take money from donotage.

  • @oibal60
    @oibal60Ай бұрын

    Thanks again.

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