I've published a free concise report on quercetin after 6 months of research with 300+ studies, at: www.WellnessMessiah.com/Gift This is the follow-up video: kzread.info/dash/bejne/dpqOxZazktW2lNY.html

@antonystringfellow5152

Жыл бұрын

Both 🙂👍

@plenitud45

Жыл бұрын

😊u

@barrykp

Жыл бұрын

I'd say feel free to analyse the data that is available at this time.

@healthinsightsrothchildlll4402

Жыл бұрын

HMMMM, anyone else smelling raw fish: ITP's Dr. MILLER SOUNDING LIKE Fauci or one of his Orian minions has touched him. Forget their rapid about Face. Quercetin has saved countless lives and shied off C19 i'lls and wows now, all of a sudden it no l ok nger works . PLEASE !

@monnoo8221

Жыл бұрын

I doubt you could, ...or we should, wait until 2032.... When they will publish a study showing the opposite 😁

I’ve said it before and I’ll say it again-YOU HAVE THE BEST BRAIN OUT THERE IN THE THE LONGEVITY FIELD ! Thank you so much for figuring this stuff out and sharing it with us. I love you.

@WellnessMessiah

Жыл бұрын

Hi Joan you make me blush again. I'm just a cog in the system of information, trying to make sense of it all (of things that sometimes seemingly make no sense) :)

@joannsmith9

Жыл бұрын

@@WellnessMessiah You are more than just a cog. I hope you don’t lose your humility and goodness as they are far important than intelligence. Every now and then I see this childlike funny little boy in you. I bet you were the most adorable little boy ! Im old enough to be your grandmother-if you ever need a grandmother-I’d like to adopt you 😊. I pray your wife is improving. Considering all you’ve been through and are still going through it’s amazing to me that you can still maintain your focus so well. God bless you 🙏🏻❤️

@andosoup98

Жыл бұрын

thing is you would have to have the best brain in the field to know he had the best brain in the field, lol, im wondering if he might actually be the worst brain in the field. GENERALLY ANYONE WHO USES CAPS TO MAKE A POINT IS REALLY A MORON

@NOT-WOKE-007

5 ай бұрын

I’m 75. I take Quercetin daily.

@romaniamyland6191

6 күн бұрын

@@NOT-WOKE-007 sooo? is it working?

That was a lot of work putting these interviews and studies together… thank you for shedding light on fisetin / quercetin … I’m going to keep taking it for now 🤷🏼‍♀️

@WellnessMessiah

Жыл бұрын

Hi Lucy, you're very kind. I think this story is the epitome of confusion in our community.

@WellnessMessiah

Жыл бұрын

Ho Lucy - should I do data interpretation now or wait for the full study?

@mikelangele

Жыл бұрын

@@WellnessMessiah as someone mentioned you should do both :)

@lucycooper55

Жыл бұрын

@@WellnessMessiah I would love to follow as it unfolds. Is both asking too much ? 😀

@WellnessMessiah

Жыл бұрын

@@lucycooper55 no :)

Impressed with your approach to addressing this topic logically without any individual disparagement. Appreciate you helping people find their way to the truth.

@WellnessMessiah

Жыл бұрын

Hi Mike, sometimes humans, the more we are alike (e.g. me and Brad) the more we try to hurt one another. It's really stupid, I think anyone has their own values, contributes and we're all in this together. I age, you age, and Brad ages. Trying to cause pain to others because they are similar doesn't help much.

@dasein9980

8 ай бұрын

@@WellnessMessiah you don't think it's at least a little pompous call yourself the wellness messiah?

It's worth noting that Brad is pretty young. Him deciding to wait for further research is pretty reasonable. If he were 50, 60, I imagine his risk calculus would be different.

@WellnessMessiah

Жыл бұрын

Make sense Coyork. I'm 36 and that's exactly what I do. So far this is the interpretation of the study this is what we know. kzread.info/dash/bejne/dpqOxZazktW2lNY.html

@johna5484

11 ай бұрын

Even though he’s young it appears he would rather just shift to supplements that work.

@urastus9202

8 ай бұрын

@@johna5484 exactly, and based on science, not "interpretation"

@DanaVastman

10 күн бұрын

​@@johna5484You obviously don't understand what's going on here. Bloviating BS seems to be what people like to do these days. The whole point is He's young and not old and old is when toxic buildups accumulate

If I was Brad Stanfield's age I wouldn't take fisetin either. But I am 71. I take 2,400 mg in 1 dose 3 days in a row monthly. I take it with fat, usually olive oil and piperine because it is hard to absorb. When I first started 2 years ago I felt distinctly different on the days that I took it. I believe I was killing a lot of senescent cells. I do not have as much of a reaction now as I believe the senescent cells are now under control. Ironically I use Brad's discount code when I buy it. Personally I don't have time to wait for a published study when I can see results myself.

@WellnessMessiah

Жыл бұрын

Very interesting experience. It definitely sounds like something happening in your body. if only senescent cells would indicate their own demise, we should not have waited for other human studies to be sure what happens inside

@g.......g

11 ай бұрын

May I ask, what differences have you seen since starting Fisetin? In particular changes to joint health, skin and hair, if any. Also where do you get your piperine. Thanks in advance.

@bene88597

8 ай бұрын

Very interesting keep me posted bro

@DOLEWDREW

7 ай бұрын

Piperine is extracted from black pepper. You might/should be able to get all your peperine requirements from simply using ground black pepper! @@g.......g

@Christina_Yang1217

6 ай бұрын

How much piperine do you take with Fisetin? I am taking 100mg Fisetin everyday now, maybe I should just take it like the way you do.

I have approximately over 60 supplements and drugs including fisetin, quercetin, nmn, resveratrol and spermidine. What i found according to my experience is that nmn has strong results. Fisetin is also effective in increasing oxygen tolerance throughout the body. In fact all of the five longevity supplements do have a positive effects. Remember i m not referring to any lab results, i am all about what i felt or experienced on my own.

@WellnessMessiah

Жыл бұрын

Thank you for sharing. Would you object explaining the "increasing oxygen tolerance throughout the body" benefit?

@Battery-kf4vu

11 ай бұрын

Perhaps you could do a google search on spermidine absorption, it is not absorbed by the gut. Liposomal spermidine might be a solution I would guess.

@nukenfry

10 ай бұрын

Its pretty well established that resveratrol doesn't promote longevity and nmn, although increases NAD in the bloodstream, does not increase NAD in tissues, thus severely limiting what positive benefits it could have. Once again, it doesn't do much for increasing longevity.

@barbarafairbanks4578

7 ай бұрын

​@@nukenfry Agree with you👍 Thanks for speaking out on this issue - with FACTS!

@barbarafairbanks4578

7 ай бұрын

​​​@@WellnessMessiah well, apparently they DID object to sharing proof of their claim about fisitin's ' increasing oxygen tolerance throughout the body' (someone explain to me please, what that statement even means)😅 And... TADA! No answer to your request. ... And therein lies your answer. 😊

These work for me, I'm 148 years old and still going!!!

@WellnessMessiah

Жыл бұрын

Cool - You will live long enough until the full study will come out....!

@ameliagarcia1483

5 ай бұрын

148 yrs ?

@danielstraka17

3 ай бұрын

You lucky youngster! I'm 242 years old...

@catman4471

Ай бұрын

I'll race you to 200!

I think Brad also states he’s around 30 or 35 so it doesn’t make sense for him to take them personally since senescent cells do not build up until older. Age matters.

@WellnessMessiah

Жыл бұрын

Hi could be. In the videos I showed addressing specifically fisetin+quercetin, he didn't mention that at all. But he might have mentioned that in following videos that are not around fisetin-quercetin.

@giovannidominoni

Жыл бұрын

@@WellnessMessiah he does take decisions based on his age, I think I remember him saying, for example, that he will not take NAC until he's 45. Regarding Fisetin, I don't recall him talking about his age

@TudorIrimescu

Жыл бұрын

​@@giovannidominoniWhat's his reasoning for not taking NAC before 45? Want to find out cause I'm 21 and I dose 600-900 mgs almost daily

@giovannidominoni

Жыл бұрын

@@TudorIrimescu I don’t remember… Anyway, it’s in the video about the five supplements that he recommends. It’s easy to find it if you search for it in KZread.

@mattsmith1440

Жыл бұрын

@@giovannidominoni He promotes collagen, which is bs. Don't pay attention to him.

Dr. Stanfield is very cautious about spending for supplements that have doubtful effect. Quercetin and fisetin may require large doses that would be waste and reduce our budget for the more important ones.

@PedroGonzalez-me1qb

5 ай бұрын

And what are the most important ones ?

@alan2102X

3 ай бұрын

​@@PedroGonzalez-me1qb Lots of things, but melatonin is among them. Quercetin and fisetin are not expensive, especially when used episodically; cost is not an issue. And whether or not they eliminate senescent cells is not the only issue. They have many other benefits. Re fisetin, see: "Fisetin: A Dietary Antioxidant for Health Promotion" on pubmed. It is dumb to rule out fisetin just b/c it may have failed at ONE thing (expunging senescent cells) in ONE study. But then, Stanfield is none too bright.

@Mirror142

2 ай бұрын

Dr Fraud Stanfield 💩 I bought his supplements and ended up admitted to the hospital. He is a Fraudster. Beware 🛑 ⚠️ ⛔️

@pramuanchutham7355

26 күн бұрын

​@@PedroGonzalez-me1qb Stanfield cherry picks and makes arbitrary conclusions, always.😊

Hi Rimon, you videos are great! With the Quercetin intermittent hit and run, alternate days for 3 days exposure, how frequently should we do this please? Weekly, monthly or what time intervals are best in your opinion please? Thank you

Brad is too rigid and swayed by every latest study, no matter what it says. He will be changing his mind when the next study says the exact opposite. The fact is that fisetin is proven many times over to be effective.

@Vgallo

Жыл бұрын

Spot on. My son is autistic and I’ll go he if Stanfieid isn’t also autistic. He’s far to conservative for my liking and places waaaaay to much emphasis on studies, as if studies are 100%. Imo studies should be one of the more important factors in deciding which supplement to take and they shouldn’t always have the same emphasis in every situation, for every supplement. These kinds of attitudes are common for autistics, especially autistic drs, they’re extremely inflexible in their thinking and cling to rules and studies to calm their anxiety about uncertainty. Also stanfield is young and healthy, I’m not, I don’t have the luxury of being so cautious, I’ve been sick for 4 years and my autistic dr, whose alot like Stanfieid Has done very little to attenuate my condition- hence why I’m here. I like this guys insights, but the aesthetic on the channel is insufferable, like some unbearable PowerPoint conference at work.

@ingramdw1

Жыл бұрын

That's what I would expect from people that follow the evidence, though. I'd be more worried if he didn't change his mind if more evidence comes to light.

@BiblicalLongevity

Жыл бұрын

@@ingramdw1 not when it’s back and forth, back and forth, though. He’s blown by every wind, it seems. Interpreting the studies properly is important, as we both know. I think the Fisetin video he just wrote off Fisetin when the study didn’t even say whether the Fisetin was taken with food or not. If it wasn’t taken with food, then it wouldn’t be absorbed well at all, and that changes the entire results. But Brad just made up his mind about it based on that.

@alterego157

Жыл бұрын

Proven where? The more I look into studies the less I believe "longevity community" hypes. More often than not either studies are deeply flowed or interpretations are taken to absurd. Sometimes both. And let's not even go into ridiculousness of looking at some half-assed study done on worms and flies showing that something might work and extrapolating that into "I must stuff my mouth with a bunch of shady pills to live longer". The quackery masquerading as science is rampant in "longevity community".

@Vgallo

Жыл бұрын

@@alterego157 I agree with much of what you said. But it sounds like your taking it to the extreme and being cynical , there is a lot of exciting cutting edge science coming out of this space, if your saying there isn’t, then your definitely a cynic. I mean you can’t argue with some of the results from prominent longevity personalities, also there’s a tonne of formerly - very sick people who’ve been sick for a really long time and have exhausted all options through specialists and gps, once they discover sone supplements in the longevity community there lives turn around for the first time in years. I’m one of those people, I could barely get off the couch after work and was struggling to even get to work most days, I had dementia like symptoms and had one illness after the next, now after developing my own stack my life has completely turned around, I have enough energy to go to the gym 3 times a week and am now looking to increase that too. Not to mention all my blood work has improved and I no longer need blood pressure medications. So this is compelling evidence for me too. And yes I was already growing my own food and doing keto, I.f. Before I discovered the longevity community, I was doing everything the drs suggested and more and still wasn’t getting results.

Thanks Rimon, I was very disappointed and confused over Brad Stansfield’s decission on Fisetin and Quercetin although on balance decided to continue my own regime. So hearing your take on it I agree strongly that accurate data interpretation is vital on which we can all base our personal approach to supplementation

No doubt that data interpretation is important along with scientific replicability. All data should be submitted to independent examination(there is far too little of this!). Apart from the effects of Fisetin & Quercetin, IMO the best way to get rid of senescent cells is to do 24 hr, fasts, which I do every weekend. This promotes effective autophagy & as a 79 year old, it is most likely I have a plethora of senescent cells. Maybe autophagy using the body's own processes is more effective than adding exogenous molecules through supplementation, I have lists of foods that supply Fisetin & Quercetin & I try to eat these as much as possible as well. Congrats on your thorough analysis of the science. As for Stanfield, I find him to be somewhat impulsive in drawing conclusions.

@heyyou9839

11 ай бұрын

Agree

Brad is driven by peer reviewed studies that are well designed. Sure he can change his mind, but that’s what you are supposed to do in light of new evidence.

Stanfield just makes contrarian headlines to generate clicks. Then he cherry picks data/studies to support the video title. I've unsubscribed from him recently. Particularly when he singled out one of my comments in his IF video and then misrepresented the study i cited to him.

@timskolnik3819

Жыл бұрын

Yup. I totally understand why Sinclair blocked him

@bq3538

Жыл бұрын

he is in Confirmatory bias

I do apreciate your angle and interperetations very much so. it is of the essence to keep this community (and any other community for that matter ) properly and accuratly informed. i feel your coments and findings are genuine and sincere and that helps a lot. ive learned a lot from you. please go on.

@WellnessMessiah

Жыл бұрын

You're very kind Nikola

Enjoyed this take on the issue. Keep it up. Really appreciated your approach.

Great video 10/10. Keep pushing out content of this quality and your subscriber count my double.

Thanks for the video. As for Dr Stanfield, his channel was really helpful at first. Then all of a sudden he became pessimistic and negative about everything, to the point I didn't feel his channel was useful anymore. Glad I found yours!

@gunjangupta6690

Жыл бұрын

Amen. Dr Stanfield's channel has become very random, misleading and political shooting gallery dressed as "science"

@heyyou9839

11 ай бұрын

I think his feud with David Sinclair has wounded him

I appreciate when we hold each other accountable for accurate scientific conclusions…especially in this rapidly developing field of longevity. Thank you for being additive to this process!

I have a friend who is 92 years old. His leg was swollen and painful. He was using a cane. I bought him a bottle of Quercetin and told him to take one at night and one in the morning. I saw him 2 weeks later and he said, “I feel like I’m 35 again!” That is better than a study on mice!

Quercetin has other benefits aside acting as senolytic. It tackles nad+ depletion from a different angle of that taken by NR or NMN by affecting cd38 levels and act as attenuator. So that alone is a good reason to take this supplement. The claim is that in high dosage it also could operate as a senolytic and was shown to act as sirt6 activator.

@WellnessMessiah

Жыл бұрын

Nice to meet you, Yuval

@naguarachamo1

Жыл бұрын

It's also a powerful antihistamine.

@ChuckleberrySoup

Жыл бұрын

Quercetin is also a Zinc ionosphore - helps transport zinc into cells

@alan2102X

3 ай бұрын

YES. Many other benefits. This thing of rejecting a substance because it failed in ONE study of ONE action is just ridiculous. But that's the kind of thing that I expect from Stanfield, sadly.

Great video and very insightful as always 😊 thank you.

Hi. I am continually amazed by your insights into studies done by other researchers, and how you often find significant issues being overlooked. Well done!

Dr Stansfields stand on quercetin was probably based on that research (Kirkland, perhaps) showed that fisetin was more effective than quercetin. So, if fisetin doesn't work, the weaker quercetin wouldn't work either. This is just my guess. That quercetin works better together with that cancer pharmaceutical might indicate that senolytics work better in combinations. Such as quercetin and fisetin together, perhaps.

@heyyou9839

11 ай бұрын

If Fisetin, does not work, how is it “more potent” than anything else? If it’s not potent?

Fisetin does work for me. I tested by applying it on my right hand and use left hand as control. My age is about twice Brad's.

@KatSchlitz

Жыл бұрын

You applied it by placing it into a cream or lotion?

@weiminyang7206

Жыл бұрын

@@KatSchlitz Yes. it only works for old people, I'm pretty sure.

@alan2102X

3 ай бұрын

@@weiminyang7206 And you noticed... what? Fewer age spots? Better turgor?

Excellent analysis as always and very helpful. I just wish it could be more concise and less repetitive.

@WellnessMessiah

9 ай бұрын

Noted!

Hi! Big fan here in Brazil. Regarding your couse, how the content is delivered? It is video lessons, pdf material, zoom meetings, telegram groups? I am willing to join but could not find this piece of information in the subscription page. Thank you!

@WellnessMessiah

Жыл бұрын

Hi, video lessons in a collaboration mode (Alex and me), pdf, and excels with breakdowns

@DrNoeNutrologo

Жыл бұрын

@@WellnessMessiah how many hours of video lessons?

Since it is likely that senolytic cells start accumulating above the age of 50, it is not a big risk to younger people to delay the taking of anti-senolytics compounds until further evidence. Also, there are researchers that hypothesize a delicate balance between senolytic cells and cancer cells that is not yet understood.

I like clear logic, different molecules & unpublished, enough. I am on Quercetin started today (side effect it fixes exercise rhinitis and I exercise daily, no more runny itchy nose is awesome). Will play with dose/frequency. subbed.

Rimon, thanks for your work. With regards to Dr. Stanfield, I stopped following him awhile ago as I believe he is more interested in click bait than actual analysis. I have confidence in your data interpretation so please continue the great work. Any update on your wife’s condition?

@WellnessMessiah

Жыл бұрын

Hi, thank you for asking. Well, she's at home and it's not easy. We're doing oxygen chambers almost every day, I estimate at least 6 more months of intense recovery and then slow and gradual over a period of 1-2 years.

@jgs9911

Жыл бұрын

@@WellnessMessiah the good news is there is light at the end of the tunnel. Good luck to you both.

@bill9989

11 ай бұрын

I generally trust Dr Stanfield. However, his fundraising to finance his own Rapamycin study gives me concern. Any such study is probably beyond his capability (no insult to him). Such a study is a huge undertaking requiring expertise in many advanced fields including statistics. Does he have that depth? So, is the fundraising on the up and up? I question it.

So happy to know such a masterful researcher as yourself, my brilliant internet buddy!!!

Thank you! I have been a big fan of quercetin and have tried fisetin. I think the research is young and since these compounds are widely distributed in nature. They seem to be well tolerated. I don't think it hurts to err on the side of taking them.

Dr. Kirkland's observations in the video regarding the lack of senescent cell markers leads me to wonder: 1.How are the senescent cells themselves detected...and characterized? Does one detection methodology fit all senescent cells? 2.Are there degrees of senescence? 3.Can senescent cells definitely NOT be resuscitated? If not, why not? 4.Can senescent cells be typed by origin, i.e., used as organ early warning indicators in their own right? 5. Are there common and predictable epigenetic markers for senescent cells, or are they all unhappy in their own way? Declaring senescent cells themselves the problem seems analogous to a mechanic discovering metal in an oil pan and installing a magnet in the oil filter as a "solution." Some bearing is in trouble.

@WellnessMessiah

Жыл бұрын

Good questions. I can tell you that in longevity research senescent state is 100% recognized once you look at the cell. It's irreversible on principle (albeit they can become cancerous. Low chance of that happening.). But when we try to see the accumulation of MANY cells, we need markers cells that show different markers. This is where we're unsure. What Kirkland addressed.

There are a variety of positive reasons to take Quercetin and perhaps Fisetin aside from senescence - incidentally assisting longevity. Unless testing a specific pathogen, most test mice, worms, etc. are NOT exposed to various viral, bacterial or fungal infections. Zinc is VERY valuable to strengthen the immune system and resist viral infection, but unassisted zinc has trouble. Quercetin appears to be a zinc ionophore, assisting more zinc cations to cross the plasma membrane.

Great background information! As there are no risks found (yet?) taking Quercetin/ Fisitin other than spending money on a possibly useless drug, I will take it and wait for more data.

@WellnessMessiah

Жыл бұрын

Yes, as you said, in situations where we have limited data, sometimes taking things that are unlikely to cause harm yet don't have absolutely 100% proven benefits, make sense nevertheless as aging is a much greater risk factor.And a certain one.

HI Rimon: I agree with your line of reasoning. Could you please explain how in research they measure autophagy or senescent cell death amount?

@WellnessMessiah

Жыл бұрын

Hi there, autophagy could only be measured locally, by tissue sampling. Senescent celll death, it depends on the study. So far this is the interpretation of the study this is what we know. So far this is the interpretation of the study this is what we know. kzread.info/dash/bejne/dpqOxZazktW2lNY.html

Love that you question and breakdown these video

@WellnessMessiah

Жыл бұрын

Nice to meet you Gina, see you in the next episode of this controvercy

What’s the ideal frequency for taking these? I’ve seen some reports that taking these infrequently was a better approach. A couple times per week for Quercetin and as little as one or two per month for Fisetin. I can’t remember where I saw this but Rimon if not for you I’d be taking too much Resveratrol daily until I saw your video so I thought you might have insight into quercetin and fisetin frequency.

@WellnessMessiah

Жыл бұрын

As I will show more research on these in the next episodes, possibly you can make up your own mind. Remember we don't have a ton of data on the perfect doses right now, but close.

@TomLe79

Жыл бұрын

@@WellnessMessiah Thanks Rimon. Understood, I are an engineer and appreciate the way you approach these from not just your scientific profession but also an engineering mindset. You also gave me some additional insight that being 43 and healthy/fit (and told I look a lot younger), maybe senolytics should be the least of my focus now but for a once a month dosage? Always interested in your feedback and your next video with more of this research.

@WellnessMessiah

Жыл бұрын

@@TomLe79 Cool to meet more intelligent people like you. see you, I think the next episode this Saturday

@TomLe79

Жыл бұрын

@@WellnessMessiah Thanks Rimon, I’m looking forward to it. And hope your wife is doing well. I’ve been keeping you both in my prayers.

What happened to nmn with David Sinclair? Do you have a video where I can see it?

how often do you take Fisetin/Quercetin combination? Every month, 90 days??

I am happy for once somebody said the word that many peoples think, it’s very frustrating for the consumers to receive contredit confirmation on product he invest and use for a certain time and moneys, thank you.

@WellnessMessiah

Жыл бұрын

Yes, listen I'm just like you. I'm too confused and then try to clarify by research and thinking. This is why I don't cooperate with supplement companies, because I think it will reduce the clarity of my videos, hurting the very purpose of trying to alleviate confusion instead of causing one.

What brands do you guys go with for fisetin and quercetin?

I was ready to not like your video but your honest and open manner converted me into a subscriber. I do like Dr. Brad although I certainly do have differences of opinion from him in certain areas. I also credit Dr. Sinclair for getting me interested in longevity to begin with although I question his motives sometimes after the debacle with Resveratrol where his studies seem to have been found flawed while his company made over $700 million from selling it to GSK who then shut it down once it didn't look like they could profit from it.

@WellnessMessiah

9 ай бұрын

Thank David, in my opinion, confusing contradicting information prevents us from sticking with habits. I view that as damaging if not based on solid science. Better to stick to what you're certain about and wait until the data is out. I have the privilege of seeing results with clients, to make me more certain that interpret data correctly.

Thanks Riman. I go crazy with these scientists posting they take something and 5 minutes later changing their mind and then changing it again. Then they put those little irritant disclaimers. This is not medical advice. Go and try to make money somewhere else.

@WellnessMessiah

Жыл бұрын

Yes, listen I'm just like you. I'm too confused and then try to clarify by research and thinking. This is why I don't cooperate with supplement companies, because I think it will reduce the clarity of my videos, hurting the very purpose of trying to alleviate confusion instead of causing one.

@jenxsj3902

Жыл бұрын

@@WellnessMessiah You do a great job man. Keep. It going. X

Thank you for your very profound analyses, I really do appreciate it very much. I ordered therefore the 120+ course a couple of days ago, but did not receive it, although I payed the affordable amount. Can you help me, where I can get the access? Again, thank you for your work!

@WellnessMessiah

Жыл бұрын

Hi Walter, I'm just double check with the support on this. Will get to you. in the meantime, check the spam. maybe the access email was sent there.

@walterantosch7133

Жыл бұрын

Thank you very much! Indeed, I just found an E-Mail in my spam.-.-.

@WellnessMessiah

Жыл бұрын

@@walterantosch7133 cool Walter, for every issue, I talked to customer service, and they acknowledge you as a special one, send an email to info@ultiself.com

Great work. Really like what you’ve done so far to present every angles of information:-)

I like Brad Stanfield and he does very good work analyzing the various studies out there - better than most by far. Lots of people jump on the longevity hypewagon and ride it as far as they can citing mice data and seriously flawed human studies. So, my question would be where is the long term, human studies (properly conducted) that show that either fisetin or quercetin provide senolytic benefits? I don't think there are any and that's what Brad says most often. If there isn't solid science around it he's not going to recommend it. He almost always says that it's your choice and if it works for you do it as long as there are no harmful or long term side effects. Mice data is only "interesting" at best. There are an almost uncountable number of tests on mice with various interventions that yielded no result in humans. There's still questions about the bioavailability of fisetin and quercetin in the first place when taken orally. So, let's not misquote Brad here. He says this is why HE stopped taking it. He didn't say you should stop taking it nor did he say it's ineffective. What he did say is that from what he sees of the science, there just isn't enough evidence yet to say it's truly effective. I tend to agree and want to limit my supplement stack to those things that we know are effective instead of making the pharma and supplement companies rich. Also, let's be honest and build in a little "bias interpretation" into our opinions. Brad has nothing to gain from recommending or discouraging the use of certain supplements and drugs. Sinclair and the rest of them often do since they have built a business around selling them. Show me some unequivocal proof and science that this stuff works and I'm all in. Until then, it remains "interesting" to me.

@kiramiftari9486

Жыл бұрын

well put!

@WellnessMessiah

Жыл бұрын

Hi, I didn't misquote him. I put the exact segments of him, speaking and said what is my understanding (which I said, could be wrong). I will add that I do like Brad channel, as I said. Sometimes humans, the more we are alike (e.g. me and Brad) the more we try to hurt one another. It's really stupid, I think anyone has their own values, contributes and we're all in this together. I age, you age, and Brad ages. Trying to cause pain to others because they are similar doesn't help much.

@bq3538

Жыл бұрын

we are Biohacker, you not, you can waiting for .....

@bmm9842

Жыл бұрын

@@WellnessMessiah It's all good. I appreciate the efforts of everyone who's trying to earnestly and honestly help us all understand to extend lifespan and healthspan. The biggest problem I think we (people in general) face today is that there just haven't been enough good studies yet to tell us what supplements are ideal AND the mechanisms by which they work. Even with the enormous amount of research being done into lifespan and healthspan it's shocking how little we really know and how much is changing. Remember the resveratrol hype? Sinclair made a fortune on that molecule and now there are new studies showing that is doesn't do what he claimed it would - that it was a lab error related to the dye used. It might even have some detrimental effects. Someone here commented to the effect that Brad changes his mind on things a lot. GOOD! that's not him, that's a result of the test results being published that tell us new things. We should all be changing our minds regularly on this issue as new data becomes available.

@monnoo8221

Жыл бұрын

Yes, indeed he just argued that this is why HE stopped taking it. He didn't say you should stop taking it nor did he say it's ineffective. However, it should be clear to you that your are following an idol. You model him as a saint, kind of. He is running a channel, meaning he is trying to build trust in what he is saying,, and with that and his title comes authority.. AND responsibility. In such a channel, there is no "neutral zone". He himself was removing that. Furthermore, he is not just telling it, he is preaching it. Trying to appear as important as it can get. Body language, intonation, just look at it. IT IS DISGUSTING. Boy, that's not serious, honest communication. I got his channel recommended by others ...and found a clown, who wants to be important, and has no clue about the things he is talking about.

I'm glad your channel exists

Well Brad also says Vitamin d3 800iu are enough..so much about his credibility

@antonystringfellow5152

Жыл бұрын

Good point!

@giovannidominoni

Жыл бұрын

Careful about this, there are studies that show that supplementation of D3 in large doses can crete problems in the long term. What Brad is saying (I think) is that is better to eat more fat fish and reduce D3 supplementation, rather than taking only large doses of D3 through supplements

@peterraidt5244

Жыл бұрын

Giovanni Dominoni you are right about the nutrition but then you need to explain it every time ..D3 800iu is like Zero.. if you eat a Hering per day you got it all covered

Is only 100 mg of Resveratrol doing me any good. Is it to low. I also do take Quinoline.

Dr Brad changes his mind all the time. I only watch his channel because he is eye candy. 😍

Thank you for you in-depth and analytical description of the study, I will continue to take fisetin and quercetin and NMN.

@WellnessMessiah

11 ай бұрын

Nice to meet you here. I've published a free report on quercetin in a few days after 6 months of research with 300+ studies, into short at www.Wellnessmessiah.com/gift

@kianleyon6613

11 ай бұрын

@@WellnessMessiah Thank you, I will check it out

Thank you for all your hard work.

@WellnessMessiah

6 ай бұрын

Thank you and happy new year, full of youth and love

oooops. My jaws dropped... You are doing great work. Thank you!!! It is this kind of work that makes your channel so trustworthy. You are a genius :)) ...so they claim to made a study in 2018, Stanfield talks about it in 2021 \ 2022, and in 2023 it is still not published ??? Serious academic research works differently (I am trained as a natural scientist, in biology). In a world where publishing is everything, not to publish for 5y means that the persons doing the study long left the organization, and the studies were not at all clear. Also, they refer to a Fisetin hydrogen sulfide study... Interesting part, this hydrogen sulfide. Probably it was a study about provoked senescence. ....and Mr. Stanfield is just a clown. His way of thinking, as revealed in this affair regarding the relation of fisetin and quercetin, has structural deficits and he should not feel entitled to give any recommendation, not even express his opinion on YT. That was not just a small mis-take. He has absolutely no clue about biochemistry.

@monnoo8221

Жыл бұрын

@@RandomGuy-qg9xf they started at age 20months (@15:40), and they live maybe 28..34 mo... so it is +8 to +14, roughly a year. I correct. study finished in 2019 etc etc

@monnoo8221

Жыл бұрын

@@RandomGuy-qg9xf why not scientific? It is done in many studies. In some studies they start even later in their life. And no, it does NOT start a age 0. check out the few moments around 15:40. They start giving the substance at age 20 mo. (ps. the scientific principle is : ceteris paribus, as long as everything (!) is controlled, it is fine. Now, that institute makes a huge mistake regarding that, but i will not spoil Rimons next episode :)

@WellnessMessiah

Жыл бұрын

My jaws dropped as well. When I said "am I turning blind or what" I indeed thought I was to blame for not finding the study :) Thanks for the compliments, you're very kind.

@milutzuk

Жыл бұрын

And I'm a physicist working with medical data and I'd say one can still publish an inconclusive study. Maybe not on Elsevier, but on your own website, but publish it somehow nonetheless. More than once my team published such studies, it's a way to say "don't try my target because you'll hit a dead end or, if you try, change the study design". I think the only reason a study cannot be published is if there is a design flaw that nobody caught until the study was finished. Now, there's the small matter of the money this study consumed, but that's another problem.

The study he based his decision on was one without a lipid but only water. If no oil is included the fisefin and quercetin may not have absorbed at all??

There are currently are no precise biomarkers for measuring senescent cells

In a way, you have confirmed Dr. Brad's conclusion. If the information/data does not show efficacy of the compound the default should be to NOT take the supplements. Too many people in this community are too quick to get on the next supplement, the next drug, the next go to product. There are not enough studies or proof of the efficacy of these supplements, so every professional should be advising their community to be careful, and only take that which science and studies have proven with a statistical confidence. You should be an advocate for science and proven studies and the interpretation of those studies by the scientists who are associated with those studies.

@kianleyon6613

11 ай бұрын

I got a totally different understanding from the video. I understood that when taking fisetin supplements, the total amount amount taken per kg of body weight is very important. If enough is not taken, then one will not experience the longevity benefits of fisetin, it will only kill senescent cells at the correct dosage as related to body weight.

@campersruincod6134

8 ай бұрын

@@kianleyon6613how much per kg?

I'm 50 yrs old had covid twice thought I was gonna die. Started taking queceritin and been around several people really sick and I haven't been sick with anything g for at least a year I think it works at keeping me from getting sick

@WellnessMessiah

6 ай бұрын

Thank you - check the survey in my community tab. your advice helps a lot!

@malin1635

3 ай бұрын

I have not gotten sick either with Quercetin.

@taniamariani7064

3 ай бұрын

Is this something u take forever or take breaks?

Did the ITP study use hit and run dosing of Fisetin?

What about the Mayo protocol that does Fisetin loading 3 days a month?

Thank u for this so much! Very logical and clear !

@WellnessMessiah

9 ай бұрын

thank you, you're very kind

Brad Stanfield has been caught out on the Vitamin E (tocopherols vs tocotrienol) debate using similar illogical arguments. It's starting to look like a pattern.

I like your humorous use of music... i.e. "another one bites the dust"... I've always thought that it be apropos for your name to sung for the intros to your podcasts... ...in the style of "dream on"...

Rimon: In your experience is it normal for a study (being run by ITP?) in 2018 still NOT being published in 2023? Is it due to the study only being started in 2018 and not being completed until recently? If so, how could the 'experts' on fisetin / quercetin risk their credibility by commenting on an incomplete study before it is published? If the target of fisetin / quercetin is removing/recycling senescent cells (in all their varieties), how effective are each of the various types of fasting (8/16, OMAD, 3 day water fast, 7 day water fast) when compared with the two supplements noted?

@WellnessMessiah

Жыл бұрын

HI Ken, I think they only started the study in 2018. The issue is even if the ITP completes t the study - then they work on publishing previous studies, a waiting list kinda thing. They are slow, so it is normal. As to whether the researcher comes out with their findings 2 years prior to the data... that's up to you to decide.

re At 12 minutes... Delighted that you said one of my life-guiding wisdoms---Mr Perry, my high-school physics teacher, had us do an experiment each week and report it, by stating results AND CONCLUSION. I myself urge reasonable as separate from the merely rational. For example, I do not believe there are witches---so the premise is wrong, even when a witch-trial case appears solid.

Let Brad stop taking all the supplements what he has consumed so far. He can then use the money for his rapamycin study. Unfortunately his fundraising efforts for this are not moving forward 🤷

LE produces Senolytic Activator, I don't have it yet, but I want it, the fisetin and quercetin are in phytosomes, stabilized with galactomannan fiber gel etc. to get it past the stomach and the phytosomes get it into the bloodstream. 3/week is all they recommend.

From my experience you must beware of fisetin and dosage if you've any kind of degenerative condition. I've noticed when I take it in high doses the pain is greater where I have the condition and subsides when I stop taking it. Maybe it's doing what it does on the senescent cells or maybe its just me but I'm wary of fisetin.

@WellnessMessiah

3 ай бұрын

Yes it makes sense! Thanks for sharing

What about grape seed extract which is reported as a good senolitic ? Great Work Rimon.🎉

@WellnessMessiah

Жыл бұрын

HI I haven't researched it enough. I'm not sure it was extensively researched for senolytic activity as fisetin and quercetin, so it's difficult to make data interpretation.

@snave59

Жыл бұрын

@@WellnessMessiah How much fisetin and quercitin should I take?

Whether on not Fisetin or Quercetin help clear senescent cells, each has other things that they may do that may beneficial, and neither has been shown to have any downside other than price. I personally take Quercetin for it's effect on mast cells and allergies. Here is another video related to Fisetin and effects that it may have against cancer: kzread.info/dash/bejne/aaSkp9aJmcLAeKg.html

Brad should look into the research from Life Extension who has introduced compounds that allows for body to actually absorb them. Most if not all of these compounds aren't absorbed as capsules. You would likely need to get expensive shots to make them work and even then, the absorption issues are still there.

@johna5484

11 ай бұрын

That’s hilarious. Research from the manufacturer lol 😂

Curcumin is ALSO a serious senolytic - why is everyone ignoring it? I know it's not easily bioavailable, but there are solutions for that, e.g., Longvida's preparation.

I read your quercetin document. It is great!!!!!!! But I have one question: if you give a SMALL MOUSE 2000 mg of Quercetin that will obviously have a more dramatic effect than 2000mg would have on a big human body. So we can not even consider the study where the mice got 2000 mg to draw any conclusion for humans. What am I missing here??

I'm going to start taking Fisetin a few days a month as I'm in my mid 40s now. There are brands formulated to be much more bioavailable and that seems the route to go. The same goes for Quercetin, which I've bought in bulk powder but haven't taken because it tastes awful. I'll get a more absorbable form in a pill instead.

This is my favorite longevity channel!

@WellnessMessiah

Жыл бұрын

Thank you :)

For someone who attacks other doctors because there is no data to support taking nmn only to turn around to have an opinion based on no data is all I need to know about him.

Thankyou for your information. But I am still confuse.🙈

Any chance you could get an interview with the head or a researcher at the ITP? Would be interesting if you’d ask all those questions directly to the people working on those studies.

@WellnessMessiah

Жыл бұрын

Could be Dan, my understanding Miller is not the "head" but one of the heads. Whatever he says, I want to see the full data first.

@dan01399

Жыл бұрын

@@WellnessMessiah Totally agree, would definitely be interesting to see. Awesome work on the video you did, great as always! :)

So whats the conclusion, should we still take it or not?

@ketokarbs3671

6 ай бұрын

He's probably on big pharms payroll

I am confused about the comment about losing our only arsenal of defense against senescent cell buildup. Not only are there alternatives, there are free alternatives. Mankind has been fasting for thousands of years. Although not popular with the masses, we have know since the early part of the 20th century about clinical proof of caloric restriction with optimal nutrition. Among the many approaches to finding longevity, caloric restriction (CR) has received a lot of attention in the last few years. The first evidence indicating the benefits of CR date back to the 1930s in studies conducted by Clive McKay, an American biochemist and gerontologist. Most people myself included would love nothing more than to be able to pills as a first line defense against aging.

@WellnessMessiah

Жыл бұрын

Hi Michael, I didn't refer to habits as much as external agents (supplements) and nothing innate. Apologize for the confusion. Obviously, a strong immune system will be able to clear them as well, depending on what you mean by "tools".

@homeontherange733

Жыл бұрын

@@WellnessMessiah Thank!

@IrrasciblePoet

Жыл бұрын

How about cold showers

Very impressive Great work Thaaaank you ❤ Rimon

@WellnessMessiah

9 ай бұрын

Many thanks!!

Awesome video 👍 excellent analysis skills 👌 👏 👍

A lot of scientists build their whole careers and obtain millions in grant research dollars on flawed theories. When their research eventually produces data that disagrees with their theory they either never report it or throw it out.

Has Dr Brad reaponded to this ?

Man, it takes one week or less to write and publish the study once you have all data! That's because you already have the framework for what you're going to do. You set a target, you design the study, you gather and adapt your tools, you start gathering data while making adjustments to your tools and, by the time you close the study, you already have 80% of the paper. Everything else after that is statistics and letter picking from the keyboard. And, one more point, you hurry up because you don't want other teams who are working on the same subject, to have their studies published before you. The only reason you don't publish your study is if your resident statistician was already dead at the start of the study and you can't guarantee that the sampling stage/process was correct.

@heyyou9839

11 ай бұрын

Not always

I hope in future we have a KI who does meta study analyses.

Thank you for this!

Quercitin has been recommented to get rid of the spike protein injected into your veins or as a prophlyactic against catching the virus or an early intervention. I've never, ever heard of taking it for longevity, but I still eat an apple every day.

I followed the same paper trail that you did and came to the same conclusions although you went further with regards to quercetin. I am about to view your next video. I sent a request to the IPT. I don't expect a response.

One reason for " scecence" is genetic deterioration... it happens when copying plant cells repeatedly.. copies og copies. . Anyways, keepining cells healthier and protected from damage seems the main issue.. Id say looking into things like Astaxanthin and melonin such, ate worth looking at, for health n longevity...

The FDA doesn't sell drugs either. Doesn't eliminate the board conflicts of interest. When you have to consider data interpretation, it's a pretty usual sign there is corruption involved.

It's not a total loss if these two supplements don't work. We still have autophagy from fasting for dealing with senescent cells. There is also exercise which is the other way of naturally boosting autophagy.

I am continuing to take it because I know that it works

This is the first time I've heard of these other two supplements. Any video on these?

@longevitylover6273

Жыл бұрын

I saw one on in this channel. Search senescent cells and the channel name

@WellnessMessiah

Жыл бұрын

Yes, go here: kzread.info/dash/bejne/oJ9lzbd6j8LWac4.html

You are right that you can't guess that something doesn't work in different combinations. On the other hand in the field of longevity there are many guess what sale of nutrions are based on 😂. Guesses that something dosn't work have the same quality as guesses that something works.

Thank you so much.

I’ve been taking Quercetin to help control uric acid as David Perlmutter suggested and it seems to work as good as allopurinol, I never knew about these other potential benefits.

@WellnessMessiah

9 ай бұрын

Really, this quercetin is one of the most powerful supplements I have ever researched. Check my free newsletter, I give inside my research on tis supplement. what you said supports my findings

Good video but a bit of a tease as to why the study was flawed. I suspect bioavaialability has much to do with it.Curcumin is another good senolytic, and that as huge absorbtion issues. Fisetin, though is not just a senolytic, which is where Stansfield was unwise - the length and breadth of the studies on fisetin are remarkable.