Parkinson's Disease:- "Parkinson's and the B1 Therapy" with Daphne Bryan

Ойын-сауық

An excellent interview with Daphne Bryan, Author of the book "Parkinson's and the B1 therapy", explains this very interesting treatment.
In 2011, the Italian neurologist Dr. Antonio Costantini began treating his Parkinson’s patients with high doses of vitamin B1. As a result, he saw many of their symptoms improve, with no obvious progression in the disease over the five years he worked with them.
Daphne Bryan outlines the research and the theories in her book ‘Parkinson’s and the B1 therapy’ and will talk about the therapy’s protocol, its difficulties, and its successes.
Daphne Bryan is a musician and a teacher and has a doctorate in music psychology. In 2010, she was diagnosed with Parkinson’s. Her first book “Music as Medicine, particularly in Parkinson’s” explores how music can be used to reduce symptoms.
In 2017 she read of Dr. Costantini’s work and decided to try the B1 therapy herself. Within a few months, she realised that she had lost most of her Parkinson’s symptoms. The improvements have remained to the present day.
After advising people on how to adopt the therapy on a FaceBook group, she decided to bring together all the information Dr. Costantini had left and write a book which would explain the available research and provide a handbook on the protocol.
Daphne lives in Scotland with her husband.
We do not usually plug products however will take exception with Daphne's book as proceeds go to the "go fund me" page to raise money for a comprehensive trial into B1
So here is a link to Daphne's book on Amazon www.amazon.co.uk/gp/product/B...
This is a link directly to the Go Fund me page www.gofundme.com/f/high-dose-...
IF YOU CAN, PLEASE DONATE TO NO SILVER BULLET 4PD.
We are self-funded, so pay for our costs ourselves, which include licenses for our secure Webinar platform, our Podcast hosting platform and soon-to-be-launched paid advertising on Facebook and Instagram so that we can target and share these sessions with more PwP worldwide, in the hope that some of our speaker's content, may improve the symptoms of another PwP
Thank you & just follow this link:-
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You can follow Daphne on social media;-
Instagram / daphne__bryan @daphne_bryan
Twitter / dmbryan1 @dmbryan1
Facebook / parkinsonsb1therapy
Dr. Costantini's official website highdosethiamine.org/
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Пікірлер: 173

  • @peggywoodson1475
    @peggywoodson147510 ай бұрын

    We started the B1 therapy after having read your book. Didn't think too much about it but made sure he got his dose three times a week (1/2 tab). That was six months ago. Yesterday we had my husband's six-month checkup and the doctor remarked that he could find no muscular stiffness in my husband at all. We reminded him we had started the B1 therapy six months before because we discussed it with him before starting the therapy. His doctor had approved it six months ago. The doctor was so impressed with my husband's exam here six months later that he said for us to continue it and increase it as we saw fit. Thank you, Daphne! We have not increased his original dosage but now are considering adding a fourth day as his increase. We are not going about this in any rush.

  • @susanedghill6597

    @susanedghill6597

    9 ай бұрын

    3 x day maybe ??

  • @lynnpoag8173

    @lynnpoag8173

    9 ай бұрын

    That’s amazing!!

  • @susanedghill6597

    @susanedghill6597

    7 ай бұрын

    I know it worked for me ! Amazing. I’d even wonder if I really had Parkinson’s !

  • @Sanam3105

    @Sanam3105

    6 ай бұрын

    ​@@susanedghill6597can you specify what is the medicine name? Did you had Parkinson

  • @susanedghill6597

    @susanedghill6597

    5 ай бұрын

    What is the dose you took.? I can’t remember for sure but I think it was every day for me. . Don’t know why I stopped but getting back on it now

  • @BrendaCampbellThe-Lupus-Effect
    @BrendaCampbellThe-Lupus-Effect2 ай бұрын

    This is brilliant! I started my husband on 100mg a day. Within 2 weeks, the shaking and nightmares stopped! However, he had to have a minor surgical procedure. In the hospital they didn’t give him his B1. When he got home, his shaking and nightmares started again, I had to give him 200 mg a day and he no longer has any symptoms. I have purchased the book and it’s a must read. Also, prior to giving him his first dose, I had him call his neurologist to see if okay. They said it’s fine, but they don’t expect anything. Well, at his next appointment, he took the book with him. They noticed no symptoms and asked to borrow the book. I never got it back lol. So, I’m purchasing a 2nd book.

  • @bradmaybury3747
    @bradmaybury3747 Жыл бұрын

    Brilliantly done Daphne! I read your book a month ago, began high-dose B1 therapy right away. It took a couple weeks to dial in my dose. I think I've got it now - about two weeks on what seems to be the right dose for me. I'm looking forward to positive results. The book and protocol are mandatory for anyone with Parkinson's - IMO.

  • @PJKallhoney

    @PJKallhoney

    Жыл бұрын

    how much are you on? Benfotiamine?

  • @annegordon6725

    @annegordon6725

    Жыл бұрын

    I'm going to give it a go nothing to lose after being diagnosed with PD 18 months ago.

  • @easycookingwithbindu5207

    @easycookingwithbindu5207

    Жыл бұрын

    😊

  • @vinpatel5452

    @vinpatel5452

    Жыл бұрын

    ​@@annegordon6725o88

  • @lynnpoag8173

    @lynnpoag8173

    9 ай бұрын

    Any updates on your B1 therapy? My husband may have Parkinson’s.

  • @janadoe3401
    @janadoe3401 Жыл бұрын

    Thank you very much for this interview.

  • @SouLightness
    @SouLightness Жыл бұрын

    Great work, Daphne!

  • @ciao98496
    @ciao98496 Жыл бұрын

    Thank you so much for this....

  • @richardcannon4090
    @richardcannon4090 Жыл бұрын

    Thanks for a very helpful interview.

  • @AlexHop1
    @AlexHop1 Жыл бұрын

    Thank you!

  • @judysprague258
    @judysprague258 Жыл бұрын

    Thank you so much for sharing your knowledge on this important subject ..

  • @michelp7342
    @michelp7342 Жыл бұрын

    Thank you very much everyone for your very nice and encouraging comments. I am delighted that this session was of interest and am excited about the other great sessions we have already scheduled for after the summer. Stay tuned for more details! Michel

  • @tobiahstar
    @tobiahstar Жыл бұрын

    Thank you so much for this information and very helpful interview xx*

  • @ronwolf6409
    @ronwolf6409 Жыл бұрын

    Thank you Daphne. I will order your book…

  • @evajackson9470
    @evajackson94707 ай бұрын

    Thank you so there’s hope 😊

  • @mindfulnesscoaching6048
    @mindfulnesscoaching6048 Жыл бұрын

    Daphne and Michel. Thank you so much for your very informative and useful talk that I would share. Thank you for giving informed hope to so many !

  • @hilaryhayes6461
    @hilaryhayes6461 Жыл бұрын

    Thank you so much for sharing your wisdom and knowledge🙏

  • @TheSabineBliss
    @TheSabineBliss Жыл бұрын

    So grateful to you for this!!! You give me hope for my father!! Eternally grateful!! 💛💛💛🙏🏼☺️✨

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Thank you very much Sabine for your very nice message!

  • @user-mz6of2tl4q

    @user-mz6of2tl4q

    Жыл бұрын

    In July last year, I started on Parkinson’s disease TREATMENT PROTOCOL from Natural Herbs Centre (ww w. Naturalherbscentre. com). One month into the treatment, I made a significant recovery. After I completed the recommended treatment, almost all my symptoms were gone, great improvement with my movement and balance. Its been a year, life has been amazing

  • @Rosie_Apple_Delight
    @Rosie_Apple_Delight Жыл бұрын

    Thank you to you both for your advocacy. You are both inspirational for how you are using your situation to perpetuate good. I hope to do the same. I’m enjoying this talk very much. Thank you

  • @philgardiner6012
    @philgardiner6012 Жыл бұрын

    Excellent interview, easy to keep listening to the end. Book bought.

  • @anitasibal3329
    @anitasibal3329 Жыл бұрын

    Fabulous Informative and giving a WORLD of hope , to them who feel hopeless. God Bless U richly ,Madam. Stay well and remember ,you are a very great INSPIRATION. BUT i reqest watchers/viwers to not ask repetitive questions. We must have respect for this Great Lady and not waste her energy and time.

  • @lmwlmw4468
    @lmwlmw4468 Жыл бұрын

    Great interview. Well done.

  • @paddymackenzie2153
    @paddymackenzie2153 Жыл бұрын

    Thank you both of you, very clear interview.

  • @florenciacerruti
    @florenciacerruti Жыл бұрын

    Thank yo Daphne and Michel! Great interview and very inspirational! I am looking forward to begin the protocol,

  • @salwashenouda783

    @salwashenouda783

    Жыл бұрын

    What dose of b1 to start with

  • @253georgica
    @253georgica Жыл бұрын

    Daphne I’d like to get your book my wife has parkensons and would like to know so we can start the B1

  • @colsandannie
    @colsandannieАй бұрын

    Bravo Cuz!

  • @banzobeans
    @banzobeansАй бұрын

    Finding the correct dosage 20:16 31:30

  • @scottmerrell4337
    @scottmerrell4337 Жыл бұрын

    Started EZ Melts B1 under the tongue last night. Came same day from Amazon. Not bitter. We will go slow as in the book. You've given us Hope and that is a precious commodity with advanced Parkinsons.

  • @debp.2599

    @debp.2599

    Жыл бұрын

    EZ melts are not sublingual…they are absorbed just like capsules…which are much cheaper.

  • @scottmerrell4337

    @scottmerrell4337

    Жыл бұрын

    @@debp.2599 So what’s this EZ Melts B1 25MGs non-capsules that have been melting nicely under my tongue and have been helping these last few weeks?

  • @scottmerrell4337

    @scottmerrell4337

    Жыл бұрын

    Dallas GA USA

  • @debp.2599

    @debp.2599

    Жыл бұрын

    @@scottmerrell4337 Although those melt they are not considered sublingual because they are not absorbed directly into the blood through the membranes under your tongue...Those actually go through your digestive tract.

  • @scottmerrell4337

    @scottmerrell4337

    Жыл бұрын

    @@debp.2599 That does not make sense. Do you know something about the formulation that would make it not work under the tongue? Seems to work for me😁

  • @lewisbob51
    @lewisbob51 Жыл бұрын

    Is oral B1 dosage the same as Sublingual B1 ?

  • @michelenj9380
    @michelenj9380 Жыл бұрын

    What is the name of the book

  • @caroliverach4212
    @caroliverach421210 ай бұрын

    I am really interested in trialling B1 but would this interfere with other medicines.

  • @cheryllewis7548
    @cheryllewis75484 ай бұрын

    Where do i get the book i live in trinadad

  • @theluckyman74
    @theluckyman74 Жыл бұрын

    For anyone that hasn't looked at the Studies. Vitamin d3 and omega 3 also had miraculous results in many conditions. The dose was 2000 iu of d3 and I think 1 gram of omega 3 daily.

  • @glenliesegang8935

    @glenliesegang8935

    Жыл бұрын

    measure cholecalciferol levels. my patients often need 20,000 u D3 /day x 3 months and MEASURE because too much, level over 80, is dangerous. NO calcium while on high D3 as can cause kidney stones or hardened coronary artery plaque

  • @theluckyman74

    @theluckyman74

    Жыл бұрын

    @@glenliesegang8935 True and always measure. K2 can also balance it.

  • @veerani6164

    @veerani6164

    Жыл бұрын

    ​@@glenliesegang8935how can you get rid of artery plaque,

  • @lovesarita

    @lovesarita

    9 ай бұрын

    D3 must *always* be taken with K2 to push it into bones and teeth, otherwise it clogs arteries. I think it's generally very important but in Dr Laurie Mishley's large scale PD surveys it is nowhere near as effective as gingko biloba.

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    K2 mk7 seems important to take to transport the increased calcium into bone storage, so ask your doctor.@@theluckyman74

  • @marklimebear4359
    @marklimebear4359 Жыл бұрын

    Just to echo Michel's comments. It was a pleasure creating the interview and we have some very exciting speakers lined up in the coming months and hope they all help in someway

  • @banzobeans
    @banzobeansАй бұрын

    13:42 placebo effect: remarkable answer however I did however hear Dr. Costantini's nurse express that her doc told her personally (as a patient) that she was going to feel better soon. I thought that was problematic tbh.

  • @keitymarley733
    @keitymarley7334 ай бұрын

    Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine that truly works that helped treat, cure and reversed all his symptoms totally 💯. My Dad is well again…

  • @aquestforrest6978

    @aquestforrest6978

    4 ай бұрын

    Please tell us what medicine you used for your dad!!!

  • @usharaveendran3683

    @usharaveendran3683

    3 ай бұрын

    Please tell us the medicine and treatment that worked for your dad as I have parkinsons

  • @sheila7814

    @sheila7814

    3 ай бұрын

    When they make posts like this but do not state anything about the miracle cure….. it is usually a fake post.

  • @donnarichardson2888

    @donnarichardson2888

    3 ай бұрын

    Hello, why would you make a statement like that, then not tell everyone what worked for your Dad. We are all put on this earth to love and help one another, as Jesus said. So, please comment on what his regimental that, " he took. You might just bring relief and joy at being able to get back some of their former life. Praying you do the right thing. Just look inside your own heart and ask the question "should I help these people". Then do what your heart tells you to. From a daughter whose mother has parkinsons and desperately needs help. Be Blessed.

  • @keitymarley733

    @keitymarley733

    3 ай бұрын

    @@donnarichardson2888 if you need the treatment you should contact Dr Madida on KZread

  • @jane2133
    @jane21339 ай бұрын

    What dose of vitamin B1 is best?

  • @angeloricci8225
    @angeloricci82257 ай бұрын

    Dr Costantini recommended taking vitamin B1 by intramuscular injection

  • @raykinney9907
    @raykinney9907 Жыл бұрын

    Can B1 deficiency be important right in the gut environment, as well as in the CNS later, for pathogenic initiation?

  • @daphnebryan4578

    @daphnebryan4578

    Жыл бұрын

    I see you’ve asked several questions. I’m afraid my understanding of the action of B1 comes from the only research into B1 and Parkinson’s. There is yet no research out there to answer your questions and it’s definitely beyond my qualifications to enter into a discussion on it I’m afraid. The research we have from Dr Costantini suggests that high doses of thiamine can influence cellular energy metabolism which has been disrupted or inhibited by other factors. The theory is that by using high doses of thiamine, certain enzymes involved in energy metabolism are stimulated and metabolic function in the cells is restored, so they can work efficiently once more.

  • @raykinney9907

    @raykinney9907

    Жыл бұрын

    @@daphnebryan4578 Yes, there seems to be quite a bit of research on some of these questions, but the more I read, the more questions I have, I guess that is good. You certainly have brought a lot of B1 questions to the fore, thanks, i'll be reading a lot of related papers.

  • @landmarcmusicdotcom

    @landmarcmusicdotcom

    Жыл бұрын

    Most likely, Check out youtube videos from EONutrition, Elliot Overton talks about the role of thiamine in digestive function. Also check out a video interview of Chandler Mars about thiamine deficiency. She wrote a book with Dr. Lonsdale called: High Calorie Malnutrition; You need to use a more bioavailable form either: benfotiamine or ttfd, regular thiamine-hcl is only absorbed about 3-6% Also, be sure to add magnesium and a b-complex vitamin as well, as these help the body utilize the B-1 better

  • @veerani6164

    @veerani6164

    Жыл бұрын

    ​@@landmarcmusicdotcomhow much benfoitamine and ttfd is absorbed orally

  • @user-dt1jm1nn3f
    @user-dt1jm1nn3f10 ай бұрын

    How do I get B1 vitamin sublingual? I have tried amazon, I couldn't find the sublingual B1. Where could I find or purchase this vitamin.

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    10 ай бұрын

    You can ask Daphne via this Facebook page facebook.com/groups/512119977204633/?hoisted_section_header_type=recently_seen&multi_permalinks=798435068573121

  • @landmarcmusicdotcom
    @landmarcmusicdotcom Жыл бұрын

    You need to use a more bioavailable form such as: benfotiamone or ttfd. Also, make sure you are taking magnesium and a b-complex vitamin as these nutrients become much more needed now that the body is using thiamine.

  • @dede54460

    @dede54460

    Жыл бұрын

    Hi, I had exactly same reflexion as yours since a couple of days I discovered this treatment method but then I told myself that Dr Costantini was naturally also aware of the other forms of thiamin, like the sulbutiamin and if there was an added value, he would have told it. I order the Daphne Bryan's book and maybe it contains some explanations. There is probably a reason why he didn't talked about the other alternatives, I would appreciate to know if somebody found real added value with other than natural Thiamin. Also if somebody tried NADH remedy It would be interesting to know about. Father of the inventor of NADH is the one who proposed levodopa to manage Parkinson, according to videos I found about. Thks

  • @glenliesegang8935

    @glenliesegang8935

    Жыл бұрын

    alternatives very expensive esp on 4000 mg/day. NOW brand by Swanson $8.50 for 100, so much less costly.

  • @vinpatel5452

    @vinpatel5452

    Жыл бұрын

    L😊

  • @rethap3612

    @rethap3612

    3 ай бұрын

    Methylated B vitamins absorb better.

  • @debp.2599
    @debp.2599 Жыл бұрын

    You mention needing to also use magnesium and B complex but what form of magnesium? I take magnesium threonate…is that sufficient?

  • @glenliesegang8935

    @glenliesegang8935

    Жыл бұрын

    Must measure blood levels. certainly stop if diarrhea. no more than 400 mg bid x 2 months w/o measuring.

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    Currently, I take both Mg threonate and glycinate. There is some research about threonate better getting into brain. But, apparently not much of what you take stays in the body long. Glycinate.

  • @253georgica
    @253georgica Жыл бұрын

    Daphne what’s the name of your book my wife has Parkinson’s and we’d like to buy it

  • @britxxmaster
    @britxxmaster Жыл бұрын

    Will b complex 100 work as well?

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    Dr. Stasha Gominak has clinical evidence that B100 can become problematic, and B50's seemed far better to her point of view. Goggling her, or YT, brings her comments up.

  • @daphnebryan4578
    @daphnebryan4578 Жыл бұрын

    In this video I mention EZmelts B1 in connection with it possibly being a sublingual tablet. We now know EZmelts is NOT a sublingual tablet. It does NOT pass through the mucous membrane under the tongue, but travels through the digestive system. This means that if you use it for high dose thiamine therapy you would need between 20-160 tablets a day!

  • @landmarcmusicdotcom

    @landmarcmusicdotcom

    Жыл бұрын

    try a more bioavailable form like benfotiamine or ttfd. these need to be used in high dose, like 1000mg a day. Also adding magnesium and a B-complex vitamin will help (very important)

  • @daphnebryan4578

    @daphnebryan4578

    Жыл бұрын

    @@landmarcmusicdotcom More is not necessarily better in this therapy. You have to find the right dose for the individual. Too much and Parkinson’s symptoms worsen. There are little or no cases of individuals finding their Parkinson’s symptoms reduce using benfotiamine or TTFD. There are several cases known to me of people shooting into overdose symptoms on these derivatives even on a far smaller dose than 1000mg a day. One overdosed on 25mg! More bioavailable can make it just too strong for this therapy.

  • @glenliesegang8935

    @glenliesegang8935

    Жыл бұрын

    ​@@daphnebryan4578 stop increasing at effective dose, else high cost and no more benefit.

  • @kenbrookes6569

    @kenbrookes6569

    Жыл бұрын

    ​@@daphnebryan4578 how does one recognise their sweet spot given it may take weeks to identify benefits?

  • @mishkaned7777
    @mishkaned7777 Жыл бұрын

    How many mg should one take per of vitamin B1?

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Hi, if you would like Daphne to reply then best to post the question on her Facebook group facebook.com/groups/512119977204633

  • @conobrien1743
    @conobrien1743 Жыл бұрын

    What is the recommended dose of B1

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Daphne will probably not see this comment. She does run a Facebook group that she comments on daily so suggest asking the question there. This is the link facebook.com/groups/parkinsonsb1therapy

  • @eaglemotive
    @eaglemotive5 ай бұрын

    In Parkinsons there is calcium buildup in the brain. To remove it use EDTA. Then to address the issue, try Vitamin K2 MK4 type because that is what our cells need. Vitamin K2 opens calcium ion channels, and may prevent the calcium buildup by getting the calcium where it is intended to go. Calcium is what sends the signal for neurons to release neurotransmitters. If the calcium ion channels begin opening and taking the calcium in properly, your condition may improve. The α7 nAChR subtype has one of the highest permeabilities to calcium, the activation of which can raise cytoplasmic calcium levels and trigger a series of calcium-dependent intracellular processes. Calcium ions are one of the most versatile intracellular messengers known, and impacts almost every aspect of cellular life, including excitability, exocytosis, motility, apoptosis, and transcription; this is achieved by interacting with thousands of proteins and their downstream effectors9, 10. Calcium influx through nAChRs, particularly through the α-bungarotoxin-sensitive α7-containing nAChRs, is a very efficient way to raise cytoplasmic calcium levels. Here we will present a brief summary of the calcium signals initiated by the activation of neuronal nAChRs, and its possible physiological relevance. www.ncbi.nlm.nih.gov/pmc/articles/PMC4002362/ Another thing to try is a Nicotine Patch or other form, gum, lozenge, pouch, etc. Nicotine is a super agonist for the activation of neuronal nAChRs. Nicotine is present in all Nightshade Vegetables, Eggplant having the highest amount. It is in celery, potatoes, tomatoes, and more. So you see plain nicotine is not addictive. Tobacco products have many additives that make them addictive. Don't use them.

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    Yes, but I'd like to know why K2mk7 is not also helpful, by getting increased Ca into bone?

  • @tritter2001

    @tritter2001

    6 күн бұрын

    Yes mk7 is the most effective form.

  • @dickmccall4343
    @dickmccall4343 Жыл бұрын

    Hi Daphne As I think you already know I am a new Parkinsonee and am keen on B1 and trying to see what else is available as treatment. I have just watched a presentation on red light therapy which impressed me considerably. I had seen references previously in my research and thought can this be real but there is a much more believeable evidence I am interested in your view or anyone who has tried the treatment. Dick

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Dick, we have Dr Catherine Hamilton talking about Red light therapy in a couple of wks, so you may want to join us and ask the question directly www.eventbrite.co.uk/e/update-on-red-light-therapy-and-its-potential-benefits-for-people-with-pd-tickets-413654430537

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    Quantum biology discussions of near infra red light, especially from daylight, CAN benefit mitochondrial function, which appears in the literature to be approaching the 'root cause'. Now, many things can increase that dysfunction, so reading as much of the research as possible is important, to find ways of improving those energy problems. Find doctors that are looking specifically at this research, and find one that knows more adequately about quantum biology. IMHO

  • @ravindrakango6266
    @ravindrakango6266 Жыл бұрын

    Unbelievable but have to believe because it is a fact that has been working with several hundred folks. I have read the book mentioned in this session. One basic question is can human body absorb such a high dose of B1 or any other vitamin or nutrient for that matter, and still won't have any side effects ? I am not an expert in this domain but the general knowledge is that daily dose of most of these vitamins is few milligrams and excess intake esp. synthetic or artificial ones is flushed out by the human body. So what happens in case of B1 therapy wherein you take multiple times higher dose than required by the human body ? Is that converted into new cells of various types which includes dopaminergic ones ? If part of the higher intake is converted, where goes the remaining ? If remaining quantity is stored by the body in some form, will that stock build-up not cause any problems in the body in future, may be after some years ?

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    A good question and one perhaps best to address to Daphne via her Facebook group that she monitors closely facebook.com/groups/parkinsonsb1therapy

  • @lovesarita

    @lovesarita

    9 ай бұрын

    In theory surplus B vitamins get excreted in urine but B6 for sure can cause neuropathy in its most common (cheapest) form at high doses over time.

  • @antonioandrino2390
    @antonioandrino2390 Жыл бұрын

    Good afternoon. To get the vitamin B1 dosage adjustment, we started with 500mg. But how much can we safely increase this dosage? Can you reach up to 2 g, for example, without major risks?

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Daphne will probably not see this comment. She does run a Facebook group that she comments on daily so suggest asking the question there. This is the link facebook.com/groups/parkinsonsb1therapy

  • @chinko1953
    @chinko1953 Жыл бұрын

    Is there any verified B1 sublingual tablet? Please provide name and source. Thank you

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Daphne recommended this www.pureformulas.com/no-shot-b-1-100-mg-100-dissolvable-tablets-by-superior-source.html Not sure where in the world you are but hope it helps

  • @yvettenoronha2236
    @yvettenoronha2236 Жыл бұрын

    Hi good evening. I would like to know is B1 and BeOne the same

  • @wayneschenet5340

    @wayneschenet5340

    2 сағат бұрын

    B1 is the proper name for Thiamine.

  • @raykinney9907
    @raykinney9907 Жыл бұрын

    If B1 level is important in normal gut environment, and in the vegas nerve pathway to the brainstem, is it also important physiologically in the dopamine-producing cells in the brain tissue? Is it important in mitochondrial functioning? If the brain volume shrinks as cells die, and near infrared light passing into the brain from the sun can help restore mitochondrial optimal function and numbers in such brain cells, does B1 play a vital role in this strengthening? Is B1 making its way through the BBB to be present there, and can a deficiency from normal levels there be overcome by increasing it? Is it additive, or synergistic, with melatonin produced in mitochondria by the NIR light? Does it help in Nitric oxide production to dilate capillaries to facilitate erythrocyte passage through to provide more O2 for ATP production?

  • @raykinney9907

    @raykinney9907

    Жыл бұрын

    Does a-synuclein mis-folded protein form fibrils that obstruct erythrocyte passage? Do these tangles limit O2 supply too much? Is melatonin level in mitochondria enough to deal optimally with the ROS production? Does B1 help in all of this, as well as in the gut?

  • @raykinney9907

    @raykinney9907

    Жыл бұрын

    Well, yes, a short Pubmed search brings up ample research suggesting importance of B1 levels in brain tissue: (eg.Mol Cell Neurosci . 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Epub 2012 Sep 13. Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes Gary E Gibson 1 , Joseph A Hirsch, Rosanna T Cirio, Barry D Jordan, Pasquale Fonzetti, Jessica Elder

  • @raykinney9907

    @raykinney9907

    Жыл бұрын

    Glycation of the erythrocytes must also add to difficulty of maintaining good flow through small vessels, complicating the problem of the fibrils, and if the nitric oxide is not adequate?

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    If so, do we have 'erectile dysfunction of brain'?

  • @raykinney9907

    @raykinney9907

    3 ай бұрын

    And, for ATPase turbine 'lubrication' deuterium-depleted water Exclusion Zone water, increasing spin of the turbine and safeguarding ETC functionality? Can many 'hibernating' dopamine-producing neurons (under-fueled by glycation of supply system), and starving mitochondria into having to ration suboptimal ATP to more essentially needed neurons than those that produce dopamine, can hibernating but undead ones be refueled by use of exogenous ketone ester use?

  • @Shoshin777
    @Shoshin7774 ай бұрын

    Anyone have the correct dose? I just got diagnosed at 39 with PD I’m devastated I’m very scared about my future I have young kids I need to find some hope 💔💔💔💔💔

  • @cosmichealth3907

    @cosmichealth3907

    4 ай бұрын

    Start slow at 50mg multiple times a day with mag citrate ,nutritional yeast ,and 10000 iu vit d....

  • @dpfreeman1
    @dpfreeman1 Жыл бұрын

    Did she take levadopa also?

  • @nosilverbullet4pd998

    @nosilverbullet4pd998

    Жыл бұрын

    Yes. It is not a substitute to it.

  • @mishkaned7777
    @mishkaned7777 Жыл бұрын

    I am astonished that the supplement of vitamin B1 is not known to most doctors...so very sad...

  • @ziontours5893

    @ziontours5893

    11 ай бұрын

    I took vitamin B1 for a month following this video. There was no improvement at all with my Parkinson's. Probably that's why neurologists don't automatically prescribe it. I've now bought some mannitol which somebody told me improves the brain and relieves Parkinson's symptoms. Here's hoping.

  • @mishkaned7777

    @mishkaned7777

    11 ай бұрын

    @@ziontours5893 My husband too with parkinson, took vitamin B1 and nothing really changed...

  • @sheila7814

    @sheila7814

    3 ай бұрын

    @@ziontours5893Did the mannitol work?

  • @ix-Xafra
    @ix-Xafra Жыл бұрын

    Benfotiamine and L-tyrosine in my coffee with cream (they're both lipophilic)

  • @tonightlyfan60
    @tonightlyfan60 Жыл бұрын

    interesting if true!

  • @michaeloconnor9465
    @michaeloconnor94657 ай бұрын

    I take 600mg benfotaimamine. That is fat soluable does it work getting B1 that way. It is meamt to get into the cells easier.

  • @marcismiles

    @marcismiles

    2 ай бұрын

    Have you seen improvement with the benfotamine?

  • @michaeloconnor9465

    @michaeloconnor9465

    2 ай бұрын

    @@marcismiles I stopped taking benfotamine because it doesn't get into the brain. I take 1600mg of B1, 200mg thiamine B1, 1200mg TUDCA. A Dr is doing stage 2 clinical trials on UDCA for Parkinson's with promising results. UDCA is converted by the body to TUDCA, protects the neurons by stopping the mitochondria from telling the cell to die. TUDCA has loads of other health benefits. It is a bile acid salt. I take 2400mg of NAC, is converted into glutathione the body's main antioxidant, NAC gets into the brain to boost brain levels of glutathione. I take 900mg Alpha Lipoic acid, protects the neurons and mitochondria, stops the mitochondria from telling the neurons to die when under stress. They all help. You can research TUDCA, and search UDCA for Parkinson's. You van research NAC, and you can research ALA. Everything I do is aimed at protecting the neurons. I do a keto diet as well. That helped me lose 3 stone in weight. They all help. Hope this helps. I spend many hours looking for supplement that protects neurons. ALA is very good for Type 2 diabetes.

  • @michaeloconnor9465

    @michaeloconnor9465

    2 ай бұрын

    ​@@marcismiles I replied to you but it disappeared. Take 1600mg B1 and 200mg Thiamine B1 With TUDCA, NAC, and ALPHA LIPOIC ACID. Keto diet and they all work.

  • @michaeloconnor9465

    @michaeloconnor9465

    2 ай бұрын

    ​@@marcismilesI try to reply to you but the reply disappeared.

  • @raykinney9907
    @raykinney9907 Жыл бұрын

    If PD starts in the gut, with a-synuclein, and 'normal' form of it mis-folds before it begins moving into the vegas nerve, to move up toward the brainstem via retrograde axonal transport, is it likely that a b-vitamin1 suboptimal presence in the gut allows increased mis-folding? Some observers of sleep dis-orders, and daily headache suggest that it takes enough vitamin D3 to allow the four symbiotic bacteria species (or genera) to be producing and sharing each other with the eight B's between them, for a 'healthy' bacterial assemblage to be present. What might the D3 level need to be to provide this ecology of gut? Given D3 being so commonly deficient in populations, can a B1 deficiency, because of aberrant gut bacterial assemblage, be causative? Is a-synuclein (with its 'normal' form actually doing some important function in gut not known yet), but under less supportive bacterial gut assemblage (with sub-optimal D3), have increased mis-folding to yield a dysfunctional protein, or even a more aberrantly-toxic protein to enter the vegas? Does the mis-folding process begin with deficiency of a metal such as zinc in zinc finger, or similar metal substitution by the toxic metal lead? Or, an amino acid sequence that includes adjacent placement of glycine/glycine near either end of the chain, where it can be readily subject to glycine replacement by glyphosate? Or, is there research currently that shoots holes in these suggested possible mechanisms? Both metal/metal substitutions, and glyphosate/glycine substitutions have some supportive evidence as real mechanisms. IMHO

  • @drpanditkale

    @drpanditkale

    Жыл бұрын

    In ayurveda India its told by Charak aacharya and give treatment like basti - anal enema n other

  • @bethwokabi5070

    @bethwokabi5070

    Жыл бұрын

    Ray, it seems you are well researched in this. Following your thinking

  • @snowyowl6892

    @snowyowl6892

    Жыл бұрын

    RAY KINNEY WHAT A BRILLIANT COMMENT ! Listen up everyone … everything he says is very significant … IGNORE RAY AT YOUR PERIL 👍

  • @snowyowl6892

    @snowyowl6892

    Жыл бұрын

    Ray Kinney 👈🏿 BRAVO …. Best comment here. 🤗🌟✅👍

  • @raykinney9907

    @raykinney9907

    Жыл бұрын

    @@snowyowl6892 Or, follow him at your peril, I'm ' just some guy on the internet', no alphabet soup following my name. And, probably more wrong than right.

  • @banzobeans
    @banzobeansАй бұрын

    11:48 Fatigue

  • @martincleaver6463
    @martincleaver6463 Жыл бұрын

    Constantini essentially rediscovered the same mechanism of action as Dr.Derrick Lonsdale

  • @PJKallhoney
    @PJKallhoney Жыл бұрын

    Love your show. I wish you would talk much slower so we can understand what you are saying.

  • @valdarasela8719
    @valdarasela8719 Жыл бұрын

    😊😊😊 24:12 😊😊

  • @JohnJohnson-wy6fk
    @JohnJohnson-wy6fk Жыл бұрын

    Benfotiamine is good for neuropathy, but only accumulates in the peripheral and does not cross the BBB as it is not truly lipophilic. Sulbutiamine and all allithiamine arr better for getting into the brain.

  • @lrduff
    @lrduff Жыл бұрын

    Does benfotiamine (another form of B-1) have the same effect? I believe it has an affinity for the nervous system. She seems to have answered my question.

  • @paulcook7986
    @paulcook7986 Жыл бұрын

    This protocol doesn’t work for everyone with Parkinson’s. I have Parkinson’s and Celiac. Celiac disease can inhibit absorption of vitamins and nutrients.

  • @cosmichealth3907

    @cosmichealth3907

    4 ай бұрын

    This will work...with Celiac you need to go carnivore...then after few days add b,1....quit dairy d gluten and sugar

  • @pamelabrown7368
    @pamelabrown7368 Жыл бұрын

    Can't get rich selling Vitamins

  • @rexeverything6249
    @rexeverything6249 Жыл бұрын

    It certainly seems to work two benfotamine and a magnesium threeonate my tremors are gone for at least 8 hours ,,,

  • @veerani6164

    @veerani6164

    Жыл бұрын

    What dose is each tablet

  • @sheila7814

    @sheila7814

    3 ай бұрын

    How many mg for each tablet?

  • @raykinney9907
    @raykinney9907 Жыл бұрын

    Yes, some of the questions sparked by this presentation, listed below, are also clarified in significant research In Pubmed: (e.g. Mol Cell Neurosci. 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Epub 2012 Sep 13. Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes Gary E Gibson 1 , Joseph A Hirsch, Rosanna T Cirio, Barry D Jordan, Pasquale Fonzetti, Jessica Elder So, deficiency of B1 can definitely play important roles in brain pathogenicity.

  • @ninarichard2013
    @ninarichard2013 Жыл бұрын

    𝐩𝐫𝐨𝐦𝐨𝐬𝐦

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