18.6 Nucleophilic Aromatic Substitution | Organic Chemistry
Chad presents a comprehensive lesson on nucleophilic aromatic substitution of aryl halides. Chad presents both possible mechanisms for this reaction: 1) Addition-Elimination and 2) Elimination-Addition (the Benzyne mechanism) and explains how you can tell which mechanism is more likely for a particular aryl halide.
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00:00 Lesson Introduction
00:47 Nucleophilic Aromatic Substitution
02:04 Addition-Elimination Mechanism
07:44 Elimination-Addition (Benzyne) Mechanism
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Thanks Chad. Your videos have helped me a great deal throughout my pharmaceutical chemistry degree.
@ChadsPrep
8 ай бұрын
You're welcome - glad to hear it!
I'm really really happy i came across this channel Thank God for Chad's prep...... you're a life-saver man😇 God bless you!!!!!!!❤
@ChadsPrep
Жыл бұрын
You're welcome - glad you found us!
Thank you for helping me pass ochem II
@ChadsPrep
2 жыл бұрын
Good for you, Bridget!
love these thankssss
@ChadsPrep
Жыл бұрын
You're welcome
I have a quiz tomorrow for ochem (and an exam for another class too) so I'm binge watching your videos (: hope I do well
@ChadsPrep
Жыл бұрын
All the best.
for the elimination-addition reaction to form the benzyme intermediate, if the methyl were a pi donating EDG would regioselectivity be impacted for the final product? would the meta be favoured because EDGs add electron density to ortho and para positions? or would the reaction not happen?
very nice video
@ChadsPrep
2 жыл бұрын
Glad you like it, sajjad anjum!
7:06 Isn't nitro group a better leaving group than cl? Then in the reaction, wouldn't NH2 substitute NO2 instead of Cl?
@ChadsPrep
7 ай бұрын
If you look at the flow of electrons within the pi system, NO2 is withdrawing electron density towards itself and so the electron density at that point in the ring would be relatively higher making it less likely that substitution will occur there.
@local3128
7 ай бұрын
Oh, true. Thanks for the reply. 😊
@ChadsPrep
7 ай бұрын
You're welcome! happy studying :)
is there supposed to be NO2 in the product @ 8:26 ?
@ChadsPrep
2 жыл бұрын
:( It absolutely was supposed to still have a nitro group para. ARRRRR! Thanks for the heads up and nice catch!
@maxsingh1117
11 ай бұрын
@@ChadsPrepshould there also be a nitro at the ortho position, or did that one leave?
@maxsingh1117
11 ай бұрын
@@ChadsPreplso great vids they do really help a lot 🙌🏾