18.6 Nucleophilic Aromatic Substitution | Organic Chemistry

Chad presents a comprehensive lesson on nucleophilic aromatic substitution of aryl halides. Chad presents both possible mechanisms for this reaction: 1) Addition-Elimination and 2) Elimination-Addition (the Benzyne mechanism) and explains how you can tell which mechanism is more likely for a particular aryl halide.
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00:00 Lesson Introduction
00:47 Nucleophilic Aromatic Substitution
02:04 Addition-Elimination Mechanism
07:44 Elimination-Addition (Benzyne) Mechanism
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Пікірлер: 21

  • @johnnytaylor9784
    @johnnytaylor97848 ай бұрын

    Thanks Chad. Your videos have helped me a great deal throughout my pharmaceutical chemistry degree.

  • @ChadsPrep

    @ChadsPrep

    8 ай бұрын

    You're welcome - glad to hear it!

  • @Czar_Char
    @Czar_Char Жыл бұрын

    I'm really really happy i came across this channel Thank God for Chad's prep...... you're a life-saver man😇 God bless you!!!!!!!❤

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    You're welcome - glad you found us!

  • @bridgetbaber8718
    @bridgetbaber87182 жыл бұрын

    Thank you for helping me pass ochem II

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    Good for you, Bridget!

  • @amandaplong210
    @amandaplong210 Жыл бұрын

    love these thankssss

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    You're welcome

  • @strugglingcollegestudent
    @strugglingcollegestudent Жыл бұрын

    I have a quiz tomorrow for ochem (and an exam for another class too) so I'm binge watching your videos (: hope I do well

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    All the best.

  • @laurenpare1888
    @laurenpare18886 ай бұрын

    for the elimination-addition reaction to form the benzyme intermediate, if the methyl were a pi donating EDG would regioselectivity be impacted for the final product? would the meta be favoured because EDGs add electron density to ortho and para positions? or would the reaction not happen?

  • @sajjadanjum2695
    @sajjadanjum26952 жыл бұрын

    very nice video

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    Glad you like it, sajjad anjum!

  • @local3128
    @local31287 ай бұрын

    7:06 Isn't nitro group a better leaving group than cl? Then in the reaction, wouldn't NH2 substitute NO2 instead of Cl?

  • @ChadsPrep

    @ChadsPrep

    7 ай бұрын

    If you look at the flow of electrons within the pi system, NO2 is withdrawing electron density towards itself and so the electron density at that point in the ring would be relatively higher making it less likely that substitution will occur there.

  • @local3128

    @local3128

    7 ай бұрын

    Oh, true. Thanks for the reply. 😊

  • @ChadsPrep

    @ChadsPrep

    7 ай бұрын

    You're welcome! happy studying :)

  • @miray7945
    @miray79452 жыл бұрын

    is there supposed to be NO2 in the product @ 8:26 ?

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    :( It absolutely was supposed to still have a nitro group para. ARRRRR! Thanks for the heads up and nice catch!

  • @maxsingh1117

    @maxsingh1117

    11 ай бұрын

    @@ChadsPrepshould there also be a nitro at the ortho position, or did that one leave?

  • @maxsingh1117

    @maxsingh1117

    11 ай бұрын

    @@ChadsPreplso great vids they do really help a lot 🙌🏾