Nucleophilic Aromatic Substitution - Benzyne Intermediate and Meisenheimer Complex
This organic chemistry video tutorial provides a basic introduction into nucleophilic aromatic substitution reactions. It discusses the conversion of para-chloronitrobenzene into para-nitrophenol using an addition elimination reaction mechanism that passes through a resonance stabilized carbanion intermediate known as the Meisenheimer complex. This video also discusses the conversion of para-bromotoluene into meta and para-methylaniline using an elimination addition reaction mechanism that passes through the benzyne intermediate.
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You're my favorite chem guy. Thanks for all you do!!! You're consistently amazing.
Never quit. I love this!!!!
Meisenheimer? More like my, so much higher...in educational value than almost every other video on KZread. Thanks again so much for making and sharing these!
Beautiful
W video man, big up.
In Chlorobenzene there should slight negative charges in Ortho and para position due to resonance. Then why does a Neucleophile attack the H in the ortho position? Wouldn't it make more sense if it attacked the H in meta position where the electron density is relatively lesser?
9:40 3️⃣50 C
Nice
ok, but what are the other reagents that can go through the benzyne intermediate 😠😠?
Will NAS occur if there is an activating group and a good leaving group? Or is this process restricted to a deactivated ring and a nucleophilic reagent?
@ansingh1338
4 жыл бұрын
Same doubt...
@PunmasterSTP
2 жыл бұрын
Doesn't the reaction starting at 14:56 have an activating group (methyl) and a good leaving group (bromo)?
You are a breathing miracle
In the last reaction. How's the ratio of meta to ortho and para? 1:2:1 (orto:meta:para) Or is para more likely to happen than ortho because of steric hindrance of the CH3 group?
@janrenehaak
6 жыл бұрын
I think that the methyl-group isn´t so bulky, so their is no hindrance. Because of that I suggest, that the ratio ist 1:2:1 as you said. I hope this didn´t come too late :D
17:30 which one is major and minor
@tom_winguill
3 жыл бұрын
fuck you
@tom_winguill
3 жыл бұрын
F;U;C;K||||||Y;O;U
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@PunmasterSTP
2 жыл бұрын
From your asking that question, I take it you two have chemistry together?
tw