18.2 Friedel Crafts Alkylation and Acylation | Organic Chemistry
Chad gives a thorough presentation covering Friedel-Crafts Alkylation and Friedel-Crafts Acylation. He begins with the mechanism of the Friedel-Crafts Alkylation and reveals the three shortcomings of the reaction:
1) The reaction is prone to occur multiple times (polyalkylation),
2) It is subject to rearrangements,
3) It doesn't work with strongly deactivated benzenes
Chad then presents the mechanism for the Friedel-Crafts Acylation and goes on to show how it is not subject to the first two shortcomings experienced by Friedel-Crafts Alkylations. Finally, Chad concludes the lesson with the Gattermann-Koch reaction, functionally a special case of the Friedel-Crafts Acylation.
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00:00 Lesson Introduction
00:39 Friedel-Crafts Alkylation
07:57 Friedel-Crafts Acylation
13:49 Gattermann-Koch Reaction
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Пікірлер: 34
A very beautiful and interesting explanation. I am a student at the College of Pharmacy, University of Baghdad. I have been following you for a while, and I was very impressed by your wonderful explanation.
@ChadsPrep
8 ай бұрын
Glad to hear and Thank You.
@user-ku6ue7cd7t
8 ай бұрын
@@ChadsPrep ♥️♥️♥️
Thank you all the way from South Africa. I am doing chemical engineering and you're the best!
@ChadsPrep
2 ай бұрын
You're welcome and Thanks from USA!
This is extremely useful! Thank you for such a great explanation!
@ChadsPrep
2 жыл бұрын
You're welcome!
thanks alot from Egypt 🇪🇬 ❤
@ChadsPrep
7 ай бұрын
Very welcome from USA.
Awesome video, Chad! Will you get a product for the top 4 EAS reactions even if NO2 is present? My understanding is that the only time NO2 will interfere is if it is Cl-R, or R-O-Cl (the bottom 2 reactions) Thanks!
@ChadsPrep
2 жыл бұрын
Hey Abby - do you mean will nitrobenzene still react? It does but will direct the addition of the new substituent to the meta position due to ring deactivation - did you check out this video kzread.info/dash/bejne/fWRpxKaDfbnNhaw.html on reactions of substituted benzene?
THANK YOU ALL THE WAY FROM ZAMBIA.
@ChadsPrep
Ай бұрын
You're welcome from USA!
Thank you so much sir .......🎉🙏🏻 And where are you from
Awesome video. Thanks alot
@ChadsPrep
3 жыл бұрын
Glad you liked it, Minh - thanks for commenting!
Great Video!!
@ChadsPrep
2 жыл бұрын
Thank you!
Instead of Chorine, could you use Bromine (with FeBr3) to carry out Friedel Craft Alkylation?
@ChadsPrep
3 жыл бұрын
You totally could Joe!
@joeburreaux7953
3 жыл бұрын
@@ChadsPrep Thanks for the quick reply, Chad!
@ChadsPrep
3 жыл бұрын
You're welcome Joe! And I will get back to you soon regarding your Biochem post :)
Ty!
@ChadsPrep
Жыл бұрын
Welcome!
Thank you 🙏🏾
@ChadsPrep
4 ай бұрын
Very welcome.
If I have a akyl chloride, can it react with FeBr3?
@redkritter1225
Жыл бұрын
Yes since it’s a halogen
Thank you so much... From Pakistan 🇵🇰
@ChadsPrep
4 ай бұрын
You're welcome from USA.
I like the way you say Koch
@ChadsPrep
Жыл бұрын
Happy Studying!
I'm not quite grasping this concept at all 😩
@ChadsPrep
7 ай бұрын
What are you struggling with?