Bioinformatica

Bioinformatica

BY BIOINFORMATICIANS - OF BIOINFORMATICIANS - FOR BIOINFORMATICIANS

"BIOINFORMATICA" is an initiative to provide quality videos on bioinformatics related topics for a better understanding of the students who are studying bioinformatics or those who want to join bioinformatics.

Pairwise Alignment

Pairwise Alignment

BLOSUM matrix

BLOSUM matrix

PAM matrix

PAM matrix

Sequence Comparison

Sequence Comparison

Пікірлер

  • @melvinverdinanmulia7052
    @melvinverdinanmulia70524 күн бұрын

    Is the traceback step the same as the global sequence alignment?

  • @jho1116
    @jho11168 күн бұрын

    Thanks

  • @sharonraj5964
    @sharonraj596412 күн бұрын

    So so helpful, thank you so much

  • @khushichitania6009
    @khushichitania600919 күн бұрын

    I was trying to understand it from the past few hours from ample of videos but this was the best one that explained the method very clearly and in an easy manner. Thanks a lot.

  • @sudhavani4306
    @sudhavani4306Ай бұрын

    Thank u so much for biologist is very good explanation

  • @neverever7821
    @neverever7821Ай бұрын

    THANK YOU SO MUCH!!! YOU'VE SAVED ME!!!

  • @Priyanshu_Kumar_Pandey
    @Priyanshu_Kumar_PandeyАй бұрын

    Thanks

  • @ritvihasija1260
    @ritvihasija1260Ай бұрын

    Please upload more and detailed videos of topics ma'am. If possible

  • @LocNguyenTien-yh4hp
    @LocNguyenTien-yh4hp2 ай бұрын

    wtf is cij,bro dont even give the equation ?

  • @hMF580
    @hMF5802 ай бұрын

    I have learnt it from the first time, thank you

  • @prabhu5220
    @prabhu52202 ай бұрын

    thank you so much sir!! great explanation!!

  • @vaibhavadicherla5145
    @vaibhavadicherla51452 ай бұрын

    Needed some better explanation

  • @tonypepper
    @tonypepper3 ай бұрын

    Sir , i didn't understand How you got GCT as second sequence. Is it same like Needleman?. Or is it like 3,2,1,0. And 1,0 from A-A? And we dont need to go sideways? But if we have to stop , stop till 0 and continue with next highest number?

  • @gamingwithnoobs8448
    @gamingwithnoobs84483 ай бұрын

    The best lecture I have watched on global alignment !

  • @aleeshakb5317
    @aleeshakb53174 ай бұрын

    Please add more videos related to bioinformatics

  • @ganapathyk3307
    @ganapathyk33075 ай бұрын

    I guess in local alignment all positive values are considered to be 1 and all 0 and negative values are consider to be zero. So local alignment should be binary completely. Tell me if we can use major values as well

  • @tlili3990
    @tlili39905 ай бұрын

    very informative, helped a lot, thank you!

  • @Czarlsen
    @Czarlsen5 ай бұрын

    based on what we adding -2, -4, -6? to row and columns

  • @bushraborsha6435
    @bushraborsha64356 ай бұрын

    Thank you sir,your teaching is so clear and good.

  • @Umaizah_Janat
    @Umaizah_Janat6 ай бұрын

    Excellent bro

  • @AqsaMateen-rn6lq
    @AqsaMateen-rn6lq6 ай бұрын

    Can you please tell me which software you are using for making these videos?

  • @meetwadekar811
    @meetwadekar8116 ай бұрын

    No the identical twins don't have identical gene sequence because their VNTR sequence would be different this could be proved by their fingerprint

  • @user-gn3sc2tz3j
    @user-gn3sc2tz3j7 ай бұрын

    No it's not important that identical twins have identical genes. they may have similar gene only for their physical properties (so they look similar).

  • @sudipkumarmukhi726
    @sudipkumarmukhi7267 ай бұрын

    ❤ Crystal clear

  • @HOOMANESMAILIAN-mf1yz
    @HOOMANESMAILIAN-mf1yz7 ай бұрын

    Thank you sir for making the concept easier to understand. Please do make more videos.God bless u

  • @yijingwang7308
    @yijingwang73087 ай бұрын

    thank you for your video. But I have a question: can I traceback according to the largest value, so it would be 2, 1, 0, 0, 1, 0 instead of 2, 1, 0, -1, 1, 0?

  • @saurishsengupta844
    @saurishsengupta8447 ай бұрын

    Same question

  • @arpitabadatia7308
    @arpitabadatia73084 ай бұрын

    But according to this method you cannot go to 0 after 2,1,0 as it's a match (G and G) so you have to go diagonally, which is 2,1,0,-1. Note: here you can't go according to the highest value if the nucleotide sequence matches. If it doesn't match then you can go for the highest value.

  • @berlincmos
    @berlincmos7 ай бұрын

    GREAT first class 👍

  • @ibnaysaif2959
    @ibnaysaif29597 ай бұрын

    Thank you.breif that easily

  • @mehmetalitoy3929
    @mehmetalitoy39298 ай бұрын

    This is a great explanation, thank you so much sir.

  • @gschitz
    @gschitz8 ай бұрын

    ⥊ 733: 799 0: Good (if not good, then not zero) 0001: Uniqueness 001: Identity 002: Individuality 003: Variability 004: Diversity 005: Tolerance / Inclusion 006: Acceptance 007: Consonance / Harmony 008: 009: Transcendence 01: Awareness 02: Diversion 03: Sensing 04: Love 05: Grace 06: Reasoning 07: Ingenuity 08: Purity 09: Truth Seeking 1: Ethical 2: Problem-Solution 3: Situation 4: Abstraction 5: Expression Concrete 6: Why/Who/When/How/Where/What 7: Information/Code 8: Stability 9: Sanity 10: Network (Good Network, because zero) 11: Justice 12: Time/Spread/Dissipation/Easter 13: Death / Fact 14: Cognition 15: Agent 16: Reason 17: Discourse 18: State 19: Discipline / Control 20: Judgement 21: To Solve Problems with Ethics 22: Resistance/Endure Introspection 23: Consideration 24: Humor / Mental State 25: Behavior 26: Motivation 27: Cohesion 28: Dependability 29: Prognostic 30: Liberty Subject Wellness 31: Consent 32: Discernment 33: Response 34: Ideas 35: Showing 36: Option 37: Opinion 38: Decision 39: Optimism 40: Wellness 41: Attention / Idea 42: Critical Thinking 43: Acknowledgment 44: Free Love 45: Plan / Task Force 46: Purpose 47: Perspective 48: Character 49: Ambition 50: Good Expression 51: Manifestation 52: Support 53: Respect 54: Care 55: Peace / War 56: Pointing / Profiling 57: Tell / Counter-Terrorism 58: Invoking / Building 59: Proficiency / To Excel 60: Certainty 61: Identification 62: Qualification / Characterization 63: Inquiring 64: Conjecturing 65: Function / Role 66: Investigation 67: Arguing 68: Indicator 69: Scrutinity 70: Validation 71: Illustration / Knowledge 72: Construct 73: Explanation / Informing 74: Data 75: Materialization 76: Delineation / Instruction 77: Flow / Cadency 78: Share 79: Accountability 80: Personal Soverenity 81: Independency Constancy 82: Resilience 83: Established 84: Autonomy 85: Executing 86: Authority 87: Stream 88: Consistency 89: Boldness 90: Wisdom 91: Assertiveness 92: Science 93: Scrupulousness 94: Integrality 95: Composure 96: Blockchain: ⥊ (TRACE MARKER) 97: Anarchy 98: Veganism 99: Revolution 100: Liberation 101: Space and Time Peer-2-Peer 102: Decentralized Network 103: Financial Revolution 104: Production Revolution 105: Labour Reorganization 106: Needs Evaluation 107: Instruction 108: Personal Sovereignty 109: Resources Availability 110: Frankness 111: Honor 112: Distributed Ledger 113: Privacy 114: Abolitionism 115: Pride 116: Justifiable 119: Mission 120: Harvest 121: To Revolt 122: To Sort Out 125: Differentiate 126: Distinguish 130: Realization 131: Fulfillment 132: Regard 133: Perform 134: Address 135: Execute 136: Obtain 138: To Mark 140: Serenity 141: Idea 144: To Notice 148: Mindfulness 150: Good Character 151: Virtue 155: Honesty 160: Technology 161: Communication Systems 166: Causality 167: To Label 170: Knowledge 185: System Accessibility 181: Structure 199: The Mission 200: Sanctuary 209: Enlist 210: Resolution 211: To Engage 212: Secure 215: Mobilize 219: Annihilation 220: Contemplation / Meditation 221: Either Way / Alignment 222: Cooperation 230: Resilience 250: To Thrive 255: To Emerge 266: Correlation 300: Crusade / Jihad 301: Confront 309: Consensus 310: Cell Net 311: Agreement 320: Deliberation 322: Oportunity 330: Win-Win Energy Management 333: Abundance 340: Abolitionism 355: 360: Technology 373: Remote Killing 370: Efficiency 390: Economicity 400: Earth Population 410: Permaculture 430: Ecosystem 440: Fellowship 444: Direct Digital Democracy 500: Assumption 501: Leadership 510: Admiration 511: Honorable 512: Altruism 520: Proficiency 530: Acceptance 535: Denoucing 540: Appreciation 550: Diplomacy 555: Gathering 556: To Pick Up Someone/Something 590: Excellency 600: Organizator 620: Diagnose 660: Operation 661: Operator 665: Role 666: Method 676: Deduce 700: Constitution 710: Intelligence 717: Desing 720: Quantum Mechanics 733: Argorithm Explaining 747: Artificial Intelligence 750: Consolidation 751: Enlightment 757: Prompt 766: Plan 770: The Gear 771: File 773: Algorithm Recoginzing 775: Output 777: Pattern / Rhetoric 778: Development 780: Systematization 799: Revolution Algorithm 800: Providence / Heroism 801: Production 802: Necessities 803: Resorces 804: Energy 808: Renewable Cycle 810: Permaculture 820: Management 830: Logistics 831: Scheme 832: Reach 833: Demand 834: Stock 835: Distribution 840: Consumption 850: Labor 860: Human Resources 863: Assignments 870: Structure 880: Peace 888: Globalization 890: Needs 899: Conception 900: Transparency 910: Institutions 911: Emergency Call 930: Energy Distribution 931: Only One Global Currency 960: Blockchain 962: Traceability 970: Optimination 990: Inspection 995: Accountancy 998: Regulation 999: Implementation 1000: Militancy 1001: Nova Era 1312: Boycott 1042: Drug Liberation 1100: Liberation Army 1160: Pacifism 1400: Unity 1500: Benevolence 1550: Charity 1807: Black & Yellow 2222: Paradox 3000: Freedom 3100: Triumph 3330: We All Can Live In Abundance 4000: Coexist 4411: Riders of Justice 5000: Glory 5500: Greatness 6999: Mystery 7220: Unified Field Theory 8000: Sustainability 8999: Finitude 9997: Discovery 9998: Unknown 9999: Universe 10000: Existence . This is a numeric Matrix for communications purposes. . This can be used to convey meaning. Ex.: 6022: Good Reason to Resist. . Mathematical operators can be used to calculate meaning. Ex.: To liberate with a good force: 340. 300 + 40 = 340. . Logical operators to create statements. Ex.: ¬11: 13. If not Justice then Death. . Colors can also be used as information. - You can help build it.

  • @gschitz
    @gschitz8 ай бұрын

    777: 58

  • @ranaabcdabcd2084
    @ranaabcdabcd20848 ай бұрын

    Best video i have ever watched❤thank you

  • @gorillapanda6160
    @gorillapanda61608 ай бұрын

    You mentioned previous video 3 times in just 2.5 minutes

  • @DJmisterpeluca
    @DJmisterpeluca9 ай бұрын

    6:09 why is the second T from S1 and the last T from S2 a 0? From the technique explained shouldn't it be 1 since 0-2 = -2 = 0; but the T and T match so 0+1 = 1?

  • @miguelalvesmiguel7688
    @miguelalvesmiguel76886 ай бұрын

    maybe you only turn it into a 0 after adding the 1, so 0-2=-2, -2+1=-1 and -1 turns to 0

  • @utkarshranjan5787
    @utkarshranjan57879 ай бұрын

    Your voice is really sweet☺

  • @kingsleynwabueze-vo3xk
    @kingsleynwabueze-vo3xk10 ай бұрын

    The explanation is so on point

  • @jibinzhang2938
    @jibinzhang293811 ай бұрын

    Excellent illustration. But the accent is very hard for me to understand.

  • @alizeysheikh7698
    @alizeysheikh7698 Жыл бұрын

    Behn thora explain b kr deti to mehrbani hoti👀 slides to me b read kr skti hu🙏

  • @pratikshamukherjee9150
    @pratikshamukherjee9150 Жыл бұрын

    thanks for the amazing explanation sir 🙏. but sir in last row , column no. 3, why is it not1 instead of 0 ? because in column no. 3 another T is present so it should be a match right ? i am a little confused at this point.

  • @ammakr
    @ammakr7 ай бұрын

    You are right, this is the error in the video.

  • @user-kq9ld1hj4e
    @user-kq9ld1hj4e Жыл бұрын

    simplest and clearest explanation of Needleman-Wunsch I have seen! Thank you!

  • @smritiprajapati3068
    @smritiprajapati3068 Жыл бұрын

    Thank you so much for making this video... I really needed to understand this concept. it was really nice learning this way.

  • @mohamedmahmoudfathy3027
    @mohamedmahmoudfathy3027 Жыл бұрын

    it is so easy & simple explanation but I have a question, we know that local alignment compare between highly similar regions in the two sequences but how the smithwaterman determines the highly similar regions before searching for the optimal alignments for them ???

  • @masoomahussain3898
    @masoomahussain3898 Жыл бұрын

    Very well explained..! But I wanna ask some question. Why do you add these digits - 2 , - 4 , - 6, - 8, - 10 & -2 , - 4, - 6 ,- 8 in First row and column respectively why do we need to add this zero These points are bit confusing please reply me..

  • @arpitabadatia7308
    @arpitabadatia73084 ай бұрын

    Because this is the 1st rule. Before filling up a matrix you have to fill the first row and column by adding the given score of a gap penalty (which is -2 here) with 0. And the first one will always have to be 0.

  • @user-ry2xf7hm5c
    @user-ry2xf7hm5c Жыл бұрын

    Man I just love you I love you so much (இдஇ; ) u just saved me from a deep suffering and failure omg I'm so so so thankful to u 😭😭😭 I love u dude thnk u 😭🌸🌸🌸🎉

  • @smritisrivastava3495
    @smritisrivastava3495 Жыл бұрын

    Thank you so much..

  • @smritisrivastava3495
    @smritisrivastava3495 Жыл бұрын

    Thank you so much for such a wonderful explanation

  • @velusaravanan9750
    @velusaravanan9750 Жыл бұрын

    Tq .i got good understanding

  • @maharshpatel9243
    @maharshpatel9243 Жыл бұрын

    I love you bro, you saved my grades!

  • @deepanshualuria8435
    @deepanshualuria8435 Жыл бұрын

    nice video but it should it no more than 62% divergence instead of less than

  • @ohohjournal5828
    @ohohjournal5828 Жыл бұрын

    please upload more videos, there are very helpful

  • @halafares333
    @halafares333 Жыл бұрын

    what about semi-global???