Global Sequence Alignment & Needleman-Wunsch || Algorithm and Example

Global Sequence Alignment & Needleman-Wunsch || Algorithm and Example
In this video, we have discussed the types of common sequence alignment techniques used in Bioinformatics i.e Local alignment and Global alignment. We have also discussed the working of the Needleman-Wunsch algorithm and discussed how to do global sequence alignment with examples.
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Пікірлер: 168

  • @nepzel42069
    @nepzel420693 жыл бұрын

    You saved my semester.

  • @randomvideos2293

    @randomvideos2293

    3 жыл бұрын

    I was going to write the same thing

  • @HelloPetsVlogs

    @HelloPetsVlogs

    4 ай бұрын

    me too @@randomvideos2293

  • @shusrutorishik8159
    @shusrutorishik81592 жыл бұрын

    This is the simplest and clearest explanation of Needleman-Wunsch I have seen! Thank you!

  • @codghosts3676
    @codghosts36763 жыл бұрын

    you saved me, my professor kept stuttering for an hour and couldnt say any useful shit at the end in his hour long online lecture

  • @nmz344
    @nmz3442 жыл бұрын

    This is amazing explanation, just saved me and my classmates from a major headache. Thank you!

  • @borngreat2624
    @borngreat2624 Жыл бұрын

    You have done what my lecturer could not do. Thank you so much for this simplified and easy video. Looking forward for more wonderful videos like this brother

  • @combatnikisi617

    @combatnikisi617

    9 ай бұрын

    😂😂😂 I agree

  • @user_27357
    @user_273572 жыл бұрын

    What a great video! you made this super easy to understand (you just saved my bioinformatics midterm grade). THANK YOU

  • @user-kq9ld1hj4e
    @user-kq9ld1hj4e Жыл бұрын

    simplest and clearest explanation of Needleman-Wunsch I have seen! Thank you!

  • @amysacademy
    @amysacademy Жыл бұрын

    Sir literally I was trying to understand this for a whole week but not a single video on the internet explain this clearly and easily as you...

  • @annmatt5837
    @annmatt58372 жыл бұрын

    The video explains everything in a concise manner. It was very helpful to understand the concept clearly. Thank you Sir!

  • @cankale8002
    @cankale80023 жыл бұрын

    this was the best video that i could found about this topic. Thank you so much

  • @rowanterry1822
    @rowanterry18223 жыл бұрын

    Amazing, and even better explained than my lecturer👌🏾👌🏾👌🏾👌🏾🔥🔥🔥🔥🔥

  • @khushichitania6009
    @khushichitania600927 күн бұрын

    I was trying to understand it from the past few hours from ample of videos but this was the best one that explained the method very clearly and in an easy manner. Thanks a lot.

  • @sumaib1
    @sumaib13 жыл бұрын

    you taught better than my teacher. helped in solving my assignment. thanks.

  • @abhimannthakran5516
    @abhimannthakran5516 Жыл бұрын

    Most appropriate video conceptually as well as in terms of explanation .Thank you so much sir!

  • @News_In_Snap
    @News_In_Snap2 жыл бұрын

    this is the single best explanation i found here, great job sir

  • @tholkappianramasamy6111
    @tholkappianramasamy61112 жыл бұрын

    content and the quality and clarity in explaining the video is too good, Thank You.

  • @jacquelinemattos
    @jacquelinemattos3 жыл бұрын

    Great explanation. Thank you very much!

  • @kyungcheolkoh4517
    @kyungcheolkoh45173 жыл бұрын

    good explanation with great visual aids! keep posting bioinformatics videos!

  • @Lynsha44
    @Lynsha442 жыл бұрын

    Thank you for this ! Sequence 1 : CCGTCG Sequence 2 : CCGCG Aligned Sequence : CCGTCG CCG-CG

  • @jingliu2524
    @jingliu25242 жыл бұрын

    Nice video, explained everything clearly in a simple way!

  • @karmanpreetkaur9156
    @karmanpreetkaur91563 жыл бұрын

    BEAUTIFULLY EXPLAINED

  • @danieljanostoth8068
    @danieljanostoth80682 жыл бұрын

    Very very clear, big thumb up you all! Thank you

  • @lililia1304
    @lililia13043 жыл бұрын

    thank you so much , finaaly i understand it

  • @amarkar11
    @amarkar113 жыл бұрын

    Best video on. Global sequence alignment 👌👌👌

  • @aliawedixvi
    @aliawedixvi3 жыл бұрын

    THANK YOU, you are the best!

  • @gamingwithnoobs8448
    @gamingwithnoobs84483 ай бұрын

    The best lecture I have watched on global alignment !

  • @smritiprajapati3068
    @smritiprajapati3068 Жыл бұрын

    Thank you so much for making this video... I really needed to understand this concept. it was really nice learning this way.

  • @aarondesalvio
    @aarondesalvio2 жыл бұрын

    Thank you for the fantastic explanation!

  • @milicaplavsic39
    @milicaplavsic392 жыл бұрын

    Thank you! This explantion helped so much!

  • @hMF580
    @hMF5802 ай бұрын

    I have learnt it from the first time, thank you

  • @skyescrawford9774
    @skyescrawford97742 жыл бұрын

    Thank you, you saved me. They gave me 2 hours video and I got nothing. What a beautiful 11 minutes video here

  • @justsoil15
    @justsoil153 жыл бұрын

    Thank for your example. It's very interesting.

  • @pallabihojai8076
    @pallabihojai80763 жыл бұрын

    Thank u so much .... Finnally I understood

  • @neverever7821
    @neverever7821Ай бұрын

    THANK YOU SO MUCH!!! YOU'VE SAVED ME!!!

  • @ihorrible
    @ihorrible3 жыл бұрын

    best explanation ever !!!!

  • @bongmou2845
    @bongmou28453 жыл бұрын

    Clearly explained , looking forward to more videos .Great job .

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    We are glad that you liked our video 😊

  • @bushraborsha6435
    @bushraborsha64356 ай бұрын

    Thank you sir,your teaching is so clear and good.

  • @MBCGayathriM
    @MBCGayathriM2 жыл бұрын

    Very easy to understand, Thank you Sir

  • @tanvirasraf7772
    @tanvirasraf77722 жыл бұрын

    Guys like you are changing the world.

  • @HectorUch123
    @HectorUch1232 жыл бұрын

    Great video! Thank you.

  • @umm2825
    @umm28252 жыл бұрын

    I actually didn't get anything regarding bioinformatics, bein in 2nd semester, and having a little bit idea of this, i will try my best to understand this. Tysm sir. ◉‿◉

  • @jyothishshailan6885
    @jyothishshailan68853 жыл бұрын

    Excellent explanation ❤️

  • @mehmetalitoy3929
    @mehmetalitoy39298 ай бұрын

    This is a great explanation, thank you so much sir.

  • @Sadi-dear
    @Sadi-dear2 жыл бұрын

    Effective way of teaching 👍

  • @ranaabcdabcd2084
    @ranaabcdabcd20848 ай бұрын

    Best video i have ever watched❤thank you

  • @tlili3990
    @tlili39906 ай бұрын

    very informative, helped a lot, thank you!

  • @JayantMaini
    @JayantMaini Жыл бұрын

    Very well explained.....Thank you..!!!

  • @sandaruwaninayanthara4274
    @sandaruwaninayanthara42742 күн бұрын

    Thank you best ever explanation so far 🥳🥳

  • @Psyblader501
    @Psyblader5013 жыл бұрын

    Great video!

  • @sharonraj5964
    @sharonraj596421 күн бұрын

    So so helpful, thank you so much

  • @kahkeshantarannum5058
    @kahkeshantarannum50583 жыл бұрын

    Very helpful... Thankuu so much

  • @nabanitadash9581
    @nabanitadash95813 жыл бұрын

    Nicely explained.

  • @evadibisceglie1096
    @evadibisceglie10963 жыл бұрын

    thank you !!! very good

  • @varsharamesh636
    @varsharamesh6363 жыл бұрын

    Thank u soo much for this👍👍

  • @angalenar8018
    @angalenar8018 Жыл бұрын

    Superb explanation Vineeth ...God bless you 🙏

  • @lingha2
    @lingha2 Жыл бұрын

    wonderfully explained

  • @psta2
    @psta23 жыл бұрын

    Thank you so so much 👍🏼👍🏼👍🏼

  • @akmalazar2741
    @akmalazar27413 жыл бұрын

    First of all thank u very much. Very clear explanation!

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    We are glad that you liked our video 😊

  • @mesosiderite4670
    @mesosiderite4670 Жыл бұрын

    you're better than my teacher, greetings from canada

  • @saqainashafique1861
    @saqainashafique18613 жыл бұрын

    Thankuu soo muchhh finally i understand it thanks alott

  • @aisyareza
    @aisyareza3 жыл бұрын

    THANK YOU SO MUCHHHHHHH

  • @himanskss3749
    @himanskss37493 жыл бұрын

    Very good explanation sir.

  • @s.campusano
    @s.campusano3 жыл бұрын

    You are amazing! Thank you a lot!

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    Happy to help 😊 😊

  • @user-ru7be3jg3t
    @user-ru7be3jg3t3 жыл бұрын

    This is gold

  • @ibnaysaif2959
    @ibnaysaif29598 ай бұрын

    Thank you.breif that easily

  • @smritisrivastava3495
    @smritisrivastava3495 Жыл бұрын

    Thank you so much..

  • @snehahs9460
    @snehahs9460 Жыл бұрын

    Thank you so much it is very helpful 😁😁

  • @sakshamshrestha6081
    @sakshamshrestha6081 Жыл бұрын

    thank you!

  • @velusaravanan9750
    @velusaravanan9750 Жыл бұрын

    Tq .i got good understanding

  • @04ananthrajj45
    @04ananthrajj452 жыл бұрын

    Thank you 💥💥💥

  • @dmitryvoznuk8344
    @dmitryvoznuk83443 жыл бұрын

    thanks a lot!

  • @francescamazza7303
    @francescamazza73033 жыл бұрын

    great explanation, thanks a lot!

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    Happy to help 😊

  • @momitaboro2018
    @momitaboro2018 Жыл бұрын

    Thnks for explanation

  • @vaishnaviramani8875
    @vaishnaviramani88752 жыл бұрын

    Thanks for helping 😌🥰

  • @shreyashachoudhary480
    @shreyashachoudhary480 Жыл бұрын

    Superb!

  • @todorbalabanov2620
    @todorbalabanov26203 жыл бұрын

    Really clear explained. Can you tell me the answers of Seq 1 CCGTCG and seq 2 CCGCG and again for se1 1 CGCTCGCT and seq 2 CACTCGT in regards to compare my answers. Thanks in advance.

  • @ibtihegesouda2407
    @ibtihegesouda24073 жыл бұрын

    thank you very much, it's soo clear

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    We are happy to help 😊

  • @gotaya855
    @gotaya8553 жыл бұрын

    thank you so much for posting such interesting and well explained videos

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    We are glad that you liked it 😊

  • @yijingwang7308
    @yijingwang73087 ай бұрын

    thank you for your video. But I have a question: can I traceback according to the largest value, so it would be 2, 1, 0, 0, 1, 0 instead of 2, 1, 0, -1, 1, 0?

  • @saurishsengupta844

    @saurishsengupta844

    7 ай бұрын

    Same question

  • @arpitabadatia7308

    @arpitabadatia7308

    4 ай бұрын

    But according to this method you cannot go to 0 after 2,1,0 as it's a match (G and G) so you have to go diagonally, which is 2,1,0,-1. Note: here you can't go according to the highest value if the nucleotide sequence matches. If it doesn't match then you can go for the highest value.

  • @neelambibi7426
    @neelambibi74263 жыл бұрын

    Thanks

  • @aquarius_gaurav
    @aquarius_gaurav3 жыл бұрын

    There can be multiple optimal answers as well.

  • @gorimasahu8621
    @gorimasahu8621 Жыл бұрын

    Very verryyy very helpful vdio it is 🥰🥰🥰🥰

  • @abhiraj2734
    @abhiraj27343 жыл бұрын

    Well Explained. Thank You !

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    We are glad that you liked our video, Mr Abhi. Please let us know if you are not able to understand any topic related to bioinformatics we would try to make video on that particular topic, Thank you 😊

  • @abhiraj2734

    @abhiraj2734

    3 жыл бұрын

    @@BioinformaticaYT Nussinov Algorithm, Zuker Algorithm, Protein Folding Algorithm, Hidden Markov Model, Viterbi Algorithm, = These are some from my syllabus.

  • @jyotirmoygupta8809

    @jyotirmoygupta8809

    2 жыл бұрын

    what are you studying brother ?

  • @abhiraj2734

    @abhiraj2734

    2 жыл бұрын

    @@jyotirmoygupta8809 BTech in CS. Have an optional subject- Bio Informatics

  • @numankhan4319
    @numankhan43193 жыл бұрын

    Sir...very zabrdast...exclnt... Love from pakistan...

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    Thank you so much numan, it means alot to us 😊😊

  • @Kalinikathai
    @Kalinikathai3 жыл бұрын

    Nice video. Bro. Well explained. Keep it up.

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    Thank you

  • @masoomahussain3898
    @masoomahussain3898 Жыл бұрын

    Very well explained..! But I wanna ask some question. Why do you add these digits - 2 , - 4 , - 6, - 8, - 10 & -2 , - 4, - 6 ,- 8 in First row and column respectively why do we need to add this zero These points are bit confusing please reply me..

  • @arpitabadatia7308

    @arpitabadatia7308

    4 ай бұрын

    Because this is the 1st rule. Before filling up a matrix you have to fill the first row and column by adding the given score of a gap penalty (which is -2 here) with 0. And the first one will always have to be 0.

  • @winstonliu4189
    @winstonliu41893 жыл бұрын

    I love u man.

  • @km2052
    @km20523 жыл бұрын

    thx

  • @hemastandard7649
    @hemastandard76493 жыл бұрын

    great video man

  • @BioinformaticaYT

    @BioinformaticaYT

    3 жыл бұрын

    Appreciate it

  • @aryanitishpatel9971
    @aryanitishpatel99712 жыл бұрын

    now my confusion is cleared

  • @mohddilshad8166
    @mohddilshad81663 жыл бұрын

    Great

  • @rajagopal.g3533
    @rajagopal.g35333 жыл бұрын

    How you have aligned second sequence like A-GCT only .

  • @Thriver21
    @Thriver21 Жыл бұрын

    tq

  • @Czarlsen
    @Czarlsen6 ай бұрын

    based on what we adding -2, -4, -6? to row and columns

  • @srgk26
    @srgk263 жыл бұрын

    Thank you soo much for this! This explained what 1 hour of my lecture didn't lol

  • @henny9862
    @henny98623 жыл бұрын

    👍👍👍👍

  • @evgenia._.b
    @evgenia._.b Жыл бұрын

    I want to ask, the right corner in global alignment has always the HIGHEST value? is it possible for an another cell to have higher value? Thanks.

  • @nareshapat
    @nareshapat3 жыл бұрын

    👍

  • @santupaul5360
    @santupaul53603 жыл бұрын

    👌🏻👌🏻👌🏻

  • @ricodsanchez6792
    @ricodsanchez67923 жыл бұрын

    Hi there, where is the link using python with scoring matrices. Thanks