Myeloproliferative Neoplasms (MPNs) - Myeloproliferative Disorders - CML, PV, ET, PMF
Myeloproliferative Neoplasms (MPNs) - Myeloproliferative Disorders - Chronic Myeloid Leukemia (CML), Polycythemia Vera (PV), Essential Thrombocytosis (ET), Primary Myelofibrosis (PMF) or bone marrow fibrosis.
Myeloproliferative neoplasms (MPNs) are a group of disorders affecting the bone marrow.
Myeloproliferative disorders are characterized by proliferation of all bone marrow cell lines (including red blood cells, white blood cells and platelets).
Myeloproliferative neoplasms include: multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), essential thrombocytosis (ET), chronic myeloid leukemia (CML), mastocytosis,...etc.
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@catherineportland503
Жыл бұрын
Antibiotic bring down my platelets with et jak2. Why. Can you do a video on this
Bro, you've accomplished something my teacher couldn't do in an hour...THANK YOU!
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 I am honored! Can you please help me by sharing?
You’re amazing 😉 My favorite part is “Pay attention,pay attention!” I was actually losing attention 😂❤️
@MedicosisPerfectionalis
3 жыл бұрын
Haha 😂
Lifesaver for hematology haters
@MedicosisPerfectionalis
5 жыл бұрын
You are absolutely correct 😂
@debbie9962
4 жыл бұрын
Alanoud Alessa agree!!
@manalmuneeftamer8846
3 жыл бұрын
Can't agree more
This channel has become a lifesaver in this pandemic. I Should've come hare sooner, coz I can barely understand a thing that my lecturer says.
Thank you for producing the quality of informative videos. Your strengths in knowledge and comfortable delivery of the subject matter is very appreciated. I am 65 anf recently diagnosed with JAK 2 positive - ET working on a partial intestinal blockage tomorrow with a colonoscopy evaluation. Your gifting of this knowledge has helped me get a grasp on the mechanisms that are in place. Thanks much gratitude, Rob'O
I just wanted to say thank you for all the work you have put into your channel. I understand that the information provided is primarily intended for individuals in medical school. However I was diagnosed with myelifibrosis related to an issue with CLR2 genetic defect. You have provided me with a great deal of comfort by way of educating my simple a$$. Good luck to you.
Another precise comprehensive lecture. You are making study easy day by day.
@MedicosisPerfectionalis
5 жыл бұрын
Yeah! We’re making history 😁
week of lectures on this at school, first aid, and like 3 other resources and this one video made it click. KEEP DOING WHAT YOU DO
@MedicosisPerfectionalis
4 жыл бұрын
I sure will! Thanks a ton! Please share:)
CAN'T THANK YOU ENOUGH !!!! @medicosis you're a genie! My finals are near and your videos are helping me more than I could imagine.
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 😊 Good luck 🍀
Hi im a 4th year medical student from SRILANKA.. :) your videos are sooooooooooooooooo much helpful in my studies Keep up doing these! Greetings..
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much 😊
Everytime I go on your site its like a Treasure hunt! Thank you!!!
The best lecture channel in youtube, thank u so much for sharing ☺️🙏🏻 Love from Indonesia 💕
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 Thanks a million! Can you please help me by sharing my videos with your friends?
@mirasoraya909
4 жыл бұрын
Medicosis Perfectionalis my pleasure 💕, and off course I’ll share ur video to my friends 👍🏻 keep sharing, can’t wait for the new one 🥰
I had found this channel randomly and I watch all haemat videos from here😍 love this channel ♥️
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊
What a great intro to MPNs! Just a heads up though. These do indeed TEND to be disease of the elderly, nevertheless being ‘young’ does not mean you cannot get these problems. I got diagnosed with ET just after my 34th birthday and looking at my blood test data from the years prior (and ongoing side effects) it is likely that I was already walking around with it since my 30th.
lol you cracked me up with saying don't be pessimistic I was just thinking if I really have it. You are funny makes it less boring thanks :D
@MedicosisPerfectionalis
4 жыл бұрын
You’re welcome 😇
MPN may no longer be just a condition for the elderly anymore, there is a certain population that develops the condition earlier on in their life
I loooooove the way you explain the subject.
Best explanation👏👏 Thank you so much 💙
This really helps grasps the concepts of MPNs thank you!!!!
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 Can you please help me by sharing?
@andreyscumpieru1371
4 жыл бұрын
Shared with everyone in my class!
this was so so so helpful, really appreciate the time you took to create this :)
@MedicosisPerfectionalis
Жыл бұрын
You're very welcome! Would you please help me by sharing?
Thanks a lot for this amazing explanation 👏🏻👏🏻👏🏻
that was really helpful. thank you so much for sharing. this was such a good addition to the lectures i was totally confused. it has been very well explained.
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much 😊
Woooow vielen Dank!!!!
Myeloproliferative Neoplasms are interesting. I was originally diagnosed with ET, and after 2 years my hematologist now says it's PV, but wants to monitor close, as my wbc is now climbing as well! At the ripe old age of 23.
@MedicosisPerfectionalis
5 жыл бұрын
What! I am so sorry to hear that...Please, remember to never let the disease beat you...and tell me if I can help...Thanks for sharing!
Thank you so much, makes it much easier to differentiate between those disease now
@MedicosisPerfectionalis
4 ай бұрын
I am happy to help!
I needed this thank you!!
You are simply awesome and made it sooo easy to understand.just loved d videoooo❤️❤️😍😍
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much 😊
OMG this is really awesome
@MedicosisPerfectionalis
5 жыл бұрын
You’re always welcome 🙏
I've already finish mi MD but i think just now i can call myself a MD indeed. Grattings from Paraguay! Please, do not stop making videos
@MedicosisPerfectionalis
2 жыл бұрын
Thank you so much ☺️
YOU MADE MY DAY. THANK YOU
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
I'm in medical school and this guy is 10/10
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 😊
think you so much I wish my prof can explain this as good as you do
@MedicosisPerfectionalis
5 жыл бұрын
That’s a great compliment...Thanks a ton!
Really filled in the gaps, thanks
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Amazing video ❤❤ thank you.
That's amazing , thanks a lot
very good demonstration excellent work 👏👏👏
@MedicosisPerfectionalis
5 жыл бұрын
I am honored...Thanks a lot 😃
very helpful :) Thank you!
You are gr8!! I’m impressed! And thank you for the info on MPN-ET
@MedicosisPerfectionalis
4 жыл бұрын
You’re very welcome 😊 Are you a medical student?
@jeanwarech4982
4 жыл бұрын
Medicosis Perfectionalis No Sir, I’m a retired RN. I’m still learning. Everyone is enrolled in a full time school called “Life” Thanx again!
@MedicosisPerfectionalis
4 жыл бұрын
You’re absolutely right. I am so honored to talk to you.
@jeanwarech4982
4 жыл бұрын
Thank you so much Dr! It’s likewise, an honor to talk to you! As long as we are alive, there are lessons to be learned! HEMOC always fascinated me! It’s difficult, but interesting nonetheless.
U are the best always and know i watch this vedio 9.5.2024 Thursday for my last medicine exam at “six stage” and i may be i well back after graduation … too much thanks 🤍
@MedicosisPerfectionalis
Ай бұрын
All the best!
Great job. Thank you 🙏🏻 😊
@MedicosisPerfectionalis
Жыл бұрын
My pleasure 😇
Thank you the best lecture❤
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
I LOVE THIS CHANNEL
@MedicosisPerfectionalis
4 жыл бұрын
This channel loves 😍 you too 🥰
Great video ! Thanks !
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Because you explained it well, i just subscribe to your channel.. 'MANTAP' 👈Search for this word.. It's malay word.. It's describing your video as a whole 👍👍😁
I Love you medicosis ❤
Thank youu so much for this video!!!!
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
you made it so smooth be blessed!
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊 You as well
Can we take a screenshot of the vedio ?! And thanks for your help it's awesome
Great 😍😳🔥
@MedicosisPerfectionalis
Жыл бұрын
Thank you 😊
Really useful video for training scientists. Could you consider an update including CALR and MPL? 🙂
@MedicosisPerfectionalis
4 жыл бұрын
That’s a good idea
actually you are Amazing Thank you so much
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Thanke you ...You are amazing
Your genius...lifesaver
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much 😊
Thank youu🙏🏻
Awww you're so funny and amazing teacher. Thank you a lot!
@MedicosisPerfectionalis
4 жыл бұрын
Thanks a million! That’s a great compliment. I am delighted 😃 I’ve just graduated!
@wem3121
4 жыл бұрын
@@MedicosisPerfectionalis Oh thanks for answering! It's really rare to have the doctor in KZread answer you. And you're very welcome, you're actually saving my hematology module! Btw, can I ask you something unrelated? it's about QT and PTT. why do we need a witness for each patient? Why can't we just take references (say, 13s is the reference time) without needing to compare it ? Thanks in advance!
I like these Hematology videos! My family has unusual bone problems but there has never been any Doctor Who diagnosed anything in particular, but there continues to be unusual bone issues and hematology issues and I have been trying to learn about hematology so that I can know which test to request! So for the things I have learned have helped me to request the tests that have helpful and the abnormal levels help narrow it, but they still do not seem to fit into any specific category. I need to continue to learn more! Have you done a video on bone expansion, bone islands, teeth and finger nail abnormalties? These are blood factories correct? Something is causing these to be abnormal and there are other symptoms but they do not seem to fit exactly into any category. In me there seems to be iron deficienct anemia but there seems to be possible iron overload as well? I have always been Mycrocytic hypochromic and get sick when I get to much iron , I vomit and have menstrual like bleeding from iron or excersize and aleopecia worsens especially with added sun exposure. I have reduced unlimited the amount of sun for one month and not allowed bright lights and my skin is turning back to normal it had turned to bronze, my bone pain improved as well. It has not went away all together and I am still having pains in my organs. My youngest son shares some things such as constipation, and hand and feet pain, He had frontal embossing and at age 1 his new teeth began to turn colors and deteriorate. His blood work was opposite of mine, RDW low , MCV normal, MCH normal, rbc high, wbc high lymphocytes high, eosinophils high, basophils high. They seem equally high. My RDW is high, MCV low, MCH low. Even though our levels seem opposite we both have constipation from birth( his stool was normal when except when I breast feed him for three years because he did not tolerate formula) ( I had from birth, So we share constipation and pain in his hands and arms and I have pains in my long bones and and my hands arms and feet. Now that I am older my organs seem to be disfunctional and painful. Maybe we have a shared dysfunction with different alles causing different issues? Or one shared issue or mutation? and other seperate issue? I have other family members with so.e similar issues but but I will not complicate it more. So for me, I love the hematology videos because it seems to me that everything can be deciphered within the blood! In fact after learning so much about blood I wonder if cancer is not the results of something that was going wrong that was ignored for too long and that if we could have seen the imbalance in the first place and corrected it maybe cancer will not come? Thank You for sharing your videos! Angie
@chicken2846
Жыл бұрын
Hello, how are you now? Any better? Any changes or tests confirming a diagnosis? ❤️🩹
Well then, I'm 29 and have been diagnosed with an MPN, that's why I'm here learning more about it, my consultant told me that my blood is basically like a 70 year olds
@MedicosisPerfectionalis
3 жыл бұрын
I am so sorry to hear that. It's true that the majority of MPN patients are old. But, it can happen at any age! Keep fighting the good fight, and don't give up!
You re really smart 😰😰😰 thanks a lot 🔥🔥🔥🔥🔥🔥
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 I don’t think I am smart! Thank you so much 😊
Ty! Very informative vid
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Are myeloproliferative disorders a larger umbrella that includes myeloproliferative disorders or are the two synonymous?
Thank youuuuuuu💛
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Man u goooood. Thanks
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Om Aldunia, Bhabk from Kuwait!
thank you
@MedicosisPerfectionalis
Жыл бұрын
My pleasure 😇
Thank you ❤️
@MedicosisPerfectionalis
2 жыл бұрын
My pleasure 😇
I think that jak2 is a non-receptor tyrosine kinase means that it works in the cytoplasm not on the receptor !! Correct me if I'm wrong ... thank you
"where I grew up" looool we definitely grew up in the same place
@MedicosisPerfectionalis
2 жыл бұрын
Haha 😂
you are the best .
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much ☺️
What percentage of population with the JAK2V617F mutation do not go on to develop a myeloproliferative neoplasm?
Thanks 🙏🏻
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Thank you!!!!
@MedicosisPerfectionalis
2 жыл бұрын
My pleasure 😇
very helpful thank you
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
thank you great vedio
@MedicosisPerfectionalis
5 жыл бұрын
My pleasure 😇
Is the mthfr mutation involved in any of these myeloproliferative diseases ?
You are extremely amazing good jobb
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much 😊
Thanx a lot
@MedicosisPerfectionalis
5 жыл бұрын
My pleasure!
What kind of genetic blood work does a hematologist order. Talk about that sometime please.
thank you so much
@MedicosisPerfectionalis
2 жыл бұрын
My pleasure 😇
but doesn't JAK2 work intracallularly, how doesn't stumilate the receptor form out side??
appreciated:)
@MedicosisPerfectionalis
5 жыл бұрын
Thanks 👍
T LGL . Hard to find info about. Or having it with B cell pancytopenia an thrombocytopenia
So good
@MedicosisPerfectionalis
4 жыл бұрын
Thanks 🙏 Can you please help me by sharing?
Hi thnx for all,i am from Albania i have 2 years that i have a high couNt of EOSINOPILS,I HAVE ALL THIS MUTATION NEGATIVE> FIP1L1 PDGFRA PDGFRB FGFR1 JAK2 BCR ABL,SORRY WHAT CAN BE MY CONDITION ?
Thank you sir
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
Hi, I have a relative who is suffering from Chronic Eosinophilic Leukemia, do you mind explaining more about CEL, its causes and its treatment? It would be greatly appreciated.
@MedicosisPerfectionalis
3 жыл бұрын
I can refer you to 2 textbooks: Harrison’s Internal Medicine. Goldman-Cecil Internal Medicine. (hematology chapter).
I live in Portland Oregon can you suggest someone like you they say I have et cythemia with jak 2. I acquired this after a forced stroke by a doctor. Chemo does not work for me I have been thru 3 oncology/ hematologist. None of them are educated on this. My platelets have come down some 1,029,000. Wbc not much increase rvc perfect. But immature granules are high. I feel I have not been diagnosed correctly 2 Dr's said biopsy last one says I don't need one. You seem to have smarts. Is mayo clinic or fred Hutchinson in Seattle. If I can fly and come back by night it doesn't matter where. Just want a research dr about my disease. Just like an opinion
This is the only chapter which i understood well.. Cradiet goes to Medicosis .?. thanks
@MedicosisPerfectionalis
5 жыл бұрын
I am honored 😊
"some students are very suspicious because they are itchy after shower, they think they have it [PV]" - I AM DEAD HAHAHAHAHA
@MedicosisPerfectionalis
3 жыл бұрын
Haha 😂
Helpful
@MedicosisPerfectionalis
2 ай бұрын
Glad you think so!
How can all leukemias become lymphoproliferative ? For ex in acute myeloid leukemia the problem is in the myeloid linage?🙁
@MedicosisPerfectionalis
3 жыл бұрын
Not all leukemias are of myeloid lineage. Moreover, cancer doesn’t follow rules! It’s a disease!
Thank you 😊 you are the best
God bless ❤ only thingh I can say
@MedicosisPerfectionalis
6 ай бұрын
God bless you too!
Kindly make a video on mastocytosis
@MedicosisPerfectionalis
4 жыл бұрын
That’s a good idea 💡
🙏🏼🙏🏼
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 🙏
3:40 LMAO just came back from a shower and saw this
@MedicosisPerfectionalis
Жыл бұрын
:)
No Acute myeloid leukaemia in thrombocytopenia !
@MedicosisPerfectionalis
5 жыл бұрын
What do you mean?
Can I get the link of facebook
Hi symptoms of mpn are
@MedicosisPerfectionalis
4 жыл бұрын
????
Can we live long life with mpn
@MedicosisPerfectionalis
3 жыл бұрын
It can happen, but there are no guarantees in life. Please talk to your doctor and make sure to follow up to understand your risk.