Myeloproliferative neoplasm (MPN) is a malignancy of hematopoietic stem cells that is associated with hematopoietic proliferation resulting in peripheral blood cytosis. MPN is subclassified on the basis of the dominant cell line involved and each subtype has a different prognosis. The diagnosis of MPN must include an integrated approach and combine the clinical findings with laboratory results. Dr. He discusses the subclassification of MPNs and the use of JAK2, CALR, and MPL mutational analysis in diagnosis and prognosis.
A presentation by Rong He, MD