► 💊Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/

📝 Download my handwritten notes: www.medicosisperfectionalis.com/

🩸 Hematology Playlist: kzread.info/head/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

❤️ Cardiac Pharmacology Course: www.medicosisperfectionalis.com/ 📝 Download my Notes: www.medicosisperfectionalis.com/

Ive never enjoyed hematology this much. Thank you for the complete hard work.

@MedicosisPerfectionalis

Жыл бұрын

You’re very welcome 😊

@3:32 1 gene deletion = silent carrier, 2 gene deletion = trait

You have a slightly comedic voice and ur content is good (y)

@MedicosisPerfectionalis

5 жыл бұрын

Thanks ☺️

I have heterozygous alpha Thalassemia. It literally took 2 years to diagnose it and my doctor said this type of Thalassemia is sooo rare

@Lokshili

Жыл бұрын

It took me getting pregnant at 21 for my doctor to finally diagnose me they always to me was anemic

@nishatjahan821

25 күн бұрын

Same here

@EltonCarrMusic

19 күн бұрын

I have alpha thalassemia, I'm 5' 7" keeping my weight around 152 to 162, exercise and plant base B12 helps me decrease my days of fatigue.

You sound like chandler’s new roommate in freinds😂 I honestly like your channel, great videos 👍

doctor you are the best .no one can explain easier and clearer than you . thank ypu very much for those free very useful videos

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😊 Can you please help me by sharing?

@a.m.e.r.k1805

4 жыл бұрын

@@MedicosisPerfectionalis of course doctor. I will share your videos with all my friends

I wish there was a medicosis channel for each subject 😭❤

Hgb Barts is detectable on newborn screen for the trait as well. It disappears once beta globin is produced.

You're such a GOOD teacher!!! I'm doing an assignment on thalassemia (alpha and beta) and this was just what I needed to get started.

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏

You made medical school so fun for me. THANK YOU

@MedicosisPerfectionalis

7 ай бұрын

You’re always welcome!

Thank you for your excellent explanation! And you have a beautiful handwriting btw Keep it up

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 😊

U R BRILLIAAAANT ❤ plz consider metabolic disorders as a separate series in ur near future plans 😁

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏 Can you give me examples?

You’re helping me a lot for my ASCP exam ...

@MedicosisPerfectionalis

5 жыл бұрын

I am so delighted to hear that! Good luck 🍀 with your exam!

@JA-eq5um

5 жыл бұрын

Meryem did you pass and what were you testing for? MLT or MT?

Love your videos! Thank you so much for making them! 1 Quick question: I was under the impression that "Alpha Thalassemia minor" and "Alpha thalassemia trait" is same thing with 2 out of 4 genes missing or mutated. Shouldn't missing 1 gene/locus be called a "silent carrier"?

@MedicosisPerfectionalis

6 жыл бұрын

I think you are absolutely correct. It was a mistake. Thank you for noticing it and informing me. You are so sharp! I’ve made a correction in the description below the video. I can’t thank you enough.

@esperanzaesquivel5504

2 жыл бұрын

Sxizt

Just wondering if this is something that I picked up. If one locus deleted then that person is a CARRIER, If two loci deleted then they have THALLASEMIA TRAIT which is also known as ALPHA THALLASEMIA MINOR. Maybe I am wrong here so would appreciate your input. (i maybe wrong I maybe right)

Globin chain synthesis unbalanced - dec globin - dec Hb - dec RBCs - Anemia. Also hemotetramers form (water insoluble) - ptt in RBCs - spleen destroys them early so hemolysis سبب التكسير اهو - BM tries to compensate & make new RBCs but the globin is always defective so defectine erythropoiesis.

thanks for your vidoes, can you explain why is it low MCV please

Thanks dear for teaching us very good love the way that u explain the lecs ❤

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏

Thank you so much! I learnt a lot watching each of your videos!! Could I ask 1 question? IDA is microcytic due to concentration of Hb Is Thalassemia the same case?

@MedicosisPerfectionalis

6 жыл бұрын

+Lee Romeo Can you explain more your statement “Iron deficiency anemia is microcytic due to concentration of Hb”?

@romeolhk1008

6 жыл бұрын

Oh sorry I edited my sentence too much so it became odd. In previous videos you said that in iron deficient conditions, the RBC will become small due to: 1.They are waiting for iron 2.They shrink the volume to make the Hb look bigger Is Thalassemia the same case? Thank you very much!!

@MedicosisPerfectionalis

6 жыл бұрын

+Lee Romeo Yeah, I believe so, but may be to a lesser extent.

Sir, for alpha thalassemia carrier, the DNA analysis will be normal? Or it will show some deletion like alpha thalassemia trait?

Hb Bart's/alpha tetramers occur when all 4 alpha are deleted and not 3

Sorry I have a confusion at 3:47 do u want to say 4 alleles?

May i know that alpha thalassemia carrier or silent carrier has high red blood count but normal haemoglobin?

Is anyway you can make video on WBCS? Thank you!

@MedicosisPerfectionalis

6 жыл бұрын

Yes...It’s coming...I will try to finish all hematology and oncology as soon as I can...Thanks for writing me! 👍

Is the expansion of Hematopoiesis seen in Alpha Thalessemia due to the anemia ? or It is only seen in Beta Thalessemia ?

Hi! Amazing video - thank you. One possible correction (I could be wrong) - αα/α- is silent carrier (not trait) and α-/α- or αα/-- is trait or minor

@MedicosisPerfectionalis

6 ай бұрын

Yes, you are right!

If only one locus is deleted it is called silent carrier . Two loci deleted is called trait . Reference- Harrison’s 18th/ 859 . Misleading but thanks anyway.

@MedicosisPerfectionalis

5 жыл бұрын

Have you read the description under the video?

@meniladaniel1167

4 жыл бұрын

Yeah what he given in the chart is wrong

@meniladaniel1167

4 жыл бұрын

Silent carriers are single gene deletion cases having hemoglobin in normal range. Trait is when 2 locus are deleted

this was extremely useful

@MedicosisPerfectionalis

6 жыл бұрын

Excellent...Thanks for watching! 👍👍 ..There is a whole playlist for hematology and more videos are coming! Good luck!

what about alpha thalassemia minor? does it show up in electrophoresis?

does hemoglobin electrophoresis give a quantitative analysis?

I have Sickle Cell trait and Alpha thalasemia. I can't find much on the two together. I found that there is a S-Beta Thalasemia, but is there a name for those like me with SC trait and Alpha Thalassemia?

thanks a lot your videos helped greatly + awesome channel name

@MedicosisPerfectionalis

6 жыл бұрын

You’re very welcome! Thanks for watching! 👍

Hi there I have a question. Can this cause itchy skin?

that's me tired and pale, pale and tired 😣 I have been told that I'm a alpha -thalassemia carrier, is there anything I can do to face tiredness and muscles fatigue ? ( I'm already integrating iron ) thank you

Great thanks,god bless you

@MedicosisPerfectionalis

6 жыл бұрын

+Doc tor My pleasure. God Bless you too! Thanks for watching and leaving a comment!

thank you so much

@MedicosisPerfectionalis

6 жыл бұрын

Of Course! Don’t mention it :)

I don’t fully understand what a hemotetramer is?

The hallmark feature of HbH is the presence of Golf Ball inclusions in red cell demonstrated with supravital staining 👍

My hematologist told me that I have Alpha Thalessemia like two years ago and I’m so confused because I didn’t know it was a rare/ serious thing now I’m scared

@MedicosisPerfectionalis

5 жыл бұрын

Hey 👋...Thanks for your comment. I can’t give medical advice because I am not a doctor. So, please talk to your doctor. And don’t be worried, because it won’t help. I really wish you the best! Keep me updated 👍

@SeranSenevirathna

3 жыл бұрын

@@MedicosisPerfectionalis I guess you are a doctor now???

Thank you so mach

@MedicosisPerfectionalis

6 жыл бұрын

You are always welcome! Thanks for watching!

At minute 1:43 you said decrease in Hb will result in decrese in NUMBER of RBC and this is not true because in thalessemia number of RBC is usually elevated .

@MedicosisPerfectionalis

5 жыл бұрын

Have you watched my video on “lab results in thalassemia”?

@nsas955

5 жыл бұрын

sure, thank you

@MedicosisPerfectionalis

5 жыл бұрын

You’re welcome

Ok, 2 big questions: #1: Why don't the beta-4 hemotetramers show up in the bone marrow & just in the RBCs? #2: I accept the Hgb electrophoresis of alpha-that trait looks just like a normal Hgb electrophoresis, but what do the electrophoresis patterns for the other thalassemia actually look like?

@MedicosisPerfectionalis

3 жыл бұрын

Hey Kevin...Thank you so much for being a member of my channel. I don't know the answer to the first question. Regarding the second question...In Beta thalassemia major, you will find about 90% of hemoglobin F, and about 10% of hemoglobin A2. Hope it helps!

ahhhh thank you so much again!!!!

@MedicosisPerfectionalis

Жыл бұрын

My pleasure 😇

Thanks, needed to know what I have

@MedicosisPerfectionalis

3 жыл бұрын

You’re welcome! Best of luck to you!

I'm a hemoglobin E carrier. I don't know what that means lol🐸

i read there are alfa0 and alfa+ genes, what is that mean?

Thank you 🙏

Isn't alpha thalassemia silent is one gene missing and alpha thalassemia trait is two genes missing

Thank you.

In beta Thalassemia trait, the A2 is elevated, usually above 3.5 %. Thank you for your videos

@MedicosisPerfectionalis

5 ай бұрын

Thank you for your support!

@DoniazadAssous

5 ай бұрын

I confused with Beta Thalassemia. Thank you, it's a pleasure to follow your videos@@MedicosisPerfectionalis

U R fantastic bro🤸‍♂️❤️

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

Actually in alpha-Thalassemia there is a normal or increased RBCs

@MedicosisPerfectionalis

5 жыл бұрын

Yes! I discussed that in my video on “lab results in thalassemia” kzread.info/dash/bejne/eqKDyaWAYbSxl7g.html

I like the way u r talking

@MedicosisPerfectionalis

3 жыл бұрын

Thank you 😊

I will now send this video to people when they ask me to explain Alpha Thala

@MedicosisPerfectionalis

5 жыл бұрын

Nice! I am so delighted that you liked it.

What are hemotetramers ???

Is that slides present as pdf?

Great! Thank you

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇

i think alpha thalassemia minor is called trait and the first one is called minima correct me if i am wrong

I have this.. I been having heart problems.. sucks

Pls sir Can you make leukaemic portions

@MedicosisPerfectionalis

6 жыл бұрын

Leukemia videos are coming soon...No worries, you have asked, and we will make it happen :) Thanks!

I thought there is no alpha thalas minor. 1 locus will classified as silent carier, 2 loci thalas trait, and next straight to hbh and hb bart?

@MedicosisPerfectionalis

Жыл бұрын

You’re correct!

very nice mathematical pattern in those genes! 2*2 = 4, 2 loci, 4 genes. 4*4 = 16, chromosome 16. easy to remember!

Usually diagnosed at birth but my son is 10 in a week and a few months ago the Dr's called me telling me he has thalassemia and they missed it like no big deal and that's all they said so now I'm figuring it out on my own

@whowhatwen

2 жыл бұрын

I only got diagnosed with it a few months ago and I'm twice as old as your son! The healthcare system could really be improved. Hope everything goes well for you both!

@eyes2c..519

2 жыл бұрын

@@whowhatwen agreed they experiment and I can't stand them sorry for your dx

flow cytometry

Which could be heavier between alpha and beta please help me thank you very much

@MedicosisPerfectionalis

3 жыл бұрын

I am sorry I didn’t understand!

Thank you so much

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇

You are the best

I think with your channel I will be the first this year again .

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

Great jobbbb

I got (-a/aa) and my husband got (-a/-a) are my future children in danger ?

@ZyNeEnZyNe

5 жыл бұрын

I'm still in my studies and not a professional, but, I can see that there are 2 possible outcomes, these are: (a-/a-) or (aa/a-) The first being (a-/a-) being known as a+ homozygote and the other one (aa/a-) being known as a+ hetrozygote. [(a-/a-) a+ homozygote] may result in mild microcytic anaemia. [(aa/a-) a+ hetrozygote] will normally be harmless to the individual and cause no haematological abnormality but they are still a silent carrier of the mutation. Again, i'm no professional yet but that's what I think, if you're concerned it is advisable to seek help from a professional

@Shodyalghamdy

5 жыл бұрын

@okay thanks that’s what I thought too so they will become ether like me or like there father , Unfortunately I couldn’t find a professional person in my country 💔 they all told me they will become extremely ill or they will die

@ambredurimel5604

3 жыл бұрын

shahad ALG late reply but my doc told me the child had 1/4 chance of dying

@Shodyalghamdy

3 жыл бұрын

Ambre Durimel in my case?

@Shodyalghamdy

3 жыл бұрын

The abnormal genes on opposite chromosome

I think 🧐🙂α-thal trait is a Deletion of two α-globin genes

Does this affect your bones. I’m aching more

@nirmalfrancis3648

4 жыл бұрын

That is jus generally life and being an adult..everything aches

@divinedavis9150

3 жыл бұрын

I have it and I take Flax Seed pills for a healthy heart and aching bones. But I also take Tumeric and Ginger capsules, Black Seed Oil, Moringa

merci infiniment

@MedicosisPerfectionalis

6 жыл бұрын

De rien :)

@999Patriots

4 жыл бұрын

Bonjour de Fort Worth!!!

How long does the blood test results take to get?

@MedicosisPerfectionalis

5 жыл бұрын

Good question...It depends on the type of the test, the lab itself, and how the doctor orders it...For example, if it STAT, which means as soon as possible (e.g. within hours)...So, talk to your doctor and ask about that!

@LindsayComitoYeah

5 жыл бұрын

@@MedicosisPerfectionalis Thanks! I happen to be a carrier for this and currently am pregnant and getting my boyfriend tested so we can find out if it's a possibility for our baby and it's been about 3 weeks and still no results

@MedicosisPerfectionalis

5 жыл бұрын

Do you mean genetic studies?

@LindsayComitoYeah

5 жыл бұрын

@@MedicosisPerfectionalis Yes

@MedicosisPerfectionalis

5 жыл бұрын

Ok...Normally these tests take long time...But if I were you, I would call the doctor’s office and the lab until they give you the date when your results are available...Don’t leave them alone, it’s YOUR money after all...So, keep calling! Best of luck!

amazing

@MedicosisPerfectionalis

6 жыл бұрын

Thank you! Glad you liked it!

Isint alpha thal trait supposed to be mutation of 2 genes and mutation of 1 supposed to be silent carrier?

@MedicosisPerfectionalis

2 жыл бұрын

Yes!

@onellafernandes

2 жыл бұрын

@@MedicosisPerfectionalis oops just read your description…my bad. Love your videos!❤️

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

What is hemotetramer .? How it is formed in thalassemia?

@MedicosisPerfectionalis

4 жыл бұрын

Identical hemoglobin chains fuse together because not all chains are produced due to a genetic defect.

@akashbaburaj2349

4 жыл бұрын

@@MedicosisPerfectionalis thanks👍

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇

@RoRo-ny3tw

2 жыл бұрын

@@MedicosisPerfectionalis Isn't that a homotetramer?

Great 🔥🔥❤️

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏

Pls make more videos

This was great

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

You are awesome ❤

@MedicosisPerfectionalis

2 жыл бұрын

Thank you so much ☺️

Decreased hematocrit and RBC but in lab tests u mentioned increased RBC count... I’m a bit confused

@Mariamhamwi

4 жыл бұрын

+ Isn’t RBC count the same as Hematocrit? >.

@MedicosisPerfectionalis

4 жыл бұрын

Thalassemia is an exception where patients can have anemia with normal to high RBC count.

@Mariamhamwi

4 жыл бұрын

Medicosis Perfectionalis yes but u mentioned Decrease hematocrit and Increase RBC count.. aren’t both the same

@MedicosisPerfectionalis

4 жыл бұрын

No

@Mariamhamwi

4 жыл бұрын

Medicosis Perfectionalis Where is the source of info please? Because in our PBL session the case showed decrease RBC count which i think is wrong as u mentioned but I couldnt back up my point with evidence to the group members

Sir does this disease occur at a time of birth or it can also occur later in life ?

@MedicosisPerfectionalis

2 жыл бұрын

People are born with thalassemia. Whether they will suffer symptoms, how bad the symptoms are, and when they will manifest are different issues!

Thaaaank you

@MedicosisPerfectionalis

5 жыл бұрын

My pleasure!

Thanks💝

@MedicosisPerfectionalis

Жыл бұрын

You’re very welcome 😊

I’m suffering this disorder right now

@MedicosisPerfectionalis

5 жыл бұрын

Oh! I am so sorry to hear that...and how is your health now?

@itzsNico

5 жыл бұрын

Medicosis Perfectionalis unfortunately I have to go to the hospital the next day but I’m fine

@MedicosisPerfectionalis

5 жыл бұрын

I hope you hear some good news...Please Keep me updated...Never let the disease win! Good luck 👍

@jennymayashley

3 жыл бұрын

@@itzsNico i have thel trait alpha. im not sure what are all of the symptoms i just found out last year and i think im learning that im not lazy i just have little to no energy i knew i had anemia but not thel trait alpha. i need to get my kids check. do you have any advice for me to help me understand it better to live a normal life & not see myself as lazy

@itzsNico

3 жыл бұрын

JennyMay Ashley I know how you feel. At first I feel like I have no energy, but that’s completely normal for a person who has this disorder. What I did to recover my energy is firstly I had to get blood transfusion, and everyday I have to take this medicine called “folic acid.” Apparently it’s suppose to help my blood or something, but there are other options to recover your strength either by eating a lot of greens, meaning in like vegetables, I ate spinach the most. Or you can exercise, and go to bed pretty early. This what I did to recover my energy. But if you do feel you have no energy, don’t hesitate to sit down and take a breather, that always help me out.

I have HbH disease

You speak by nose ??

Tq

@MedicosisPerfectionalis

Жыл бұрын

My pleasure 😇

Been told by my Dr that I have alpha thalassemia however I do not require any treatment, is this normal?

@MedicosisPerfectionalis

4 жыл бұрын

What kind of alpha thalassemia? It has 4 types.

@rmorton8281

4 жыл бұрын

@@MedicosisPerfectionalis silent carrier

@lindag4658

2 жыл бұрын

@@rmorton8281 Silent carrier means you have one abnormal allele in your genes. Generally these patients are clinically asymptomatic; so therefore, they do not warrant any treatments. Yes, what your doctor has informed you is a reasonable response.

@rmorton8281

2 жыл бұрын

@@lindag4658 Thanks

Best 👌

@MedicosisPerfectionalis

10 ай бұрын

Thanks!

Homotetramer not hemotetramer, please note

@MedicosisPerfectionalis

3 жыл бұрын

You're correct

I love u man

@MedicosisPerfectionalis

4 жыл бұрын

😊😊😊

My doctor let me know today have it IAM 32 week prengnant, looking more information...

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇

الله يوفقككككككك🦋✨✨✨✨🌷🌷🌷🌷🌷🌷🌷🌷😭😭😭🙏🙏🙏🙏

@MedicosisPerfectionalis

3 жыл бұрын

Thank you 🙏

@mjk9152

3 жыл бұрын

Medicosis Perfectionalis I desperately needed information that I did not understand, and I found this wonderful video. Thank you from the heart. May God grant you success