🦠Antibiotics Lectures: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

"If you haven't subscribed, there is no hope for you" LMAO

Love your channel still lol. And I’m not even a med student. Your humour and honesty compliment pathology really well and help make medicine meaningful. Thanks!😊👍🇨🇦

@MedicosisPerfectionalis

5 жыл бұрын

My pleasure...Thanks a lot for your kind words.

Please, help me reach 35,000 subscribers and I will start uploading videos on “bleeding and coagulation disorders” instantaneously. Thanks 🙏

@hollywoodinnewyork

5 жыл бұрын

You are amazing.

@MedicosisPerfectionalis

5 жыл бұрын

Thank you, dear :)

@Besho320

5 жыл бұрын

I shared your channel with my classmates on WhatsApp group . You are amazing 💕💕

@MedicosisPerfectionalis

5 жыл бұрын

Thanks a bunch...I am really grateful!

@Chocolateganache19

5 жыл бұрын

Medicosis Perfectionalis I was diagnosed at 15 with an average platelet count over 4 million with terrible headaches, after three years of low dose oral chemo and just baby aspirin after, my platelet count 8 years later is just over 500,000. Have you heard of someone so young having ET?

so glad i found your channel....my hemato module is saved!

@MedicosisPerfectionalis

5 жыл бұрын

Wonderful 😃

Your videos are so helpful. Please! don't stop doing the amazing work. ❤️

@MedicosisPerfectionalis

5 жыл бұрын

Sure! Thanks for your encouragement ❤️

Thanks for producing a very informative video. You are appreciated.

@MedicosisPerfectionalis

Жыл бұрын

My pleasure 😇

Yes ur correct. Best channel ever

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏

GREAT HUMOR!!!!!👍🏼👍🏼

@MedicosisPerfectionalis

5 жыл бұрын

Thanks 🙏

Thanks a ton..

i love your work💖

@MedicosisPerfectionalis

2 жыл бұрын

Thank you so much 😊

if im gonna pass my tmrws hematology exam its thanks to u !!!!!!!!!!!

@MedicosisPerfectionalis

5 жыл бұрын

Go get them 👏

Hi Please note in the case study the last option was >20% myeloblasts .. your interpretation was CML.. that is not the case, i think you meant AML .. thanks for your nice useful videos

@krishnapriyasamaleti886

2 жыл бұрын

Yep Or it could have been blast crisis of CML

Thank you 😍

@MedicosisPerfectionalis

5 жыл бұрын

My pleasure 😇

Yeah! This channel is awesome 😂😊💕.

@MedicosisPerfectionalis

Жыл бұрын

Thank you for your continuous support!

Thanks alot

thanks alot for these videos❤❤

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇

Thanks a lot!!❤❤🌹

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇

My exam is the next week so you save, thanks!

@MedicosisPerfectionalis

3 жыл бұрын

Thank you so much 😊

Why INF - alpha is given in PCV or ET? And could you pls 🙏🙏🙏make videos on cardiology also it would be really helpful ☺☺

Hmm you didn't include anything about the CALR mutation that is found in ET patients.

Excellent

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

Thank you very much 🎉

@MedicosisPerfectionalis

Жыл бұрын

My pleasure 😇

hello awesome channel. I'm looking for the history of tyrosin kinase and all the genetic related to jak2 kinase. what make the jak2 mutation. why it changes, what genetic and dna cause this. thank you.

Blood test results came back with insertion 30bp, deletion 52BP. Couldn’t help but to do a bit of research and came to this. Also “PV” and “ME” were written multiple times on my test in some spots for test results on the right. Any ideas? I’m Only 20 and not much I’m hearing right now back.

Friend please make a video on leukoerythroblastosis if possible.

thanks. can you explain about topics in surgery ?

@MedicosisPerfectionalis

5 жыл бұрын

Sure! I will...After finishing internal medicine! Thanks

Study hard🔥🔥🔥

Another great video

@MedicosisPerfectionalis

5 жыл бұрын

Thanks a lot!

Could bloodletting help ?

Why increase in platelets leads to increased risk of bleeding?

Is this treatable ?

my mother has double of normal platelets counts and had jack 2 mutation,after had operation at carotid and the day after had big stroke in brain .now is completely paralized for 1 year already .why did they operate carotid when they knew she had to much platelets just before operation ? they had to remove exess platelets before operation but didnt do that ,why ???

@helenTW

3 ай бұрын

I'm so sorry! Although I know any amount of apologies won't fix it 😢 I can't stand it when people fall victim to medical malpractise, it makes me so angry!

I'm undergoing this testing

@MedicosisPerfectionalis

Жыл бұрын

Best of luck!

Hey, one thing that isn't clear to me if you could elaborate. You're saying ET is an "exclusion diagnostic" which means you have it when all other possible causes don't fit. However, what about Jak2 (or calreticulin) mutation? Isn't that an explicit diagnostic and not an exclusion diagnostic? 🤔 Or maybe jak2 can "go back to normal" after the first cause (infection or inflammation or anyone you listed) vanishes?? Thank you

@marisolserrano3107

Жыл бұрын

Great Q

I (F45, now) was diagnosed with ET @29yo, jak+ and feel like there’s nothing there for people like me. It’s all about old people and nothing for younger patients like myself. Medical professionals don’t know what to do with me. I’m not healing well and I was told it’s because I’m aging and I’m basically old and therefore nothing to do with my et. I’m in a process of changing my medical team as I’ve been gaslit by this clinic way too many times and above is just one example. Also medication to treat et cause to many side effects for younger patients to function at full capacity but I’m forced to work full time and all my complaints about any side effects from any of the meds above (and I was on all of them already), are treated as I’m saying lies. Doctors don’t know how to help me effectively so I can live my life and stop comparing me to their elderly day to day patients.

I am going to comment hope I get an answer...I have had high platelets and high wbc since 2010,two bone marrow biopsies showing same as blood work anemia. I have recently had some problems namely the H-pylori bacteria hopefully after treatment and recheck it will be gone,but I am still being sent back to hematologist oncologist he already did bloodwork everything came back except for the JAK2 could the H-pylori been causing the high platelets and high wbc all these years????

@truthbtoldwright6411

Жыл бұрын

All I know is having the jak2 mutation will produce high platelet count. Have you got ET or PV? My platlets were at 700 when I was first diagnosed a few years ago. I'm now 55 and my platelets are 1200. Currently on 75mg of aspirin only.

Quiero esta información en Español

Im a 23 year old male and I've been diagnosed with Essential Thrombocythemia. I'm JAK2 negative, but CALR GENE is present. I had a good laugh when you said it's a disease of the elderly and more common in women since I'm a young man 🤣🤣🤣🤣

@nuclearstevex4516

4 жыл бұрын

I have it too Jak2 positive.

@millr9916

3 жыл бұрын

@@nuclearstevex4516 me three!! Makes me feel a little bit better knowing I am not the only one.

@riaverongunday1695

3 жыл бұрын

@@millr9916 Me four? Had it when I was 21years old :( JAK2 positive also

@21zimm

3 жыл бұрын

Me five. 38 year old male. So far so good with just a baby aspirin and regular monitoring. JAK 2 positive and platelets typically in th 750 range.

@jacobjasch4397

3 жыл бұрын

@@21zimm I am on aspirin and a small dose of Hydrea (Oral chemo, 3 tablets a week) My platelets have settled at 880... going to up the does to try get it down to 600-700 as I have had a couple of clots (that healed themselves). So far no side effects from Hydrea.

I don't know if I would classify it as something only the elderly are diagnosed with. I'm 27 and was diagnosed a couple months ago, and I am in a couple FB groups that have a good amount of young people in there. I think due to the improvement in technology, maybe we are able to diagnose sooner? I'm no expert, of course, and I am still learning a lot about this disease.

@MedicosisPerfectionalis

3 жыл бұрын

It’s not “only”, but generally. I am sure there are young people who has it, but you will find that the overwhelming majority are old. You can even ask your physician to confirm. I really wish you speedy recovery. Take care!

@kayteapod

3 жыл бұрын

@@MedicosisPerfectionalis makes sense! I will. There’s so much out there! Lots to learn. Thank you. I appreciate that!

@ahxian9976

2 жыл бұрын

@@MedicosisPerfectionalis I'm 27years old too. My Platelets count is 697 and my JAK2 test positive. I have MPN .. I going to do biopsy soon

@lenamichellejames

Жыл бұрын

Same. I was diagnosed at 33 with JAK2 positive. ✨🤗 Wishing you both health and happiness!

@kayteapod

Жыл бұрын

@@lenamichellejames thank you!! Healing and positivity sent right back to you! ✨🤍

my doubt is related to von willebrand factor. how does it help in platelet aggregation

@MedicosisPerfectionalis

5 жыл бұрын

Good question...Platelets have an outer coat, outside of the lipid bilayer plasma membrane, called glycocalyx...This glycocalyx contain receptors that bind the subendothelial collagen and the vWF (which is part of factor 8)...That’s how the platelets recognize trauma and start to bind to the collagen, activate, release, aggregate, start the coagulation cascade and fuse together...We will discuss all of that in future lectures.

Can a asymptomatic person can still have ET if jak2 and calr is negative but ONLY platelets are persistent 4 months high ranging 550-800 ?? Having no symptoms ESR and CRP all inflamations normal??

@cocolee8396

2 жыл бұрын

How are you?

It is awesome ..indeed

@MedicosisPerfectionalis

5 жыл бұрын

Thanks 🙏

What is the difference between pt and ptt and the bleeding time

@MedicosisPerfectionalis

4 жыл бұрын

Bleeding time measures platelet function. PT measures extrinsic coagulation pathway (as well as the common pathway). PTT measures intrinsic coagulation pathway (as well as the common pathway)

انت رائع

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

Platelets have no cell nucleus, so there is not going to be increased Uric acid as a final nuclei degradation product , thrombocytosis have no risk for gout

@MedicosisPerfectionalis

5 жыл бұрын

Good point, but remember that essential thrombocytosis is a myeloproliferative neoplasm where all cell lines are increased including WBCs which have nucleus...I hope it helps.

Still watching in 2024…for my exams😂 Live savior ❤

@MedicosisPerfectionalis

2 ай бұрын

I wish you all the best!

Hi currently 19 and just got diagnosed with this and the Jak2 mutation. Is that abnormal?

@MedicosisPerfectionalis

Жыл бұрын

ET is way more common in old people, but it can happen at any age. Only a doctor (hematologist) can confirm the diagnosis.

I'm 29 and thrombocytes 414. Is this very abnormal? I have higher than normal leukocytes and positive leukocytes in my urine. I only know because I was having a blood test for lithium and over the past weeks I've had a huge amount of migraines and random sudden nosebleed

@72matyas33

Жыл бұрын

That is in the normal range as far as I am aware 250-450(*1k). Above that you can be considered as having thrombocytosis, if you had much lower numbers a doctor might want to check it out tho. But you are having symptoms that bother you so I'd get checked out.

I got ET when I was 32, am now 43. It is now becoming common in children as well. Very interesting that you show little symptoms until about 40 and then haematologists start with medications. Luckily I am on aspirin but I do definitely notice a change in symptoms. You almost feel like a fraud when you first get it as you don't have any visible symptoms except high platelets and tiredness. Took me a long while to get to grips with mentally.

@MedicosisPerfectionalis

5 жыл бұрын

So sorry to hear that...How is your health now?

@chanelfitzgerald

5 жыл бұрын

@@MedicosisPerfectionalis My health is ok now, take it on a day to day basis. Some days I feel awful other days fine. I find exercise helps incredibly with the tiredness and also mentally. I am taking Clopidogrel 75mg every other day. Better than aspirin because that just made me feel sick. I like to find as much information out there regarding this so I know what I am up against when visiting dr's as sometimes they are so pushed for time. Thanks for asking and your channel is very informative.

@mohamedsahal9123

3 жыл бұрын

Me too I have ET

@siafathima6343

3 жыл бұрын

@@mohamedsahal9123 this disorder cause itching? Sudden itching?

@mohamedsahal9123

3 жыл бұрын

@@siafathima6343 nope, just headaches and dizziness sometimes. When I stopped smoking I felt better.

❤️❤️❤️❤️

@MedicosisPerfectionalis

3 жыл бұрын

Thank you ☺️

essential thrombocytosis How it can cause bleeding, i don't understand plz if any one knows

@MedicosisPerfectionalis

4 жыл бұрын

Because these platelets are abnormal.

👌 ☘️

@MedicosisPerfectionalis

5 жыл бұрын

👍😊

Español x favor

My partner has just been diagnosed with ET. She is 33.

@MedicosisPerfectionalis

4 жыл бұрын

😳😳😳 How is her health?

@jontython

4 жыл бұрын

@@MedicosisPerfectionalis she is in great shape in general, eats well, goes to the gym, etc. At around 18 she got put on medication for hypertension but after the initial investigation the cause was put down to 'one of those things'. In 2014 after a healthy pregnancy (but with mild anemia controlled by iron supplements) at 30 weeks we lost our boy to a sudden placental abruption which again was just chalked up to 'one of those things'. Since losing our little boy we have gone on to have a health little girl, but with constant monitoring through the pregnancy and she was delivered at 34 +6 weeks. Both children were delivered by cesarean. Two/three years ago she had some bloods done which showed high platelets but when she called for the results she was told that everything was OK. Then about three months ago she had a weekend away abroad and when she came back she had a very tender and swollen ankle. I pushed her to seeing a doctor and they treated her for cellulitis and took bloods which is when they then saw she still had a high platelet count in the high 700's. They have had her under a hematologist who has run several bloods tests to rule out other causes and then run tests to look for genetic mutations. It has tested positive for a JAK2 mutation. As a treatment they have put her on a low dose of aspirin, 75mg daily, and she will go for blood screening now every three months for the rest of her life. Also unless she has a stroke or hematoma they will not give her any further treatment until she reaches 60. After reading about ET now she has a diagnosis we are starting to notice certain symptoms that have gone unchecked. She is tired all the time even though she gets 8-10 hours sleep every night, she's always scratching her thighs and she sweats a lot in bed ever since losing our little boy. I don't know if it has any bearing on anything but she has a black Caribbean heritage but there is no history of health issues with either side of her family. The women have lived good long healthy lives as far as we know. My partner is completely unshaken by this, feels fine and will just take it in her stride. It is me who is looking in to the disease and worrying. I'm insisting that we spend some money to go and get a private consultation. I still think the NHS is a great thing but they don't have the time or resources anymore. The hematologist didn't explain anything properly to us and it was in the car on the way home, reading a leaflet he had given to her, that cancer was first mentioned. It has left us both rather confused and looking for answers.. More me than her I have to admit. Although I have no medical background I found your video very informative and easy to follow. I will watch it a few more times I am sure. Are there any other you recommend i watch to help build my understanding of this disease?

@jontython

4 жыл бұрын

@@MedicosisPerfectionalis apologies for the essay 😬

@millr9916

3 жыл бұрын

I have been diagnosed with it and I am 23

@siafathima6343

3 жыл бұрын

@@jontython hello...how is your partner? What type of itching she had? Sudden or chronic?

Is AML a myeloproliferative disorder?

@senseii6803

3 жыл бұрын

And please why if not

❤❤❤

@MedicosisPerfectionalis

Жыл бұрын

:)

Please send for this vedio of the papers can be reader a easy

@MedicosisPerfectionalis

3 жыл бұрын

I am afraid I don't understand!

I'm a male, 20 years old. What were the odds? :(

@nuclearstevex4516

4 жыл бұрын

Do you have ET? I do

@siafathima6343

3 жыл бұрын

@@nuclearstevex4516 high platelet cause sudden itching ?

polycythemia and pv same or not

@MedicosisPerfectionalis

Жыл бұрын

Polycythemia has many causes. One of them is polycythemia vera.

You don't have videos for platelet and coagulation disorders :((((

@MedicosisPerfectionalis

4 жыл бұрын

They’re here: Bleeding & Coagulation kzread.info/head/PLYcLrRDaR8_cAqUviH6nWUwYttoVhsyQf

@abrahammatar1671

4 жыл бұрын

@@MedicosisPerfectionalis Hemophilia, vWD, ITP, TTP, Are they present in the playlist? Thank you.

@MedicosisPerfectionalis

4 жыл бұрын

ITP was uploaded today

I am confused about the JAK2 EPO receptor part. Isn't it like this: EPO binds on the EPO receptor, conformational change, JAK kicks in, intracellular signaling, etc.? So basically in PV/ ET the EPO receptor part is just skipped and the JAK remains active, right? Or why is the JAK "activating the EPO receptor"? Thank you!

@eduardosoria1614

4 жыл бұрын

xDomglmao yes I think that’s what he meant. I was a little confused too.

Your lectures are great ,but sometimes you speak very fast.

@MedicosisPerfectionalis

Жыл бұрын

Thank you so much for your honest feedback!

Spanish, please

I have ET

@MedicosisPerfectionalis

4 жыл бұрын

I am so sorry 😐

@nuclearstevex4516

4 жыл бұрын

Medicosis Perfectionalis I’m fine with it. I have a great hematologist, and the hydroxyurea seems to be helping lower the platelet count. Only downside is the side effect of being immunocompromised from the chemo. Aside from that, all good Thanks for the concern!

@MedicosisPerfectionalis

4 жыл бұрын

I am happy to hear that you’re doing fine! Take care!

@bagelbutcher

2 ай бұрын

My mother's plt rate has risen to 1,300. She has constant headaches and fatigue. They started taking medication yesterday. I don't know if her plt rate will decrease.

Elderly????? I’m 44 got diagnosed last week

@ginapuspa643

6 ай бұрын

Im on 25 got diagnosed with ET😂

if you haven't subscribed then there is no hope for you😂😂🤦🏻

Right near the start you say it is a disease of the elderly - it might be more prevalent but is certainly affects younger people too. Rubbish!

@MedicosisPerfectionalis

4 жыл бұрын

Same holds true for saying: “seat belts save lives”...There are exceptions to every rule.

@helenobrien1241

3 жыл бұрын

At least half the people on a couple of FB groups that I see are under 60. Possibly because in the UK there is a reluctance to start chemo. drugs below that age and they are struggling with symptoms.

@millr9916

3 жыл бұрын

I am 23 with Jak2 ET and have had it for about 2 years!

@siafathima6343

3 жыл бұрын

@@helenobrien1241 this disorder cause itching?

@helenobrien1241

3 жыл бұрын

@@siafathima6343 some say so. I have no symptoms and so I am lucky! Diagnosed from rising platelets + BMB

please slower ur speaking 😂😂🙏🙏im sorry but the way u speak is too fast for me.. anw thanks for ur videos

@MedicosisPerfectionalis

5 жыл бұрын

Thanks for your feedback 👍

@giuliabonetto1433

5 жыл бұрын

you can change the playback speed in the settings of your youtube player

Yeah! This channel is awesome 😂😊💕.

@MedicosisPerfectionalis

Жыл бұрын

Thank you 😊