Simon, an interesting study was recently published showing the associated risks for ASCVD, PAD and IHD risks from each specific fatty acid (ie not just “saturated fat” but all the different fatty acids that are classified as saturated fat). The study is “Association of dietary fatty acids with the risk of atherosclerotic cardiovascular disease in a prospective cohort of United States veterans” Kerry L Ivey et al. Am J Clin Nutr. 2023 Oct. You may not be all that surprised by the results. One tricky thing is the increased associated risk from “conjugated linoleic acid”. I was not aware of these until now, but they are not the same as the linoleic acids found in polyunsaturates. Also, some polyunsaturated fats are associated with increased risk, such as arachidonic acid. But… it sounds like that’s the polyunsaturated fat you mostly get from meat sources, not plants. And as you may suspect, plain old “linoleic acid” has the lowest association with ASCVD risk. “Butyric acid” (a saturated fat! 😮) also is associated with similar lowered risk, but this is only found in trace amounts and makes up only a tiny proportion of people’s diets.

People eat too much fat and too much protein. Giving up oil and butter, then relying on getting fat from whole foods is so much better. I've done that for eleven years and am doing well.

Excellent!!!!!! ❤❤❤

There are studies showing that high intake of seed oils, particularly those high in omega-6 fatty acids, can induce insulin resistance. For example, a study published in the American Journal of Clinical Nutrition found that a diet high in omega-6 fatty acids from safflower oil led to increased insulin resistance in overweight and obese postmenopausal women. Another study published in the Journal of Clinical Endocrinology and Metabolism found that a diet high in soybean oil, which is also high in omega-6 fatty acids, led to insulin resistance and increased fat storage in mice. Insulin resistance automatically increase fat in the body of mammels and humans.

@TheProofWithSimonHill

8 ай бұрын

We can, of course, selectively look at single studies in humans and one study in mice, or we can look at the balance of evidence by combining many clinical studies instead. Here is a meta-analysis of RCTs showing no weight gain as long as calories are not intentionally increased. In fact, when looking specifically at replacing saturated fat, canola oil reduces weight. www.sciencedirect.com/science/article/pii/S2161831322007037

@bendavid3129

8 ай бұрын

@@TheProofWithSimonHill With these kind of studies any result can be created by STATISTICAL MANIPULATION! They have no value in reality!

@offensivearch

2 ай бұрын

​@@TheProofWithSimonHill Canola oil has about half the concentration of PUFA as safflower oil. Despite popular conception it is only moderately high in PUFA. Safflower oil and corn oil are much higher in PUFA.

More PUFAs than SFA is shown to be healthier, but what about PUFAs compared to something like Dr. Esselstyn's diet of NO added oils at all?

Deaths from heart attacks are down since 1960 because we have significantly reduced the amount of smoking cigarettes we do as a population. We also have much better techniques and technology to prevent death from heart attacks (CPR, oxygen, defibrillators, ambulances and life flight helicopters, much better education, etc).

@TheProofWithSimonHill

8 ай бұрын

That is exactly the point, it's useless to spot ecological correlations between two variable and deduce a causative relationship.

@offensivearch

2 ай бұрын

@@TheProofWithSimonHill You are constructing a strawman when you say the PUFA argument is based on ecological correlation. There is plenty of higher quality evidence.

I have learned so much from Simon and are forever grateful ☺️ ❤

Pufa 🎉 for more torpor, because the fat that we are making in our own are toxic 😮😭.

Why do the Ray Peat people believe PUFAs are bad? I love nuts and seeds (I HATE the tiny servings size and the high calorie density though) But I don't know why Peatarians are against nuts and seeds

@AL-sb9ch

8 ай бұрын

If you are in good health a few seeds or nuts are not goin to do harm to your metabolism, the problem in excessive consumption polyunsaturated fats omega 3 and 6 in the form of oils that had been extracted using press or chemicals. Polyunsaturated fats have a tendency to oxidase easily vs saturated fats like coconut oil and in time they can slow down body metabolism

@daysoftheboo

8 ай бұрын

@@AL-sb9ch but aren't nuts and seeds better because they're a whole food? I don't eat any oils not even coconut oil , I eat nut butters once in awhile, nuts and seeds I soak them in water for a few days before I eat them , other than having osteoporosis I would say I'm in decent health

@emh8861

8 ай бұрын

They’re not talking about nuts and seeds in their whole from.

this seems to gloss over the what should be the most important aspect of this discussion, namely the omega-6/omega-3 ratio in PUFA. It seems like PUFA are good for health if those are in balance, but bad for health if too strongly tilted toward omega-6.

@TheProofWithSimonHill

8 ай бұрын

Focusing on ratios is not very important. See here: www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.191627 "Advice to reduce omega-6 PUFA intakes is typically framed as a call to lower the ratio of dietary omega-6 to omega-3 PUFAs. Although increasing omega-3 PUFA tissue levels does reduce the risk for CHD, it does not follow that decreasing omega-6 levels will do the same. Indeed, the evidence considered here suggests that it would have the opposite effect. Higher omega-6 PUFA intakes can inhibit the conversion of α-linolenic acid to eicosapentaenoic acid, but such conversion is already quite low, and whether additional small changes would have net effects on CHD risk after the other benefits of LA consumption are taken into account is not clear. The focus on ratios, rather than on levels of intake of each type of PUFA, has many conceptual and biological limitations."

@dkeener13

8 ай бұрын

@@TheProofWithSimonHill contra to what you said here, speaking about omega-6 and omega-3 competing for enzymes and the need to limit the former to get the benefits of the latter. kzread.info/dash/bejne/g4uIp9CAn6m4gso.html

@Parker_Miller_M.S.

8 ай бұрын

​@@happyhealthylife4everwhat do you mean by the "omega 6 arachidonic acid system is saturated?" Even when linoleic acid is increased by 6 fold or reduced by 90% there is no physiologically relevant increase in AA production from LA. As the 2009 paper by Harris et al reference, the conversate is about than 0.2%. So what you're saying makes no sense and is not in line with the evidence. No one is saying omega 3 isn't important but to fixate on the ratio is just majoring in the minors and does not seem to matter much at all.

@Parker_Miller_M.S.

8 ай бұрын

@@happyhealthylife4ever I'll give it a listen next time I drive to work

@Parker_Miller_M.S.

8 ай бұрын

@@happyhealthylife4ever if you can provide the evidence for that claim then I'll put more consideration in it but as of right now I don't believe what your saying about health deterioration from oils is in any way shape or form substantiated by the totality of human evidence nor do I believe the more rapid rise in blood LA to be a problem in the slightest given tissue level of LA is inversely associated with various health outcomes (Marklund et al 2019).

Complaining about ultra processed food being bad but pretending UPF isn’t the single biggest driver of serum linoleic acid is quite at odds

@nelsonhoffman5922

8 ай бұрын

1. those pufas are damaged. 2. Ultra processed foods are driving caloric overconsumption / energy toxicity.

Please have Mary Ruddick on the show 🙏😊💗

@TheProofWithSimonHill

8 ай бұрын

We'll look into inviting her.

@katherinefiori

8 ай бұрын

@@TheProofWithSimonHill Thank you 🤍 Cannot wait! 😊

@denniscerletti2244

7 ай бұрын

Also ask Dr Paul Saladino onto the show.

I think PUFAs caused my FUPA

There are also equal or more papers that prove that pufas are dangerous for health. So I don’t agree with you. Small quantities okay but not as a regular usage.

Heart disease is still the number one, leading cause of death in the world. The reason why it's decreased since the 1960s is because death rates have gone down, in general. I may be a carnivore, and thus don't quite align with Simon's perspective on food, but I do appreciate the work and effort he puts into his content. Referring to studies like these can be quite misleading, though.

@TheProofWithSimonHill

8 ай бұрын

I specifically brought that up as an example of why making such arguments based on ecological evidence is poor.

@DillaryHuff

8 ай бұрын

@@TheProofWithSimonHill Ah, that's my bad. I didn't have time to watch the entire video during my lunch break, so I skimmed through parts of it instead.

People aren't any more sedentary actually. Believe it or not, people used to sit around and read, write, draw, play games, knit etc... People seem to glamorize/exaggerate their work and energy output. maybe if you were a lumberjack or had a large farm, but most people didn't work those sort of jobs. There's no way vegetable oils are good for you, haven't you seen how they're made? You're reading the studies paid for by seed oil companies. He's doing the old appeal to authority like Layne Norton or whoever where he desperately wants to look like an 'expert'. You're just some dude with a mullet pal

@TheProofWithSimonHill

6 күн бұрын

Nice comment!

The weakest data is Simon Hill saying “he’ll post studies” and chicken out

@TheProofWithSimonHill

8 ай бұрын

Full episode with studies in the description here 😉 kzread.info/dash/bejne/o6yrksp7mcy1oNo.html

@profd65

8 ай бұрын

Feel dumb now?

Rubiish theories