This was fantastic! As have been all your recent videos about essential fatty acids. Great work. The last few minutes of this video addressed why even though *increased* omega-6 (LA) intake is correlated with *better* CVD and diabetes outcomes, that doesn't mean that increased LA might not cause other problems (like RA or other inflammatory diseases). We need more studies! One question I have was prompted by Dr. Harris' admission that he didn't definitively know if LA has metabolic roles aside from being the precursor to AA. I have the same question about ALA: is ALA used by the body other than as a precursor to DHA and EPA? Because if not, it might be better to consume DHA and EPA directly rather than rely on the low conversion rate (1%-10% depending on the person - women do it better) of ALA to DHA and EPA. Also, what about the idea that cells function more efficiently ("better") when they have more omega-3 (DHA and EPA) than omega-6 (AA) in their cell membranes? Lastly, I'm still dying for you to do a deep dive into Dr. Brooke Goldner's "hyper-nourishing protocol" in which people are advised to massively increase their intake of ALA (via flax and chia seeds), and to drastically decrease their intake of LA (by avoiding all other nuts and seeds), in conjunction with eating copious amounts (16 oz or more daily!) of cruciferous vegetables such as kale, chard, arugula, cabbage and spinach. She claims a high success rate of curing people of Lupus and other inflammatory diseases, all based on the theory that her protocol causes the body's cell membranes to transform for the better by replacing AA with DHA and EPA, thereby greatly improving their efficiency.

Simon looking like Barry Gibb. (

@jrmint2

8 ай бұрын

haha...so its not just me 😄

@Joseph1NJ

8 ай бұрын

@@jrmint2 Nope, it's not.

@Newmexicobirds

8 ай бұрын

Yes! And I agree most definitely a compliment❤

@brendawood6712

8 ай бұрын

Simon is a hunk!

Can we get a dscussion on science studies that shows Soy foods are better for bone building vs beef or animal protein? So important to menopausal women, but the internet yields conflicting info.

@nancykowalczyk2070

8 ай бұрын

Not in this plant good…meat bad, world. The verdict is in🙄

@k.h.6991

8 ай бұрын

The science is pretty clear: exercise is a more important factor than diet, for bone health.

I havent watched the full podcast but does he talk about the competition between ALA and LA for the enzyme that helps convert them to long chain? Dr Brooke Goldner talks about this and how it could be the reason behind the low conversion rate of ALA to DHA/EPA.

@plantbasedposer

8 ай бұрын

Delta 6 desaturase

It would be great if you could have a podcast with some scientists that have a different view, like Ramsden or Brenna

If I eat a lot of omega-6 rich seed oils, my psoriasis flares up on my head, when I eat flax seeds it dampens the effect. I've done so much self-experimenting and I simply stay away from omega-6 rich oils.

What is the RDA for omega 6? Also, what is the optimal intake? And, how much is too little or too much? Most plant foods, including processed foods, already contain omega 6. Do we really need to add exogenous sources of omega 6 in our diet? So many questions.

@-johnny-deep-

8 ай бұрын

Agreed! Along with "what's the optimal omega-6 to omega-3 ratio?" Simon's other videos with various other experts address some of them.

@stellasternchen

8 ай бұрын

@@-johnny-deep- The ratio is BS, have you heared that omega 6 do not cause inflammation. The problem is that most people do not get enough omega 3's and are deficiant. Omega 6 does not have any negative effects that have been proven. Why stll insist in an outdated hypothesis?

@jamesmurraylegal

8 ай бұрын

@-johnny-deep- Why not give us the link?

@-johnny-deep-

8 ай бұрын

@@jamesmurraylegal - Because adding links always seems to get my videos delete by our google overlords. But here are the best videos "How Much Omega-3 Should You Really Consume? | Philip Calder | The Proof Podcast EP#278" and "What You Need to Know About Omega 3 and 6 Fats | Prof Philip Calder | The Proof Podcast EP #278". The first is a shorter 15 minute excerpt of the longer 2 hour one.

The thing about arachadonic acid being regulated has been well understood for a long time. William Lands covered this, and charted it. Arachidonic levels will top out at about 4 percent of calories. This is why if you compare any intake above 4 percent you'll get pretty much the same result. If you get down to 2 percent of calories from omega 6 and include some omega 3, that's when you'll see the ratio IN THE TISSUES will change. Not the blood. Measuring the blood is unreliable, as noted here. Old info. Well known. As for the essentiality of omega 6 or 3, it's not clear to me that the experiments that were initially used to establish this have been adequately reproduced. I heard that others could not reproduce the sterility in rats or other negative outcomes when they controlled for all other nutrient needs. The symptoms noted match symptoms for other nutirent deficiencies. It does appear that if these PUFA really are essential, its on the order of about 0.5 percent of calories from linoleic and alpha linolenic. It's almost impossible not to get that much unless you eat just pure sugar, which obviously isn't going to sustain life. So it's really hard to do a rat study where they actually completely eliminate just the pufas while still having all other nutrients adequately provided.

Does anyone know where/ how to determine to say plus or minus 10%, 20%, or even 50% accuracy - I bet may health-conscious individuals would be interested in such details. Thank you all for considering to provide your comments.

@-johnny-deep-

8 ай бұрын

Know how to determine what?

What about the relationship between Omega 6, seed oils and cancer.

@stellasternchen

8 ай бұрын

Linoleic acid (omega-6) Seems to decrease cancer risk in meta analysis`. So the fact that seed oils increase cancer risk is not based in any science. The whole "seed oils are bad" originated as a social media trend, not based in science. I wonder what will be the next food we are told to eliminate. How about pasta. Pasta could be bad because of gluten, and gluten makes you gain weight more quickly and the wheat flour is refined so it incrieses cancer risk and it has phytochemicals that are toxic and cause autoimmune disease. LOL

@Parker_Miller_M.S.

8 ай бұрын

In the aggregate with all evidence, higher omega 6 leads to lower cancer risk for various types of cancer.

Simon, do you think we can get enough omega 6 with nuts instead of using oils?

@TheProofWithSimonHill

Күн бұрын

Yes!

Dr Brooke Goldner seems to think she has the answers to the omega 3 questions

Im of the position that the evidence is so strong for PUFAs to be health promoting (excluding weight gain situations from high ultraprocessed food heavy diets) that I make it a part of my daily nutrition routine to include 1-2 table spoons of flaxseed to foods I usually eat including smoothies, chilli, etc. No I'm not concerned about arachidonic acid, no I'm not concerned about oxidation.

@Parker_Miller_M.S.

8 ай бұрын

I have several critiques of that argument/position. 1: seed oils and oils in general are not by definition of the NOVA classification considered "ultraprocessed" (category 4) and are actually considering minimally processed (category 2) as there are considered culinary ingredients. 2: the amount of saturated fat contained in coconut oil and red meat vastly outweighs any unsaturated fats contained within these foods, thus negating any potential health benefit from said foods. Thus they would not be considered "health promoting" beyond very small amounts in the diet. I for one would never use coconut oil in any circumstance because of how much saturated fat it contains. That, and I dislike coconut. 3: I'm completely in agreement with the idea that unsaturated fats from whole foods like nuts and seeds is a great health promoting way to get said unsaturated fats. However, the notion that nuts and seeds are "safer" is unsubstantiated in the evidence. The meta-analyses of controlled feeding studies and prospective cohort studies overwhelming shows health benefits from both nuts and seeds, as well as seed oils when in a weight stable calorie intake. Now when we talk ultraprocessed food heavy diets, sure cutting out foods that contain these oils to reduce calories would be a smart move, but replacing those fat calories with butter or coconut oil would not be wise for cardiometabolic health. 4: an evolutionarily consistent diet often suffers from the appeal to nature fallacy and antagonistic pleiotropy. I'm in agreement that more unprocessed and minimally processed foods are generally considered health promoting (whole grains, fruits, veggies, nuts, seeds, lean-non red meat protein, low fat dairy), but if this pattern entails large amounts of butter and red meat (two things that can fit this criteria) health is very likely to suffer as per the enormous amounts of data we have on the subject.

Animal products are the main source of arachidonic acid for most people.

@timothylink4386

3 ай бұрын

Plants don't have it. So yes.

The problem of seeds oils is not only the unbalanced ratio of omega 6 vs 3, it’s the problem that they are oxidized very easily. Just by light or any heat they will get oxidized… and that causes inflammation in your body. Furthermore, these oils are not natural, so they need a manufacturing process that usually includes heating or chemicals. Guess what happens with those polyunsaturated fats during the process? Yes, they are oxidized.

@TheProofWithSimonHill

8 ай бұрын

What you described is mechanistic speculation. "I think because they are oxidized they will lead to poorer health outcome. Actual outcome evidence beat mechanistic evidence in the evidence hierarchy. And in terms of outcome, we simply do not see that.

@user-ud5sm2de4l

8 ай бұрын

@@TheProofWithSimonHill In terms of what outcome? You mean the observational study that Bill mentions in the video where people with higher blood omega-6 had less heart attack deaths? First of all, I’m not saying that Omega-6 is bad so that study could be right and still it doesn’t say anything about seed oils. I have a high Omega-6 without any gram of seed oils and I guess anyone eating a high fat diet with eggs, chicken, pork, avocado or almonds will have high omega-6 too. Anyway, I haven't read the study, but it sounds like an absurd conclusion to say that because the population with high omega-6 in blood has less hearth deaths therefore seed oils are bad. There are many factors that can be at play there, as with any other correlation observational study it is just impossible to know what factors can be the cause of that… It could be that eating more fat is protective… it could be that a high LDL and HDL is protective… It could be that people with low Omega-6 have a worse nutrition, or take less care of health, or they are not eating enough eggs or just that they are vegans that don’t like nuts or seeds. Oxidized oils are not harmful for your health? Are you arguing against that? Do you recommend taking rancid oils? Polyunsaturated fats are extremely easy to get oxidized and you can imagine that oils don’t come from soy or canola just by cold press like olive oil. Canola oil is extracted by slightly heating the crushed canola seeds dissolved in the hexane solvent or by cold press method. Finally, it is refined using water precipitation and organic acid to remove gums and free fatty acids, filtering to remove color, and deodorizing using steam distillation. Does it seem like a natural and healthy food for you?

@TheProofWithSimonHill

8 ай бұрын

Describing the process by which seed oils are made is not a substitute for health outcome data. Do you have data showing that animal fats are healthier than canola oil?

@user-ud5sm2de4l

7 ай бұрын

@@TheProofWithSimonHill In absence of strong evidence I think it was actually good to remark that we’re talking about an ultra processed artificial product. But more importantly, we are talking about polyunsaturated fatty acids, the more unstable type of fat, that get easily oxidized. But it can also become hydrogenated… Canola oil refined using high-heat could have upwards of 4% trans fat content. You probably know what trans fats are and why they have been banned from many countries. On the other hand, animal fats are saturated fats, the most stable type of fat, as they contain only single bonds in the carbon chain, with all excess carbon electrons bonded to hydrogen. So you can put it on light, oxygen or heat them without problems, which makes tallow the best fat that you can use for cooking. So what more evidence do you need? Are you scared about cholesterol levels? It’s time that you understand that cholesterol is good for your body, every single cell in your body NEEDS cholesterol to function. It’s also used for many processes in the body like repairing tissues, building hormones, immune system, vitamin D and any fat soluble vitamin, creating bile, .... without cholesterol you would die within minutes… Instead of looking at absurd correlational studies that just read statistical data wrongly, you would do better by understanding how cholesterol metabolism actually works. And how the mechanism of artery calcification happens. And how is it possible that the body produces cholesterol and creates complex mechanisms to transport it around the body… to harm us? The myth of bad cholesterol has been debunked a long time ago, the current literature does not support the notion that dietary cholesterol increases the risk of heart disease in healthy individuals, and even higher cholesterol has been associated with longer longevity. Unfortunately the official medical advice is outdated and stuck in the 50's, there are many studies that support that, and the ones that associate cholesterol with CVD are weak correlation studies that we can’t trust. pubmed.ncbi.nlm.nih.gov/27292972 pubmed.ncbi.nlm.nih.gov/36059207 www.ncbi.nlm.nih.gov/pmc/articles/PMC6024687 pubmed.ncbi.nlm.nih.gov/25685363 pubmed.ncbi.nlm.nih.gov/26268692

Sorry I am just not buying that, he is saying that I should swap out my olive oil for canola or corn oil.

@stellasternchen

8 ай бұрын

Olive oil has a low smoking point, cannola is far better for frying for example. And olive oil has 10% PUFAS as well, it does not need to be replaced.

@hiphopaneer

8 ай бұрын

@@stellasternchen well I use coconut oil for cooking

@TheProofWithSimonHill

8 ай бұрын

It would be wise to replace coconut oil with any nontropical plant oil with much lower saturated fat content.

@rejiequimiguing3739

8 ай бұрын

Look at countries that consume omega-6 vs countries that consumes coconut oil. Which of them looks like an elephant or rhinocerous.@@TheProofWithSimonHill

Not sure there was high value in interviewing someone, who, when asked the question "Is there any reason to fear Omega 6's", say's that he doesn't know, and that you should stay away from processed foods that contain Omega 6's.

@relaxgood5214

8 ай бұрын

What is bad about processed foods is the high level of sugars salt processed carbohydrates artificial additives preservatives etc. that’s why people should not eat that crap.

@davidzip8841

7 ай бұрын

Yes, what is the point in interviewing the leading expert in the field? I just want someone that says what I heard at the low-carb conference.

No. You absolutely don't need more. You need a much higher ratio of omega 3 to omega 6

@DJTCOOPS

8 ай бұрын

In response to caption. Watching the video now

@jeffreyjohnson7359

8 ай бұрын

The ratio doesn't matter. That comes from the belief that omega 6's are inflammatory. There have been dozens (at least) of studies on this, with all different doses and time frames, and there's zero inflammatory effect. All unsaturated fats have positive health effects, in terms of reducing mortality and AS-CVD. That said, it's probably a good idea to take an omega 3 supplement, since some studies have shown benefits.

@YaYippieYeah

8 ай бұрын

@@jeffreyjohnson7359 Also from the belief, that you can synthesize significantly more DHA and EPA if you keep your ratio low. This reasoning is purely based on mechanism and not based on any strong evidence. Still the influencers, Simon Hill included, support this narrative. I tested it on myself. I was strictly between 1:1 - 1:2 for a few months and did a blood test (HS-Omega-3 Index). My EPA/DHA level was still very bad (without supplementation). For most males the ratio probably does not matter at all.

@johnhollar6001

8 ай бұрын

Confused no. Eat soy oil for arthritis and auto immune diseases. Sounds great to me. Simon your bias shows through..

@stellasternchen

8 ай бұрын

No you just need more omega-3, most people do not get enough. And if you cut out vegetable oils you cut out an important source. The ratio does not matter, geting enough of both does.

1sr

All 4 of my grandparents lived past 95. None of them were obsessed with any of this. They ate what they enjoyed, and lived their lives. This obsession over nutrition is what's unhealthy.

@-johnny-deep-

8 ай бұрын

I'm sure good genetics played a significant part. All my grandparents died in their 70s.

@jrmint2

8 ай бұрын

so what did they eat?

@TeeGar

8 ай бұрын

@@jrmint2 Everything from beef and chicken to potatoes and greens. Omnivorous. And they didn't "track their macros"

@katherinefiori

8 ай бұрын

@@TeeGar 🙏💗

@Parker_Miller_M.S.

8 ай бұрын

This is a key example of anecdote vs general nutrition for the wider population. Genetics play a huge role in longevity and because of that we can't rely on that to disregard nutrition advice. Thus we have population level dietary advice as a way to capture as many people as possible to enhance health and longevity.