Worth every minute I listened. I am not either a scientist or a researcher. I am just the average Joanne who is so grateful that there are enquiring minds always striving to know more

@Ashystar067

Жыл бұрын

Average Joanne. I've never heard that one 😄 we're forever learners! You don't need an excuse to seek wisdom

"New directions in science are launched by new tools much more often than by new concepts. The effect of a concept-driven revolution is to explain old things in new ways. The effect of a tool-driven revolution is to discover new things that have to be explained." Freeman J. Dyson, Imagined Worlds.

@KalebPeters99

2 жыл бұрын

This is a really great quote, thank you!

@GREATLORDPOOH

2 жыл бұрын

Nothing like a new tool be ita hammer or a new rail gun

@bruceolga3644

Жыл бұрын

Ewe muôns realize that ewe huemans are cliche clone drone parroting pssiticorum 🦜

That alien analogy works well in every branch of science....what a wonderful way to establish a context for such an engaging lecture...thank you

@KalebPeters99

2 жыл бұрын

Right? I thought it was brilliant too!

@yanikkunitsin1466

2 жыл бұрын

This though experiment is lifted directly from Carl Sagan's "Cosmos" TV series.

To visually see, the smallest machines working in a living cell is a wonderment. The smallest machines in the cell exhibit intelligence and decision making. To actually see them in action in real time is astonishing.

@MyMy-tv7fd

2 жыл бұрын

almost like they were intelligently designed

@lastchance8142

2 жыл бұрын

@@MyMy-tv7fdYes, even the individual proteins, especially the enzymes, are a marvel of design. It's so conspicuous, one must actively ignore the obvious to deny it.

This lecture just flew by - always a good sign (for me) and kept me interested throughout - thanks. Love how seemingly unrelated events/discoveries lead to more investigation, experimentation and discovery. Reminds me of that great BBC series Connections.

@contemplations6881

2 жыл бұрын

Uuji

The start was excellent. A good metaphor! Maybe it's the way we understand the world around us. And the way we learn any subject! Thanks for sharing!

شكرا للجمعية الملكية لتقاسم هذا العرض الممتع، والشكر موصول للباحث وقد أمتع وأحسن اختيار المقدمة كما أجاد في انتقاء الخاتمة.

Great way to pass an hour.....LEARNING.

🥰 That end quote!!!!!! Thank you for sharing

The best analogy of science ever? I think so.

Really enjoyed every minute of that, thanks for posting.

How I end of here??? All I know I watched the whole thing!!! Wow great work great video.

I really wish I was born 200 years later than I was. I am going to miss all these medical miracles that are coming down the line. The only comfort I do have is knowing that all the kids today, including my 20 yr old triplets and one day grandchild will benefit from healthier and much longer lives. Thank you to all the people who have dedicated their lives to improving the world.

Incredible presentation. These guys are geniuses.

A truly great talk for the general public. Inspiring. Great many thanks!!

this was fascinating and the personal stories of the scientists was enough fodder for several films

@peterotoole2266

2 жыл бұрын

You can hear directly from many of the scientists themselves and their stories, lives, influences, hobbies etc on The Microscopists podcasts (Eric Betzig, Jennifer Lippincott-Schwartz, Marty Chalfie (coming soon) and Dan Davis himself!)

Loved every minute of this talk. Thank you!

Beautiful! Thank You for BEING YOU!

Such admirable people. I am stunned.

Amazing so exciting! Just in time for A BIG REVOLUTION in medicine needed technology is on work! Thank you all good people of our planet!

Incredibly illuminating!

This was absolutely fascinating! One of the best lectures on KZread ever; well presented, very enthusiastic, knowledgeable and informative. I look forward to making my choices in the future. (I think!) The quote at the end was superb.

@SevtapThurston

2 жыл бұрын

Amazing so exciting! Revolution, A BIG REVOLUTION is finding its technology!

"The Secret Body" book arrived yesterday, and it was difficult to put down. (Just a warning for anyone thinking of getting it.)

Thank you for this lecture. I'm still amazed about origin of those tools.

Just Awesome! It's inspired me even more to try and get involved in this area

One of the best Ri talks I've ever seen, thank you!

Stochastic discoveries and chance contingencies combined with courageous and brilliant thinkers and hard work. Captivating presentation!

thank you Dan keep it coming

In my dissertation work, I used the non-fluorescent halves of different fluorescent proteins and engineered expression vectors for genes that encoded these appended to target proteins (wt and oncogenic mutant c-Fes kinases) such that the targets would be competent/functional with the attached FP halves, but then when they bind/dimerize/oligomerize to perform phosphorylation-dependent enzymatic activity, then the FP halves would bind as well to become a whole fluorescent protein tagging the target protein dimers! This approach allowed us to observe the action of our targets, localization, quantify dimerization (as a proxy for kinase function in this case as well), etc. Molecular biology is built upon so many tools/techniques that are in and of themselves amazing!

@jamesstuartbrice420

2 жыл бұрын

It is too complicated, I cannot understand this paragraphs. It is more for scientists and not laymen like me. I usually do not even try to understand complicated things like this. It sounds impressive though.

@jesselucier7251

2 жыл бұрын

Can you translate this into “idiot” for me?

@jamesstuartbrice420

2 жыл бұрын

@@jesselucier7251 Probably nobody but professors and their students can understand what he is saying. Presumably the rest of us do not need to read what he says. Or he wants to impress us. Such a paragraph really belongs in a scientific journal, perhaps as an abstract of some research the author did.

@kermitdfrogz

Жыл бұрын

Sounds like you made a lighting system to watch what your target protiens do as well: kind of like putting color on a certain component being assembled, and whatever it interacts with in assembly would also light up, highlighting what the target protien did in the process of it's activity within a working part.

Thank you, sir! Wonderfull video!

This is a great talk. Thanks.

Amazing and awe-inspiring! Thank you!

Thanks! Love from Sweden

Great talk Thanks for sharing your experience and thoughts with all of us 👍😀

The football analogy is very similar to Feynman's analogy of someone watching two people playing chess without knowing the rules.

That was amazing. Thank you so much

Brilliant presentation!

Excellent lecture!

Excellent. I am buying the book for more

Nice quote to end on!

Oh, as an animator I really enjoyed your alien-footbal metaphore. It deserves the animation I saw in my head :)

Thank You, Good Sir.

How fascinating, a Human Cell Atlas! What an amazing work.

Great talk! Thank you so much!

Great presentation-thanks.

Very well done. I liked your analogy with football (soccer) and the microscope to start. As you went on I got more interested and I had to buy the book to learn more. Although I am not a scientist of cells, I am a scientist of knowledge, so your book will add to my knowledge base and maybe a breakthrough for me in certain aspects of my domain.

@lightbeingpontifex

2 жыл бұрын

You mean foosball,,,,

@nilesh76777

2 жыл бұрын

👍

Incredible analogy...

Amazing, fascinating lecture

Thank you that you do this great effort for US who did not know:)))

Great lecture! we need to promote that football analog as its the best description of science that I've heard since Feynman. and the closing wasn't bad either ;)

@yanikkunitsin1466

2 жыл бұрын

You lost the point. It's about acquiring more and more powerful tools for observation and processing of data. In original Carl Sagan's thought experiment it was just aliens and telescope.

@shinjirigged

2 жыл бұрын

@@yanikkunitsin1466 I don't think I did, but if I did, I wouldn't think so. but its just my opinion so feel free to skip. Sagan's aliens thinking cars are dominant metaphor was a warning about assumptions leading to falsely positive assertions. yes based on the resolution of data. he wasn't expressly describing the method of how we refine our modeling. The soccer metaphor is more precise. I think better for affirming the scientific method in light of new evidence. you could have your better tools and higher resolution data, but if you don't see a ball, or ignore it because it doesn't fit the current model, you lose the opportunity to correct course. as Sagan said the method has a ""built-in error-correcting machine"

Amazing !!!

A wonderful report! Thank you so much! My study is actually on Consciousness, and I know theses things you've shared feed into what I am fascinated with!

The introduction is a masterclass in how to present, and from then on it’s completely enthralling. So many great science discovery stories seem to be about the people involved, their quirks and coincidences. Really interesting: thank you!

Expected something else, got a surprise, which turned into a delight. I‘ll buy this book tonight.

Wonderful 🔥♥️

Fascinating!

Very interesting, many thanks.

very lovely talk, thanks. miss my visits to the Ri

Astonishing!!

great talk, thanks

Thankyou so much

GFP is sooooooo important. Huge breakthrough tool.

Wonderful!

awesome! normal smart dude doing incredible micro science. I hope his work gets some decent collaboration. you do realize that's the future of for todays science to advance is cooperation from different fields. good lecture.

Marvelous

Incredibly well presented.

awesome!!!

That football stadium describes a relation between two kinds of movement, the linear adding of points, each with a value which can be added to increase that value: the other is a lens like swelling and contracting of the crowd. The stadium is contained in that single object which is the jump up, same object quality amplified, perhaps the will to power gone wrong as a quasi religious endeavour, but balanced by the lens like action of the crowd. This balance is the dissemination of energy into the individual units which also contain those two kinds of movement.

just amzing info

Good ideas!

Brilliant! Great presentation! The future is going to be exciting and scary at the same time. Great technology seems to get weaponized asap in our world. Thank you!

@lightbeingpontifex

2 жыл бұрын

Governments and militaries try to weaponize everything,,, even drugs ,,,

Please write down summary of this video if anyone who watched this video completely?

very fun opener

Have you tried using this technology on Type 1 diabetes and why the white cells attacks the cells in the pancreas that produces insulin?

Excellent

if ya can ever see really deep into the brain, you will eventually find you are in space,inner space witch is just as infinate as outer space, evrything in between which we can see normally is our event horizon.this is what we should nurture and make sure continues so that we can, the inner and outer space will always be there, people wont if we dont ensure the planets well being first or you will run out of time.

I can see the ball, but why are they treating it so roughly?

So...a cell doesn't need the chemistry of the protein or hormone... just the quantum recognition that the hormone/protein hit the net? And the body reacts. The affect of simple recognition.

@enrgz

2 жыл бұрын

Is this the tech that brought us all the vaccines that play out a mysterious end run in our bodies, similar to the first move of a chess masters game? No one knows what that 'end run' looks like, unless they played that very game.

This is awesome. I am hoping to get a Nobel prize soon myself. Because I know things. 🤔

@NegativSpace-pd6cz

2 жыл бұрын

how very humble of you...

@spiralsun1

2 жыл бұрын

@@NegativSpace-pd6cz thanks, yes 🙌 🥰

@andrewmays3988

2 жыл бұрын

I will pray for you!😇

6:00 How good a light microscope could _ever_ be: In the radiative regime anyway. *near field* microscopes using so-called "superlenses" (which are flat and not actually lens shaped, as it turns out) have in fact been constructed. The resolution limit shown holds when you are more than a couple wavelengths away from the object.

@SI-ln6tc

2 жыл бұрын

Theres laser topography. Better than any microscope or MRI.

The plot of cell sorting (about 50:00) is undercompensated for the "label B" flurochrome ;-)

While I can not relate to the football analogy at the beginning of this video, I find the rest of it very interesting.. i am glad that I pushed through the ill placed analogy to try to understand the heart of what you were trying to say.

@alanhenderson9092

2 жыл бұрын

Football is by far the single most popular sport in the world and is understood by the vast majority of the global population. In this respect it’s a pretty good analogy to use. I’m guessing you’re from the US.

@troychampion

2 жыл бұрын

@@alanhenderson9092 That was a good guess, but to be honest, even American football wouldn't be a good analogy for me either. I played one year of it in high school, and had one video game of it years later for the playstation 2 , and only played that to enjoy spending time with the kids I was raising at the time. Just a personal point of view, I found it to be a good video though and am glad to have watched it.

@elkiness

2 жыл бұрын

Actually, I just paused it because of the drawn out analogy. After what you say, I'll go on. ;-)

Green glowing worms would be the ultimate bait for bass fishing! How can I get some?

This is very interesting. I've since applied this concept to the working of Western governments to see if any of my observations begin to make sense. So far no luck! Maybe I'll get a grant to further my research!

Very interesting speech... 👍

Right off the bat ,I was thinking of the wrong football. I must be alien here.

Make our decisions, our choices for our health. Enter mandated procedures.

three issues. cloth merchants used lenses for thread counting before the development of the microscope. Mr Carry Mullis never called his invention a test, it is used for assays. HCoV (I guess high resolution microscopy in the 60's, not the electron microscope?) isn't the same as CoV discovered in battery chicks in the 1930's. As far is i can recall RNA doesn't have proteins? Still no route of infection established. Could you wrap dry clay or mica dust in the masks, then tap over slide? Other wise that was an awesome adventure. Didn't notice any editing? If that was one take you can add incredible to awesome.

Now that's what I call gain of function; I can't see covid development scientists winning a Nobel prize!

Dan - totally fascinated. Great lecture. We are an R & D co. applying nanotechnology to water [purification. With molecular identification we could apply same to rogue cells. Want to work with you?

I could not find his Nobel Prize end quote on the internet. It would be nice to write it down and post it in images.

@Neilhuny

2 жыл бұрын

Eric Betzig, Nobel Prize speech ending ... “The last thing I would like to say is about taking risks. People are always exhorted to take risks, and that’s fine, but you’re hearing that from guys whose risks paid off. It’s not a risk unless you fail most of the time, and so what I’d really like to do is I’d like to dedicate my talk to all of the unknown people out there in any walk of life who have gambled their fortunes, their careers and their reputations to try to take a risk but in the end failed. I’d just like to say that they should remember that it’s the struggle itself that is its own reward, and the satisfaction that you knew that you gave everything you had to make the world a better place. “

HA! A micro cellular strobe light, brilliant.

From what I know Robert Hooke competed in this field with Isaac Newton they opposed each other Newton had to publish a book

Just read Erwin Chargaff's book "Heraclithian Fire" ...

what are the 'overarching codes'? I get everything else, but that one is a mystery to be revealed

@tippytops4121

2 жыл бұрын

I strongly suspect this is the direct interaction between a healthy mind communicating at cellular level.

31:00 important image immune synapse

@ 34:30 the amine on the benzene ring of lenalidomide has a single, not a double, bond.

52:10 I imagine this would be great to catalogue how on average these cells change over a lifetime of a human and how vaccines f.e. would impact them in comparison to direct virus infections.

Wouldn't attaching GFP to other proteins alter their shape in some way? Would that not result in some change in the behaviour of the protein?

@Ragusubedi

2 жыл бұрын

Maybe the GFP protein is very small WRT the other protein. Like a whiteboard and a pinhead

@abilsingh4955

2 жыл бұрын

@@Ragusubedi May be, but in that case when you see the glowing things in microscope you would be seeing only very small part of the whole thing, cause out of the whole whiteboard only the part where the pinhead is, would glow.

@OpticalTurkey

2 жыл бұрын

Yes, this does happen sometimes. You have to be clever how you attach it to your protein of interest, and some proteins just don't work for one reason or another.

@kiedranFan2035

2 жыл бұрын

They attach the gfp with a thin linker section like glycine amino acids to put distance between it and the gfp so they can fold independently or something similar.

I withdraw the question after the Freeman Dyson quote, since I realize it's not about resolution. It's about a new tool using color that opens up new ways of looking and measuring and that in turn opens up a tool-driven revolution. -This may be an infinitely dumb question to anyone who actually uses microscopes on a daily bases, but didn't we already have an electron microscope, that surpassed the optical microscope 500 times in resolution? Or is the significance of this new micrography just about size and cost of the apparatus or maybe how we as humans like to think and observe in terms of visible light?-