older lady I work with gets startled ALLLL the time. You can't approach her without startling her. Never in my life have I seen someone with such a dramatic startle response.

Thank you a million times over, Chris, for making this video. I am so glad that someone is investigating these biochemical mechanisms with the attention to detail that you possess. I am starting to get answers to questions that have been plaguing me for years because of this video, and I am eager to investigate further. God bless you and your work.

Hey Chris, off topic but did you know that the fingernail moons can be an indicator of folate status in the body? I used to be on the anti-biotic Bactrim for about a year and Bactrim interferes with folate synthesis in the body, and i noticed my fingernail moons basically disappeared while taking the anti-biotic, supplementing with folic acid brought my fingernail moons back. I didn't realize it at the time but i was folate deficient and anemic and such but supplementing with the folic acid really helped. Heck i was slacking on all my b vitamins so i started supplementing with em' all after that lol. But yeah the fingernail moons should technically i guess be near-about in the middle of each fingernail, but all mine where at the very bottom of the nail and my nails were purple, i asked the doctor what it meant and they didn't know, go figure lol, so i figured it out on my own.

Your knowledge about biochemistry is unmatched !

Please do more videos on this subject. This and learned helplessness in general.

👍 My wife is startled at the thought of trying glycine…. SIGH! 🥺

I have noticed just what you were saying regarding histamine reaction, i.e. glycine not being the culprit/catalyst but rather the other compounds within gelatin and especially collagen supplements being the potential initiators. Your videos are informative and always seem to lay out all the potential causes known and biochemical reactions that could be occurring. 🙏🏼

@lenavoyles526

6 ай бұрын

Does anyone know exactly which compounds in bone broth cause the histamine reaction?

Damn man you looking Hella fresh lately❤

I’ve tried anecdotally taurine and Niacinamide for severe exaggerated startle reflex which was made worse with caffeine (Glycine antagonist). Neither of those worked or gelatine powder, so I tried Glycine itself with great success. It seems better with magnesium carbonate and creatine. I think this was brought on by night shift work with terrible sleep patterns. Low sleep causes activation of conventional protein kinase C, which leads to desensitisation of GlyRs.

Can you tell me what's up with an excessively high b6 test when I haven't supplemented with b6 vitamins and no fortified foods? Is it because cellular utilization is low causing excess serum level?

OMG SLOW DOWN CHRIS!! Gawd almighty!

I find I startle horribly when my adrenals are fried from stress. Does stress burn through glycine. It’s like my nerves are rattling.

Interesting, could the use of glycine for sleep be related to the startle response too? Like make you less likely to be awakened by loud noises etc?

What watch r u wearing? I like it

In the schizophrenia studies with glycine, from what I remember, they saw positive effects for negative symptoms, anhedonia, blunted affect, low motivation. To me this tells me it has some stimulatory effects. Especially in higher doses like they used. That's what I always got out of it. Some mild inhibitory effects but it always gives me a nice mood and motivation lift that is very noticeable. And when I read about it being used for sleep I'm not convinced it's totally inhibitory for everyone. I always read people saying they have more energy when they wake up when they take glycine. Maybe because of the stimulatory effects? Could be the NMDA stimulation as glycine is a co-agonist?

@Harshitkumarimprovement

6 ай бұрын

yeah it also relaxes me down

@lenavoyles526

6 ай бұрын

Hildegard, I would say it has more of a regulatory effect on the autonomic nervous system. It makes it easier to relax when relaxation is needed (e.g. time to fall asleep) AND easier to be alert when it’s time to be alert (e.g. waking in the morning). This makes me think that it may be supporting proper cortisol cycling and circadian rhythm. For me it feels almost like an adaptogenic effect, as though it is toning the autonomic nervous system. Would be interesting to see its effects on vagal tone studied. I hope that helps. (Great screen name, btw.)

I just started taking Glycine a few weeks ago for other reasons and just realized that I haven't been startled ever since. Something which used to happen to me every other day.

@christiansweden

8 ай бұрын

I also started supplementing with a vitamin B-complex which could play a part too.

@jannz1942

8 ай бұрын

How much glycine are you taking ..??.. It's encouraging to hear It's helped you.

@hellie_el

8 ай бұрын

can you tell us how much you take and when? thank you.

I have had nighttime leg cramps for 7 years on and off since going low carb & carnivore. No amount of experiments with electrolytes would reliably fix it. But collagen supplements do! That's why they've been coming and going depending on whether I'm eating straight up beef or chicken/sausage/broth. Straight up beef reliably gives me cramps within 2-3 days. I just figured this out like last week and if anyone can explain it I'd be grateful. Possibly I have a mild EDS? I do have webbed toes and have been told my joints are loose.

Hi Chris, I am wondering if Glycine supplementation is the cure to gaining weight & high LDL Cholesterol, etc while on Seroquel/Quetiapine??

Glycine gives me sleep paralysis so it’s a no from me.

I eat around 300g of carbs a day yet taking even 1g of glycine gives me racing heart/dizziness for a couple of days. I wonder if that means i have high glutamate/low GABA. B6 P5P gave me a soothing effect (for a short time) which i believe is a cofactor in converting Glutamate to GABA? I dont want to give up protein and B6 is a tricky one. Slow COMT/MTHFR both het, AHCY het, CBS C699T het Fast MAOA. SNP wise it does not make any sense to me. I take B2 (100mg), retinol A, 1300 mg choline from food and sometimes take a methylated multivitamin though B12 and folate serum lvls were on the high end (with B12 going over the upper range).

Could there be another gene defect besides MTHFR that causes b6 deficiency? I got a intracellular micronutrient test that found I had a severe deficiency in b6 and serine and lots of other nutrients. My folate was fine though. The functional dr put me on all the vitamins, I was doing good them bam all my health problems came back. I ended up being in and out of the er cuz I had some sort of seizure from being startled at night. I get startled easily and leading up to the attack I had all the symptoms of severe b6 deficiency, I realized the b6 I was taking was mostly inactive form, I was continuing to have attacks I couldn’t breathe my heart hurt and I got scared constantly, I was loosing feeling in my legs, sweating, lost perception of time all kids of weird things. So I overnighted active b6 Pyridoxal 5 phosphate, I took high doses of this and it completely erased every symptom I was having, when it wears off the symptoms return, Kaiser wanted me to go to psychiatry they told me I was crazy. I found another functional dr who found I have porphyria, so I was experiencing severe attacks that could of been fatal. B6 deficiency can also cause porphyria. I’m doing way better since switching to completely active b vitamins. My fiancé and friend got their tests done and found they too are severely deficient in b6 and serine ! What is going on

is glyoxal the oxalate thing

What is the best nutritional database website??

Would Masterclass Membership get Chris to answer why things like why prolonged (an entire year) unusually high stress would cause fat to build in the face at a disproportionally high level , and strategies to combat this . I’m aware fluid retention and Inflammation are usually part of the equation . I’m 28 and I’ve stayed the same weight for years , fluctuating 5 pounds at most no matter what I do . Can’t seem to put on extra muscle either, even with workout + creatine and sufficient protein (sleep quality isn’t great tho, I do get at least 20 minutes of sun most days). Stress is still high but not nearly as high or as much anxiety as that one year period which was a few years ago . Also taking more supplements now to help stress/anxiety and making sure I’m generally covered when it comes to most vitamins/minerals/nutrients..

@lenavoyles526

6 ай бұрын

Puffy face plus inability to build muscle are indicative of iodine deficiency. Please research iodine. The RDA set by the government is not sufficient for many people for a variety of reasons. I highly recommend the book The Iodine Crisis.

Any clue what's going on with Solgar and Glycine? Can't seem to find it anywhere anymore!

I am just listening Pet Anthony Mind( in German) she talks about trauma, but it is much more like from the point of cortisol, she is right what she says, like my whole mind set up, reactions and I really think even the chemical processes has been changed due to being traumatised, listen further now. See I cannot stop until I am very tired and I sleep in everage 4 hours per night like my sleep gets continuously discontinued or my mind thinks it must get up after 4 hours, but never mind this is ust an idea. if a trauma is explaonable as a chemical process. Thank you.

@lenavoyles526

6 ай бұрын

I have meditated and practiced yoga for over a decade. While these things have their place in balancing the nervous system, I also find that nutrition provides a very important piece of the puzzle. Vitamin C is necessary to replace lost cortisol. Salt supports the adrenals. Vitamin A helps the body recover from all kinds of stressors. And now we are hearing about the power of glycine. I encourage you to look into all of the available tools to support the body’s stress response. I believe that we were designed to be able to bounce back from stress. I wish you many blessings on your healing journey. 🙏

How common is it really that people notice some brain-effect from glycine or other food stuff? I have been using glycine for a good while now for building collagen and glutathion. But have never noticed any neurological effect from it. I have tried a couple of gram glycine 1 h before sleep, with no effect. Neither has melatonin, 3 or 6 mg, has any effect on my sleep. It actually seems like my brain is isolated from the food stuff I eat! I find that a very good way to be, and wonder if that isn't quite normal. To react so directly on things like amino acids seems to me quite out of place. We consume them all the time in various amounts. Am I wrong about that?

@chrismasterjohn

8 ай бұрын

The normal reaction to any supplement is for nothing to happen. Everyone is abnormal in some way, but the way in which each person is abnormal is different from the way in which everyone around them is abnormal.

@lenavoyles526

6 ай бұрын

I am noticing a major positive reaction to glycine, less major but still noticeable reaction to Vitamin C. Rather than label myself “abnormal”, I am giving thanks for finally finding what has been missing from my life for so many years. When you are suffering, and you finally find that missing piece that is the building block of your wellbeing, you rejoice. Count your lucky stars if you have never known such suffering - it is purely by the luck of the draw that you have always received the building blocks that you needed to experience optimum health.

The interesting is what she talks nis also the gray hair through trauma, she talks about studies etc.... or change face expression.

Can you do addiction from the point of chemistry, I would like to know how you see it. To me things what are happening can have to do also something with dopamine, methylation, MTFHR, B2 and as also B/ and other B vitamines. It is interesting that people around are suddenly ill or even dead. I am using a smart phone too often noticing I am addictive to all the listening not really ndoing myself any long term good. I am annoyed about being that way and to cut it I practically decided to quit my phone internet connection. I have listened podcasts on dopamine, my npersonality was shapaed this way through traumas, I still think a trauma or even inherited trauma can be responsible for a polymorphism and a necessary different methylation? You know better. Like parkison the disease it also has to do something with dopamine. Also when you talkl about hormones I think hormons play a big role in lots of stuff, I eat different way through the months and actually notice the food is fitted to my hormones. Even DAO and estrogen and histamine etc.... it is different within a certain time of the moth.Thank you.

What about 5htp for people who get startled easily?

even mitochondria etc...

I have a negative reaction to glycine, it gives me bad anxiety. Do you know it does this to some people?

Oh jeez the sound quality

How much glycine do you take?

My last amino acid panel showed a very high ( too high) glycine status. I don‘t dare taking it now, l hadn‘t either before making the panel, but l used to put 10 grams of hydrolyzed collagen in my coffee every morning. What could too much glycine do?

@aliendroneservices6621

8 ай бұрын

Ingesting too much glycine causes diarrhea, nausea, upset stomach, or vomiting. If you're not experiencing those symptoms, you're not ingesting too much.

@larsnystrom6698

8 ай бұрын

@monag.769 10 g of hydrolyzed collagen doesn't give you more than 2 - 3 g of glycine. That's actually not nearly enough to reach an optimal level. Experts say that we need at least 10 g of glycine a day for all its functions. I think a good strategy for collagen is about 12 - 15 g hydroliyzed collagen a day, and some extra glycine because it's also utilized for building glutathion, and other stuff the body really needs. When younger, you don't notice much from a too low collagen turn around. But it creeps up on you when older. The bodys ability of converting amino acids into those you need for building collagen (glycine, prolin and hydroxyprolin) are reduced.

@monag.769

8 ай бұрын

@@aliendroneservices6621 Then l really don‘t know where my elevated glycine level comes from…

@monag.769

8 ай бұрын

@@larsnystrom6698 l have an unopened batch of glycine, l did not dare taking it because of the high blood level l cannot explain.

@lenavoyles526

6 ай бұрын

What if high serum glycine actually means it is NOT getting taken up by the receptors, which is the main problem Chris outlined in the video? There are many nutrients for which high serum/urine levels actually indicate deficiency in the tissues/bones/nervous system.

Startling information.

nice 1

Ha ha i've just mentioned diazepam i take lol. Now that works!

*By “not methylfolate” did you mean folic acid? *How can I lower glutamate? Very interesting! Thank you so much! 🙏

Haha i think Chris needs a diazepam to calm him down lol. I've never heard someone talk so fast..............

Have you looked at hypokalemic periodic paralysis as a genetic hyperactive startle response? That is genetic. Also could you talk a bit slower? Wanted to understand but too many words too fast.

@1truthseeking8

8 ай бұрын

Adjust playback speed... Look for the three little dots and click on that - menu to select playback speed is there

May be it doesn't matter and all my thoughts are a nonsense, even the question why I have chosne you to watch, understanding half way as you are studied and I wish being it myself doing all this on my own. I would think this is about me, but the people I stop by and listen to often have a similar beround within their cell. you also once talk about addicton, even alkohol but in a different contect that the way I mean it nit being an alkoholic I drink zero alkohol myself,but my grandfather was an alkoholiclike but a war prisoner traumatised alkoholic not a weak druker ok just to dlear that a creative hard working person. Like alkohol in the history had a use to sterilise bactezies etc... thisis an example. I cannot be looking away at all who are ill or dead within a seconds a short death. People who were smanrt thinking live the now are suddenly dead plus the cancer overgrouth. Please don't get mad at me, but you studied guys must do all this now, all together. I don't think Iam in any way negative or worry too much of my own existence. THis way I am at ease. I simplydon't like and don't won't to be ignoring what is happening.

Oh my God! i will have to leave this. I cant even write anything down, he is talking so fast.

I take 2g glycine daily

@KDF54321

5 ай бұрын

This is probably too little

@thepatternforms859

5 ай бұрын

@@KDF54321 what makes you think that?

Get to the point man! Too much technobabble.