Its over my head but i feel this is definitely a big piece of the puzzle.

I tell every medical student, resident, and attending that is willing to at least kind of listen about all the evidence that is accumulating showing neuroinflammation likely being a profoundly important contributor/likely causative agent in many symptoms we see in psychiatry-depression, anhedonia, fatigue, loss of appetite, negative symptoms of primary thought disorders, a contributor to neurodegenerative disorders, alzheimers, etc. So far no one seems to care. It blows my mind. Thank you for this presentation.

@capri2673

2 жыл бұрын

I have no medical training but a great interest in this subject because of my own issues with anhedonia, depression, etc. I've observed my diet having a direct correlation with how I feel. I've put this down to inflammation. I think refined sugar is public enemy number one.

@OllertonMD

2 жыл бұрын

@@capri2673 this makes sense. there is mounting evidence a plant-based, Mediterranean diet can reduce depressive symptoms, presumably through lowering inflammation. Check out the SMILES trial.

@PsychiatrySimplified

2 жыл бұрын

Thanks for bringing this up. We have a playlist dedicated to this important topic. kzread.info/head/PLV0KZkVDyoOFDamIcYHa7Hu3XbUYJmfEp

@randallhesse5011

2 жыл бұрын

I've came up with the same conclusion. Root cause of lots and lots. Neuro inflammation, that and gut microbiome, mitochondria malfunction, free radicals getting through the sloppy tight junctions in the blood brain barrier, etc. To bad a lot of things that could fix this has such poor bioavailability. It maybe could be an easy fix. I've been researching M.C.T. oil as a transporter in through the gut/liver access to get these anti-inflammatory a to the blood brain barrier, but no one seems to be talking about any of that. Maybe even beta glucans, types of Algae, types of mushrooms, etc. For killer T-cell production, etc. Anyway BAD GUT, BAD MICROBIOME and bad tight junctions, bad free radicals, bad mitochondria, etc. I'm one of the few people that care.

for a long time, mental illnesses were thought to be idiopathic or even hysteria. hopefully, researchers can prove that they are neuroinflammatory (in nature).

Also neuroinflammation clearly ties together a lot of "loose end" obervations in depression. Serotonin deficiency from neuroinflammation. causing increased 2,3 IDO, which shunts tryptophan into the neurotoxic pathway. These neurotoxins bind to NMDA receptors and agonizes them, and we know that NMDA receptor antagonists quickly improve depression and suicidality (ie ketamine, esketamine). So there are 2 observations potentially explained by the cytokine model of depression. But theres more: neuroinflammation decreases monoamine signaling generally (decreased release but also decreased receptor signaling). Inflammation decouples the nucleus accumbens from the rest of the brain, potentially explaining anhedonia for millions of patients. Inflammation reduces BDNF, dentate gyrus/hippocampal size, neurogenesis, etc. It all seems like a plausible unifying explanation for at least a subset of patients.

@PsychiatrySimplified

3 жыл бұрын

Excellent comments. You've covered the key concepts of neuroinflammation in your comments 👍

@webharom

10 ай бұрын

Thank you for the explanation. Is it possible to reduce the toxicity of kynurenine metabolites / does for example taking 5-HTP or SSRIs help with this?

@OllertonMD

10 ай бұрын

@@webharom I doubt it but I don't think this has been studied. I think taking 5HTP will allow the brain to sidestep the relative serotonin deficiency but probably won't actually reduce inflammation that is causing the problems go begin with. And studies suggest that SSRIs are overall less effective for inflammatory depression. There are some human trials showing that if inflammation is high (usually as defined as a CRP of over 1-3 mg/dl) SSRIs are less effective compared to noradrenergic meds or anti-inflammatory meds. In studies looking at depressed people with a high CRP, so far it looks like nortriptyline, bupropion, SNRIs, EPA fish oil and minocycline appear to work better.

I think research should investigate using hsCRP as a way to sub-categorize depressive disorders. For example, a few studies have shown people with high CRP (ie 3+) tend to do relatively poorly on SSRIs but do better on noradenergic meds (the studies I have seen have used bupropion and nortriptyline) and high CRP also is correlated with treatment resistant and they also do better with anti-inflammatories such as high-EPA fish oil, TNF inhibitors (pricey I know) and even OTC NSAIDS! If psychiatry has finally found a reasonable, cheap, ubiquitous, easy blood draw / lab that can potentially change psychiatry forever, why is this not at the forefront of research? This could very quickly go from bench to beside given how cheap and easy this would be. One study I found using CRP to guide medication selection had a NNT of like . FIVE. That means any psychiatrist in clinical practice seeing patients all day could change a patient or two's life-every single day!

@MrEthanhines

Жыл бұрын

can we rely on hsCRP only as a marker for neuroinflammation ?

@OllertonMD

Жыл бұрын

@@MrEthanhines i would argue YES for that question. A study I read recently showed that blood CRP correlated very strongly with inflammation in the brain as measured by looking at various markers from the patient's cerebrospinal fluid from a spinal tap. AKA if the body and blood are inflammed, the brain is as well. I still think CRP is an excellent candidate for quantifying brain inflammation in psychiatry.

Fascinating lecture Dr. Sanil . You have a gift for presenting complex information and ideas in a manner that the average person can follow and at least partially " understand " , although I'll need to watch the lecture at least 2 more times to digest it all . Am I correct that you said that lithium can play a role in brain inflammation ? Under very specific circumstances , of course . As a layman , I can appreciate the necessity for a blood /brain barrier more fully now .

@PsychiatrySimplified

2 жыл бұрын

Sorry missed this message. Appreciate the feedback. Lithium has a neuroprotective effect overall and also enhances neurogenesis. Inflammatory depression is a subset of depression. Many psychiatric medications have anti-inflammatory properties.

I've seen so many similarities with 'Porphyria' especially AIP, VP, HCP and PCT.

Can u do a presentation on food additives effect on the brain

thanks!

Might explain centuries of societal issues. Post pandemic psychological issues beyond PTSD... Or even misdiagnosis of PTSD or brain trauma in returning soldiers was actually some missed diseases that were asymptomatic for some. 🤔🤔🤔🤔🤔 Anyway... Hugs and good vibes 💗🌈💗🌈💗🌈💗

@randallhesse5011

2 жыл бұрын

Certainly Gulf war syndrome as well as many others.

Interesting...10 years after resolved MDD with psychotic tendency I have Multiple Sclerosis.

@PsychiatrySimplified

2 жыл бұрын

Did you have any symptoms back then? As in all cases of depresion ruling out organic cause is so important. Thanks for sharing your story. Here is an article I wrote psychscenehub.com/psychinsights/the-neuropsychiatry-of-multiple-sclerosis-what-should-psychiatrists-know/

Where is the full length video?

@PsychiatrySimplified

3 жыл бұрын

Please see.this playlist for the whole series kzread.info/head/PLV0KZkVDyoOECQv5zs4ZLFXGWqiGNBWhz

I’m getting jerks & twiches after covid . I believe I now have ME due to brain inflammation. I cant even walk far without my legs fatigue

@PsychiatrySimplified

4 жыл бұрын

@tessgirl Sorry to hear. Fatigue is a common complication. Here is a article we reviewed - psychscenehub.com/psychinsights/covid-19-and-the-brain-pathogenesis-and-neuropsychiatric-manifestations-of-sars-cov-2-cns-involvement/

@tessgirl383

4 жыл бұрын

PsychScene Hub is there anything I can do to help rid the inflammation & get my immune system functioning ? . That was a bit much read for me ?

@PsychiatrySimplified

4 жыл бұрын

Tess Girl I can’t provide medical advice but I would recommend seeing a physician for evaluation. There could be a number of causes for the twitches and fatigue. A physician and or neurologist would be indicated here

@tessgirl383

3 жыл бұрын

Richard Brice hi ya . Yes I’ve been seen now . I had some brain vessel damage . The twitches & jerks are still there but not as bad . I’m doing better but time will tell . I do lots of stress relief techs . It’s been a terrible time .. I’ve had terrible depression. I’m praying I recover fully 🙏🙏🙏

@tamzinmole530

3 жыл бұрын

@@tessgirl383 hope you are feeling as well as possible.

I have neurotoxicity due to long time exposure to toxic mold and formaldehyde at work. I have white matter inflammation in my frontal lobe and just got results back from an MRI that showed two lesions in my frontal lobe. I have 7 years of depression, anxiety, ocd, and adhd that started out of nowhere. I am now experiencing a lot of neurological problems and cognitive decline. I’m having brain mapping done today, but haven’t found a neurologist that can actually care enough to help. Any suggestions? I’m desperate.

@PsychiatrySimplified

5 жыл бұрын

Contacting a neuropsychiatrist would be beneficial.

@salomewashere

5 жыл бұрын

I'm so sorry to hear that. How are you feeling now? I've read great things about the benefits of drinking celery juice first thing in the morning. I've been drinking celery juice myself and am currently on day 3. So far so good. You can learn more at MedicalMedium.com or check out his Instagram, he has a ton of information on there but I've noticed that he's really pushing people to buy his new book. Just start out with the free information you can find on his website and if you see positive effects you can proceed... Also look into the relationship between gut health and mood. Studies show that there is a strong correlation between gut health and mental health. The Western diet has completely ruined our gut health. Reddit is a fantastic source for more information on that. You can start with searching keywords on Google like 'gut health Reddit', and look through the queries. Good luck!

@freedomwarrior5087

5 жыл бұрын

If you have the access go and see a Naturopath, they will help you to detox.

@agrenier5622

5 жыл бұрын

You may want to try to have Dr. Datis Kharrazian as Doctor. Trained in toxicity, he has a deep understanding of the brain, the research evolves because of him... !! He also trains Doctors and patients :) and see patients

@T3Temporal

5 жыл бұрын

You should see a Doctor of Functional Medicine. Dr. Ken Sharlin in Missouri is a Neurologist who also practices Functional Medicine. Here's a link to his website: functionalmedicine.doctor/.

Is there a test I can do to see if I have neuroimflamation ? Blood test, MRI/CT ? Thank you

@PsychiatrySimplified

2 жыл бұрын

MRI and CSF examinations can sometimes help but it all is clinically correlated to clinical features and symptoms. A neurologist or neuropsychiatrist can generally assist in these situations

@Bogdanbmm

2 жыл бұрын

@@PsychiatrySimplified thank you, appreciate. will ask my doc. cheers !

I got hsv2 - is it possible that this can cause the body to attack itself? Because I am constantly feeling my body is in fight and I got depression because I nearly constantly have pain in my genitals.

@franceskakovaci9423

4 жыл бұрын

No, the body is not attacking itself, is fighting the virus, and probably you have symptoms and pain because your immune system is fighting against it. Once entered in the body this virus can stay in an inactivated form in neurons and then when your immune system is weak it can be reactivated. It is not a fatal virus and most people have it, the prevalence is high. It is not a case to get depression. Just try to keep in balance your immune system by having good dietary food reach in vitamin C as well.

Dr. Sanil, what's your opinion of lectins and their alleged role in autoimmunity? Can P.A.N.D.A.S be a chronic disease?

@PsychiatrySimplified

Жыл бұрын

Gluten for example is a lectin. In some individuals due to vulnerabilities ( e.g genetic etc ) - they may cross react with brain antigens in neuroinflammation or other organ tissues causing range of symptoms in autoimmune diseases. Pandas can be chronic if untreated .

@ToxoplasmosisVsRodents

Жыл бұрын

@@PsychiatrySimplified Thanks for the answer doc. Do you think humans really have free will when so many factors play a role in their behavior? Microbiome (including infections), hormones, diet (including micronutrients), exercise, genetics (the most important factor?), exposure to sun, etc all seem to play a role. Just today, I read articles on how mold exposure can influence a person's psychology, a correlation between genes associated with height and genes associated with intelligence, toxoplasmosis, a correlation between strong immune system and physical attractiveness, etc. It seems that psychology is basically a product of biology and sociology.

What can I do I got sick last summer and now I feel like my brain blood vessels are on fire

@PsychiatrySimplified

2 жыл бұрын

Sorry to hear. Please see a doctor and consider a referral to a neurologist or neuropsychiatrist for an evaluation

I am 23 male and i had diagnosed with fibromyalgia, ibs ans chronic pelvical pain before the allodynia started. Actually nobody diagnosed me so far because its my 3th day with this hell. I have muscle contractions all over my body, heavy diarrhea and inflating gas, lower back pain and the worst is back right side stabbing pain when moving with clothes. Here doctors dont want to deal with patients with me. They are not aware off chronic sufferers. I am in real trouble and i really dont know what to do. I wish you are reading this comment.

@PsychiatrySimplified

3 жыл бұрын

Sorry to hear. It sounds like you should see specialists if possible - pain specialist, psychiatrist or neuropsychiatric and rheumatologist.

@b3rkolas235

3 жыл бұрын

@@PsychiatrySimplified thanks for the answer. Do you think allodynia can go into remission? Its been 4th day now.

@PsychiatrySimplified

3 жыл бұрын

@@b3rkolas235 it’s a difficult question to answer without evaluation. Can it be treated - yes. Allodynia can coexist with a number of other symptoms especially CFS. Please have a read of this and discuss with your doctor . psychscenehub.com/psychinsights/neuropsychiatry-of-fibromyalgia-etiology-and-management/ Chronic fatigue syndrome - psychscenehub.com/psychinsights/chronic-fatigue-syndrome-myalgic-encephalomyelitis/

@PsychiatrySimplified

3 жыл бұрын

@@b3rkolas235 I have replied earlier in the thread. Do have a read of the articles and discuss with your doctor

@GoldPeakLLC

2 жыл бұрын

What do you think started it? I have allodynia also ? My neurologist thought it was a silent migraine. I had sleep apnea and a disc herniation that contributed or caused it not sure. I fixed my sleep and got surgery for my back but still deal with some pain.

Does the inflammation show up on an MRI

@PsychiatrySimplified

4 жыл бұрын

Not always. In some cases if there has been structural damage then yes.

It is this that will one day lead to the cure for tinnitus..among other things..

@capri2673

2 жыл бұрын

I guess tinnitus is inflammatory, so sounds plausible. Zinc is anti-inflammatory from what I've read. Maybe zinc deficiency could be a factor? Apparently, it's a global issue.

Sir ,I know that human brain has no nociceptor. But if I ask you this - If someone touches my brain gently,will I be able to feel that?

@PsychiatrySimplified

Жыл бұрын

How would that happen?

I liked the vid. I've been trying to research for a KZread video like yours that really breaks down the ideas in this vid. 🧑🏻‍⚕️ 🩺 That knowledge at 1:06 is really knowledgable. Your tip totally is like the videos of this insightful Dr Ethan! Doctor's explanations are actually useful and he actually helped me on my finals. He is an insightful Dr on KZread and he talks about vaccines and diabetes. You should check out his KZread out and give the doc a like! ➡️ #DoctorEthanOnKZread

Haha still saying "Blood" T and B cells are in the lymph and that is the correct understanding. No wonder they are kinda lost :D