When The Immune System Attacks The Brain - Antineuronal Antibodies Discovered in a Case of Mania
This video is about a clinical case that provides further compelling evidence for the role of autoimmune mechanisms in the pathogenesis of psychiatric disorders and the need for vigilance for autoimmunity in psychiatric practice.
This case was published in ANZJP.
The poor response to psychotropics, followed by a good response to immunosuppressants, the presence of antineuronal antibodies indicates immune dysfunction and is consistent with synaptic encephalitis. Dr Sanil Rege is a Consultant Psychiatrist and co-founder of Psych Scene and Vita Healthcare.
Informed consent was obtained to present and share case details.
Full article: psychscenehub.com/psychinsigh...
Пікірлер: 12
Strange he never said the words "neuropsychiatric lupus" which seems like the most likely conclusion, especially with the anti-dsdna. Atleast the treatment was the same.
@PsychiatrySimplified
2 жыл бұрын
It's a good point. Strictly according to the diagnostic criteria lupus could not be diagnosed. This is an issue as neuropsychiatric symptoms of lupus can occur before systemic manifestations. This was also the reason why the rheumatologist and Immunologist did not get involved in Rx as they deemed it psychiatric. This is an issue as many patients with neuropsychiatric manifestations may not get optimum treatment. The treatment was initiated based on the clinical presentation with steroid as an empirical trial.
Glad you found it useful
@jimimased1894
4 жыл бұрын
thank you also!
Thank you so much for this video! Very helpful!
@PsychiatrySimplified
7 жыл бұрын
The following video may also be useful as it covers a young female presenting with seizures. psychscenehub.com/video/power-serendipity-multidisciplinary-learning-medicine-dr-sanil-rege/
Do you have any information on what are the different reasons for Catatonia?
@PsychiatrySimplified
2 жыл бұрын
In this video there is a section where we cover catatonia and delirium. We go through the various medical causes. Besides medical causes psychiatric disorders such as depression, mania and schizophrenia can be associated with catatonia. kzread.info/dash/bejne/ZnqZxZNrktaafM4.html
Please help.me understand npsle I can't seem to control my temper. When I spoke to my doctors they referred to to psychiatrists but then the psychiatrists prescribed me some anti-depressants. I am not happy with the diagnosis
@PsychiatrySimplified
3 жыл бұрын
It's difficult to clarify this on comment section. NPSLE can affect moods - so both Autoimmune conditions and psychiatric conditions can coexist. Diagnoses in psychiatry are always provisional.
@wanda5416
3 жыл бұрын
Thank you... there are times when I stummer as well especially when I am stressed at work. It becomes difficult for me to adjust my personal family life with my work. Giving up my job is also not at option. Rest is very essential