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Highest mobility on electrophoresis ?
a. VLDL
b. Chylomicrons
c. LDL
d. HDL
The mobility of lipoproteins on electrophoresis depends on their size and density. The four main classes of lipoproteins are VLDL (Very Low-Density Lipoprotein), Chylomicrons, LDL (Low-Density Lipoprotein), and HDL (High-Density Lipoprotein). Their mobility in an electrophoretic field is inversely related to their size and directly related to their density.
Here's a breakdown of each option:
a. VLDL: These are larger and less dense than LDL and HDL but smaller than chylomicrons. They have moderate mobility on electrophoresis.
b. Chylomicrons: These are the largest and least dense of the lipoproteins. Due to their large size, they have the lowest mobility on electrophoresis and often remain at the origin.
c. LDL: Smaller and more dense than VLDL but less dense than HDL. They have higher mobility than VLDL and chylomicrons but less than HDL.
d. HDL: These are the smallest and most dense of the four. Due to their small size and high density, HDL has the highest mobility on electrophoresis.
Therefore, the correct answer is d. HDL. HDL particles, being the smallest and most dense, move the furthest in an electrophoretic field compared to the other lipoproteins