*00:00:00* - Intro. *00:00:48* - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. *00:02:47* - Overview of NAD+ *00:05:12* - NAD+ plays an important role in mitigating DNA damage. *00:05:30* - Excessive DNA damage can decrease NAD+ levels by 20-30%. *00:05:42* - Lymphoblastoid cells from centenarians show increased PARP-1 activity. *00:05:55* - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. *00:06:36* - *Lower organism evidence:* A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. *00:06:43* - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. *00:07:03* - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. *00:07:37* - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. *00:08:13* - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. *00:08:48* - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. *00:09:48* - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. *00:11:56* - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. *00:12:30* - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. *00:12:50* - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. *00:13:10* - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. *00:13:47* - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. *00:15:57* - Plausibility of dosing: comparing animal and human doses. *00:18:05* - Tissue-specific metabolism and bioavailability of NR and NMN. *00:24:32* - Oral administration of NAD produces NR and NMN in the intestine. *00:24:19* - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. *00:26:15* - *Human study #1:* 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). *00:27:12* - *Human study #2:* 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. *00:29:08* - Concluding thoughts and recap.

@dg7438

4 жыл бұрын

00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. Yikes..that's scary

@vinster9165

4 жыл бұрын

Such research developments, give all of us hope, for more youthful longevity on the horizon. I hope scientists like you and others who are similarly dedicating their lives to the study of anti-aging medicine, will discover the Human immortality reality holy grail within the next decade or two. I don’t wanna leave this plane of existence, just yet. With all my heart I would love to live beyond 120 years, not as a crusty old fart, but as someone Trapped in their 30s. Time is running out for all of us who are long past half a century in age. Our hopes and dreams are in you, and your colleagues. We wait in great anticipation for your latest developments and understandings in these regards.

@glennmiller9768

4 жыл бұрын

Scary for mice, yes.

@vinster9165

4 жыл бұрын

Suzanne Ito scary for humans too. We use mice to help predict outcomes or give insight into medical research possibilities for humans. We share sixty percent of our genetics with mice.

@Re3iRtH

4 жыл бұрын

Not raining on anyone's parade here. Let's stop for a second and think. They have been searching for a single molecule in a pill that could extend life for going on 60+ years now. Nothing has been found to be effective yet. NOTHING. What makes us think the next 60 years will be different? The only think that works is plain hard work and sacrifice - eating healthy, sleep more, exercise, fasting (still debatable), and caloric restriction (prohibitively hard for most people). Where is the pill in that. Do you see one? I don't. I am above average optimistic person precisely for the reason that life has a definite start and endpoint.

Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos!

@amperage8032

4 жыл бұрын

Chuck A or saying NR or NMN. I don’t think she’s abbreviated once. The more you say it out loud the easier it becomes. I’m certain it helps with warding off cognitive decline also.

@Entheogenical

3 жыл бұрын

I have a stutter issue sometimes... hope its from anxiety

@ChannelSRL1

3 жыл бұрын

@@amperage8032 Yes, the video would have been about 15 minutes shorter with some abbreviation. Ribo and Mono would work for me...great info though.

@s0cializedpsych0path

3 жыл бұрын

Did you mean qudos? Kudos was a snack bar in the 90s.

@jossfangirl

3 жыл бұрын

@@amperage8032 🤣🤣

Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done.

@swisstrader

4 жыл бұрын

pablopolski cuz she’s one of few on YT that speaks pretty quickly which I appreciate

@KaneCiticani

4 жыл бұрын

David Lloyd-Jones spoiler alert. You probably divorced more than twice and you never let anyone else talk. I’m joking

@TheDavidlloydjones

4 жыл бұрын

@@KaneCiticani Nope.

@KaneCiticani

4 жыл бұрын

David Lloyd-Jones Yep

@KaneCiticani

4 жыл бұрын

David Lloyd-Jones Cause it’s a joke, you can’t say nope 🤪🤪

How Lucky we are to have Dr. Patrick in our lives. She is amazing. Knowledge just oozes out of her..

I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks. My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol. Live Long Enough to Live Foreever.

@ownpetard8379

Жыл бұрын

@Peter Davila I take Metformin, too. Cleared liver enzyme and liver glucose issues almost immediately. Lost a few pounds too. I'm on a "low dose" of 500 mg. I'll look into the Aligenin. And the Fisetin. Thanks. Not to "sharp-shoot" your comment, but the best nuts (common) are pecans and almonds. Lowest in polyunsaturated fat, more like animal fat. Cashews are legumes, not nuts, I think. Walnuts have value in other ways. Thanks again.

@peterdavila3045

Жыл бұрын

@@ownpetard8379 Pretty cool. Good luck. I just ordered CaAKG. I start taking that as well next week. I still take Metformin, Apigenin and Fisetin. I just turned 67 and I feel great.

@ownpetard8379

Жыл бұрын

@@peterdavila3045 I'll look into that CaAKG. If I take a typical calcium supplement, it makes me feel relaxed, but it also shuts down my bowels. Whatever else it does, if it avoids the shutdown, it would be a plus.

@Pat206

Жыл бұрын

@@ownpetard8379 Almonds are [I think]. the only alkaline nut. Good thing.

@Pat206

Жыл бұрын

@@ownpetard8379 Cashews are not legumes. Either called nuts or seeds! They form at the bottom of the cashew fruit. Have to Google it because it's a strange process to end up with the edible cashew.

5 months later and I'm still coming back to relisten to this video. Very informative and so well put together.

few notifications on youtube get me as excited as a video from Dr. Rhonda Patrick.

I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough

@MicroUrb

3 жыл бұрын

Not so rare Dr. Gary Null was teaching us this material for over a decade on WBAI and now on PRN.fm, not to mention the many books he has written, the AIDS patients he cured including one famous basketball star and the diabetics he cured. You can look up old episodes of the Tony Brown Journal for some documentation.

I simply love your style of presenting with the latest facts. You speak fast, which I like! The data you provide and the research you do prior to presenting makes you one of the best health span advocates on KZread. Thank you Rhonda! ♥️

What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda.

Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail.

I could look and listen to her all day.

Thank you . Please do not stop helping people the way you do.

A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you.

Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤

@AL_THOMAS_777

2 жыл бұрын

Yep ! Nobel prize candidate !!

So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process.

This is the most comprehensive video I have seen on this topic. You are a gem. Thank you.

DOC!!!! your the best! I wish there were more docs like you.

@tprmd

4 жыл бұрын

Superb presentation!Thank you for making a potentially difficult discussion very manageable.

Best video I’ve seen on the subject. Thank you!!

Been looking into this a bit recently. Thanks for the new upload, Rhonda! 👍

This is just about the most thorough and intelligent PP presentation I've ever seen. She is one smart lady! Wow.

So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research.

Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed!

Holy crap, this was amazing. This 30 minute video took me 2 hours to get through. Had to pause and read and then pause and research. Thank you!!!

This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video

Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards!

Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful.

The best all-in-one-video on KZread that explains NAD+

It appears that Dr Rhonda does a lot of preparation and compilation of subject matter for making each video. Her tone and presentation skills are excellent. She seems to be interested in sharing her in depth knowledge for the good of the people. God Bless Dr Rhonda Patrick 🙏

I've been taking 1g of NR daily for 2 years. I find that I don't get jet lag or hangovers anymore. My contribution to this fascinating science.

@drewp1974

4 жыл бұрын

Jason Humm What Brand are you taking?? I’m using TruNiagen by Chromadex.. but only 300mg a day. 3x that would get kinda expensive, no??

@jhumm007

4 жыл бұрын

@@drewp1974 I have a triple subscription to TruNiagen. Can't put a price on life extension 😎

@swimbait1

4 жыл бұрын

Have you noticed other benefits? Changes to endurance, recovery, overall health?

@jhumm007

4 жыл бұрын

@@swimbait1 I was already healthy but joint pains after heavy workouts have stopped.

Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰

I like to watch informational videos like this while doing my hour of piano warm ups. Nope....can't do it on this one. Need to give this video my 100% attention. Thanks Dr. Patrick.

Thank you Dr Patrick this is above and beyond anything that is out there.

Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content!

Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique.

@sleepsmartsmashstress740

2 жыл бұрын

Perfect presentation

@bobrags1976

Жыл бұрын

@@sleepsmartsmashstress740 I coq10

@sumyabolormaa8601

Жыл бұрын

​@@sleepsmartsmashstress740⁰

Best presentation on the NAD/NMN potential and current status I have seen anywhere.

You remind me of my favorite med school professor- one of my favorite instructors of all time Thanks for the clear and concise video!

You are amazing!!! This material is so useful!

Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health...

Thank you, Dr. Rhonda Patrick! Great information!

Thank you so much for the thorough long-form video, all of this information is very important.

NAD+ is a miracle drug and no mistake. The hype is real. It has had a profound effect on my mental and physical health at the age of 41, after many years of drug abuse, persistent old injuries, and the general exhaustion brought on by 25 years of OCD and sky-high anxiety.

@lifeisforlivinghereandnow877

2 жыл бұрын

How.many mg do you take?

@squamish4244

Жыл бұрын

@@lifeisforlivinghereandnow877 I actually get it intravenously, at a clinic, 3 times a year to keep my blood levels high. In between I take it nasally, 15 mg at a time, twice a day, so 30 mg total, $120 for a three-month supply. Intravenous NAD is ~$700-$1,000 a session, 5-8 hours a day (the higher cost is for treating serious disorders, for longer), but if you can afford it, it is WAY more powerful than if taken orally, sublingually or nasally. WAY more powerful. They should be doing studies on IV NAD, not oral, because it is there that they will find the effect.

@vclocals5536

2 ай бұрын

​@squamish4244 where do you get the nasal spray?

@jenna9690

2 ай бұрын

Here for the nasal spray! I had my first 200mg NAD IV. Was one of the worst 60 minutes of my life 😂😂😂 But the benefits by far outweigh the risk!!! I also love the 200mg shots. Want to start the injections myself to save some $$$

@alexlyee

Ай бұрын

@@jenna9690 I'm interested in doing the injections myself since I cannot afford it right now, any suggestions?

Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60.

@capgains

2 жыл бұрын

What brand of each are you liking ?

@ravivermaverma5573

2 жыл бұрын

kzread.info/dash/bejne/hoqdu9WahbCepc4.html

@lifeisforlivinghereandnow877

2 жыл бұрын

How many mg Nad do you take?

@Tar791

2 жыл бұрын

@@lifeisforlivinghereandnow877 I'm about

Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work !

Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks!

It is a fascinating topic and I love how scientific Dr. Patrick approaches it!

@JunoBeach1944

4 жыл бұрын

She's the most articulate legitimate research scientist I've ever come across. I filled a pool full of NAD+ boosters and I take 10 laps every morning, sipping as I swim.

@optimizewithscience8883

4 жыл бұрын

@@JunoBeach1944 I am finishing my PhD soon. Maybe she is looking for young PostDocs in her lab :D

@KekeeBlack

4 жыл бұрын

Love your channel man, good to see you here :)

@optimizewithscience8883

4 жыл бұрын

@@KekeeBlack Always very happy to hear that. Thanks :) Dr. Patrick is just a great source of information!

@optimizewithscience8883

4 жыл бұрын

@Zeek Banistor Nice to meet you, George.

What a masterpiece! Thank you!

I think you can't make more concise and comprehensible than this

This is a wonderful video. We will probably be sending our patients this video when they ask about NAD+ from now on!

Excellent lecture. Thank you for this presentation Dr. Cheers

@firehorse_44alpha-omega

4 жыл бұрын

@Zeek Banistor can we both agree that her title allows her to be addressed as "Doctor" ? LoL Cheers

Dr. Rhonda, the people's champion! 😁

THANK YOU SO MUCH!!!! I AM LOOKING FORWARD TO VIEWING OTHER VIDEOS FROM YOU!!

Thank you Dr. Patrick I appreciate the honest review as someone who was just looking into this I really appreciate the data and information you've brought forward. Please continue to be an Amazing Doctor! ❤

I'm exactly 180lb, thank you for this vid!

Thank you for such an educational clip . Please keep it up

Thank-you Rhonda!

Stellar presentation as always, thank you Dr. Patrick!

Dr. talks to us like we could really get it....I do!!!

I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+

Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches.

Good work! You certainly did the research and can explain it with great accuracy. Thank you.

I personally get NAD IVs@24:30 and use them with my patients and notice an increase in energy and improved cognition.

@viorelg9499

4 жыл бұрын

Weren't those banned by the fda?

@danashannon8234

4 жыл бұрын

Do you know if it helps with depersonalization/derealization....or is it being sold as snake oil for that?

@danashannon8234

4 жыл бұрын

@@viorelg9499 has it been banned?

@sirt1353

4 жыл бұрын

Can you supplement with NADH directly? If so, how much mg is considered safe and effective?

@theancientsancients1769

4 жыл бұрын

@@sirt1353 NADH Birkmayer is an expert he is from Austria and i know it works! Check him on KZread for normal health 40mg is ok. For Alzheimer up to 80mg a day mostly take in the day. It helps with alertness and jetlag too

You’re so smart it’s scary!!!!!

What a great video doc. I saw you in person once but did not want to bother (Fashion Valley). I would consider you to be one of my hero’s in the health field… I’ve been greatly inspired by you and Dr.Sinclair to understand health from a scientific basis in hopes that I can pass this knowledge onto my mother who has MS and the rest of my loved ones. Thank you for what you do.

Wow amazing job and the best, most concise source of information I've ever seen for NAD oh, great job!

The year is 2063, Dr Rhonda Patric still looks 23 and now posseses levitation has awakened her 3rd eye.

@gatorkea

4 жыл бұрын

I would love to awaken her 3rd eye ;)

@Ahov

4 жыл бұрын

My buddy and I always make similar jokes

@sleepsmartsmashstress740

3 жыл бұрын

Do you her real age is 73?

@DANA-pp4cg

Жыл бұрын

Your crazy

@swim610

9 ай бұрын

😂

its bonkers to conceive that this is free. ty Dr Patrick

Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you!

I weigh exactly 180 pounds... this is great.

@thor4164

3 жыл бұрын

Not if you're 4' 11"

@justinajones3000

3 жыл бұрын

That's funny. Are you taking NR or resveratrol?

@MrJamesdryable

3 жыл бұрын

@@justinajones3000 Both.

@justinajones3000

3 жыл бұрын

@@MrJamesdryable Thank you.

@ownpetard8379

Жыл бұрын

@@MrJamesdryable Well, you're you auditing this course, then. 😄

Damn. I need an IV of this channel straight into my brain. Oh, and that other stuff you were talking about, as well.

@robertjopling9217

4 жыл бұрын

i think they do niacin on a IV and the results are pretty good! they do a quick iv push that takes like 5 mins but its pretty uncomfortable on the subject. However the results again are very good

@PinataOblongata

4 жыл бұрын

@@robertjopling9217 Is this above the sorts of levels you would find in a healthy diet?

@robertjopling9217

4 жыл бұрын

Piñata Oblongata totally much higher , it’s not cheap either , for a regular b12 Iv it’s about £600 not sure on the 5 minute push Iv ?

@PinataOblongata

4 жыл бұрын

@@robertjopling9217 So what evidence supports such doses? How long does last in the system? What are the effects?

@mikajendreas

4 жыл бұрын

Me too😂💯

Thank you for being honest and thorough. You are the best

Great concise presentation as always. Thank you.

Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦

@gatesroyale

2 жыл бұрын

Why? Is their benefits?

Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏

So helpful + informative for learning about aging. Thank you for this video!

Amazing content as always Rhonda.

She’s awesome

I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing.

@Yazzie101

2 жыл бұрын

I also started NAD plus at night .. bad idea I had too much energy 😂 I’m very sensitive so I find out pretty quick.. let’s hope 🙏

@Pat206

Жыл бұрын

WOW! I'm so happy for you. Life can turn out okay. Yay! from Oz

Love the videos! Still want to see more Dr. Ames!

Very helpful - comprehensive - much appreciated!

I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too.

@sirt1353

3 жыл бұрын

If you don't have acsess to NMN or NR, is it still a good idea to supplement directly with NADH? It says it should be taken on an empty stomack in the morning, and perhaps I can fast as well for a few hours after consuming it.. And then break fast with a little meal, and add reservatrol and quercetin etc. to enhance the effects? Will that still be good? (Using NAD supplement, instead of NMN or NR, is basically what im asking). And if so, how can I best enhance the effects?

@tomymelon6293

3 жыл бұрын

@@Shaylas please be careful. Even the highest dose study was barely absorbed...there is no long term clinical data. Even in IV form data is very limited ...almost all good news was fr animal studies

@tomymelon6293

3 жыл бұрын

@@sirt1353 I would say make an appointment with a naturopathic doctor. Self medicating with supplements can provide good symptoms, but may have insidious effects. in the video at the end, she mentioned she is not ready to jump the gun on the efficacy of NAD boosters

@a2audrey

3 жыл бұрын

Tom y Melon thanks for the advice. I have direct, personal evidence of its benefits and effectiveness. I’ve lost 15% of my body mass and had pretty severe inflammation related to a leg and ankle injury that is gone since starting the regimen. I haven’t felt this healthy in 15 years, so I’m going to keep going thank you very much...

@selene7134

3 жыл бұрын

Which brand do you take? Thank you

Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again.

@Agapy8888

2 жыл бұрын

Sometimes the damage to your body takes longer to repair.

Thank you so much for giving this teaching on this topic. Valuable information!🥰

@sleepsmartsmashstress740

2 жыл бұрын

Valuable information How ?

Thank you Rhonda I will watch this again you explain NAD+, NR and NMN excellent easy to follow. I will come back to this video on referencing one of the best out there. God Bless you.

Every time she says "enzyme" you have to pop an NR capsule

@joey4481

3 жыл бұрын

Bet

@metricmoo

3 жыл бұрын

Cheaper than a bottle of alcohol 🍷

@metricmoo

3 жыл бұрын

$50 a bottle. Meanwhile people pay hundreds or more for a bottle of cancer 😳

I just hope she appreciates me keeping this comment classy. -Thank You, Rogan again soon?

I found out about dr ronda a few months ago! I’m 26 and haven’t became 27 yet! I owe it all to her and my broccoli sprouts

@lookmomitsthatboy1869

4 жыл бұрын

Do you consult People’s diets ronda? I wish you could go over what I eat and tell me how I’m doing hahah

Congratulations 🎊 - It's pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time

Please Rhonda, the Floxing community needs you to make a video about Fluoroquinolone Toxicity!

@phreedomphile

4 жыл бұрын

FYI : Mercola has some good articles on that topic. His most recent one >> articles.mercola.com/sites/articles/archive/2019/01/09/antibiotics-trigger-heart-disease.aspx and those listed in a search >> search.mercola.com/results.aspx?q=Fluoroquinolone#stq=Fluoroquinolone

@davlmt

4 жыл бұрын

I keep waiting for a major public figure to come out with floxing and bring this major public health issue to light but it never happens. I'm 8 years out and now at 41 years old I have no more friends, and family just look at me like I have simply been a weak unambitious whiney loser all my life whereas I used to be strong, athletic, passionate about many subjects, a polyglot, a musician, a dancer, a traveler... You just learn that our existence is insignificant and we should never expect people to care about anything but their own problems. It's extremely humbling but hey we gain a perspective on life most people never get until maybe their last breath.

@moonoom764

4 жыл бұрын

@@davlmt i feel you :( I can relate to a degree. All the best❤✊🏻

** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you!

Best NAD research on KZread!

Wow, thank you for that full explanation. I have cut sugars, am into intermittent fasting, with 4 prolong 5day fast a year, and now looking into Mr Sinclair's research. I don't look anywhere my age, I'm told. Exercise and eating right is crucial. I am a nut at getting my DNA and any acetylation or methylation repairs done. Doing the autophagy route for this right now. I was thinking of these surpluses, but I think, I'll stick with my diet and exercise routine. Thank again, great explanation, backed with studies. I'm loving you already!

@dominysynclair

2 жыл бұрын

Luc, can you go into detail on what you mean by "getting my DNA and any acetylation or methylation repairs done."?

@lucmarcoux2144

2 жыл бұрын

@@dominysynclair DNA damage is caused by Acetylation and/or Methylation(environment markers) which increases over time, from what I understand. Well, at least, when they occur in the wrong place with time... In other words, aging! To slow this down, I fast 5Days, 4x/year or every 3 months. I know that on day 5 or towards the end of my fast, my body is looking hard for amino acids to use for protein synthesis. It therefor, unspools the whole chromosome in the nucleus looking for damage DNA to recuperate those strands for amino acids, while replacing them with a newly constructed one. To my knowledge this is where Methylation and Acethylation repair can be done too. If it's going in for a DNA check, chances are, it will be fixing this small carbon problem as well. Once you feed a new, the stem cells produced from the fresh/or repaired DNA provide a fresher or more youthful figure. I can't say I'm getting any younger, but it stopped my grey hair in its tracks, returned some elasticity to my chinney chin chin, and you couldn't tell that I am 60yrs old. Trust me, I work at an airport ticket counter, I open passport and occasionally fall on that guy who is the same age I am. Ouch! I use the occasional NMN too, but only for 2 weeks in every 3 month session. I like to research this kind of stuff, so yeah, look it up! Have a great evening!

For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.

@scottwilliams2136

4 жыл бұрын

I decided to add some links for support into the need of discussion about NAD and certain Cancers. After yen years cancer free, I was diagnosed with Lymphoma. Just finishing my six months of Chemo. The Cancer reappeared just after 5 month of NAD. Brand was TRU NIAGEN.. THEY HAVE FAILED TO RETURN MY CALLS.. ANYWAY, HERE ARE THE LINKS I WISH I HAD READ BEFORE STARTING NAD www.scientificamerican.com/article/cancer-research-points-to-key-unknowns-about-popular-antiaging-supplements/ www.frontiersin.org/articles/10.3389/fonc.2018.00622/full www.ncbi.nlm.nih.gov/pmc/articles/PMC6315198/ www.mayo.edu/research/centers-programs/cancer-research/research-programs/gastrointestinal-cancer-program/mayo-clinic-pancreatic-cancer-spore/research-projects/targeting-nad-catabolism-pancreatic-cancer-cells My only wish is that they put into the selling of their products, " the possibility of Cancer.

Very good and objective presentation from Dr. Patrick about NMN supplement, unlike Dr. Sinclair, who seems just want to promote and present NMN information in a selective way.

@sleepsmartsmashstress740

2 жыл бұрын

Dont invest in NMN stocks to be safe

That was a very thorough explanation Dr. Patrick. Thank you.

@lsporter88

2 жыл бұрын

Your knowledge of physiology and biochemistry is quite striking.😁

thanks for sharing ..after taking it for about month , so far I noticed improvements in endurance (running, sparring) . and as a guitarist it helped me increase my picking hand fingers endurance when playing long trains of trills and tremolos...the bottom line, for me it works for endurance and energy .

@SciSciToys

2 жыл бұрын

How are you doing now?

Yessss, feed me knowledge

@badlandskid

4 жыл бұрын

So I can apply knowledge to my feed.

@georgeindestructible

4 жыл бұрын

Very nutritious xD

Great video Rhonda! I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat. As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising. Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it? Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state?

Dr. Rhonda - you are such an amazing speaker and i have learned so much from you. I just want to respectfully remind you that the word "associated" does not have the "sh" sound in it. So many people make that same mistake so probably most don't notice it.

Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda