Implanted, Glucose Responsive Beta Cells
Ғылым және технология
In this video, I outline the results of a new possible stem cell-based therapy to cure type 1 diabetes. Viacyte's PEC-Direct therapy was tested for efficacy and tolerability. Clinicaltrials.gov identifier NIH NCT03163511.
This video summarises the paper: Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
by: Adam Ramzy, David M Thompson, Kirsten A Ward-Hartstonge, Sabine Ivison, Laura Cook, Rosa V Garcia, Jackson Loyal, Peter T W Kim, Garth L Warnock, Megan K Levings, Timothy J Kieffer
This is a link to where you can find a copy of the article for yourself to read:
www.sciencedirect.com/science...
Sections:
0:00 Introduction
5:38 Importance
6:19 Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
6:43 Results
11:20 Summary
12:04 Significance
12:37 Future Directions
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Пікірлер: 57
Hi folks! Let me know your thoughts on the video, or anything else 😀 Are all of the cells in the implants beta cells? What else are the cells differentiating into? 🤨
@brianbourke75
Жыл бұрын
It would be great to have a follow up to this looking at some of the immunological modification therapies.
@AngelaEnjiePark
Жыл бұрын
It would likely be better to just revert our own old dormant pluripotent stem cells to young active ones again so that there are no possible negative outcomes and so our bodies can just use them where we need them most. New advanced health technologies like what I mentioned are already available, and have been for 4 years now.
The real question is why after 100 years of finding insulin still there is no cure for diabetes! Treatment of diabetes is a billion dollar business ( annually) for pharmaceutical companies I wonder if they would let that happen!!! They don’t care about people they just care about their profits!
@jorgemendoza9616
Жыл бұрын
This topic would make for a great documentary... the abuses of pharma in diabetes, together with the #wearenotwaiting DIY movement
@najmazainul8065
Жыл бұрын
Thats right
@durgabisheti1733
Жыл бұрын
100 % u r right
@sumanrawat8288
Жыл бұрын
You are right
@khalilnabi9229
Жыл бұрын
Correct observation . Unethical business attitude is responsible for most of the disease .
Awesome explanation, thank you!
1 person has been mostly cured. They gave him half the dose they were initially gonna give him. Should have gave him 70% and he would be completely healed.
Thank you for your insight. Have you read about the trial in Harvard university by Vertex Pharmaceuticals? Brian Sheldon was the first successful case in the early phases of the trial. Need no more insulin injections.
Thank you for a great explanation! In fact, I had sort of the same questions you pose at the end of your video, i.e. about the possibilities of not having to take inmunosupressing drugs and about how many of these devices would be tolerated in order to completely get rid of insulin pumps and CGMs. Another question is how long do these implants currently last and how often would we need to exchange them. Finally, looking way ahead, the million dollar question: what would be your best guess at a time period to have a final cure with no implants? 5 years is no loger credible!
Great Video but do you think it will be released soon ?
How long will Pec-encap clinical stages 3 and 4 last?
Can I get this and my loved ones too
I think that viacyte is trying to create one of those pods with bioengineered cells that they hope people won't reject, but it sounds like that is still early on in the effort. I'd love to know more about generating more beta cells of your own for type 2's. If they could produce the cells from your own blood/stem cells, they wouldn't be rejected. I've seen that type 2's don't have enough beta cells and perhaps that could help, albeit it wouldn't be a cure, but it could buy the type 2 more time if they are careful with what they eat.
God I pray that I can get a stem cell without immunotherapy. 🙏 please. My type 1 diabetes is way out of control. I'm not able to enjoy life.
What about type 2 diabetes?
Thank you a bunch for your expanded explanation!As a mother of t1 des boy I'm really looking forward to having a cure for my son🙏I believe a potential cure will be released within 5 years🙏What do you think?
@InvestigateExploreDiscover
2 жыл бұрын
I think it is completely possible that there will be a cure within 5 years
@huduumar6469
2 жыл бұрын
I was cured by #drijogbe who's Herb's and remedies saved my life. From diabetes If you have any problem looking for a cure try #Drijogbe
@touchbytonymikael
Жыл бұрын
I hope so😑but i have been waiting that for 27y. 💯 And if they ja manige to fix Dia type 1. What that cost? I know i'am little bit a cynical to big Pahrma act🤭but i hope son is doing good and find balance in life 😊Whit a cure or without it 🤝
Why not any considerations given to transplant beta cells to rype 2 or type 3 diabetics?
@InvestigateExploreDiscover
Жыл бұрын
Because the cause of the disease of type 2 and 3 diabetics is not dysfunctional beta cells
Where can you go to have this procedure of implanting insulin producing cells?
@Callvortex
Жыл бұрын
Just do a 7 day dry fast. It’ll save you $30,000 & 3 months of stem cell therapy
Metformin seems to make me want to eat all day
One up to guy fawks. I wish I could afford good strong stem cells 😕
Thank you for being the dedicated, thoughtful, and compassionate doctor that you are, you are more honest than I imagined, thank you so much Dr Igudia KZread channel for curing my Type 2 Diabetes, you are amazing
Hello Dr. My question is the use of UCT and Peptides. Do UCT turn into beta cells? Do these injuctions bring relief to diabetes at all? And if so in what way. Thank you
@InvestigateExploreDiscover
Жыл бұрын
Hello! What is UCT? could you please give me the definition of the acronym? From these results, it looks as if these implants reduce the amount of insulin required by people with diabetes, but it is not sufficient to replace the need for insulin shots entirely.
@oioiii6271
Жыл бұрын
@@InvestigateExploreDiscover UCT = Umbilical Cord stem cells.
@InvestigateExploreDiscover
Жыл бұрын
@@oioiii6271 Umbilical cord stem cells can be influenced to turn into beta cells if given the correct stimuli in the correct order. So this would be a way to generate the cells in the first place.
@oioiii6271
Жыл бұрын
@@InvestigateExploreDiscover Could you tell me the order?
@oioiii6271
Жыл бұрын
@@InvestigateExploreDiscover I have saved for over a decade to have a treatment to help my daughter with diabetes, I would like your opinion on what's available and will give her some relief?
Need information type 2 diabetes
@huduumar6469
2 жыл бұрын
I was cured by #drijogbe who's Herb's and remedies saved my life. From diabetes If you have any problem looking for a cure try #Drijogbe
NEVER BE AFFORDABLE AND IT WILL NEVER HAPPEN.
they need to get going with this stuff, its going too damn slow.
@noidontthinksolol
Жыл бұрын
they are dragging this on for funding i think. one company even bought the competition to get a monopoly on this stuff.