How to Design a Total Synthesis

For astonishing organic chemistry help: chemistrybootcamp.com/
In this video, I include footage from a lecture I delivered teaching students the basic principles of how to design a total synthesis of a molecule, focusing on retrosynthetic analysis.

Пікірлер: 56

  • @debakshikashyap9892
    @debakshikashyap98923 жыл бұрын

    Okay sir..i just want to tell u one thing i m doing masters in chemistry with organic specialization and i have learnt more reaction and reagents from this video then my entire 5 yrs as chemistry major.. please upload more video...ur students are really lucky to know all this stuff so early..thank you sir..thank you very very much h🙏🙏

  • @chemistryunleashed4348

    @chemistryunleashed4348

    3 жыл бұрын

    Thanks, Debakshi, Kashyap! I am so glad that my videos are helping you. To see a huge free collection of my organic chemistry videos, specifically, please check out chemistry.teambootcamp.com/

  • @kevinbyrne4538
    @kevinbyrne45388 жыл бұрын

    A useful introduction on how to build bigger molecules from smaller ones and on formulating the strategy for doing so. Thank you for posting this video.

  • @timecode37
    @timecode373 жыл бұрын

    Sounds like someone from an early 2000s Call of Duty lobby is teaching you chemistry

  • @jhyland87
    @jhyland874 жыл бұрын

    Great video! I find this very fascinating.

  • @Felixkeeg
    @Felixkeeg7 жыл бұрын

    I like how you keep your students attention with this sorta interactive lecturing stlye

  • @chemistryunleashed4348

    @chemistryunleashed4348

    7 жыл бұрын

    Thanks, Flelixkeeg. I'm glad you're enjoying my videos. I apologize, by the way, for my delayed response. I've been swamped with so much work this semester that I haven't been able to reply to my KZread comments as swiftly as usual. Anyway, thanks for watching and posting. Please have a wonderful day!

  • @Felixkeeg

    @Felixkeeg

    7 жыл бұрын

    Nothing to apologize for, it's still finales season after all and professors have just about as much work to do as we have.

  • @chemistryunleashed4348

    @chemistryunleashed4348

    7 жыл бұрын

    Thanks, Felixkeeg. I appreciate your patience and understanding. A good day to you!

  • @Hello_Friends

    @Hello_Friends

    7 жыл бұрын

    Mike Christiansen but is this project your interest and self work....

  • @chemistryunleashed4348

    @chemistryunleashed4348

    7 жыл бұрын

    Kind of. I make these videos mostly for my university students who are actually taking my classes. I assign them to watch certain videos according to a schedule I give them. Unsurprisingly, I also have lots of people who watch them from all over the world, because I place them here on KZread.

  • @lunchbr4ke528
    @lunchbr4ke5283 жыл бұрын

    Thank you so much for this lecture, I’m currently in the third semester of my Bachelors in Chemistry at the University of Vienna, Austria. I’ll be (re)taking the Organics 1 exam next week and this surely helped a lot! :)

  • @chemistryunleashed4348

    @chemistryunleashed4348

    3 жыл бұрын

    You are VERY welcome, LunchBr4ke! I am so glad that my videos are helping! I wish you great success with your studies. Thanks for watching and commenting!

  • @jacobjamar
    @jacobjamar8 жыл бұрын

    Not boring at all. I really enjoyed watching your video.

  • @chemistryunleashed4348

    @chemistryunleashed4348

    8 жыл бұрын

    I'm glad to hear that, Jacob. Thanks for your kind words and thanks for watching!

  • @GitMunny1
    @GitMunny12 жыл бұрын

    Thank you for the information!

  • @ranjanpaudel698
    @ranjanpaudel6986 жыл бұрын

    thank u ser....this helped me.......

  • @Moritz___
    @Moritz___ Жыл бұрын

    wow that was interesting! will enjoy more of this content soon!!! Ty have a nice one

  • @chemistryunleashed4348

    @chemistryunleashed4348

    Жыл бұрын

    Thanks!

  • @a.s3748
    @a.s37482 жыл бұрын

    Taught me alot

  • @sportshighlights4188
    @sportshighlights41886 жыл бұрын

    Hey can you talk a little bit louder? I cant hear you.

  • @jhyland87

    @jhyland87

    3 жыл бұрын

    Smartass, lol.

  • @spiderdude2099
    @spiderdude20994 жыл бұрын

    Lol, I have that textbook you reference it’s actually a great textbook

  • @movax20h
    @movax20h3 жыл бұрын

    Is there some reasonably formatted cheat sheet (with conditions and approximate yields, and specificity notes) of various reactions, common and less-common, that are useful in synthesis. Something like 6-10 pages long, with various schemes. Everybody remember the simple ones, even from high school, but the more esoteric ones are sometimes then ones you struggle to find.

  • @chemistryunleashed4348

    @chemistryunleashed4348

    3 жыл бұрын

    Yes indeed. The best resource I can recommend is chemistry.teambootcamp.com/, which is also free. You can also go to datbootcamp.com and get a free trial membership, which includes access to condensed reactions lists. I make tons of videos for that site, so the style and approach are similar. Does that sound okay?

  • @Anderson_Hwang
    @Anderson_Hwang2 жыл бұрын

    Thanks so much for this lecture. Now I know that phenylacetic acid comes from benzyl bromide and a cyanide. Then if I treat the phenylacetic acid with CH3-Li it converts into phenylacetone. Now with reductive amination of the phenylacetone I could get racemic Methamphetamine /:)

  • @Anderson_Hwang

    @Anderson_Hwang

    2 жыл бұрын

    @lilou zekabyle replace the H of an NH2 with a CH3? Just use iodomethane. Sn2 reaction

  • @usernamehere94
    @usernamehere944 жыл бұрын

    Is sodium cyanide used to replace the carboxylic acid because carbon is more elecronegative than sodium, making the carbon bound to the sodium partially negative?

  • @NapoleonGelignite

    @NapoleonGelignite

    3 жыл бұрын

    Aaron Forbes - you got it backwards. The sodium cyanide reacts to give the carboxylate

  • @chemistryunleashed4348

    @chemistryunleashed4348

    3 жыл бұрын

    That is correct, Aaron Forbes. When exposed to H3O+ and heat, the cyanides (CN) transform into carboxylic acids (COOH).

  • @chemistryunleashed4348

    @chemistryunleashed4348

    3 жыл бұрын

    Aaron Forbes got it correct below. When exposed to H3O+ and heat, the cyanides (CN) transform into carboxylic acids (COOH). Does that make sense okay?

  • @NapoleonGelignite

    @NapoleonGelignite

    3 жыл бұрын

    @@chemistryunleashed4348 - I read it as he was saying the nitrile substitutes the carboxylate. Not the nitrile is the precursor group to the carboxylate.

  • @chemistryunleashed4348

    @chemistryunleashed4348

    3 жыл бұрын

    @@NapoleonGelignite You may be right, Andy, that this is what Aaron was asking. I'm not completely sure, but hopefully Aaron's question did get answered somewhere along the way, because I was really late to the game in responding. Thanks so much for responding and helping out! Please have a wonderful day!

  • @BashirAhmad-ju7ib
    @BashirAhmad-ju7ib4 жыл бұрын

    Plz make a vidio also on the synthesis of Al Cu Ag Fe doped tio2 nano structure

  • @nicougrikify
    @nicougrikify9 жыл бұрын

    have a few months before i understand what the hell is going on here..haha. what is the class called and what year is it ?

  • @chemistryunleashed4348

    @chemistryunleashed4348

    9 жыл бұрын

    nicougrikifyThis particular video is for undergraduate organic chemistry lab, which at my institution is called CHEM 2315 (first semester) and 2325 (second semester). These courses are usually taken by students during their sophomore years.

  • @cm-ns9vv

    @cm-ns9vv

    4 жыл бұрын

    @@chemistryunleashed4348 How do you design CH4 ---? ---> CH3-CH2-C = O-NH2 synthesis ?👆👆

  • @cm-ns9vv

    @cm-ns9vv

    4 жыл бұрын

    @@chemistryunleashed4348 I am waiting for you teacher

  • @ivantimofeev2233

    @ivantimofeev2233

    3 жыл бұрын

    @@cm-ns9vv did you really expect a response to a several year old comment reply? LOOOL

  • @Hello_Friends
    @Hello_Friends7 жыл бұрын

    i m from India..where do u teach

  • @chemistryunleashed4348

    @chemistryunleashed4348

    7 жыл бұрын

    In Utah (western U.S.)

  • @Hello_Friends

    @Hello_Friends

    7 жыл бұрын

    Mike Christiansen thank u sir...please upload any video about pericyclic and photosynthetic reactions

  • @chemistryunleashed4348

    @chemistryunleashed4348

    7 жыл бұрын

    I will put these on my list of videos I should make in the future. Unfortunately, I am currently working on a very intense video-making project that prohibits me from making very many new KZread videos anytime soon. I apologize for that, Krisha. With that said, there is a fantastic book that summarizes pericyclic reactions very well. I highly recommend it: "Strategic Applications of Named Reactions in Organic Synthesis," 1st edition, by Kurti and Czako.

  • @Hello_Friends

    @Hello_Friends

    7 жыл бұрын

    Mike Christiansen thank u sir

  • @chemistryunleashed4348

    @chemistryunleashed4348

    7 жыл бұрын

    You are welcome, Krishna. Have a great day!

  • @flixerstudios1862
    @flixerstudios1862 Жыл бұрын

    Lol he knew what he was doing when he put in phenyl acetic acid

  • @chemistryunleashed4348

    @chemistryunleashed4348

    Жыл бұрын

    Indeed! A very simple choice.

  • @thecasualfront7432
    @thecasualfront74325 жыл бұрын

    Ahh the disconnection approach

  • @iamsonedisoncahaya4845
    @iamsonedisoncahaya4845 Жыл бұрын

    Is that Methamphetamine?

  • @chemistryunleashed4348

    @chemistryunleashed4348

    Жыл бұрын

    No, but there are some structural similarities, such as the aromatic ring.

  • @noahway13
    @noahway134 жыл бұрын

    What is that creepy woman in right of screen in beginning?

  • @yams3954
    @yams39544 жыл бұрын

    Ngl I came cuz I wanna learn to make LSD