What do YOU think about the two syntheses? Let me know in the comments! Massive thank you to all channel supporters! instagram.com/totalsynthesis_official/; www.patreon.com/totalsynthesis

must admit, as a high school student, i barely understood anything yet i found it quite amusing. I'm in awe. chemistry is wonderful.

@tamarisauce1278

7 ай бұрын

same lmfao

4 mg, from 96 kg after 10 columns, and then you have to convince the NMR guys to make good 2D spectra... Thank you for putting huge effort into another brilliant video!

@totalsynthesis

Жыл бұрын

I am in awe of chemists

The ingenuity of synthetic chemists never ceases to amaze... Also doing this work.must be a great test of your resilience and character..just think of the many days and months in the lab when all reactions are failing... can be quite soul destroying.

@totalsynthesis

11 ай бұрын

Oh for sure, few things are worse than trying the same step/ reaction for months without success!

@chadkline4268

5 ай бұрын

The plants man .. the real chemists. They didn't use any glassware or expensive chemicals 😂

As someone whos doing their bachelors thesis in bioorganic chemistry rn, i’m just in awe… long way to go but wow, if it isn’t worth the ride

@totalsynthesis

Жыл бұрын

Good luck on your thesis 💪

Damn! You outdid yourself again. That second synthesis was insane. Keep up the good work.

@totalsynthesis

Жыл бұрын

Thanks!

Wow just found this channel, what a phenomenal content! I love it, subscribed instantly :)

@totalsynthesis

Жыл бұрын

Awesome man, thanks!

In The Rych-guy's synthesis, the enol ether D-A reaction is actually very interesting! DBU first deprotonates the unsaturated ketone at the delta-position, then the silyl group captures the oxygens. Then a very facile [1,5]-H migration happens before the cycloaddition, so if you deuterates the ketone alpha-H, you will find it in the single bridge in the product. Came across this in a quiz, and missed it

Outstanding!

@totalsynthesis

Жыл бұрын

Thank you!!

Amazing video as always ❤

@totalsynthesis

Жыл бұрын

🔥🔥🔥

Great content, thank you.

@totalsynthesis

Жыл бұрын

Thanks!

Great video. That purification process the first group did to obtain the natural product from fruit was insane. It was like comically long. I wouldn't want to be the person to have to do all of that hahah. Very impressive. Not to mention those total syntheses were definitely wild rides. Also very impressive.

@totalsynthesis

10 ай бұрын

Thanks mate! I've literally just published a new video that covers quite some chemistry if you are interested!

Always a pleasure. Here's one for the algo

How would you synthesize Alstoscholactine and Alstolaxepine?

fantastically insightful video as always, quick question do you work in the field of synthetic organic chemistry?

@totalsynthesis

Жыл бұрын

Not anymore!

I'm in awe at the patience of this creator.. If you draw out reaction schemes in chem draw, I'm humbled. I'd predict this molecule class would be toxic with all those epoxides.

I would prefer the natural isolation if i was going to ingest🎉

I have a degenerative brain disease. It's in it's early stages but scary non the less. This is a huge leap in my opinion. Where do I donate?

@totalsynthesis

Жыл бұрын

These molecules are unfortunately years away from pre-clinical research, let alone clinical! All the best

@luke144

Жыл бұрын

@@totalsynthesis right but we are thinking in the right direction. If I drop dead right now I could die knowing we are on the right road. This will only be available to the rich for a while but that's why you befriend a good chemist!

Maybe I’m being dumb, but should there not be another carbon in the transition state at 5:08? After the diels-alder, the ring on the left seems to be 5 membered, but based on the transition state, it ought to be 4 membered. Also great video, super interesting!

@totalsynthesis

Жыл бұрын

Yea very well spotted, they lost one carbon in that drawing :)

Interesting video could you please send me a link to the Illusionism A rat study I would like to check out that paper

@totalsynthesis

Жыл бұрын

Illisimonin A: www.sciencedirect.com/org/science/article/abs/pii/S1523706021016321 Jiadifenolide: pubs.acs.org/doi/10.1021/ol9021029

I hope enzyme chemistry could be used more... so many harsh solvents and reagents.

@user-yz2hn4nw6o

Жыл бұрын

We may think about how the enzyme in organism that create so much complex molecules with only one stereoisomer they want. That is a good reason that we protect the environment, not to challenge ourselves to acheive the works of the enzymes. All organisms are the master of organic chemist, right?

5:37 is it just me or is there an extra carbon coming in out of nowhere for that ring. I’m not too good with organic synthesis but I’m counting more carbons in the diels alder product than there is before the reaction. Am I completely missing something?

@totalsynthesis

10 ай бұрын

Yes, the authors drew the intermediate just prior to the rxn with a carbon less! (just a slip up)

I love organic chemistry and I can't follow literally anything in this retrosynthesis.

@totalsynthesis

Жыл бұрын

😂 I hope the first step was ok? For the other stepy, I intentionally did not show every detail or talk too much theory so the video doesnt get too long

@Grak70

Жыл бұрын

@@totalsynthesis not your fault at all! And yes, I did see the ester disconnection. But when it went into the ring contraction pinacol rearrangement my head started hurting.

And I thought strychnine synthesis was hard 😂😂😂