Dr. Sandoo, thank you so much for your lessons. Your videos provided the foundation upon which I began my medical literacy. I simply want to add that perhaps due to time constraints, you didn't mention that L-Arginine is converted to L-Citrulline (dietary sources for both are eggs, meat, plant based proteins such as chick peas and watermelon rinds respectively). They combine to produce nitric oxide as a by-product (which is really a free radical). By the way, I found Ein Rand's comment about English being a second language to you very presumptuously offensive, but your gracious response was classy. Keep up the good work.

@physiologymadeeasy216

3 жыл бұрын

Hi Brian, thanks for taking time to leave this comment. Yes, time constraints mean't that I could not discuss this and other things that I wanted to mention. However, I hope it opens a window into this area that then enables viewers to develop further knowledge. I do hope to come back to this topic and provide new videos soon. All the best with your studies, and thanks again for your positivity.

Very concise and comprehensively explained.. hellow from luton

If u have a zero knowledge in this topic this is the perfect video for it... Tnx Dr

@physiologymadeeasy216

3 жыл бұрын

Glad you liked it and thanks for taking time to leave positive comment.

Great video sir

thank you very much

@physiologymadeeasy216

6 жыл бұрын

Your welcome!

Hello good work but i would like to point out something.What you dont explain is how Ca-Calmodulin complex and subsequently the binding of eNos to calmodulin is influenced by l-arginine. You just say that l-arginine is a precursor and is converted into nitric oxide. You should elaborate better the connection/interaction between l-arginine and eNOS+ calmodulin. Its like you skip a step in the explanation of the underlying mechanism. Thank you for your video though ,its really helpful.

@physiologymadeeasy216

5 жыл бұрын

Hi Angelo, Thanks for the positive comment. I agree with what you say, however, my aim was to provide a short intro to the topic and keep the video under 10 minutes. I therefore needed to keep the information concise and try present a general overview. I have noted your point though, and will keep it in mind when making future videos.

Sir, please do a video on Intra pulmonary,Intrapleural and Intrathorasic pressure relations..

Sir it was a really good explanatory video. I would further like to know how cGMP in muscle causes Ca+2 reuptake?

What about a solid form for nitric oxide R-107 that can be injected and reduce the time and use of equipment for ventilation?

What are your thoughts on citrulline malate supplements?

Your fluency in acronyms given English as a Second language (?) is impressive! Could an increase in 'shear stress' induce greater production of nitric oxide? Would increased shear stress be caused by muscle contraction? Are there cofactors and limitations on eNOS production? Phosphorylation, ascorbic acid...? Could supp Arg be useless w/o increased 'shear stress', aka isometric weighted holds? Any road signs to further info much appreciated.

@physiologymadeeasy216

5 жыл бұрын

Dear Ein, thank you indeed for this positive comment. Although I can fluently speak Urdu and read Arabic, my first language is actually English (I was born and raised in the UK). In general, when we increase shear stress from muscle contraction, we produce more NO which leads to greater vasodilatation. However, with continued shear forces, the artery may undergo remodelling to 'normalise' the shear stress. This will usually result in a larger artery allowing more blood flow. Phosphorylation is usually responsible for longer term release of NO. See the link for academic review article I published in 2010 about this in the description section The main co-factor is tetrahydrobiopterin (BH4), but as far as I know, studies supplementing this show mixed results on vasodilatory function. Supplementation (whether it be L-arginine or nitrate from dietary sources) does not need shear stress to cause vasodilatation. However, research is quite mixed about this, and we are not sure about whether there are any effective supplements to increase NO bioavailability. Exercise (particularly aerobic) is known to improve endothelial function via increases shear stress related NO release. If you want to know more about shear stress and nitric oxide, this review article is a good starting place: www.ncbi.nlm.nih.gov/pmc/articles/PMC2868123/

I have severe ED) therefore I'm very interested in blood flow) I'm on BP medicine) amlodipine is a calcium blocker, I think to prevent constriction of blood vessels) I wonder what would happen, if I increased calcium supplementation?)

it me wonder such complex process just to produce NO, can this happened by design or by evolution?

@physiologymadeeasy216

5 жыл бұрын

This is a good question. I believe the complexities of the human body was by design. A design created by God.

L-Arginine is an amino acid, not a protein

@physiologymadeeasy216

5 жыл бұрын

Correct. I have edited the description to highlight this mistake. Thanks!