Thank you for these videos! They make this process so much easier to understand for me.

@physiologymadeeasy216

2 жыл бұрын

You're very welcome!

It's my first time to see your videos, I Subscribe in your channel, come on 🦋

Than you for you simple and concise explanation - made it much easier grasping the concept before heading to complex topics :)

@physiologymadeeasy216

3 жыл бұрын

Glad it was helpful!

Fantastic content professor... excellent didactic and explanation. Thank you for sharing it... a hug from Brazil.

@physiologymadeeasy216

4 жыл бұрын

Thank you for these kind words (and the hug!). I am pleased this video has helped you. Best wishes for success in all your studies.

It also prevents Oxidated LDL from damaging the Glycocalyx Structure

Another fabulous video. Thank you for this presentation.

@physiologymadeeasy216

3 жыл бұрын

Glad you enjoyed it!

Thank you so much . Very well executed . Respect .

@physiologymadeeasy216

3 жыл бұрын

You are most welcome.

you really made it easy to understand, thank u!!!:D

@physiologymadeeasy216

3 жыл бұрын

Thanks for the comment Wida - I appreciate the good feedback.

Thanks, informative video!

@physiologymadeeasy216

6 жыл бұрын

Thanks for this positive comment Rose - I am pleased the video was useful to you :)

What can reverse this atherosclerosis that has already formed even though non medicated stints have been added to the artery? Thanks

What about sheer stress and its role in endurance athletes’ tendency to have more arterial calcification?!

Awesome information. . thanks Prof

@physiologymadeeasy216

Жыл бұрын

Thanks my friend.

Brilliant lecture, well presented

@physiologymadeeasy216

3 жыл бұрын

Many thanks!

Fantastic!

@physiologymadeeasy216

3 жыл бұрын

Many thanks!

😊

Can you please explain how nitric oxide plays a role in Raynauds? As secondary Raynauds is usually a symptom of many autoimmune diseases, RA, lupus, scleroderma and sjrogrens, is it possible that there is a direct link between autoimmune disease and nitric oxide with the onset of Raynauds?

Lovely presentation

@physiologymadeeasy216

4 жыл бұрын

Thanks Thamizha.

Hello doctor Sandoo. I’ve been watching your videos on endothelial dysfunction to help shape up a school project on curing heart disease. My question to you is, theoretically if the endothelium is kept lubricated by a certain substance to prevent shear stress, will heart disease be prevented? Thanks

@physiologymadeeasy216

4 жыл бұрын

Hi Juan, Interesting question. The answer is a little complex because we actually need shear stress to activate various receptors on the endothelial cell surface among other functions. These receptors help to release protective factors such as nitric oxide which can prevent atherosclerosis from advancing. Your school project could focus on ways to increase nitric oxide, which in turn would improve endothelial health. You could focus on exercise (aerobic) and diet (green leafy veg and beetroot are known to increase nitric oxide levels) as means to protect the endothelium. This would give your project the 'real world' science aspect to it. Finally, the endothelium is the protection for the vessel and self-regulates itself depending on the internal environment of the vessel. If the environment is favoured to a more cardioprotective balance then endothelium will remain intact. The opposite will happen if environment is unfavourable. I do not know of anything that can protect the endothelium like a lubricant. All the best with the School project, and let me know how you get on!

I suffer from high bp (on medication). As layman I found your presentation very helpful. I would love to know if there are any foods that can help in NO production in endothelium. Thank you

@physiologymadeeasy216

5 жыл бұрын

Hi Naj, Thank you for leaving this nice comment. At present, there is growing body of research which suggests that increasing foods rich in nitrate in your diet can help improve NO availability leading to better endothelial function and lower blood pressure. Foods with the highest level of nitrate are spinach (cooked and raw), beetroot and most other green leafy vegetables like Rocket. Most studies show that blood pressure can reduce with this 'Mediterranean' style diet but I must mention that studies are often short duration so we do not know whether beneficial effects occur over a longer period. It is important to mention that anti-bacterial mouthwash can wipe any positive benefits of dietary nitrates. This is because when we eat these food, bacteria on our tongue help convert nitrate to a molecule that eventually forms NO when swallowed. I am giving a link to a scientific research paper which you might find interesting on this topic: bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2125.2012.04420.x Please get in touch if you have any more questions and all the best. Aamer

@greensong63

5 жыл бұрын

Blessings, Naj! You can absolutely help produce nitric oxide with food. More important, you can stop eating the foods that damage the endothelial cells! FIRST, WATCH THIS 2-MINUTE VIDEO, WHICH INCLUDES A FABULOUS, FULL-COLOR HIGH-QUALITY ANIMATED GRAPHIC OF THE SAME DRAWING DR. SANDOO GAVE US HERE: kzread.info/dash/bejne/a56ftMOxfbW5j7g.html&feature=share And if that's not enough, here's more: nutritionfacts.org/video/whole-beets-vs-juice-for-improving-athletic-performance/ nutritionfacts.org/video/vegetables-rate-by-nitrate/ nutritionfacts.org/video/eggs-and-arterial-function/ nutritionfacts.org/video/olive-oil-and-artery-function/ nutritionfacts.org/video/coffee-and-artery-function/

@jahanmq5959

4 жыл бұрын

red onion nd pomegranete- search it up

Very explanatory video. 1.5 x Speed makes it even better !

@physiologymadeeasy216

4 жыл бұрын

At 1.5 speed I sound like I am on drugs! It is still clear though, so if you can process the information that quickly, then that is fine! Efcharisto para poli for leaving this comment!

@nikoscharalampidis7153

4 жыл бұрын

@@physiologymadeeasy216 Haha that's true! You have a pretty steady flow in your presentation and speech- without jumping from one topic to the other- so I can follow you really well even at 1.5x speed. Parakalo, file mou! Keep educating us!

Doctor that a lovely and awesome presentation.

@physiologymadeeasy216

5 жыл бұрын

Thanks Ajit, and good luck with your studies.

Thanks alot

thanks very much doctor very precise and nice presentation, good luck

@physiologymadeeasy216

6 жыл бұрын

I am pleased you found the video useful Francis, and thanks for dropping by to leave this comment.

Thank you for this wonderful video. May I please know how to calculate shear stress in terms of height

@physiologymadeeasy216

3 жыл бұрын

To my knowledge, this is not possible. Thank you for your kind comment.

What they don't talk about is the Glycocalyx by destroying the Glycocalyx the Endothelial cells will be damaged and the mitochondria dies and cell dies.

5

A

So why do body builder who destroy there endothelial cellsevery day never get sick,??

@physiologymadeeasy216

3 жыл бұрын

Hi Paul, I am not familiar with bodybuilders destroying their endothelial cells. Could you point me to the research paper that states this and I can then read and comment further. Thanks.

Everybody is talking about the importance of NO, but nobody tells you what to do if you are low in it. My husband had heart valve surgery and has never been the same since. He has all the symptoms of NO deficiency but nobody explains how to correct this deficiency.

@physiologymadeeasy216

3 жыл бұрын

Hi Rebekka, NO is a gas that causes molecular reactions in the blood vessels. It is not necessarily a deficiency, but a defect in the apparatus (in body) required for its release. It's release can also be affected by common heart disease risk factors (BP, cholesterol etc.), so controlling these, along with regular exercise are ways which will help improve NO release.

@rebekkad.2092

3 жыл бұрын

@@physiologymadeeasy216 My husband had aortic valve replacement and has never been the same since. Doctors tell him he's fine. He's not! He has all the symptoms of low NO. So can this not be fixed? Is it just a slow death?