Fasting | How Fasting Affects Insulin | Peripheral Insulin Resistance- Thomas DeLauer

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Fasting | How Fasting Affects Insulin | Peripheral Insulin Resistance- Thomas DeLauer
Study - Journal of Clinical Endocrinology and Metabolism:
Glucose and glutathione (GHS) metabolism was studied after 12 and 60 hours of fasting on two occasions: with and without aspirin (6 g/d) t. 6 healthy lean men participated and, as mentioned, underwent 60 hours of fasting with or without aspirin (approximately 6 g/d). Fasting decreased insulin-mediated peripheral glucose uptake by 46% after 60 h and Aspirin did not alter this effect of 60 hours of fasting on insulin sensitivity. GSH concentration decreased during fasting, but the fractional synthetic rate of GSH was unaffected either with or without aspirin. Fasting did not affect inflammatory parameters, although aspirin increased soluble TNF receptors I and II. Researchers concluded that prolonged fasting induces profound peripheral IR - in contrast to type 2 diabetes mellitus, high-dose salicylate does not affect fasting-induced peripheral IR.
www.ncbi.nlm.nih.gov/pubmed/1...
Why Does this Occur?
Generally, prolonged fasting (greater than 48 hours) in humans is accompanied by a reduction in insulin sensitivity, elevated plasma FFA levels, elevated intramuscular fat levels, but also an increase in whole-body fat oxidative capacity. Furthermore, prolonged fasting-induced insulin resistance is not accompanied by hyperglycemia or hyperinsulinemia, factors that have been suggested to cause mitochondrial dysfunction in diabetes. It could therefore be anticipated that despite the development of insulin resistance, mitochondrial function is maintained to accommodate increased fat oxidation during prolonged fasting. Conversely, if (lipid-induced) insulin resistance or factors associated with the insulin-resistant state do cause mitochondrial dysfunction, it’s believed a reduction in mitochondrial function with prolonged fasting would occur. Prolonged fasting, however, is a physiologic condition in which insulin resistance develops to spare glucose for utilization by the brain, and increased FFA levels are accompanied by increased fat oxidation. Prolonged fasting-induced lipid accumulation and insulin resistance are considered to be a functional physiologic response. As mentioned, reduced insulin sensitivity saves carbs for the central nervous system, being obligate for glucose and not requiring insulin for its uptake, whereas increased lipid availability at the same time can serve as a direct available energy source for the muscles and is paralleled by an enhanced fat oxidative capacity.
FFA & Mitochondria:
Elevated plasma free fatty acids induce insulin resistance through activation of Jun NH(2)-terminal kinase and nuclear factor-kappaB inhibitor kappaB kinase, which leads to hyperphosphorylation of the insulin receptor substrate type 1 (IRS1).
Study - Diabetes:
In this study, FFA levels were increased approximately ninefold after 60 hours of fasting in healthy male subjects, leading to elevated intramuscular lipid levels and decreased muscular insulin sensitivity
These findings confirm that the insulin-resistant state has negative effects on mitochondrial function. Given the low insulin and glucose levels after prolonged fasting, hyperglycemia and insulin action can be excluded as underlying mechanisms, pointing toward elevated plasma FFA and/or intramuscular fat accumulation as possible causes for the observed reduction in mitochondrial capacity. The increased exposure of skeletal muscle mitochondria to elevated levels of free fatty acids (FFA), seen in insulin resistance and type 2 diabetes, has been suggested to interfere with proper mitochondrial function. The acute elevation of plasma FFA by lipid infusion is accompanied by down-regulation of the transcriptional co-activator peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) and other genes involved in mitochondrial metabolism.
diabetes.diabetesjournals.org/...
References:
1) Van der Crabben SN , et al. (n.d.). Prolonged fasting induces peripheral insulin resistance, which is not ameliorated by high-dose salicylate. - PubMed - NCBI. Retrieved from www.ncbi.nlm.nih.gov/pubmed/1...
2) Peripheral Insulin Resistance and Impaired Insulin Signaling Contribute to Abnormal Glucose Metabolism in Preterm Baboons. (n.d.). Retrieved from www.ncbi.nlm.nih.gov/pmc/arti...
3) Intermittent Fasting Increases Peripheral but not Hepatic Insulin Sensitivity | American Diabetes Association. (n.d.). Retrieved from professional.diabetes.org/abs...

Пікірлер: 565

  • @TabithaEnglish
    @TabithaEnglish5 жыл бұрын

    I’m on day 5 of fasting and my glucose has gone from 63 to 94. I’m glad I found this video!

  • @strawberryme08

    @strawberryme08

    2 жыл бұрын

    i wish mine would get that low. geez. i wake up to 120 ish after 8 hours of not eating. i got tested and its high insulin and high glucose and i know i have adrenal issues so its high cortisol. ugh..

  • @MohamedWanis_Elruemi

    @MohamedWanis_Elruemi

    4 ай бұрын

    @@strawberryme08 Hi. Are you diabetic? I have the same thing here

  • @tripptank
    @tripptank5 жыл бұрын

    Thomas is a genius; He know's we'll have to watch most of his videos more than once if we want to catch everything. Professional KZreadr right here.

  • @judybanks133
    @judybanks1335 жыл бұрын

    So interesting! I'm 3 days into a prolonged fast (fat adapted). I noticed my glucose rose to 66 and keytones dropped to 3.2 after a 5 mile afternoon walk. By the evening, my glucose dropped to 49 and keytones rose to 5.5. The body is so incredibly flexible! Loving the content you put out there. My vote is to keep it "technical".

  • @SeanLunny
    @SeanLunny5 жыл бұрын

    Thanks for all your help as usual Thomas

  • @ZachSilverberg
    @ZachSilverberg5 жыл бұрын

    As a type 1 diabetic myself, I found this very helpful. The longest fast I have been able to do is 57 hours. This gave me some ideas. Thank you Thomas for sharing you knowledge!

  • @BeeCrashful
    @BeeCrashful5 жыл бұрын

    Great timing ! I planned to do a 3-4 days fast and this video encourages me to do so :) And if someone dare say it's not healthy... i have all the arguments needed now ! Thanks Thomas !

  • @DDooMRooMM
    @DDooMRooMM5 жыл бұрын

    Brother, you are amazing with this stuff. Im breaking a 48 hr fast later today then I'm starting a 60 hour fast Monday. Thank you so much for the time you dedicate to us. Love you!

  • @Reaperaxe9
    @Reaperaxe95 жыл бұрын

    Thomas, your videos have been on absolute point lately. Please keep showing people the science and justification of efficient nutrition and growth!

  • @MariniFacey

    @MariniFacey

    5 жыл бұрын

    Kushal Jaligama I agree! I love hearing about the science/wisdom and the process our bodies go through!

  • @bighurt5367
    @bighurt53675 жыл бұрын

    I needed to hear this. I broke my fast and when I check my blood about an hour later and it had spiked to 144. Then few hours later it dropped to 78. Away I needed to hear this, thanks!!

  • @Biohackthefat
    @Biohackthefat5 жыл бұрын

    I get my clients into extended fasting after 11 weeks of working with me and it always Amazes them when they take their fasting blood sugar and ketone tests. We calculate out the GKI and then compare to the GKI when they were Intermittent Fasting and the difference is amazing to see. It isn’t uncommon for the body to produce more glucose from the glycerol backbone of the fat molecule. I’ve also experienced this for myself Thomas. As at times throughout a fast my glucose will be elevated beyond what Is was throughout my Intermittent Fasting protocol. Good video here! Thanks for sharing!

  • @kendrms

    @kendrms

    5 жыл бұрын

    When I fast beyond 48 hours my glucose always drops below 70mg/dL and ketones will rise above 3mmol. Does this mean my body is not receving the added flexibility?

  • @jz362

    @jz362

    5 жыл бұрын

    New to this, how do you test for these things?

  • @MohamedWanis_Elruemi

    @MohamedWanis_Elruemi

    4 ай бұрын

    Nice comment. May I ask if you are diabetic or not? I am not diabetic and I have been on IF for the last 3 months.. my fasting blood sugar was always in the normal range.. but all out of sudden the last 3 days my fasting blood sugar elevated between 100 - 122 and it goes back to normal 2/3 hours after food

  • @MariniFacey
    @MariniFacey5 жыл бұрын

    This is amazing, insightful information! Thanks again Thomas! This is cool to study!

  • @musicboy2003
    @musicboy20035 жыл бұрын

    Wow, a great deal of fascinating and useful information! I’m type 2 using IF and weight training to help control blood glucose for going on four years now. It’s working and, at 65, I’m becoming a better version of myself. My resolution for 2019 is to do more 3-5 day fasts (did two last Fall) and this video, along with your vids on dry fasting, are a real inspiration. God bless you, Thomas!

  • @Abdulrashid22067
    @Abdulrashid220675 жыл бұрын

    most underrated channel !! Respect for you !!

  • @andrewrivera4029
    @andrewrivera40295 жыл бұрын

    Gonna watch this a few more times, great video Thomas!

  • @duanem.174
    @duanem.1745 жыл бұрын

    Another great informative video Thomas! Thanks!👍

  • @thomashewittknewit5510
    @thomashewittknewit55105 жыл бұрын

    Loving the new videos as always I learn quite a bit from your channel tbh very professional. Thanks again for sharing with us.

  • @MissDeb-jq6nz
    @MissDeb-jq6nz5 жыл бұрын

    I love this guy's videos!! I am always encouraged by his in-depth scientific reasoning. Superb!

  • @petithibou1891
    @petithibou18915 жыл бұрын

    Man I m addicted to your channel ! So instructive !

  • @briancrane7634
    @briancrane76345 жыл бұрын

    Tom you are strong, fit AND SMART! A rare combination. Really enjoy your vids! Thanks!

  • @MiekaFastingWeightLoss
    @MiekaFastingWeightLoss5 жыл бұрын

    Thumbs up for teaching me today Thomas. I am on a prolonged fast right now.

  • @miekaford7926

    @miekaford7926

    5 жыл бұрын

    Love your name.

  • @mikecreativision
    @mikecreativision5 жыл бұрын

    I really like that you still develope and learn! Good attitude!

  • @sylvieherard4880
    @sylvieherard48805 жыл бұрын

    Thank you so much for all the amazing info! This information is hard to find.

  • @nazariydmyterko1941
    @nazariydmyterko19415 жыл бұрын

    Wisdom of its finest! Nice job as always!

  • @paulam1596
    @paulam15965 жыл бұрын

    Great video.. this gave me a great perspective of what was happening why my sugar was high during a prolonged fast.. keep up the good work!!

  • @erichaynes7502
    @erichaynes75025 жыл бұрын

    Wow, that's a lot of info but you did a great job of summarizing it at the end and it really helps me understand a lot!

  • @bomerboy1
    @bomerboy15 жыл бұрын

    hi there your awesome im in canada just found out i got dibetes im watching lots of your video im cuting out carbs and doing this keto stuff your talking about i love it its been a week i lost 11lbs feel great keep in mine im a big guy weigh like 330 lbs i got a long way to go but im learning everyday with your help thanks alot and im 50 years old next week again your great ill be watching thanks thomas

  • @dana102083

    @dana102083

    5 жыл бұрын

    Keep up with your electrolytes! You're in the danger zone and easy to not add enough..sodium, potassium and magnesium. I'm in Canada too, in Edmonton. Good luck!

  • @pohkeee

    @pohkeee

    5 жыл бұрын

    Keep watching and thank your lucky stars, because you’ve found your godsend...

  • @Durtly

    @Durtly

    5 жыл бұрын

    Do your research and make sure you're getting enough (but not TOO MUCH) Magnesium, Potassium, and Sodium. Also look into Apple Cider Vinegar as an appetite suppressant, it's helped me get through some craving periods.

  • @wesszajna2597

    @wesszajna2597

    5 жыл бұрын

    Good luck... check out Dr. Eric Berg videos too!!!!!! it will help

  • @MsDestinedtoReign

    @MsDestinedtoReign

    5 жыл бұрын

    Wes Szajna Doc is my Godsend, Lost 110lbs with Doc’s advice. 👏🏻

  • @spaghelle
    @spaghelle5 жыл бұрын

    Thank you for explaining this!

  • @HatefulXP
    @HatefulXP5 жыл бұрын

    The mitochondria is the powercell of the house.

  • @Durtly

    @Durtly

    5 жыл бұрын

    TESLA branded Mitochondria are the best Mitochondria because fashion.

  • @The8lueSpirit

    @The8lueSpirit

    5 жыл бұрын

    * The cell is the mitochondria of the powerhouse.

  • @TacticalDimples

    @TacticalDimples

    5 жыл бұрын

    Wait a second..

  • @cassandramensah206

    @cassandramensah206

    4 жыл бұрын

    Mitochondria is the powerhouse of the cell.

  • @milkyshakes

    @milkyshakes

    4 жыл бұрын

    Hol up

  • @funkndrucked
    @funkndrucked5 жыл бұрын

    The title was troubling until I WATCHED the video. Very cool to learn about the CNS and brain use of glucose. Thank you young man.

  • @chloetemtchine
    @chloetemtchine2 жыл бұрын

    Thank you! Such great information.

  • @cpk2GIRL
    @cpk2GIRL3 жыл бұрын

    This is a great point / counter-point video & references on Metabolic Flexibility by way of Fasting. Nice job! Thx for always including your literature search.

  • @vesperal2
    @vesperal25 жыл бұрын

    I think this is your best video. You should do one with Dr. Jason Fung on the material shown here.

  • @alexkillsdie
    @alexkillsdie4 жыл бұрын

    This saved me a lot of confusion and stress, thank you :)

  • @Cero4everules
    @Cero4everules5 жыл бұрын

    Awsome vid Thomas. thank you

  • @juliamontalvo9717
    @juliamontalvo97173 жыл бұрын

    Thomas thank you for this video. It means a lot to me. I'm currently fasting for weight loss and to get rid of my diabetes for good.

  • @whowhy9023

    @whowhy9023

    4 ай бұрын

    Carnivore diet works much better than fasting.

  • @naturalnia432
    @naturalnia4323 жыл бұрын

    Great video! I just completed an 85 hour fast was very concerned about why my blood sugar rose so high after refeeding. I read a scientific article that explained and then watched your video, which elaborated and broke down the information perfectly. It all makes sense now. Thank you!

  • @MohamedWanis_Elruemi

    @MohamedWanis_Elruemi

    4 ай бұрын

    Hi. Are you diabetic? I have the same issue after being on IF for almost 3 months

  • @sourinmaiti
    @sourinmaiti5 жыл бұрын

    Hey Thomas, you are doing an awesome job. Can you put more videos on same topic? Elevated morning blood sugars during fasting is scary. If not explained properly, people will get scared and run away from keto and fasting. I do 20- 4hour(eating) fasting every day and see 115 avg blood sugars every morning 8am. That comes down by lunch. Appreciate your awesome work here.

  • @Jobla2000
    @Jobla20005 жыл бұрын

    Very interesting. Never heard about this before and love the science of fasting.

  • @falcon4strokeflyer
    @falcon4strokeflyer5 жыл бұрын

    This answers the conundrum I’ve been experiencing. Type 2 diabetic, three weeks in Keto, IF 16-8, and trying to reduce meds. Glucose levels actually rising to concerning levels during fasting and very minimal carb intake. Working out 5 days a week, I’ve lost 20 lbs in three weeks. Feel great, but I’m wondering if my next A1C will be better or reflect these elevated glucose levels.

  • @jonwelch564

    @jonwelch564

    Жыл бұрын

    What was your result? I'm curious to know, as it shocked me how high my glucose levels were after a 4 day fast. It took time for them to recover.

  • @stanislouse4168

    @stanislouse4168

    8 ай бұрын

    Jeesh ... a pound a day??? I go for 1 lbs. a week MAX.

  • @rohanronad6569
    @rohanronad65695 жыл бұрын

    You are a well read guy Thomas! Kudos.....thanks for the video.

  • @dennisb7930
    @dennisb79305 жыл бұрын

    Wow amazing Thomas this is so cool,it's amazing what the human body can do!Thanks again

  • @lindatsl
    @lindatsl2 жыл бұрын

    I started low carb and intermittent fasting in May this year (2021). By late June and early July I managed to get my FBG to the 5s. Then suddenly starting 1st week of August my FBG spikes up to high 6s and low 7s. I was depressed and wondered what have gone wrong. Thank God I found this video. Am going to continue with occasional fasting and go low carb as a lifestyle change. Blood pressure stayed below 120/80 though

  • @TarekAliFazle
    @TarekAliFazle3 жыл бұрын

    Awesome information thank you

  • @alphastrength3402
    @alphastrength34025 жыл бұрын

    Great video bro

  • @KeeperOfKale222
    @KeeperOfKale2225 жыл бұрын

    I sensed this video coming. Thanks for all the research! The fact that it lets your mitochondria work less means it could potentially be a powerful way to increase longevity. I remember doing some reading that over stimulating your mitochondria leads to always feeling tired. (eg elderly people falling asleep all the time) 🤔

  • @snipeuallday
    @snipeuallday5 жыл бұрын

    dude I freaking love your informational videos I've been about 30 pounds overweight for about 4 years and really want to know how the body works and become a healthy individual THANK YOU SO MUCH!

  • @Carmen-ex3nr
    @Carmen-ex3nr5 жыл бұрын

    Thank you so much for explaining this! I also noticed higher blood sugar levels after fasting and couldn't understand why this happens.

  • @kenweidemoyer2221
    @kenweidemoyer2221 Жыл бұрын

    Your videos are good , and your advise is good . Do video on exercise how to get the most out of your work out and how long too wait after eating.

  • @bonniejones36
    @bonniejones365 жыл бұрын

    Thank you so much! I have been experiencing this very thing and it was Puzzling my Medical Doctors...

  • @annettefowler4704
    @annettefowler47045 жыл бұрын

    THANK YOU THOMAS

  • @BeccaLozierTrumpet
    @BeccaLozierTrumpetАй бұрын

    I've been a Keto-IF girl for about 4 months and it gets easier and easier to stay in fat-mode. In the beginning, 50-80 g of carbs would set me back days. Now, it's a matter of hours and I'm back. I rarely eat that many carbs, but if i DO, it's super easy to get back in the fat flow.

  • @j7m7f
    @j7m7f5 жыл бұрын

    Hi there! I'm on OMAD for 6 weeks (no one plate, not keto - I eat everything). I had never any issues with blood glucose level (BGL) before (fasting BGL always below 90), although I ate a lot of sugar (sweets, cakes, etc...). To get some background: I'm 42yo. My top weight was about 230 pounds(5'10"), 215 when started OMAD. Now I'm just below 200. After 2 weeks on OMAD I've made blood tests and BGL was 94 after 18h of fasting! So I started my own BGL measurements and I've found that now my BGL usually raises above 100. Even up to 120. It is not the dawn effect, as I'm measuring it usually before eating (4-6 pm) and before sleeping. I've also made more detailed measurements - every 30mins after eating (1500-2000kcal). My BGL after 0,5 to 1h was up to 140-150, then after 1,5-3 hours dropped below 100 and then was rising again up to 105-115. BTW, I've noticed SOME dawn effect, as after wake up I have BGL around 115. But it somehow explains why I'm almost never lazy in the morning - I get up with out any need to snooze. Because of BGL I've just started to mix OMAD with IF - I'm eating a bit of fruits and nuts (about 300kcal) for about 8 hours and then have my big meal. BGL seems to drop below 100 before the meal. So it seems to work better for my BGL. I would rather like to be back to OMAD, as it allows to easier control hunger for me. And I think it works better for weight loss. My first idea is that it might be caused by insulin-resistant liver or higher cortisol. During my first 2 weeks of OMAD I felt A LOT of energy and kind of "speed up" or even kind of specific anger or "aggression". Later it stabilized. But generally I always easy get stressed, although I've got quite peaceful life and not stressful job. E.g. My blood pressure measured by a medic is high up to 150/100, but when I measure it myself it was usually below 130/90 and now even below 120/80. Should I be concerned about my high BGL on OMAD?

  • @robinah-sing6261
    @robinah-sing62613 жыл бұрын

    Thank you...

  • @arianasilesia2500
    @arianasilesia25005 жыл бұрын

    100% true after being in ketosis for 5 years my body is so flexible and able to handle carb incredibly well. I practice fasting of 24 hours. And now regardless of what I eat I can have a full eating day of the worst junk carbs massive amounts of sugar and my blood sugar is incredible it does not spike it stays at 4.7 no matter what I eat. It is the most amazing thing. Prior to doing keto and fasting 5 years ago i used to be at 6.8 blood sugar.

  • @robrae14

    @robrae14

    5 жыл бұрын

    You're lucky I don't think that's true for all.

  • @nickbardan3867

    @nickbardan3867

    2 жыл бұрын

    @@robrae14 when you're young, everything is easier

  • @stanislouse4168

    @stanislouse4168

    8 ай бұрын

    If you were a diabetic, they would consider 7.0 a GREAT level to maintain.

  • @belizeguy
    @belizeguy5 жыл бұрын

    Excellent ! Sure am noticing the surprise weight loss of after fasting. Works for me ! This was another great video . Thanks

  • @SiimLand
    @SiimLand5 жыл бұрын

    If you're not going to eat a bunch of carbs, then it doesn't matter if you have mild peripheral insulin resistance

  • @rachkate76

    @rachkate76

    5 жыл бұрын

    Says a fragile dudebro kid who shits on high grade probiotics in other countries because he's dirty he can't get them where he lives. Sounds about right. 😑

  • @jackmacellan3183

    @jackmacellan3183

    5 жыл бұрын

    @@rachkate76 Wat?

  • @madcircle7311

    @madcircle7311

    5 жыл бұрын

    @@rachkate76 nani

  • @madcircle7311

    @madcircle7311

    5 жыл бұрын

    @Siim Land make a video about this Am confused as hell

  • @narchodiaz

    @narchodiaz

    5 жыл бұрын

    We'll look who it is. Welcome siim land. I can't wait for your next video.

  • @MAINEGIRL_US
    @MAINEGIRL_US5 жыл бұрын

    Thank you very much for this information! I am Keto IF with some longer fasts every few weeks. Feeling great😁

  • @nickm8808
    @nickm88085 жыл бұрын

    Hi Thomas, great video, appreciate the science. Thanks also for your feedback on a thumbs up to add pushups (30-40 reps) and crunches with my endurance training (treadmill due to winter in DC area). I’m 50, generally fit, looking to lose 15 lbs of fat at this point. Seen a few requests for adding muscle mass on Keto for weight loss (sans carb cycling). As part of such a video, would appreciate more information on differentiating low rep (ok on Keto as I recall) weight training, normal 6-12 reps per set (to be avoided as I recall from one of your excellent discussions), and higher rep (again ok as I recall). Thanks again Thomas for sharing the research and appreciate the integrity of how you select the products you recommend as a part of these awesome clips!

  • @Indasaid
    @Indasaid5 жыл бұрын

    Solid science behind adaptability and the benefits of a blended fasting approach (IF and longer term)

  • @Mountainlion25
    @Mountainlion255 жыл бұрын

    Hi Thomas, new subscriber :) I have dabbled in IF in the past when i was 3 stone lighter, but after watching your videos over the last two days, realised how wrong i was doing things! coming to the end of a 24hr fast now and i have the RIGHT food to break fast on standby!!! Thank you for sharing all you know! its more valuable than you think! Dan

  • @markmagielse6364
    @markmagielse63645 жыл бұрын

    Awesome informative video: AMAZING how clever our bodies are.

  • @deltadoc6702
    @deltadoc67025 жыл бұрын

    Perfect timing as I’ve been experiencing this exact thing since going to 20/4 IF. I also notice it will be higher the higher percentage of fat grams I eat the day before. Still kinda freaks me out as I was on the verge of being diabetic before beginning my KETO/IF protocol and lost 40lbs. A1C is the true snapshot of your insulin sensitivity and diabetes. Thanks for the research Thomas!

  • @artofmagic1317
    @artofmagic13175 жыл бұрын

    Hey Thomas, I love your vids. First of all, I had an accident 1 year ago, got myself at 125 kg(275lb) and in 6 months I managed to get on 92.5 kg(204lb). I'm pretty proud of myself. *edit: I'm 1.94 m or 6.4 ft You say that fasting doesn't cause dizziness, but combined with keto I had some very bad days, worst of them was when I almost fainted in a bus. Oh well, you know.... Things we do to get what we want. Any advice on what to do to avoid this small problems, I don't really want to faint at work if it's possible. As for food, idk if I can call it an true keto because I adjusted it to my lifestyle. I mean I eat fat meat, fat cheese, eggs, sunflower seeds, pumpkin seeds and that's about it. Every day from 1400 to 1800 calories. Have a nice day, and thx for doing this videos, you were one of those that convinced me to try fasting and rly changed my life

  • @sibleyhoneybee427
    @sibleyhoneybee4275 жыл бұрын

    What a fascinating video Thomas! Thank you for explaining why we have more glucose in our bloodstream when we fast. Now I won't be alarmed by that anymore. Idea for future video: Can you talk about different IF time blocks for different people? I've found that I do better eating breakfast and lunch and then fasting from 2 p.m. to 8 a.m. the next morning. I have Dawn Phenomenon where I have high sugars around 110 to 120 in the mornings until I eat breakfast and then they come down into the 80s. I am eating a ketogenic diet and loving it!

  • @alikhalid76dxb
    @alikhalid76dxb5 жыл бұрын

    Yes. Agreed. I also learnt same things by going on fasts. Short fast increases insulin sensitivity and longer fast burns more fats but increases blood sugar. For example on first day fast bsugar dropped to 80 and then following days came back to 100. Diabetic need a mix of long n short to reverse it in few days. Cheers

  • @atroposmoirai2298
    @atroposmoirai22985 жыл бұрын

    Thank you

  • @nnr2dm243
    @nnr2dm2435 жыл бұрын

    It's all very very mind blowing-the stuff that's known about the human body today,all I can really say is when I think I've got a slight handle on things,i get lost and have to keep educating myself.

  • @offirgo
    @offirgo5 жыл бұрын

    Hi Thomas and thanks for your video as usual. Quick question, anything you know about the nutritional value of an avocado seed? Looked everywhere and couldn't find any decisive information.

  • @PastorSandraElziraThomas
    @PastorSandraElziraThomas3 жыл бұрын

    You are awesome and beautiful. I'm an RN and you explain it so well. You and Dr. Berg and Dr. Fung are my absolute best. Thank you and God bless you and your family.🙏

  • @charisenterprise333
    @charisenterprise3335 жыл бұрын

    Nice information...a little over my head.. But thanks for including examples like Tesla and lambo ... It makes it easier for people like me. Appreciate it.

  • @edwardwilliams1772
    @edwardwilliams17725 жыл бұрын

    lov your videos Thomas👏👏👏👏💪💪💪💪

  • @MartinS222
    @MartinS2225 жыл бұрын

    This info 👍🏽👍🏽

  • @AgentClaytonWebb
    @AgentClaytonWebb5 жыл бұрын

    I was told by my pharmacist doing keto and OMAD that for the first weeks my liver would release extra stored glucose and this would stop after a few weeks, and it did. Now, I don't have any sugar spikes, but I do find at times I'm mildly hypoglycemic 3.3 mmol or 60, even though I'm not diabetic. Still losing weight and feeling great, but mindful to check my sugar numerous times during the day, just to be safe.

  • @jP-nw7nm
    @jP-nw7nm4 жыл бұрын

    Subscribing to your channel has been a blessing. Can you do a video for nail fungus?

  • @zaidsultan5191
    @zaidsultan51914 жыл бұрын

    Damn what an amazing explanation

  • @lesadurbin9290
    @lesadurbin92905 жыл бұрын

    Thanks for doing this research, when went for my yearly physical my glucose was high. My eating window is the end of the day & I hadn't eaten that morning, only had coffee with small amount of low fat creamer. I wasn't worried about it figured it had something to do with the fasting or the somogyi effect. Thanks for the extended science info

  • @vickibacon7489
    @vickibacon74895 жыл бұрын

    Thank you, it always bothered me that though nothing is going in my blood sugar was high, thx

  • @Lamentor219
    @Lamentor2195 жыл бұрын

    Life is a pendulum. The more energy you put into one side, the more it'll transfer to the other. We're always aiming for that point of balance within ourselves. Fasting and eating are important opposites that we need to maintain balance with. Really interesting topic.

  • @im4485
    @im44855 жыл бұрын

    Thomas is awesome

  • @Jjones24680
    @Jjones246805 жыл бұрын

    Type 1 Diabetic here 22 years. Been Fasting/keto for over a year, OMAD for over 7 months. I have experienced a plethora of various blood glucose patterns that have been a delight learning about. I would be very keen to answer questions about my current experience to this point. My last A1c from my blood work was 6.4 and my endo was amazed. I go days where I use Basal insulin only and under 20 units. To days where I have around 40-60 units in a 70/30% Basal/Bolus spread.

  • @abitoffblacksmithing9985

    @abitoffblacksmithing9985

    5 жыл бұрын

    Dude type 1 and a A1c of 6.4 frickin Awesome!! The power or fasting and allowing the body to work and correct its self!! Amazing!

  • @Jjones24680

    @Jjones24680

    5 жыл бұрын

    @@abitoffblacksmithing9985 Craziest thing I have noticed. Sometimes my sugar will be at a point where before this lifestyle change I would feel shaky, sweaty, and your typical symptoms of low blood sugar. My sugar can go as low as 50mg/dL now and I have zero symptoms of low blood sugar and feel absolutely great. No need to worry either, I take so little insulin that it is impossible for me to dip low enough to the point of concern. I typically used to feel the symptoms of low blood sugar around 70-80 mg/dL. Now it takes it around 40-55 before nay symptoms occur.

  • @abitoffblacksmithing9985

    @abitoffblacksmithing9985

    5 жыл бұрын

    @@Jjones24680 that is amazing !! My wife was type 2 and she reversed it with high fat and low carb lifestyle changes I myself have lost 150lbs and I was definitely pre diabetic !! My wife's A1c is 4.5 now and it used to be 8.4 and even higher! Keep it up man!!!!! The human body is amazing!! Cheers!!

  • @dana102083

    @dana102083

    5 жыл бұрын

    Did you change to keto with your doctor's blessings or did you do it alone? Ivan imagine alot would freak out over it! I'm a nurse, I'm curious how you started your journey and what it entailed :)

  • @Jjones24680

    @Jjones24680

    5 жыл бұрын

    @@dana102083 I did it alone. I started with just intermittent fasting and healthier eating. I started doing more and more research and eventually got to a point where I felt so much better and was achieving so much, I just kept going. I am so adapted to burning fat now that even if I have a day of eating 3000 calories of McDonald's, I flush all that water and am back in ketosis within 24-36 hours. I am absolutely amazed at what my body can do. I have gone 72 hours without food as a diabetic with my blood sugar controlled entirely by my basal delivery on my pump. Blood sugar too low? Turn my basal insulin off, and it will rise ever so slightly. Blood sugar climbing ever so slowly? Turn my basal delivery up from .8 units an hour to 1.2 units. There are days where I do not take a single bolus delivery and simply turn my basal up to 2.2-3 units/hr 30 minutes before eating. The lowest amount of insulin I can recall using in a day entirely by basal was 16.5 units. This is with consuming a single 2750-3250 calorie meal. Human body FTW.

  • @freequest
    @freequest5 жыл бұрын

    I do a mix of 16/8 and OMAD mostly OMAD as my lifestyle is pretty full on at times you know being a photographer and all that plus working out. But I have learned to listen to my body and sometimes my body tells me to fast usually 3-4 days its great I call it my little cleansing reset. The body is an amazing machine I marvel at times at how efficient it is litrally the most incredible thing is yourself. (:

  • @littlevoice_11
    @littlevoice_115 жыл бұрын

    Does this elevation in blood sugar during the fast (due to insulin resistance) increase inflammation and the damage caused by high circulating glucose?

  • @ameliacarey3315
    @ameliacarey33155 жыл бұрын

    How does this impact A1C?

  • @JFWienecke
    @JFWienecke5 жыл бұрын

    Thomas, I have been on a ketogenic lifestyle for 21 months. After my last 3 day fast starting on 3/5, I have been intermittent fasting. What I have noticed is that my ketone levels have been over 0.8 to 1.7 since then. However I have noticed at times a combination of glucose levels of 104 - 106 along with the above ketone levels. For example yesterday after a light dinner at 7:00 pm the day before, then playing tennis in the morning for 2 hours (singles) and when I measured by blood at 11:30 am, by glucose was 110 and my ketone was 1.2. In the past, my ketone level would never be this high unless my glucose level was 85 or lower. Can you explain this? Where is the glucose coming from?

  • @Nitronerd
    @Nitronerd5 жыл бұрын

    My glucose does increase during intermittent fasting, 12-20 hrs. I wondered why. 60-hr fasting glucose nose dives. This vid helps to understand.

  • @MohamedWanis_Elruemi

    @MohamedWanis_Elruemi

    4 ай бұрын

    Hi. May I ask if you are diabetic? And have you got this issue solved as I am having the same thing here.... I am not diabetic and I have been on IF for the last 3 months 18 to 20 hours fasting.. my fasting blood sugar was always in the normal range.. but all out of sudden the last 3 days my fasting blood sugar elevated between 100 - 122 and it goes back to normal 2/3 hours after food

  • @Greenumbrella-2024_April
    @Greenumbrella-2024_April Жыл бұрын

    I remember reading a line in my biology book in 10th standard, which says mitochondria is powerhouse of every cell. Now I'm getting a better understanding of that line in every metabolic health related KZread channels.

  • @davidjones4063
    @davidjones40635 жыл бұрын

    Good video, You missed the the even bigger changes or reversal if you deplete the glycogen from some larger muscles while fasting. It forces the muscle to accept the glucose to recharge the muscles glycogen store. This works great for me as my glucose drifts significantly while fasting (Diabedic) otherwise.

  • @FuriousRhymesT
    @FuriousRhymesT5 жыл бұрын

    Hey thomas, can you please help me on how to cure or lessen acanthosis nigricans?

  • @JR-nw1li
    @JR-nw1li5 жыл бұрын

    Mitochondria is the powerhouse of the cell, it's literally the only thing I learnt at school

  • @petern5565
    @petern55655 жыл бұрын

    WOW!! I'm going to have to go over that more than once to get a handle on it but it always rings true to me when it's shown to be MORE complicated and specific like all sorts of different things happening at the same time all over the body. I also like your references to studies to support your arguments. My Question is this what causes High Ketones on a fast?? -- I am on my 7th day of a water ONLY fast and on both day 6 and day 7 my ketones were "Hi" and on my caresense dual meter that means >13 my blood glucose is steady around 3.6. If i get a "Hi" reading tomorow I will abort and start my refeeding protocol but would really appreciate a video on this subject from you. Many Thanks

  • @dw6275
    @dw62755 жыл бұрын

    Hi Thomas, I have been doing keto for a few month and i have a question for you. I had gastric bypass, surgery 18 years ago and as time went by I realized that I was having bouts of Low blood sugar especially after eating. Because of this I started checking my blood sugar, and my FBS would normally run in a range of 65 to 70, but after eating I would start feeling bad and my blood sugar would go down to 35 or 40. So my question is I have begun to test my blood for Ketosis and blood sugar levels. And now my fasting blood sugar is 95 to 109.?? Should i be concerned about how high it is now? Or is it that changing my diet to low carb keeps me from producing to much insulin so it allows my FBS to rinse. Pleas let me know and thanks so much for your great content Doug

  • @FLJD427
    @FLJD4275 жыл бұрын

    Excellent. This explains my basil glucose elevation. I often now see fasted glucose of 104-106 mg/dL doing 5x OMAD per week and fasted gym. Previously I was pre diabetic II but reversed it 2 years ago and routinely got to 80-90 mg/dL fasting glucose. Even at higher fasted glucose I am still producing reasonable ketones even in this higher glucose context at around 1 mmol/L. I presume though that my Glucose-Ketone Ratio (GKI) is not as low so I get less autophagy and anti-cancer effect unless I go to extended fasting.

  • @AlessandroArnulfo

    @AlessandroArnulfo

    5 жыл бұрын

    Hi Jim, I’m in a very similar situation. Pre-diabetic 1.5 years ago, got into Kito and 20:4 for 5 days a week and 2 OMAD. Initially my glucose level was going very low: 70-80. Kitones 2-3. Recently the glucose climbed up in the 95-105 and ketones down to 0.7-1 I have been wearing a freestyle libre so I know my glucose value and can compare with the past. I wanted to do an insuline test to make sure it is still low. I’m also interested to know if because of this we have less benefits on autophagy and potentially to fight cancer. I’m 2 year free 💪

  • @THEWARISWITHIN
    @THEWARISWITHIN5 жыл бұрын

    You just made IF a lot more complicated lol luckily there are those like me whos been doing it for years and it works just fine

  • @EsseQuamVideriSe7en
    @EsseQuamVideriSe7en5 жыл бұрын

    Hi Thomas. Can I get more detail on this specific fast? You said three days so I assume 72 hour water fast. At what point were you noticing the rise in glucose levels? As the fast progressed? Day 2? Details please. Also, how high were the glucose levels that had you concerned (or at least questioning)? I have just started using the Keto Mojo so I can track my glucose and keto levels and this video is pure gold. Lastly, looking at what you say here at 9:57 about balancing short and long term fasting (and I know I may be looking for the magic formula that doesn't exist) what do you think, from your experience, this balance of short and long term fasting might look like? (Probably needs its own video) Looking for this balance myself (based on your videos and answers to other questions I have asked) I have recently gone to a random week of (3x 16+/8-) (1x 21 [OMAD]) (3x regular eating) with a 36 hour fast 1x per month and 72 hour fast 4x per year. Having completed the first week I can say that I feel the short fasts more than I usually would, which I am hoping means my body is off balance. Anyway, as always, great job. Thanks for putting in all the hard work and sharing it with us.

  • @stanislouse4168
    @stanislouse41688 ай бұрын

    Makes sense. Triglycerides increased 101% on my lipid panel over the month before. This was after a 26 hour fast and exercising for 1.5 hours at the end of the fast to dump out glycogen, just for the hell of it. What I was really interested in was fasting insulin and fasting glucose. The Dr. freaked and wanted to put me on statins. I told her what I did to prove (as an ultra endurance athlete) that I was fat adapted, but she didn't get it. Asked if she ever considered measuring my Tri/HDL ratio @ 1.3 Crickets.

  • @TheRlulow365
    @TheRlulow3655 жыл бұрын

    I’m type 2 and I fast 24 hours twice a week and I recently noticed my noon test was higher than my morning test and it was freaking me out. THANKS for the info!

  • @kevinharvey9585

    @kevinharvey9585

    4 жыл бұрын

    Good Morning how long have you been fasting? and has it helped your A1C numbers gotten better?

  • @Yellowjacket45Wall
    @Yellowjacket45Wall5 жыл бұрын

    Although this sounds logical I have experienced this many times and since I used to be diabetic I became concerned that just as you stated that I was losing the ability to uptake the sugar but what I have discovered is that as I fast and drink a lot of water it seems that the cells would rather hold onto the water than let in the glucose so I get the spike but if I fast and cut water intake my glucose goes down

  • @LakerLife
    @LakerLife5 жыл бұрын

    You sound congested. Get well soon! Thanks for the informative video.

  • @thisthat1142
    @thisthat11424 жыл бұрын

    What is the connection between breaking a fast with a lean protein when you’re insulin sensitive and being insulin resistant after a fast as stated in this video? Does it have to do with the duration of the fast? Is it just peripheral cell resistance? I missed the Distinction. Big fan from Canada. Big respect for what you do and how you do it.

  • @Adamkilla9000
    @Adamkilla90003 жыл бұрын

    I learned this in med school

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