The F512 M sports a 4.9-litre (301.6 cu in (4,943 cc)) Tipo F113 G longitudinally mid mounted flat-12 engine. This provides a maximum torque of 500 newton-metres (370 ft⋅lbf) at 5,500 rpm and a maximum power output of 324 kW (441 PS; 434 hp) at 6,750 rpm. The engine features four valves per-cylinder, for forty-eight valves total and is lubricated via a dry sump system, with a compression ratio of 10.40:1. Due to new titanium connecting rods and a new crankshaft that together weighs 7.26 kilograms (16.0 lb) less than those that they replace, the engine has a 7,500 rpm electronic rev limit.
The Ferrari F512 M can accelerate from 0 to 100 km/h (62 mph) in 4.7 seconds, on to 161 km/h (100 mph) in 10.2 seconds, and can complete a standing quarter mile in 12.7 seconds or a standing kilometre in 22.7 seconds. The F512 M has a top speed of 315 km/h (196 mph).