Duchenne and Becker Muscular Dystrophy

Duchenne and Becker Muscular Dystrophy are degenerative diseases that lead to progressive muscle weakness. This video aims to explore both Duchenne and Becker muscular dystrophy in terms of discovery, symptoms, diagnosis, prevention and treatment, as well the associated genetic and cellular mechanisms. Conducting a comparison between both Duchenne and Becker muscular dystrophy will better-inform the audience of two very rare muscular diseases, potentially leading to an earlier diagnosis and the implementation of prevention strategies to improve one’s quality of life. This video is expected to spread awareness regarding the complexity of two very similar yet different conditions, and what this means for the affected individual.
This video was made by McMaster University students Gurleen Sodhi, Abesha Kuperan, Aashna Agarwal, and Laura Venier in collaboration with the Demystifying Medicine McMaster Program.
This video is provided for general and educational information only. Please consult your health care provider for information about your health.
Copyright McMaster University 2022
#DemystifyingMedicine #MuscularDystrophy #Duchenne #Becker
References:
Angelini, C., Marozzo, R., & Pegoraro, V. (2019). Current and emerging therapies in Becker muscular dystrophy (BMD). Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 38(3), 172-179.
Birnkrant, D. J., Bushby, K., Bann, C. M., Apkon, S. D., Blackwell, A., Brumbaugh, D., Case, L. E., Clemens, P. R., Hadjiyannakis, S., Pandya, S., Street, N., Tomezsko, J., Wagner, K. R., Ward, L. M., Weber, D. R., & DMD Care Considerations Working Group (2018). Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management. The Lancet. Neurology, 17(3), 251-267. doi.org/10.1016/S1474-4422(18...
Brinkmeyer-Langford, C., & Kornegay, J. N. (2013). Comparative Genomics of X-linked Muscular Dystrophies: The Golden Retriever Model. Current genomics, 14(5), 330-342. doi.org/10.2174/1389202911314...
Centers for Disease Control and Prevention (CDC) (2009). Prevalence of Duchenne/Becker muscular dystrophy among males aged 5-24 years - four states, 2007. MMWR. Morbidity and mortality weekly report, 58(40), 1119-1122.
Ciafaloni, E., Fox, D. J., Pandya, S., Westfield, C. P., Puzhankara, S., Romitti, P. A., Mathews,
K. D., Miller, T. M., Matthews, D. J., Miller, L. A., Cunniff, C., Druschel, C. M., & Moxley, R.
T. (2009). Delayed diagnosis in duchenne muscular dystrophy: data from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet). The Journal of pediatrics, 155(3), 380-385. doi.org/10.1016/j.jpeds.2009....
Crisafulli, S., Sultana, J., Fontana, A., Salvo, F., Messina, S., & Trifirò, G. (2020). Global epidemiology of Duchenne muscular dystrophy: an updated systematic review and meta-analysis. Orphanet journal of rare diseases, 15(1), 141. doi.org/10.1186/s13023-020-01...
Falzarano, M. S., Scotton, C., Passarelli, C., & Ferlini, A. (2015). Duchenne Muscular Dystrophy: From Diagnosis to Therapy. Molecules (Basel, Switzerland), 20(10), 18168-18184. doi.org/10.3390/molecules2010...
Gao, Q. Q., & McNally, E. M. (2015). The Dystrophin Complex: Structure, Function, and Implications for Therapy. Comprehensive Physiology, 5(3), 1223-1239. doi.org/10.1002/cphy.c140048
Hoffman, E. P., Kunkel, L. M., Angelini, C., Clarke, A., Johnson, M., & Harris, J. B. (1989). Improved diagnosis of Becker muscular dystrophy by dystrophin testing. Neurology, 39(8), 1011-1017. doi.org/10.1212/wnl.39.8.1011
LaPelusa, A., & Kentris , M. (2022). Muscular Dystrophy. In StatPearls. StatPearls Publishing.
Mah J. K. (2016). Current and emerging treatment strategies for Duchenne muscular dystrophy. Neuropsychiatric disease and treatment, 12, 1795-1807. doi.org/10.2147/NDT.S93873 Thada, P. K., Bhandari, J., & Umapathi, K. K. (2022). Becker Muscular Dystrophy. In StatPearls. StatPearls Publishing.
Venugopal, V., & Pavlakis, S. (2022). Duchenne Muscular Dystrophy. In StatPearls. StatPearls Publishing. www.ncbi.nlm.nih.gov/books/NBK...
What are the treatments for muscular dystrophy (MD)? (n.d.). Eunice Kennedy Shriver National Institute of Child Health and Human Development. Retrieved October 27, 2022, from www.nichd.nih.gov/health/topi...
Image References:
Dictionary of Eponyms: Becker (Peter Emil). (n.d.). Dictionary of Eponyms. Retrieved October 27, 2022, from dicci-eponimos.blogspot.com/20...
Lanska, D. J. (n.d.). Brachial plexus palsy in neonates. MedLink Neurology. Retrieved October 27, 2022, from www.medlink.com/articles/brac...

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