Duchenne Muscular Dystrophy and Dystrophin

Ғылым және технология

Duchenne Muscular Dystrophy (DMD) is an genetic muscle-wasting disease that leads to disability and early death. In all cases of this disease, the gene for a protein known as dystrophin is mutated. How does a dysfunctional dystrophin gene cause DMD? Find out in this episode of Medicurio.
Interesting to note: Becker's Muscular Dystrophy is a similar disease, but with much milder symptoms. People who have this disease also have a mutation in the dystrophin gene, but instead of making completely useless dystrophin, the protein is still semi-functional. People with Becker's dystrophy have much slower muscle wasting and live into the 50's and 60's.
Cool links to check out to learn and donate to DMD research:
Cure Duchenne: www.cureduchenne.org/
Muscular Dystrophy Canada: www.muscle.ca/
Muscular Dystrophy Association: www.mda.org/
Excellent video on how Exon Skipping works, courtesy of Cure Duchenne: • Prosensa's Video Anima...
The full process to get from DNA to protein is outlined in the central dogma of biology.
1. Genes are in the nucleus of the cell as DNA.
2. RNA polymerases make an RNA copy of the gene, known as the primary RNA transcript or pre-mRNA.
3. The primary RNA transcript undergoes some processing, such as splicing exons together.
4. mRNA exits the nucleus and into the cytoplasm, where ribosomes read the mRNA one codon at a time. Each codon corresponds to a certain amino acid or a stop codon.
5. Amino acids are linked together until a stop codon is reached, finishing the protein.
You can find a realistic animation of this process here, courtesy of the DNA Learning Centre: • The Central Dogma of B...

Пікірлер: 204

  • @jonpaul6802
    @jonpaul68027 жыл бұрын

    This video taught me more about this disease than any doctor I've been to. Its hard to find answers when no one understands it.

  • @megarayquaza6157

    @megarayquaza6157

    6 жыл бұрын

    agree

  • @ragingshawn6944

    @ragingshawn6944

    4 жыл бұрын

    I have dmd and now i even understand it more cause of this video

  • @nanishah3202

    @nanishah3202

    3 жыл бұрын

    rl

  • @paull2937

    @paull2937

    2 жыл бұрын

    Anyone watch this at school

  • @tenminutetokyo2643

    @tenminutetokyo2643

    2 жыл бұрын

    Most doctors are money-chasers. And none of them want to hear any info any patients has to give them. It's a blow to their inflated egos that you know more than they do.

  • @jackspiecker704
    @jackspiecker7044 жыл бұрын

    this vid covered my entire 4 week biology unit in eight minutes

  • @Bigzthegreat

    @Bigzthegreat

    3 жыл бұрын

    School is slow and to teach as many as possible they slow it way down

  • @mazdaksheytunak6939
    @mazdaksheytunak69392 жыл бұрын

    What a great video! Thanks for taking the time and making the effort to explain this complex disease! Much appreciated

  • @WizKidNas
    @WizKidNas3 жыл бұрын

    I'm a nursing student and this was excellent work, thank you for helping me better understand this content

  • @mmascarenhas4368
    @mmascarenhas43685 жыл бұрын

    Thank you for the simple visuals and clear explanation! Helps those of us struggling to read through heaps of information.

  • @bluedolphin4574
    @bluedolphin4574 Жыл бұрын

    Very insightful. Please keep making these awesome videos. Thank you.

  • @khoavu7674
    @khoavu76745 жыл бұрын

    This is amazing! thank you for the elucidation

  • @Manunitedfna
    @Manunitedfna6 жыл бұрын

    Great video! I loved your emphasis on what destroys the muscles. Looking forward to checking out your other videos

  • @Medicurio
    @Medicurio7 жыл бұрын

    Sorry about the hiatus! Last few weeks were final exams, so I was bogged down with studying for my classes.

  • @peoplecanbestupid

    @peoplecanbestupid

    7 жыл бұрын

    You should make a reddit account and post your video in different sub-reddits. So more people can watch the videos.

  • @Medicurio

    @Medicurio

    7 жыл бұрын

    I have my own subreddit here: reddit.com/r/medicurio

  • @jackiedaniels

    @jackiedaniels

    3 жыл бұрын

    Why would you want to study something that is naturally going to happen? haha JK! It is like can you just send a innocent person like this down the mental ward hill?

  • @pizzasloth82
    @pizzasloth827 жыл бұрын

    This is cool content! Keep up the good work!

  • @neoretrodude
    @neoretrodude3 жыл бұрын

    Incredible and so succinct. I have definitely subscribed to see what else you are hiding up your sleeve.

  • @kayeannbacalso2738
    @kayeannbacalso27384 жыл бұрын

    thank you for sharing this knowledgeable information especially to us as a student i love this video so much

  • @beebob7136
    @beebob7136 Жыл бұрын

    Amazing video , really helped me a lot! Thank you.

  • @radhikamarathe3427
    @radhikamarathe34276 жыл бұрын

    Awesome explanation.... made my work easy... thanks

  • @paull2937
    @paull29372 жыл бұрын

    This video is lesson 3 in my biology class, and at the beginning of class, my biology teacher warned us it would knock our socks off. I agree. This video is like foreign language.

  • @lorainearreglado4108
    @lorainearreglado41082 жыл бұрын

    Thank you! Nicely presented

  • @Undownn
    @Undownn3 жыл бұрын

    The more I watch it, the more I understand or learn something new.

  • @mohammedal-hammadi5085
    @mohammedal-hammadi50853 жыл бұрын

    Thank you so much, it's so helpful and clear

  • @Pawsinjaws.
    @Pawsinjaws.3 жыл бұрын

    Interesting! Thank you so much for an awesome video!

  • @nethmawickramarachchi5056
    @nethmawickramarachchi5056 Жыл бұрын

    Thank you soo much. 🥰🥰 Nicely explained with all necessary facts.

  • @sulaimanwalugembe2567
    @sulaimanwalugembe2567 Жыл бұрын

    Thanks for the information

  • @bens10143
    @bens101432 жыл бұрын

    incredible visuals

  • @dylanzhao8441
    @dylanzhao84413 жыл бұрын

    Awesome narration, learned a lot. :)

  • @ysabellawilliams7781
    @ysabellawilliams77815 жыл бұрын

    This was really helpful thank you

  • @burakdeveli2121
    @burakdeveli21216 жыл бұрын

    Very helpful video thank you! I've subscribed

  • @dobariyamiral2020
    @dobariyamiral20204 жыл бұрын

    Explains in very simple and easy way, like this vedieo

  • @sarahrose3012
    @sarahrose30124 жыл бұрын

    Thanks for the amazying explanation

  • @nyawirawaithaka4993
    @nyawirawaithaka49933 жыл бұрын

    Great video!

  • @vipashapmehta
    @vipashapmehta7 жыл бұрын

    amazing video..v well explained & v good videography😊👍

  • @juandiegodistefano335
    @juandiegodistefano3353 жыл бұрын

    Amazing video

  • @JihadAlAnsari
    @JihadAlAnsari5 жыл бұрын

    Thank you very much.

  • @rikkigupta9546
    @rikkigupta95464 жыл бұрын

    Thanks a lot 🙏 for ur guidance May god shower 😇all his blessings and love on u and u stay blessed always

  • @poopsixsixsix5732
    @poopsixsixsix57325 жыл бұрын

    0:36 weird flex but ok

  • @MaramHassan17
    @MaramHassan1714 күн бұрын

    You're amazing. Thank youuuu!!!!!

  • @neurologybysaiduzzamanmunn3349
    @neurologybysaiduzzamanmunn33494 жыл бұрын

    many many thanks. I am a doctor, still it helped me a lot.

  • @LGRacing123
    @LGRacing1232 ай бұрын

    No tears in my eyes to cry.... No any feeling when Im breathing ... No nothing to do anything except prying .... Im alone in this world .... My cute son with this problem DMD.....so sad.... If therei is any energy hidden somewhere ... Please help to find success treatment for this .... As soon as possible ... Still have a tiny hope till last breath ......😪😪😪😪

  • @ricardofr200
    @ricardofr2002 жыл бұрын

    Finally a proper explanation to something I lived with and ever (Becker's btw) and even i didn't understood in its totality. Thank you very much.

  • @johnnydepp4469

    @johnnydepp4469

    2 жыл бұрын

    Contact doctor Akhigbe for your cure with his herbal medicine

  • @johnnydepp4469

    @johnnydepp4469

    2 жыл бұрын

    Email him now

  • @nausheensaboohi4949
    @nausheensaboohi4949 Жыл бұрын

    V. Good explanation.

  • @rachelg8097
    @rachelg80977 жыл бұрын

    Very good video!

  • @ahmedsana2560
    @ahmedsana25603 жыл бұрын

    Thank you very very much

  • @misswonder9691
    @misswonder96913 жыл бұрын

    Amazing one thanks for the explanation ❤️❤️❤️👍👍👍🙏🙏🙏

  • @meeromeer8812
    @meeromeer8812 Жыл бұрын

    Thanks, really nice video.

  • @jadathomas3684
    @jadathomas3684 Жыл бұрын

    Beautiful tyy

  • @jackeline155
    @jackeline15511 ай бұрын

    Thank u so much!

  • @absurd7292
    @absurd72923 жыл бұрын

    tnx man . So much Informative💖💖💖💖

  • @haninshaker8384
    @haninshaker8384 Жыл бұрын

    Thanks 🙏

  • @SiggiAriOlafsson
    @SiggiAriOlafsson3 жыл бұрын

    My freind died because of this disease. It's hard to listen to this but its very educational and thanks for that.

  • @ninjagaminglive6587

    @ninjagaminglive6587

    2 жыл бұрын

    So sorry to hear that At what age your friend died?

  • @SiggiAriOlafsson

    @SiggiAriOlafsson

    2 жыл бұрын

    @@ninjagaminglive6587 He was only 14 years old at the time

  • @ninjagaminglive6587

    @ninjagaminglive6587

    2 жыл бұрын

    @@SiggiAriOlafsson my brother have this problem he is 21 but I don't know which type he is having

  • @deemamattar517
    @deemamattar517 Жыл бұрын

    Man you are amazing☺️ thank you very much!!!💜💜💜💜

  • @lauramazzocchitti8509
    @lauramazzocchitti85093 жыл бұрын

    thank you, i've subscribed!

  • @BasicallySteve23
    @BasicallySteve237 жыл бұрын

    Great job! Your explanation of gene mutation and why it leads to damaged proteins was well done, and it might make for a good video to explain the other types of mutations aside from frame shift and how they cause many different diseases and disorders. Otherwise, I will say this disease you covered today is especially horrible and debilitating and I truly hope advances in gene therapy can prevent the suffering it causes.

  • @Medicurio

    @Medicurio

    7 жыл бұрын

    Thanks! You're absolutely right, it is a devastating disease. I'm considering making a video just about just mutations and inheritance soon.

  • @gullan51
    @gullan514 жыл бұрын

    I know someone that is 24 with DMD.. i feels so bad for these people

  • @Speedymisha
    @Speedymisha4 жыл бұрын

    One of our family friends had 3 sons with this. They died at 27, 31, and 36.

  • @chelseahoffmann6285
    @chelseahoffmann62855 жыл бұрын

    Great video. It would be nice to have a note somewhere in the video about the relationship to lack of dystrophin and the psychological effects it has on the brain. Most parents are not warned about that and can be blind sided.

  • @cdeese2644

    @cdeese2644

    3 жыл бұрын

    Many believe the lack of dystrophin in the brain is linked to duchenne patients having adhd and/or ocd

  • @craigcambridge2484
    @craigcambridge24846 жыл бұрын

    This was brilliant !!!!!!!!!

  • @brunocvairo
    @brunocvairo6 жыл бұрын

    Awesome!

  • @jayampriya3803
    @jayampriya3803 Жыл бұрын

    Very useful pa .

  • @raenah8882
    @raenah88825 жыл бұрын

    TZ sent me here, also as a part of the medical field.

  • @engineeringlife9725

    @engineeringlife9725

    5 жыл бұрын

    Please tell me soluation of that diecies my saffering now he is only 4 year old

  • @Stevonz1234
    @Stevonz12347 жыл бұрын

    AMAZING keep up the good videos :)

  • @Medicurio

    @Medicurio

    7 жыл бұрын

    Thank you!

  • @selenasophie5245
    @selenasophie52452 жыл бұрын

    I don't know why stop making videos 💔but i hope u come back

  • @jamescole8049
    @jamescole80494 жыл бұрын

    Zootier sent me, not mad at it. Good job guys.

  • @sumamirji3956
    @sumamirji39562 жыл бұрын

    So awesome !!!!

  • @jewboi612
    @jewboi6124 жыл бұрын

    This makes Ms. Bass class super easy

  • @dylincassidy1134
    @dylincassidy11346 жыл бұрын

    I have a non server form of MD thats not as bad but the pain can still be awful

  • @callumjones4622
    @callumjones46227 жыл бұрын

    Very useful for my Biology Assignment :D

  • @Medicurio

    @Medicurio

    7 жыл бұрын

    Glad I can help!

  • @leslycalderon6006
    @leslycalderon60064 жыл бұрын

    Helpful indeed:)

  • @tarunhuda8596

    @tarunhuda8596

    3 жыл бұрын

    ✌️

  • @espinoza_9072
    @espinoza_9072 Жыл бұрын

    i have it and i'm beating the odds, work in heavy construction and lift weights at gym, 20 years old.. even though i struggle sometimes i push through

  • @mar7956
    @mar79562 жыл бұрын

    I like it thank you so much💗

  • @103priyadharshini.m8
    @103priyadharshini.m85 жыл бұрын

    Excellent 😍😍😍😍

  • @cariboowho
    @cariboowho7 жыл бұрын

    Good video! I felt that the end of the video got a little off-track with the discussion of genes, but keep up the good work!

  • @Medicurio

    @Medicurio

    7 жыл бұрын

    Thanks for the feedback!

  • @RublixCom
    @RublixCom2 жыл бұрын

    Hi! I have a question I hope you could answer. If calcium is doing the main damage to the muscle cells, would it make any good to greatly reduce or try to eliminate completely calcium from one's diet?

  • @samirasalik6118

    @samirasalik6118

    2 жыл бұрын

    you need calcium for your bones, heart and muscle. you also lose bone mass when you don't get enough calcium which really does more harm.

  • @josephhicks9454
    @josephhicks94544 жыл бұрын

    Where are your sources?

  • @mussy4everm962
    @mussy4everm96210 ай бұрын

    I’m confused about the caluim bit because I have this

  • @ANDRESIBILIS
    @ANDRESIBILIS6 жыл бұрын

    I have a question, in minute 2:00 shows a protease, is that aldolase? since lab work shows increased CK and aldolase, great video by the way

  • @Medicurio

    @Medicurio

    6 жыл бұрын

    Not an aldolase, aldolases break down sugars while proteases break down proteins. Aldolase is found in muscle cells though. High CPK (Creatine phosphokinase) and aldolase means that there is muscle damage because it means that these enzymes have leaked out of the muscle cells and into the blood.

  • @writehandman2833
    @writehandman28332 жыл бұрын

    Something no one has answered me about is: Can dystrophin be synthesized or harvested from healthy individuals and infused into patients?

  • @carolineyoussef884
    @carolineyoussef8846 жыл бұрын

    Hi, I'm doing a research paper on this disease and I had a couple of questions. 1. What determines which muscles are affected or the ones that are weakening? it varies from a family history to another but is the gene mutation random or how does it work? The symptoms are different for each person. For instance, for some people their leg muscles are the ones weakening but for others it's their shoulders yet they have the same disease. What exactly determines this? 2. Why does it get worse with each generation? Does the excessive number of the nucleotides sequence multiply or is there another reason? 3. Also, for the weakening muscles can exercice reduce this process in order to prevent the disease in a way or is it just an internal issue in the muscles as it explains in the video such as getting rid of important proteins? Thank you!

  • @Medicurio

    @Medicurio

    6 жыл бұрын

    1. Likely dependent on the mutation (is dystrophin completely dysfunctional? Slightly functional?) and lifestyle (more or less exercise? What muscles are used more often?) 2. Don't think it gets worse over generations (let me know if you find something that says otherwise). 3. Proper types of exercise seem to delay some muscle wasting, but is very controversial as too much exercise can also exacerbate the condition. "Use it or lose it" is often said for people with DMD. Read more about it here: www.ncbi.nlm.nih.gov/pmc/articles/PMC2929216/

  • @mustaphahassan1873
    @mustaphahassan18737 жыл бұрын

    thanks for supplying this amazing vedio pls keepon sir .

  • @ashinaz4203
    @ashinaz42034 жыл бұрын

    My bro also suffering from this distrophy plz pray for him

  • @CrazymarioO-cf9yf

    @CrazymarioO-cf9yf

    3 жыл бұрын

    I pray for everyone like me with this disease to get better by the power of God!!!!!

  • @ninjagaminglive6587

    @ninjagaminglive6587

    2 жыл бұрын

    Bro please reply me my brother also suffering from it

  • @torpegangofficial3736
    @torpegangofficial37366 жыл бұрын

    Hi . I am from nepal. I am suffering from Becker muscular distrophy

  • @henrikl218

    @henrikl218

    5 жыл бұрын

    Sorry to hear. Stay strong!

  • @minminwu2106

    @minminwu2106

    3 жыл бұрын

    I hope you get well soon!

  • @stephanmurugan3947

    @stephanmurugan3947

    3 жыл бұрын

    Treatment please tell

  • @protistpoop
    @protistpoop7 жыл бұрын

    Do you happen to have any links, I can't seem to find any relating to how calcium protease and muscular dystrophy actually relate...

  • @Medicurio

    @Medicurio

    7 жыл бұрын

    Here are two papers: www.ncbi.nlm.nih.gov/pubmed/6096040 jgp.rupress.org/content/136/1/29

  • @dillydallydolly6847
    @dillydallydolly68473 жыл бұрын

    Question, can a patient have becker muscular dystrophy and Atherosclerosis? If so what is the chance of living a long life?

  • @RPGguids
    @RPGguids6 жыл бұрын

    Could you do a video on Spinal Muscular Atrophy?

  • @Medicurio

    @Medicurio

    6 жыл бұрын

    I'll look into that

  • @Nejmaa_
    @Nejmaa_2 жыл бұрын

    I failed on my bio test because I failed to explain how gene expression is related to DMD.

  • @johnbeliveau
    @johnbeliveau4 жыл бұрын

    Carrot water juice. Particular water to carrot. Grow this particular way and soak with a green hay. Net el Where did that come from?

  • @breakfastberrito8990
    @breakfastberrito89904 жыл бұрын

    Any chance you could link to the sources for your information?

  • @Medicurio

    @Medicurio

    4 жыл бұрын

    These are some of the main ones. Please comment if you are looking for a specific reference to a particular piece of info in the video. 1. Rubin, M. Duchenne muscular dystrophy and Becker muscular dystrophy. Merck Manual, 2016. 2. Acsadi, G. Duchenne muscular dystrophy. National Organization for Rare Disorders, 2016. 3. Foster K, Foster H, Dickson JG. Gene therapy progress and prospects: Duchenne muscular dystrophy. Gene Ther. 2006;13:1677-85. 4. Nowak KJ, Davies KE. Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment. EMBO Rep. 2004;5(9):872‐876.

  • @DMDVIBES
    @DMDVIBES Жыл бұрын

    I have ducchene muscular dystrophy I am 21 years old but I can walk. Sometimes falls

  • @carrotcake7073
    @carrotcake70735 жыл бұрын

    I suffer limb girdle muscular Dystrophy

  • @user-vm8tg1zc5q
    @user-vm8tg1zc5q Жыл бұрын

    I have Duchenne Muscular Dystrophy is there any treatment I want help please

  • @user-ni8cy9tn7c
    @user-ni8cy9tn7c26 күн бұрын

    I have been suffering from this disease since I was 15 years old and I am currently 27 years old. Is there a treatment? Please reply😢😢😢

  • @chloebreagan5193
    @chloebreagan51936 жыл бұрын

    People complain about cancer being awful and I know it is, but loads of money is being spent on research and there is chemotherapy. For DMD there isn’t many options to help. My best friend has it and currently she is in hospital with something bad happening to her chest. It’s difficult

  • @Medicurio

    @Medicurio

    6 жыл бұрын

    Sad to hear that. There are still many researchers working on DMD (just not as much as cancer I guess, since cancer affects more people) so I hope your friend gets better and that new treatments are developed soon! For now, the only thing we can do as non-researchers is to raise awareness of this disease.

  • @chloebreagan5193

    @chloebreagan5193

    6 жыл бұрын

    Medicurio Thanks for your reply, all we can do is stay hopeful!

  • @vemanayogi
    @vemanayogi Жыл бұрын

    can we take creatine supplement to make strengthen the muscles..

  • @javiercordova2108
    @javiercordova2108 Жыл бұрын

    I thought DMD completely didn't have the presence of dystrophin, while BMD DID, but not enough?

  • @zeinabalraea8888
    @zeinabalraea88884 жыл бұрын

    My son has muscle dystrophi cogenital megaconial, a very rare muscle dystrophi, I dont know much about this disease, there is alittle information on the web sinse it is rare, do you know about it, can you help me, I will as well set him into clinical trials, but I dont know how. He is 3.5, stable, talks and shows a difficulty in learning, but understands and make himself understood..please any tips if you have.

  • @user-ie4re1nd1p
    @user-ie4re1nd1p Жыл бұрын

    6:57 for personal study (gene therapy)

  • @elizabethfox667
    @elizabethfox667 Жыл бұрын

    I have two brothers who got this a 14 year old and a 7 year old

  • @user-dr5fu6sd3x
    @user-dr5fu6sd3x2 жыл бұрын

    فقط ربي المشافي

  • @skjani1161
    @skjani11613 жыл бұрын

    Is there any cure for this

  • @antoniodimaggio484
    @antoniodimaggio4843 жыл бұрын

    6.50 The fat cat ate the big rat and the red ham ahahahha

  • @arunsakthi834
    @arunsakthi8342 жыл бұрын

    Can use creatine Supplement for DMD ?

  • @Sam-fp8zm
    @Sam-fp8zm9 ай бұрын

    A number of defective genes that can cause this class of symptoms are mannose related. Yeast is 9% mannose, and contains GDP mannose linked proteins so taking some brewers or bakers yeast each day might help.

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