Hello everyone! Apologies for not posting sooner, I have been swamped with schoolwork for the past few weeks. I can't believe that I got my 1000th subscriber a few days ago! You guys are absolutely amazing and I truly appreciate your supportive comments in my videos. Thank you all so much! I also have a Twitter account now, so feel free to follow me! twitter.com/medicurio

@NotDeadYet..

6 жыл бұрын

You should do video about LSD, THC and Amphetamine variant ( Medicine prescribe for ADHD )

@hammoodraad2011

6 жыл бұрын

You are amazing i am studying from you alot of information . Thank you ❤

@HDDidyne

5 жыл бұрын

Very good organized presentation 👏👏👏

@annoloki

5 жыл бұрын

"Somehow, caffeine can enhance their painkilling properties" - this will be down to adenosine receptors on the smooth muscles of blood vessels, causing them to constrict (which is what leads to the increase in blood pressure and faster heartbeat rate). One common cause of headache/migraine is caffeine withdrawal, which results in excessive vaso-dilation especially in the brain... this expansion of blood vessels can be very painful, so this pain can be mediated by taking some caffeine (giving people the "slow weening" process) and also anti-inflammatories like ibuprofen which also has a vaso-constrictor effect that counters the caffeine withdrawal through a different pathway (prostacyclin receptors) thus is usually a better option as it doesn't extend the withdrawal process, but may not be sufficient on its own for consumers of large amounts of caffeine.

@niranjan4231

4 жыл бұрын

so much subs by now.

3:25 "...So you wake up feeling refreshed." No, no I do not.

@tonyfriendly4409

6 жыл бұрын

• Riftis • me neither

@MikeSmith-vb8ul

4 жыл бұрын

So?? This is simply related to your adenosine removal rate *during your sleep* . And caffeine actually *increases* this rate too (by keeping adenosine less often bound to receptors and thus more open to removal), which is why some people also consume caffeine before taking a power nap as well.

@lahtine7431

4 жыл бұрын

I've never actually woke up refreshed. Not once on my lifetime.

@feelsokayman3959

4 жыл бұрын

lmao same i feel like the adenosine just gets more

@feelsokayman3959

4 жыл бұрын

@@lahtine7431 i dont wanna call you a liar but i have a hard time believing that. i mean as a baby/toddler/kid that is very hard to believe.....i think youre exaggerating. but i know how annoying exhaustion is, same for me here since a few months.

After seeing this ... this confirms my aim to quit it completely once and for all. Always losing control ...dosage higher and higher.

extremely informative, this saved me hours of time on Google scholar, thank you for your contribution!

Came from Tier Zoo and enjoying it :D

@RadiationLemon

6 жыл бұрын

Further down the video and I noticed that having music in the back would help during your pauses

@MegaAppleshit

6 жыл бұрын

Came from. Tier Zoo as well.

@dhindaravrel8712

6 жыл бұрын

Music will make the voice harder to understand, and if it's simple enough to not be engaging in its own right, it'll soon be repetitive and annoying. Some things are better without music.

@rahulsawant_pikachu

5 жыл бұрын

Mee too :'D

@shanelawrence7438

5 жыл бұрын

Me too!

I really enjoyed this video. Well-described and explained. Your voice-overs are also very good! Easy to listen to and understand! Keep up the good work!

I love how you're finally getting consistent views. You deserve it!

This was so clear and so visually understandable that it's now got me studying how different chemicals affect the body and brain thank you for your amazing work.

Xanthine family of molecules such as caffeine cause vasoconstriction which is one way it may help with migraines. Purinergic signaling is a very fascinating field and Alan North and Geoff Burnstock have many videos talking about this topic. The P1 receptors family which comprises A₁, A2A, A2B and A₃ are also expressed on cells of the immune system. It is well worth exploring further. Thank you for a good representation of what occurs in the caffeine inhibition of adenosine pathway.

This was a great video! I don't usually subscribe after one video but I've been convinced easily here. I'm sad to see that you have so few videos on your channel, but if they're all as high quality as this one I'll eagerly watch them. BTW, you're one of the top searchers if someone searches for this topic.

Thank you. This deserves to be in a school curriculum. I love biochemistry with a focus on drugs.

@thedarkerarchery3553

2 ай бұрын

I love biochemistry with focus on drugs, too...

I quit coffee and caffeine myself so i know how hard it can be. I actually have a couple videos on my channel about how ingot through it all and why I decided to step away from it for good! Great video! Thank you!

@muckfoot-4093

Жыл бұрын

you suck

BRUUUH WHY DOES THIS VIDEO ONLY HAS 165k views? This info is amazing!! Wow! Im subscribing now! Thanks for all this info man!

This video has been of a tremendous help for me. Very well explained and illustrated, which makes it easy to understand. Thank you very much for sharing it with us!

This is TOP TIER channel and content. Insane Detail and easy to follow !

Holy. Cow. This is so cool! This was presented in such an easy to understand way and I am mind boggled by how the body operates and adapts. Thank you for this new, extremely clarifying knowledge!

Wow, this was explained in such a simple and understandable way! Thank you!

How didn't I know this amazing channel before?! Your videos are REALLY good!

i went from 2g caffeine / day to quitting caffeine and trust me that first week all you want to do is sleep

@MistakenMystery

3 жыл бұрын

2000 mgs a day? Jesus

@nickisson372

3 жыл бұрын

yep.

@Ana-mp6my

3 жыл бұрын

that must have been so painful omg

@dianahincu7809

8 күн бұрын

I cant sleep

I loved this video! I'm an MD studying for a addiction boards and it was a great way to break up the reading and boring lectures!

Glad to see you posting again! And just to add my own personal anecdote, I'm pretty sensitive to caffeine. If I ingest it from sources without L-theanine to counter its effect (like soda or coffee) I get really jittery and hyper. It also makes it harder to sleep even if I had it earlier in the morning. Tea and a little dark chocolate are usually fine though. Anyway, keep up the good work!

@liseraphina2421

3 жыл бұрын

Try a chewable GABA supplement. Stops the jitters.

Thank you!! My Neuroscience Professor breezed passed this slide and I didn't understand it at all. The diagrams helped!

This is the best informational video I have seen on yt

such a good vid! Decidedto quit my coffee consumption even tho I " only" have one cup a day.

History, science and great visuals. Keep it up!

I am doing a report about caffeine, I found this to be very helpful! Thanks!!

I'm just an undergraduate student, and I just clicked this video, even though I don't have this topic in my syllabus, I clearly understood each and every point you said. The explanations are very clear.

Most underrated channel ever.

Loved this video. Incredibly well made and explained. Thanks

most underrated channel on youtube! thanks brother.

This was very well put. Nice animations with great facts!

Excellent job. This will be helpful for my patients.

Awesome Channel! This is exactly the kind of content I always wanted.

Your videos are great! learning about how the body works is plugging into all kinds of thoughts. Thank you!

If caffeine disappears in 2 - 4 hours, why can I not fall asleep that night, like 8 hours after I've drunk coffee

@Medicurio

7 жыл бұрын

Caffeine's duration is quite variable between people, so you might just break down caffeine slower than other people simply due to your genetics. I do have to clarify that not all the caffeine disappears within a few hours, only that enough caffeine is eliminated to no longer have a significant stimulatory effect in most people, but if you are genetically more sensitive to caffeine, that residual caffeine may still have an effect and increase the duration of caffeine's effect.

@sergsfault

5 жыл бұрын

for me one cup of coffee equals 12 hours...or more...i thinkt he ceffeine has long left the brain byt his time but the chaos it caused is still there

@remybuitenhuis2433

5 жыл бұрын

the 2-4 hours is BS, actually the cafeine just starts working after 2 hours. Cafeine has a halftime of 6 hours.

@luigi6485

5 жыл бұрын

*drank

@shahafsagi7257

4 жыл бұрын

it can take up to 2 months for caffeine to get out of your system.

Supplemented what was explained in my lecture perfectly!

I'm watching this video at 3:06 AM because I might've had a lot of coffee trying to study for exams...I'm always tired though unless I tell myself I need to study :( This was a very informative video; thank you! :)

This was awesome, and extremely helpful !

I love coffee. It is nice to know how it works and how it affects my brain. Thank u.

Thank you for the clear explanation of how caffeine works

These are great! Your videos are digestible and interesting, thanks for making them! I was wondering, what are the odds of you making a video on liver disease?

omg I really like this video! I've never found such informative and beneficial thing Thx for making this one

Great video! Cramming for my presentation in a few hours and this really helped!!

Thank you very much, I have been trying to get to the bottom of my sleep problem for years, soon as I unwind I fall asleep, it is frustrating to loose so much time so regularly

Thanks. Now I know more about caffeine. And because I know more about caffeine I can enjoy caffeine more responsibly.

Very informative. Thanks for uploading. A note though, acetaminophen (paracetamol) is not an anti-inflammatory.

A cup of coffee will not fix a lifetime of bad food choices. Chronic diseases are lifestyle caused. Love the video - very informative.

Wow, i'm drinking a cup of joe right now and this (and the effects of caffeine) are blowing my mind!

Just brilliantly explained. Thanks!

Thank you so much... Loved the way you explained it better than how it is explained at uni 👍

thanka a lot for this video! you explain it a lot better than my book!

Incredible work, thank you so very much!

That’s a very very good explanation how caffeine effects our neurons. Thank you so much for such a detailed information. Great work! 3:53 Amazing!

Excellent presentation!

This explains why I sometimes need an afternoon nap, even after my morning coffee ☕

Excellent, understandable explanations!

Really interesting. Will be showing this vid to my coffee addicted friend!

what a nice presentation

Thank you for such an informative video.

These videos are great! Quality explanations followed by helpful visuals. Could you work on the audio?

Helped me so much with my homework thanks dude

Thank you for this video.

Thanks for explanation.

great video!

Hey pal , good explanation..lot of things to learn..loving it🤝🏻

So caffeine affects me pretty badly. I can have a tiny bit, like a sip of coffee or a cup of green tea, but if I were to drink a whole cup of coffee I would be jittery to the point where my hands would be shaking, heart racing, and I would feel awful. Is that because I have a low tolerance? Maybe I have very few adenosine receptors? I also have anxiety issues and often have trouble falling asleep. Would having fewer adenosine receptors make it more difficult to fall asleep? It almost seems to make sense that if I were to try and slowly increase my caffeine intake (and thus increase the amount of adenosine receptors I have), I would feel better? Just a thought.

@Medicurio

7 жыл бұрын

Lower adenosine receptors, slower breakdown of caffeine, or slight differences in your adenosine receptor structures that cause caffeine to bind even better than adenosine are all possible reasons why you may be super sensitive to caffeine. These are simply due to your genetics. I've also read that people who have anxiety issues are usually more sensitive to caffeine, the idea being that the stimulatory effects of caffeine just exacerbate the anxiety. Because of this, generally it is not advisable for people with anxiety issues to take caffeine. In theory, less adenosine receptors could be a reason why you have trouble sleeping, and your idea could possibly work. However, sleep is very complex and does not just involve adenosine receptors, but many other hormones and neurotransmitters as well that may also be affected by caffeine in unknown ways. You should talk to a doctor if this is worrying you, as well as stopping caffeine intake since it may worsen your anxiety issues.

@iceeyhound3866

5 жыл бұрын

Yep some genetics cause you be sensitive and others can cause you to be more tolerable. A caffeine sensitive person could take 10 mg and feel like it’s was 100 while a caffeine tolerable could take 200mg and only feel like 50.

@osamaaslam1453

4 жыл бұрын

@@iceeyhound3866 true

@bishwastiwari4818

3 жыл бұрын

You stole my words🤣🤣

I got sleep epilepsy because I got addicted to energy drinks in the night. I've started to get better after a whilst - what's the best way of getting the adenosine mechanism back up a gear after being addicted to coffee for so long and possibly still having bits built up etc

really amazingly good video

Excellent content. love it!

Great content bro, really great. 🙏🏻

great video. described well.

Thank you so much!! This video is very helping💕

well done guy ,please keep it up,i learn so much'once more thank you...

thank you.

Ive just had the gnarliest caffeine crash of my life, 3 straight days of sleeping and complete exhaustion fatigue, quitting for sure

Thank you very much for this video!

Hi I came here from Tier zoo. Your content is great!!

good video mate! idk If you are still making these videos, but if you do, can you make one about fat breakdown and weight loss?

Excellent video. Keep it up!

that was really useful . thanks a lot

Regarding how caffeine is a diuretic (6m)... if you drink 8oz of coffee, will you urinate more or less than 8oz of water? i.e. can you become de-hydrated by drinking coffee? Also, any thoughts on the coffee nap? Supposedly, waking up before the caffeine has had a chance to block the adenosine receptors pushes out the time when you would normally start feeling tired again... as sleep pressure increases during the day, the circadian rhythm is balanced by the brain protein hypocretin/orexin, which drives wakefulness... so bathing tnf-alpha / interleukin nuerons induce sleep!

Thanks a lot for this very helpful video! However there's something I don't understand: if caffeine simply prevents more adenosin from binding, shouldn't it be that it makes us feel "not any more tired than we currently are", rather than "less tired than we currently are"?

Dude you're about to get swamped with subs from tier zoo

@SrmthfgRockLee

5 жыл бұрын

;o

man i wish i could make videos this good.

I appreciate your Informative lecture! Side note: I would recommend editing " 7:40 ", as acetaminophen is not an NSAID (Non-Steriodal Anti-Inflammtory Drug).

I really appreciate this video. It is very well done. I was just looking for how caffeine and alcohol is not a good combination; and, instead I caught myself in 8 minutes looking at this video lol #cheers

How's caffeine related to anxiety, is it anxiolytic or anxiogenic ?

Ok, so follow up question. What are the side effects of chronic high adenosine level in the brain due to habitual coffee drinking? Is the average nights sleep sufficient to prevent any ill effects from masking the brains signals to take a nap so it can clean up house?

great job. thank you

So it only takes one week to recover????? I was stalling my productivity to prevent being non-alert in the future. Screw it, I am going take all the caffeine I can buy until I get my degree.

@peacecosmonaut176

6 жыл бұрын

It actually takes 2-3 months to fully recover. First week is worst

@peacecosmonaut176

6 жыл бұрын

I have only been drinking tea for 3 weeks now. It has caffeine but a lot less. Not I am at a point where I don't drink caffeine except from tea, and I don't feel withdrawal on a day without. You can try that.

thanks for sharing

Does anybody know, whether caffeine is nonspecific or specific when binding on to the adenosine receptors?

Thanks!!

Excellent

A Brilliant video on Caffeine and Adenosine - essential to learn about adenosine receptors and SA node if you are a patient with palpitations and arrhythmias (I am one). Increases heart rate, activates your sympathetic nervous system and creates more ectopic beats. Also, understand the metabolism of Coffee - some among us are fast metabolizers, and others may be very slow metabolizers - the effects of caffeine last very long if you are a slow metabolizer (mainly depends on Liver p-cytochrome 450 and genetic factors). If you are patient with palpitations and also a slow metabolizer of caffeine, stay away from caffeine - Period. I am a physician, a patient of SVT, and a slow metabolizer of Caffeine, so this comment comes with personal experience.

@DaveThomson

Жыл бұрын

What's SVT

Great video

I like your video too, just like your other viewers. Great job!

Awesome video!!

Great video ❤

See also the "Caffeine Blues" book.