This was a very helpful lecture, thank you. For when I inevitably revisit this video, or for the sake of others, here are some time stamps: 0:00 Introduction 1:25 DNA Methylation 3:23 CpG Islands 5:42 Role of methylases/different types of DNA methylation 10:56 Methylation and transcription 14:54 Cross talk between methylation and acetylation 17:08 Gene insulators as gene silencers 20:36 Role of an insulator - genomic imprinting 26:19 Protein (histone) methylation 29:52 Coupling histone methylation and DNA methylation 34:10 Heterochromatin and euchromatin silencing

@pranavsood2058

7 жыл бұрын

You didnt state the time stamps?

You are really born to solve life science problems. Thanku

@shomusbiologyofficial

4 жыл бұрын

Thank you. Glad you liked my lectures

excellent talk..complex topic simplified in lucid manner..thanks a lot

this lecture was very helpful...omg..i have a better understanding now...thanks a million!!!

very helpful. thank you for uploading.

Thank you so much for all your videos. Could you make a video on cell signalling, MAPK ie ERK Pathway, please?

I like all of your videos. Very informative and clear. Please could you do a video on CpG oligodeoxynucleotides.

I would like to thank you for the video, which saved my darn important time. saw your video and then did a quick reading... the concept is clear. Thanks, thanks thanks

@shomusbiologyofficial

4 жыл бұрын

Glad to hear that you're getting benefit from my lectures. Please subscribe and share

Very useful video.thank you

Thank u sir.very well explained

Beautifully explain, thank you! :)

just excellent.............very much liked

I find this video very useful. I now understand the topic better. Thank you

@shomusbiologyofficial

7 жыл бұрын

+Oluchi S. Glad it helped

hi how can we download these slides for studying ? i can not find them in the website mentioned above thank you

thank u sir............................

excellent..:) thank you

!!!!! Thank you so much, Sir, this helped me a lot!!!!!

@shomusbiologyofficial

5 жыл бұрын

You're welcome

Lecture was so helpful. Thank you sir.

@shomusbiologyofficial

4 жыл бұрын

You're welcome

Could you please make a video of how to identify the genes promoter region and methylation status in the promoter regions by different software?

video is too good,,thank you sir for this video..

@shomusbiologyofficial

6 жыл бұрын

Glad you liked it

I am a self learner ,familiar with DNA RNA ,RECENTLY CAME ACROSS WITH. METHYLATION which looks very interesting Reviewed a lot of lectures ,understood them partially , now I am left with some questions about why methylation happens ,is that the only factor for cancers What is the difference between. The sequential mutation and methylation ending to mutation any reply is greatly appreciated .an old time student

Would you please explain what is the MBD2 protein size, binding/active sites and how many DNA probes can binde with one MBD2 protein..??

THANK YOU SO MUCH BRO

Thanku sr ....its vry helpful but there is little confusion dat sm CpG get methylate and sm CpG which r located near promoter & enhancer region not methylated,...? Hw is possible?

No one can teach like you..

@shomusbiologyofficial

4 жыл бұрын

Thank you so much for appreciating my efforts

Good morning , a question please, in practice does hypermethylation or hypomethylation predispose to tumors? Thanks

Sir plz make a video on ..... Core and minicore topic

how would this work in the Steven Avery case?

Can you please make a video on dna methylation in bacterium (prevention of self dna from restriction enzymes)

U are best teacher

@shomusbiologyofficial

2 жыл бұрын

Thank you so much for appreciating my efforts

Plz sir make a video on ..... Core and minicore

Good explanation!

Methylation of CpG occurs in CpG poor regions and CpG rich regions (CpG Islands) of the DNA are seemed to be protected from methylation (Lim, Maher 2010). Please clarify if CpG are really hotspots???im confused

Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?

I can't find the ppt for this lecture

thanku sir :)

@ghasipangi3471

6 жыл бұрын

Fariha Jutt gufm

Dna methylation - Turns off transcription Histone acetylation - Turns on transcription But as the Histone methylates, whether the transcription turned on or off ?? What happens when histone prtn methylates??

Wow nice video. .

@shomusbiologyofficial

6 жыл бұрын

You're welcome

Who can help me way to download the ppt in this video

really great...its vrey usefull

very helpful sir

@shomusbiologyofficial

3 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

I love you Suman, that is all.

Hi.. bro... Can you provide the references of your video..?

Read this pls..i just took a tetanus vaccine and it has differential extraction-methylation CAN THIS CHANGE MY DNA ?

Explain how DNA methylation is passed on to daughter cells.

i can not find this material in the web page, can you help me?

Why METHYLATION TAKEN IN 5 carbon position of cytosine, and why not it taken on other nucleotides bases

how to download this ppt? please

Is the euchromatin silencing by HP1 natural or a tumorous phenomenon?

so long explntn..can u plz a share a short video about it

This is difficult and complex 😣

You make easy to understandable topic more complicated.....u must work on yourself

@shomusbiologyofficial

5 ай бұрын

Thank you

God damn this is one long video haha

it is all OK, except that DNA metaylation :-) should be DNA methylation

@bonk8594

3 жыл бұрын

Read this pls..i just took a tetanus vaccine and it has differential extraction-methylation CAN THIS CHANGE MY DNA ?

@zeljkom.svedruzic8406

3 жыл бұрын

@@bonk8594 your DNA is changing every day. Everyday, every cell in your body receives about 10 thousand DNA damages, changes, because you breath oxygen, and aggressive chemical. That is what we call aging :-). Most of the damages get repaired, but if you live long enough the damages will not get repaired, and you will get cancer, or some other disease. Nobel price in chemistry in 2015 was give to the people who described all of that :-)

@bonk8594

3 жыл бұрын

@@zeljkom.svedruzic8406 i can see you know alot about DNA thank you i was scared a lil bit i didnt want the vaccine to change my DNA..so i started reading about DNA methylation and got scared but now i know that DNA changes all the time. What do you think is the best way to prevent cancer you said that DNA gets dameged ? And do you know how to improve your DNA so it dosent damage to much ? Thank you Željko and have a great day !

Please sir Hindi me vedio banaya kijiye

@shomusbiologyofficial

2 жыл бұрын

Okay

@shibupaswan8848

2 жыл бұрын

@@shomusbiologyofficial thank you so much sir

Sir please Indian English bolne se acha hy Hindi mein he lecture deliver karein.

This is difficult and complex 😣