What is Epigenetics? - with Nessa Carey

Ғылым және технология

Why your DNA is not your destiny. Molecular biologist Nessa Carey presents an introduction to epigenetics and explains how it shapes life.
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Nessa's book "The Epigenetics Revolution" is available for purchase now - geni.us/dOYAo
DNA is a vitally important starting point for life, but it's how it's used by cells and organisms that is really important. Epigenetics is a rapidly moving field that has transformed our understanding of how one set of genes can create the masterpiece that is each of us. It's also leading scientists into unexpected and exciting areas such as new ways to treat disease, understand drug addiction or unravel the lifelong consequences of early childhood trauma.
Nessa Carey is a geneticist and author of The Epigenetics Revolution. She has a degree in Immunology, PhD in Virology, was a post-doctoral researcher in Human Genetics, and a senior lecturer at Imperial College London in Molecular Biology. She's also spent 10 years in the biotechnology industry and now works in the pharmaceutical sector.
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Пікірлер: 376

  • @drewfisher1619
    @drewfisher16195 жыл бұрын

    She is an amazing educator. I am grateful to be able to access high quality lecture like this for free.

  • @Ancor3
    @Ancor39 жыл бұрын

    This has to be one of the most interesting presentations I've seen in a while. Absolutely fascinating.

  • @gracegwozdz8185

    @gracegwozdz8185

    5 жыл бұрын

    The most boring presentation. Boring verbal diarrhea and the poor woman is totally confused as to the meaning of Epigenetic. What saves her is the cute accent. She is trully the product of Rockefeller education system. Sad.

  • @Pseudify

    @Pseudify

    3 жыл бұрын

    @@gracegwozdz8185. Well that’s a rather pretentious comment, given that she is an expert in epigenetics. Perhaps you would care to enlighten us with your wisdom on where she went wrong?

  • @elenif.vlachou9126

    @elenif.vlachou9126

    2 жыл бұрын

    @@Pseudify david it seems worthless showing any sort of interest in these comments since it only demonstrates her mindset..or rather choice of one.

  • @letmecomentalready
    @letmecomentalready6 жыл бұрын

    I'm here after reading her book "The Epigenetics Revolution" to learn about possible updates in the field since it came out a few years ago. I would highly suggest the book to anyone as I had no background knowledge other than high school Biology and yet every chapter would blow me away.

  • @dannyholley
    @dannyholley8 жыл бұрын

    Imagine the world we'd craft for ourselves if all science was communicated so brilliantly and unpretentiously. Bravo.

  • @rael6974

    @rael6974

    7 жыл бұрын

    Daniel Holley agreed

  • @zaimahbegum-diamond1660

    @zaimahbegum-diamond1660

    6 жыл бұрын

    Daniel Holley 🍷. Drink to that.

  • @RobinObinray

    @RobinObinray

    5 жыл бұрын

    Imagine the world ww'd craft for ourselves, if we just understood that our physical reality is a collective subjection/egregore structure

  • @TheJoaovicente

    @TheJoaovicente

    3 жыл бұрын

    The problem is that not enough people are hearing it. The communicator is not the problem

  • @cerambyx-8
    @cerambyx-8 Жыл бұрын

    The 8 proteins are histones and form a protein complex known as a histone octamer, which is spool shaped (marshmallows were used in the demonstration). The 8 proteins in the histone octamer are actually 2 copies of 4 proteins, H2A, H2B, H3 and H4. DNA wraps around the histone octamer known as a nucleosome and they form chains like beads on a string making up chromatin. A nucleosome can be defined as a small length of DNA wrapped around eight histone proteins. The key difference between chromatin and nucleosome is that chromatin is a whole structure of complex DNA and proteins while nucleosome is a basic unit of chromatin. The beads on a string make up something called euchromatin or open chromatin that is enriched in genes and active under transcription (transfer of genetic instructions) which is why it is so important in epigenetics and changes in the phenotype (physical traits- e.g. appearance).

  • @sihintas5336
    @sihintas53366 жыл бұрын

    Amazing lecture! She takes complicated information and breaks it down into interesting info using jokes, history, stories, movies and more! Brilliant!

  • @arijkhan3706
    @arijkhan3706 Жыл бұрын

    I absolutely have to watch this again and again. She has few equals in terms of clarity and lucidity. I am going to forward this to my entire family. One of the most interesting topics explained by one of the best presenters.

  • @bonniebabird
    @bonniebabird6 жыл бұрын

    Finally! we have an exciting, summation of information about this field! Thank you for posting. Best explanations, clear analogies and diagrams I've ever found .I've been interested in this field for many years, though no longer a formal student. This great video brings me up to date.

  • @TheAIEpiphany
    @TheAIEpiphany3 жыл бұрын

    Superb presentation skills! Just the right amount of humor, story telling and information transfer to resonate with almost everyone.

  • @Slava-om1sz
    @Slava-om1sz3 жыл бұрын

    This was the the biggest eye opener for me in the past years. This knowledge opens so many doors.

  • @Dr10Jeeps
    @Dr10Jeeps5 жыл бұрын

    Wonderful talk! I can't get enough of these Royal Institution lectures.

  • @mariusciobanu2025
    @mariusciobanu20257 жыл бұрын

    This is absolutely incredible! I'm completely floored.

  • @marcusraad9708
    @marcusraad97086 жыл бұрын

    You make it so easy to absorb! You're an amazing professor! Thank you!

  • @tafrinadubois2290
    @tafrinadubois22908 жыл бұрын

    fantastic delivery of a fantastically fascinating subject -- thoroughly enjoyable, especially being a twin myself.

  • @ayetreyyy
    @ayetreyyy4 жыл бұрын

    Reading her book now after watching this a few months ago! Brilliant and exciting literature! Epigenetics is such a fascinating field! This is telling us how we can affect our future progeny!

  • @Anonymous-zy3lh

    @Anonymous-zy3lh

    4 ай бұрын

    Name of the book?

  • @ayetreyyy

    @ayetreyyy

    4 ай бұрын

    The Epigenetic Revolution by Nessa Carey@@Anonymous-zy3lh

  • @betulipekozturk8056
    @betulipekozturk80563 жыл бұрын

    I'm currently reading 'Junk DNA' and I can assure you that it is really informative and it doesn't bore you. As a first-year medical college student, it is really helpful to visualize the epigenetic differentiation. Examples she gives are hilarious.

  • @an-tm3250

    @an-tm3250

    3 жыл бұрын

    God does not make junk. Scientists don't know it's purpose so it is automatically relegated to the junk heap.

  • @deloriseconover1476
    @deloriseconover1476 Жыл бұрын

    Absolutely brilliant presentation. I just wanted to learn a little for my pathophysiology class and left amazed!

  • @calebsmit9731
    @calebsmit97319 жыл бұрын

    We really need epigenetics to advance as a civilization, some might even say it's... nessacarey

  • @annanoel-roduner6402

    @annanoel-roduner6402

    7 жыл бұрын

    Yes - but we need the right stimulus; and that can come only from the WORD of GOD, found in the Bible. We could easily deteriorate into barbarism, especially if we start copying animals, instead of reminding ourselves that we are made in the image of GOD.

  • @tjclarke238

    @tjclarke238

    6 жыл бұрын

    Eyes Open!

  • @AshleyNichole123

    @AshleyNichole123

    6 жыл бұрын

    Caleb Smit I see what you did there 😂😂😂👍

  • @jg4392

    @jg4392

    6 жыл бұрын

    Amazing

  • @letmecomentalready

    @letmecomentalready

    6 жыл бұрын

    Well done

  • @TreyPrankz
    @TreyPrankz4 жыл бұрын

    SO intriguing! How the things, habits, nutrients we do now can genetically modify our future progeny!

  • @Enonymouse_
    @Enonymouse_4 жыл бұрын

    Fascinating subject, i'd never heard of this subject before. Props to the lecturer for giving such an entertaining lecture on a complicated subject! I hope you have her back again.

  • @CFB6855
    @CFB68558 жыл бұрын

    What a great presentation. Loved it!

  • @blackdiamond3296
    @blackdiamond32965 жыл бұрын

    Thank Nessa, it is my pleasure to attend your tutorial today at MCRS

  • @renupathak4442
    @renupathak44422 жыл бұрын

    How fortunate that I in india can access this extraordinary lecture delivered so well and generously sprinkled with humor. Great contribution to science education. Have her books which are so precious for me

  • @edurbrow
    @edurbrow5 жыл бұрын

    So well done. Answered questions I didn't know I had.

  • @George_Varvoutis
    @George_Varvoutis5 жыл бұрын

    Extremely clarifying presentation, her book is also a gem of science communication...

  • @castleofcostamesa8291
    @castleofcostamesa82916 жыл бұрын

    Thank you for the very fascinating and lively lecture! I love it!

  • @dalelund3100
    @dalelund31004 жыл бұрын

    What an incredible communicator. Science needs many more with her skill.

  • @aniccadance13
    @aniccadance138 жыл бұрын

    Thank you for uploading. Very interesting☺️

  • @agnishadatta715
    @agnishadatta7153 жыл бұрын

    Such an amazing talk ma'am..really really loved it to the core...

  • @eloisegibson2010
    @eloisegibson20106 жыл бұрын

    I really enjoyed this talk thank you

  • @JurijFedorov
    @JurijFedorov8 жыл бұрын

    She destroys it. Good talk. Her book gets a bit complicated at times but this is spot on.

  • @matthewandremink3726
    @matthewandremink37263 жыл бұрын

    I would very much like to hear professor Carey's view on the mRNA vaccines and their potential influence on the human epigenetics!

  • @lucasmin3757
    @lucasmin3757 Жыл бұрын

    What a BRILLIANT educated and informative video, love it!

  • @JackT13
    @JackT133 жыл бұрын

    Her book, The Epigenetics Revolution, is fantastic by the way.

  • @hanskloss7726
    @hanskloss77265 жыл бұрын

    Fascinating. Interesting material and very well done presentation.

  • @BartvandenDonk
    @BartvandenDonk4 жыл бұрын

    Fascinating, fascinating, fascinating. Absolutely fascinating.

  • @figueiredolamofopa
    @figueiredolamofopa3 жыл бұрын

    Outstanding presentation. Very clear. Congratulations!!!!

  • @user-ey4rc5tu4t
    @user-ey4rc5tu4t4 жыл бұрын

    thank you so very much. This is wonderful. I am glad to say I was wrong.

  • @67lomeli
    @67lomeli5 жыл бұрын

    Excellent; thanks for your great work.

  • @keithcorodimas8093
    @keithcorodimas80934 жыл бұрын

    First-rate presentation on this topic. Thanks very much.

  • @arunsinghamahapatra2918
    @arunsinghamahapatra29183 жыл бұрын

    First time i am watching her. Today I purchased her book " The Epigenetics Revolution. Not my subject. But i have interest. Happy to watch. Thank you Madam. Regards

  • @EMPNETWORKS
    @EMPNETWORKS4 жыл бұрын

    excellent video to describe epigentics, its a subject i wanted to write on next for my blog.

  • @andrewsheehy2441
    @andrewsheehy24413 жыл бұрын

    Really good - packed with interesting insights and good for the RI to tackle what is admittedly a controversial topic.

  • @anananwar
    @anananwar10 ай бұрын

    So much to love about this. Even all these years later rewatching it still give me all those uh-huh feelings.

  • @shamthorani464
    @shamthorani4647 жыл бұрын

    all i can give to this lady is 🙇 Respect! amaizing

  • @KIMMYSSONG
    @KIMMYSSONG2 жыл бұрын

    Extraordinary lecture, thank you. blessings, Kimmy

  • @ahimsa79
    @ahimsa797 жыл бұрын

    Wow, really enjoyed this lecture. Any sociological/psychological applications or assumptions linked to these findings? ie, poverty, oppression, consistent trauma etc...

  • @lxMaDnEsSxl
    @lxMaDnEsSxl8 жыл бұрын

    Its all actually very simple to understand when you grasp what is actually occurring in terms of epigentics and how we are products of evolution - genetics and events - what we do and what is done to us

  • @sagarupreti2029
    @sagarupreti20298 жыл бұрын

    Its really a great lecture never had idea management student can enjoy science.

  • @35sherminator
    @35sherminator4 жыл бұрын

    What a spectacular lecture!

  • @anilsalick
    @anilsalick Жыл бұрын

    Outstanding presentation

  • @katilynalmeida4062
    @katilynalmeida40624 күн бұрын

    Thanks for making it easy to understand

  • @engjoliesoleil4571
    @engjoliesoleil45718 жыл бұрын

    thank you for sharing

  • @vazap8662
    @vazap86625 жыл бұрын

    What a brilliant lady!

  • @everlearnercaveman3990
    @everlearnercaveman3990 Жыл бұрын

    Interesting topic, delightful presentation.

  • @ernestorojo885
    @ernestorojo8853 жыл бұрын

    A great way to transmit knowledge

  • @KipIngram
    @KipIngram2 жыл бұрын

    Great presentation. And she's just a natural. Very entertaining. 🙂

  • @DocSeville
    @DocSeville2 жыл бұрын

    Well worth the listen! Thank you mame

  • @ComfortLining
    @ComfortLining5 жыл бұрын

    The DNA code starts from the same then the coding changes but the DNA coding is all the same in the start of the code. Example is like computer coding. Code DNAMOMDAD then add on EYESLASHES or DNADADMOM Liver etc etc. It's so damn AMAZING

  • @rael6974
    @rael69747 жыл бұрын

    Will be buying her book

  • @sihintas5336
    @sihintas53366 жыл бұрын

    I'd love her as a professor for all my bio classes

  • @sabersubrati2898
    @sabersubrati28986 жыл бұрын

    She's great ! ❤️

  • @frankboase4362
    @frankboase43624 жыл бұрын

    Fantastic, Love the energy your brought to your book The Epigenetics Revolution" I wonder if you can see the link between Epigenetics and Buddhist Karma. (They are both very deep matters) Any Buddhist's out there pls read this and think....

  • @davidbroadfoot4214
    @davidbroadfoot42144 жыл бұрын

    well done and entertaining presentation on the topic of epigenetics

  • @jackt3356
    @jackt33569 жыл бұрын

    Great talk

  • @rohitchat5538
    @rohitchat55382 жыл бұрын

    Amazing teaching learning knowledge about the modification and genetic codes sequence of genome 🙏🙏👏👏❤️❤️💐💐

  • @jace8575
    @jace85757 жыл бұрын

    Great delivery

  • @kevinmerrell9952
    @kevinmerrell9952 Жыл бұрын

    An awesome presentation.

  • @markbricklin3096
    @markbricklin30966 жыл бұрын

    Great lecture!

  • @lilianamendez9041
    @lilianamendez90412 жыл бұрын

    Just wonderful! 🧬

  • @Pyriold
    @Pyriold9 жыл бұрын

    Great video! I can imagine that practical living advice can come from epigenetics, like how i can change my own in a positive way. Any chance to get that?

  • @Stabacs

    @Stabacs

    9 жыл бұрын

    Hmm, for example if you don't smoke, your epigenetics for requesting more nicotin don't get switched on and your kids probably won't smoke either. Does this answer your question?

  • @Explorerlora
    @Explorerlora2 жыл бұрын

    All I want to do right now is eat strawberry laces and jelly tots.....on a serious note, this lecture was FASCINATING - thank you Nessa for your fabulous energy teaching this

  • @PeppoMusic

    @PeppoMusic

    Жыл бұрын

    Oh no! Your exposure to the video (environmental factor) has changed your mental content, which could change your behaviour which could change your epigenetics, which could change the future of your offspring? Good grief this rabbit hole goes deep...

  • @vitaliy8
    @vitaliy82 жыл бұрын

    Thank you for great presentation! Ive been thinking about one question. In the "bullied" mouse experiment epigenetics were not transmitted but in cherry blossom smell, the fear was transmitted to offspting due to epigenetics. Is that a contradiction that in some cases environmental quality gets passed in others not?

  • @kbeetles
    @kbeetles7 жыл бұрын

    Brilliant talk, engaging presentation..... - i feel for the mice, though.....

  • @estherganzon6700
    @estherganzon67004 жыл бұрын

    THANK you now I kind of get it

  • @altareggo
    @altareggo5 жыл бұрын

    This is EPIC!! Lamarck is partly vindicated, but that's the least of it. We are more "adjustable" than we realized before, and some of these adjustments can be passed on to the next generation. LOTS to think about, even for the ordinary person in the street who wants their offspring to be healthy and talented.

  • @krtdhi7007
    @krtdhi70076 жыл бұрын

    This was so interesting . Thank you very much

  • @Sublimeoo
    @Sublimeoo4 жыл бұрын

    Crocodiles and Dinosaurs share a common ancestor, crocs are not descended directly from dinosaurs. Brilliant talk, especially your dna analogies

  • @samuelgoodman2770
    @samuelgoodman2770 Жыл бұрын

    Absolutely love her x

  • @patrickboudreau3846
    @patrickboudreau38463 жыл бұрын

    What a great woman !

  • @claritas6557
    @claritas65578 жыл бұрын

    One of the best speakers I've seen on this channel. We need more sweets-based analogies in scientific discourse.

  • @christopherdahl992

    @christopherdahl992

    6 жыл бұрын

    Andri Eiríksson something with chocolate in it would be nice.

  • @gracegwozdz8185

    @gracegwozdz8185

    5 жыл бұрын

    She is long-winded and boring.

  • @teemadarif8243
    @teemadarif82434 жыл бұрын

    Actually I wouldn't say it's a new field of biology but rather one we just found out about lol ... super interesting

  • @lovinglife3847
    @lovinglife38472 жыл бұрын

    It would be interesting to know what foods could turn on or turn off gene expression in humans and the outcome of the change.

  • @TheJamesRedwood
    @TheJamesRedwood6 жыл бұрын

    Always love a new RI video, always get annoyed about the huge difference between the sound level of the title credit and the lecture itself.

  • @TheRoyalInstitution

    @TheRoyalInstitution

    6 жыл бұрын

    We've actually fixed this! We hope. For the last month or so, we've been making sure that the volume of the ident is less than half of what it was before. This video is slightly older so will still try to blow your eardrums out, but hopefully you won't run into this with any of our newer stuff. Do let us know if it's still too loud though.

  • @anonymousfigure37
    @anonymousfigure378 жыл бұрын

    If for whatever reason molecular biology doesn't work out for Nessa Carey, she can surely do well as a stand-up comedian! Very entertaining and enlightening talk!

  • @petertvp8039
    @petertvp80395 жыл бұрын

    Would a babies/child’s dna receptors be affected/changed by a traumatic birth experience? Ie would a more ‘relaxed’, non stressfull/traumatic birth experience have a better outcome for a child later in Life?

  • @stellahypnotherapist1420
    @stellahypnotherapist14207 жыл бұрын

    Brilliant Thanks

  • @RoniTaylorWatson
    @RoniTaylorWatson6 жыл бұрын

    fantastic - thank you so much for posting

  • @GoDxism
    @GoDxism4 жыл бұрын

    There's one thing I am confused about. So if the histones are wrapped around our genes, and say you become a smoker (but no one in your family tree extending hundreds of years smoked) and the chemical tag is added to the histones to make that gene become 'expressed', does that mean that the 'smoker gene' is predetermined? In other words, will I have a 'smoking gene' by default that is turned off, but will only be turned on if I smoke?

  • @bomaite1
    @bomaite12 жыл бұрын

    How do you determine if a characteristic is truly determined epigenetically or if there is some other factor, like the chemicals given off by gut bacteria, or some changes triggered by viruses, or some other mechanism I can't think of just now?

  • @audreylane8747
    @audreylane87476 жыл бұрын

    Her explanation about stress and childhood experiences is interesting. I was very fortunate because I had a pretty stable, happy childhood with a protective father who thought I was a piece of gold and a loving mother who was a great nurturer. Even though I was overweight and constantly bullied, I retained my happiness and confidence that has allowed me to be successful in my career and personal life. I am married to a great person, but have noticed that he is usually depressed and insecure. His sister has finally admitted that out of 6 siblings, he was given the least amount of attention and praise and was often criticized. This was needed information for me as his spouse because I can now understand why he rather that I remain overweight. When I lost most of my weight, my husband would exhibit jealousy and insecurity. He would retreat into his den, and not talk to me. Now that I have lost my mobility, my husband seems happy which I find hurtful, but with theory, I have learned that he feels empowered because he feels no one will find me attractive and he can now be the only person I can depend

  • @complexelectra

    @complexelectra

    6 жыл бұрын

    Emotional abuse and neglect to keep you overweight to maintain his own well-being. Understanding his behaviour should not excuse it.

  • @lilysunshine3447
    @lilysunshine34475 жыл бұрын

    Does anyone know if algorithms were used to define theoretical epigenetic research concepts individually and where to find the results? Im into pattern recognition.

  • @ScienceGeek23
    @ScienceGeek236 жыл бұрын

    Mary Poppins is awesome at science!!

  • @martoantoniuk
    @martoantoniuk9 жыл бұрын

    I would love to know the other side of the experiment, where mice with caring mothers were put with not so caring mothers and then had a traumatized life. What happens when a mice with a not so caring mother is put with a caring mother? They get better? They get "normal"? They don't get better? I don't know where to ask this question :( If someone could give me a clue, i would be very grateful.

  • @xapemanx
    @xapemanx9 жыл бұрын

    brilliant

  • @marilynvillanueva7333
    @marilynvillanueva7333 Жыл бұрын

    We need more real scientist dedicated to discover and instructs and inform us broadly . Thank Madam

  • @user-sw3ro6hh3j
    @user-sw3ro6hh3j6 жыл бұрын

    so the dna is still the same, just the little "jelly" dots that attach to the dna that a person might develop while interacting with his environment? But what's the mechanism behind the epigenetic changes (my guess it's still the DNA that gives instructions to the protein to make the epigenetic changes)...I mean could epigenetic changes lead to the eventual creation of a new species? Thinking more ahead, how much can we augment our body through tweaking the expression of various genes, like would we be able to grow a new arm through epigenetics, or is that sort of mutation still dependent on the manipulation of DNA? You say that the little "jelly" dots, sorry I forget the exact term you used for those molecules, attach to the genes and affect their individual expression, but how many genes do we have, what are each gene's functionalities, how does each gene interact with each other, and what explains the difference between us and a chimp or a bird or something? God damn it get more research done lady! My back is hurting from watching all these Royal Institute videos laying on my bed at 1AM in California, and I also don't have a car to go to work tomorrow morning, and I think it'd be really nice if DNA technology can allow me to grow a pair of wings! (though the image might be a bit grotesque) so I can fly around to work and buy groceries or something...

  • @bomaite1
    @bomaite12 жыл бұрын

    Are the 8 proteins in the nucleus of the same composition in everyone, or are they widely differing?

  • @nithyaerottuperiyar4273
    @nithyaerottuperiyar42736 жыл бұрын

    Nithya Intellectual, Kindle the mind to know more about epigenetics Thanks

  • @Zuaachen
    @Zuaachen6 жыл бұрын

    How would you explain a Monarch Butterfly’s migration from central Mexico to Canada and back to the same tree? There are four generations in a year. The migration is a year long. The returning butterfly is the great grandchild of the one that left the overwintering tree. How is the information passed on through the generations?

  • @luavasconcelos1637

    @luavasconcelos1637

    5 жыл бұрын

    Alex Chen Birds rub themselves against certain trees to leave a trace, so that might be it.

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