In this Research Spotlight episode, Prof. Connor Delaney shares his work on investigating the non canonical mechanism of a copper-based cross-coupling reaction from the Hartwig group.
Key reference:
Science 2023, 381, 1075-1085.
doi.org/10.1126/science.adi9226
Additional references (in order of appearance):
Louie, Hartwig Tet. Lett. 1995, 36, 3609-3612
Guram, Rennels, Buchwald, Angew. Chem. Int. Ed. 1995, 34, 1348-1350
Ullmann, Sponagel, Chem. Ber. 1905, 38, 2211-2212
Goldberg, Chem. Ber. 1906, 39, 1691-1692
OPRD, 2014, 18, 215-227
Bhunia, Pawar, Kumar, Jang, Ma Angew. Chem. Int. Ed. 2017, 56, 161.
Relevant review: C. Sambiago, S. P. Marsden, A, J. Black, P. C. McGowan Chem. Soc. Rev. 2014, 43, 3525-3550.
J. W. Tye, Z. Weng, A. M. Johns, C. D. Incarvito, J. F. Hartwig, J. Am. Chem. Soc. 2008, 130, 9971-9983.
R. Giri, A. Brusoe, K. Troshin, J. Y. Wang, M. Font, J. F. Hartwig, J. Am. Chem. Soc. 2018, 140, 793-806
J. Org. Chem. 2017, 82, 4964-4969; Angew. Chem. Int. Ed. 2021, 60, 8203-8211;
J. Am. Chem. Soc. 2023, 145, 6966-6975; ACS Catal. 2020, 10, 10495-10499
Singleton: J. Am. Chem. Soc. 1995, 117, 9357; Vetticatt: ACS Catal. 2021, 11, 60.