Synthesis Workshop is a channel dedicated to presenting advances in synthetic organic chemistry in an open-access format with concise explanations and clear visuals. Created by Matthew Horwitz, Ph.D.
Amazing job! Seems like a very useful methodology and the Swern type oxidation was really cool
@aidanlooby2 күн бұрын
That was a great video! Well done 🔥
@campbeja0013 күн бұрын
Excellent well executed lecture. Excellent practical research....can see where this is leading
@K0wface3 күн бұрын
I've always wondered how di-, tri-, or tetrapeptides and their R-groups may play a role in RNA synthesis and vice versa.
@aidanlooby3 күн бұрын
I did not know a lick of flow chemistry, this was a fantastic introduction, thank you Gabriele and Matt!
@vmodsm9 күн бұрын
where can I read the research the guy on the right is doing?
@DUIofPhysics9 күн бұрын
Great Lecture. Really interesting! I'm not at all a chemist, coming from an engineering side with an interest in Fluidics and Automation. I'd love to get involved in designing setups and equipment for this kind of field!
@muhangiphilemon358811 күн бұрын
I know Dr Anna Davis UVA
@aritrabarman876313 күн бұрын
Thank you very much for this valuable and essential lecture. I have a question:- Suppose we have a compound Ph-CH(OH)-CH2OH (containing secondary alcohol at the benzylic position and primary alcohol in the terminal position). I want to selectively oxidize that primary alcohol into aldehyde. Which protecting group should I use to protect that benzylic secondary alcohol selectively?
@PlexusTen14 күн бұрын
Great talk!
@anthonycohen77116 күн бұрын
Thanks for the great talk!
@dowonahn671416 күн бұрын
What wonderful explanation! Thanks!😁
@Fili22919 күн бұрын
At 23:40 You lost an oxygen atom in the cycle
@siddheshbachhav743020 күн бұрын
Thank you❤
@go_yixiong21 күн бұрын
Nice! Well done!💯
@KhadeijaAbd9221 күн бұрын
What clear explanation ❤
@shubhamdhal58921 күн бұрын
Nice explanation.
@siddheshbachhav743022 күн бұрын
Thank you...
@aidanlooby23 күн бұрын
Great video! Well done to Tracy!
@ligmabaldrich48524 күн бұрын
Been waiting for this video for a while - thanks for the well-explained lecture!!
@UniCorneliusfan2124 күн бұрын
Light magic I think I’m gonna need a course on stereoselectivity of some reactions e.g metal allylations etc.
@annaberlin400827 күн бұрын
✨✨Thank you for sharing!💖💖
@mario97br29 күн бұрын
Yannik could turn into an ASMR sleep reader xD good work
@aidanloobyАй бұрын
This research spotlight was superb! I am looking to use this strategy for our new total synthesis episode coming soon!
@UniCorneliusfan2128 күн бұрын
Good luck with that substrate scope though, it seemingly hasn’t been explored too much seemingly, it’s sort of like applying a C-H oxidation without any computational studies on the exact substrate your gonna perform it on so many things could go wrong in my opinion
@UniCorneliusfan21Ай бұрын
Naw we got olefin chainwalking catalysis for remote linear functionalisation and now THIS?!!!??? Wth am I looking at carbonyl isomerization how is this even possible!???!!?!! The fact it had been discovered in 1923 but up until now its potential is being realised…
@aidanloobyАй бұрын
Woooooo!! 🎉🎉 Anna is an incredible person and chemist. This was such a fun episode!
@aidanloobyАй бұрын
Great video. Well done Matt and thanks to Peter for an awesome problem set!
@potropiratacordobesАй бұрын
Excelente video!!!! Muchas gracias!!!
@SIVAKUMARG-vk6sbАй бұрын
An excellent talk and a wonderful topic...well done
@samjo475Ай бұрын
would it be possible to share the chemdraw and the presentation?
@UniCorneliusfan21Ай бұрын
Would be nice if there were also some less well known transformations of epoxides
@go_yixiongАй бұрын
30:38 structure of the Thiourea
@GET_YOUTUBE_VIEWS_m021Ай бұрын
Your videos help me get over my stressful day
@go_yixiongАй бұрын
9:55, why the note for the first example writes " *accessible* benzylic C-H bonds" ???
@conorloynd458Ай бұрын
Well done! Somewhere in Texas, James Tour is fuming about this.
@TheJosetiagoАй бұрын
Three years late but... very cool total synthesis !! Thank you Dr. Raluy !
@FK-ng2gfАй бұрын
and why Trisyl? Never heard of that one either. I heard of triflylazide, tho. maybe this one would have worked the same?
@brandonmiller855910 күн бұрын
Trisyl azide was discovered by Dave Evans as the now "industry standard" for azide transfer reactions. Well over 100 publications have used these exact methods. Trifyl azide and nearly all other sulfonyl azides prefer to react in a "diazo transfer" (net N2 addition) rather than "azide transfer" (net N3 addition). I suggest checking out the original Dave Evans paper on this react. It's quite comprehensive.
@FK-ng2gfАй бұрын
I never heard of nickelboride. Why is that species needed? Does it catalyze the reaction? I don't quite get it.
@brandonmiller855910 күн бұрын
Yes, it catalyzes the reaction! In the presence of just NaBH4 the nitro group is not reduced. Nickel and Cobalt boride were discovered in the mid-1900s for their utility as hydrogenation catalysts. They slowly gained traction as reducing agents and are now fairly standard for several reductions (NO2, CN, etc).
@craigsmith941Ай бұрын
this was excellent. Carbonyl reduction is a hard topic to make interesting and you smashed it. Well done !!
@UniCorneliusfan21Ай бұрын
James Tour reference
@AlphaNumeric123Ай бұрын
Where? I didn't catch it
@UniCorneliusfan21Ай бұрын
C-H activation my beloved
@AlphaNumeric123Ай бұрын
C-H functionalization is now widely used term, though I’m used to hearing C-H activation myself. I think functionalization is a better term though
@aidanloobyАй бұрын
Fantastic video, one of my favorite concepts from my organic reactions and synthesis. Thanks to Xiafeng for putting this together and Thomas for problem set and of course Phillip for great content! Congrats to all!
@collared-crowАй бұрын
Why not include this paper: 10.1021/acsmedchemlett.3c00114
@MujiboyАй бұрын
I am assuming no access
@go_yixiongАй бұрын
26:21 NaBH4
@alimansour5945Ай бұрын
“An overview of the cycloaddition chemistry of fulvenes and emerging applications” from Beilstein JOC, 2019 pg 2120 is a publication that describes a very similar transformation! The proline catalyst is eliminated after cyclization
@aidanloobyАй бұрын
PREACH I need to read this! Thank you for sharing 🙏🏻🙏🏻
@AlphaNumeric123Ай бұрын
This was a great listen. So great I decided to watch on replay, and now I can say it’s an even better watch! She’s a great communicator
Пікірлер
Amazing job! Seems like a very useful methodology and the Swern type oxidation was really cool
That was a great video! Well done 🔥
Excellent well executed lecture. Excellent practical research....can see where this is leading
I've always wondered how di-, tri-, or tetrapeptides and their R-groups may play a role in RNA synthesis and vice versa.
I did not know a lick of flow chemistry, this was a fantastic introduction, thank you Gabriele and Matt!
where can I read the research the guy on the right is doing?
Great Lecture. Really interesting! I'm not at all a chemist, coming from an engineering side with an interest in Fluidics and Automation. I'd love to get involved in designing setups and equipment for this kind of field!
I know Dr Anna Davis UVA
Thank you very much for this valuable and essential lecture. I have a question:- Suppose we have a compound Ph-CH(OH)-CH2OH (containing secondary alcohol at the benzylic position and primary alcohol in the terminal position). I want to selectively oxidize that primary alcohol into aldehyde. Which protecting group should I use to protect that benzylic secondary alcohol selectively?
Great talk!
Thanks for the great talk!
What wonderful explanation! Thanks!😁
At 23:40 You lost an oxygen atom in the cycle
Thank you❤
Nice! Well done!💯
What clear explanation ❤
Nice explanation.
Thank you...
Great video! Well done to Tracy!
Been waiting for this video for a while - thanks for the well-explained lecture!!
Light magic I think I’m gonna need a course on stereoselectivity of some reactions e.g metal allylations etc.
✨✨Thank you for sharing!💖💖
Yannik could turn into an ASMR sleep reader xD good work
This research spotlight was superb! I am looking to use this strategy for our new total synthesis episode coming soon!
Good luck with that substrate scope though, it seemingly hasn’t been explored too much seemingly, it’s sort of like applying a C-H oxidation without any computational studies on the exact substrate your gonna perform it on so many things could go wrong in my opinion
Naw we got olefin chainwalking catalysis for remote linear functionalisation and now THIS?!!!??? Wth am I looking at carbonyl isomerization how is this even possible!???!!?!! The fact it had been discovered in 1923 but up until now its potential is being realised…
Woooooo!! 🎉🎉 Anna is an incredible person and chemist. This was such a fun episode!
Great video. Well done Matt and thanks to Peter for an awesome problem set!
Excelente video!!!! Muchas gracias!!!
An excellent talk and a wonderful topic...well done
would it be possible to share the chemdraw and the presentation?
Would be nice if there were also some less well known transformations of epoxides
30:38 structure of the Thiourea
Your videos help me get over my stressful day
9:55, why the note for the first example writes " *accessible* benzylic C-H bonds" ???
Well done! Somewhere in Texas, James Tour is fuming about this.
Three years late but... very cool total synthesis !! Thank you Dr. Raluy !
and why Trisyl? Never heard of that one either. I heard of triflylazide, tho. maybe this one would have worked the same?
Trisyl azide was discovered by Dave Evans as the now "industry standard" for azide transfer reactions. Well over 100 publications have used these exact methods. Trifyl azide and nearly all other sulfonyl azides prefer to react in a "diazo transfer" (net N2 addition) rather than "azide transfer" (net N3 addition). I suggest checking out the original Dave Evans paper on this react. It's quite comprehensive.
I never heard of nickelboride. Why is that species needed? Does it catalyze the reaction? I don't quite get it.
Yes, it catalyzes the reaction! In the presence of just NaBH4 the nitro group is not reduced. Nickel and Cobalt boride were discovered in the mid-1900s for their utility as hydrogenation catalysts. They slowly gained traction as reducing agents and are now fairly standard for several reductions (NO2, CN, etc).
this was excellent. Carbonyl reduction is a hard topic to make interesting and you smashed it. Well done !!
James Tour reference
Where? I didn't catch it
C-H activation my beloved
C-H functionalization is now widely used term, though I’m used to hearing C-H activation myself. I think functionalization is a better term though
Fantastic video, one of my favorite concepts from my organic reactions and synthesis. Thanks to Xiafeng for putting this together and Thomas for problem set and of course Phillip for great content! Congrats to all!
Why not include this paper: 10.1021/acsmedchemlett.3c00114
I am assuming no access
26:21 NaBH4
“An overview of the cycloaddition chemistry of fulvenes and emerging applications” from Beilstein JOC, 2019 pg 2120 is a publication that describes a very similar transformation! The proline catalyst is eliminated after cyclization
PREACH I need to read this! Thank you for sharing 🙏🏻🙏🏻
This was a great listen. So great I decided to watch on replay, and now I can say it’s an even better watch! She’s a great communicator