Boosting MITOCHONDRIAL Health in Aging Adults [2023]

Ғылым және технология

It’s all about the mitochondria! What they are, how they go downhill, how it impacts aging and what you can do about.
I’ve talked a lot about the mitochondria on this channel before, but not for awhile now. And a lot has happened in the field. So, it’s time for a new video, filling you guys in on all the latest news. In addition to recovering old ground, we’ll be taking a look at some new developments in mitochondria and some new understanding.
The mitochondria are critical for good health. The make ATP, the universal energy source, but they can go into decline as we age, resulting in mitochondrial dysfunction…one of the hallmarks of aging.
But there are several new therapies in development and we talk about a couple of them in this video. So, let’s dive in.
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Studies used in this video:
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action:
pubmed.ncbi.nlm.nih.gov/32273...
Mitochondrial protein interaction landscape of SS-31:
www.pnas.org/doi/10.1073/pnas...
The Power & Potential of Mitochondrial Transfer:
pubmed.ncbi.nlm.nih.gov/37938...
Mitochondrial Makeover: Unlocking the Path to Healthy Longevity:
pubmed.ncbi.nlm.nih.gov/37902...
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Chapters & Timestamps:
Intro: 00:00
What Are Mitochondria: 00:29
Understanding Energy Metabolism: 01:51
Mitochondrial Dysfunction: 03:19
How Mitochondrial Dysfunction Impact Aging: 05:23
Boosting Mitochondrial Health: 06:29
Peptide SS-31: 09:01
Mitochondrial Transfer: 12:53
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Social Media:
Facebook: / lancehitchings
Instagram: / lancehitchings
Twitter: / lancehitchings
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Пікірлер: 74

  • @md82892
    @md828927 ай бұрын

    This video discusses the crucial role of mitochondria in aging and the latest advancements in treating mitochondrial dysfunction. Here's a summary: 1. **Introduction to Mitochondria**: Mitochondria are tiny organelles in almost every cell, responsible for creating ATP, the energy source for cells. They are more abundant in high-energy tissues like the heart, liver, brain, and muscles. Mitochondria have their own DNA (mtDNA), which is highly susceptible to damage and plays a significant role in aging. 2. **Mitochondrial Dysfunction and Aging**: Mitochondrial dysfunction is a key factor in aging and related chronic diseases. It involves decreased ATP production, leading to various age-related diseases like metabolic syndrome, cancer, cardiovascular diseases, and neurodegenerative disorders. 3. **Mitochondrial Health**: Maintaining mitochondrial health is essential for extending health span. Early detection of mitochondrial damage is crucial as it's reversible at initial stages. Mitochondrial health depends on efficient ATP production, the number of efficient mitochondria in a cell, and effective removal of dysfunctional mitochondria. 4. **Traditional Approaches to Boost Mitochondrial Health**: These include proper nutrition, eating whole, organic foods, taking supplements (vitamins B, C, E, and minerals), and exercise, particularly high-intensity interval training (HIIT) that stimulates mitochondrial biogenesis. 5. **New Advances in Mitochondrial Treatment**: - **SS-31 Peptide**: This peptide targets cardiolipin in mitochondria, potentially improving mitochondrial function and ATP production. SS-31 peptides are considered promising in treating mitochondrial dysfunction. - **Nomad Mitochondria and Extracellular Mitochondria**: Recent discoveries show that mitochondria can exist outside cells and exchange mitochondrial content. This understanding opens possibilities for artificial mitochondrial transfer/transplant to rejuvenate aging cells. 6. **Mitrix Bio's Approach**: Mitrix Bio is developing a system to extract young mitochondria from stem cells and package them into vesicles called "mitlets," targeted for specific tissues. Their research showed promising results in rejuvenating the immune system in older mice. 7. **Conclusion**: The video emphasizes the importance of mitochondrial health in the aging process and the potential of new therapies to extend healthy lifespans. It encourages viewers to stay informed about advancements in mitochondrial research and related rejuvenation therapies.

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Wow, I"ve never had someone summarize one of my videos before. Well done. And pretty accurate.

  • @divided_and_conquered1854

    @divided_and_conquered1854

    2 ай бұрын

    That's awesome. Now all you need are timestamps to take it to the next level for the truly impatient and the zero attention span people! hahaha - Cheers.

  • @Fern_Yaz_Pets_Music

    @Fern_Yaz_Pets_Music

    Ай бұрын

    🤣⭐❤️

  • @eopetrov
    @eopetrov7 ай бұрын

    You could have also mentioned GlyNAC, probably the simplest, the most broadly available to the public, and the most efficient supplement to rejuvenate mitochondria. I've been taking it for 6 months, as per the human trials regimen, it works wonders.

  • @VTVT1306

    @VTVT1306

    7 ай бұрын

    He already talked about Glynac in one of his videos. Look it up, interesting stuff.

  • @monnoo8221

    @monnoo8221

    3 ай бұрын

    glynac works thrugh a very different and indirect mechanisms sure , itt elevaes glutathione, which is very important, and in the long run it can prevent damage to the mites. but that is, as said, indirect

  • @divided_and_conquered1854
    @divided_and_conquered18542 ай бұрын

    Thank you so much for not dumbing this down to a degrading level. You _simplified it_ but didn't dumb it down. THANK YOU SO MUCH!

  • @mariejones7136
    @mariejones71363 ай бұрын

    Yes since having cancer i excercise..fast .take ala.. coq10..pqq...red light therapy...keto diet to stay in ketosis..

  • @MapleWorld
    @MapleWorld7 ай бұрын

    This is absolutely fascinating! Thank you so much for the update.

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Glad you enjoyed it!

  • @noishpa7
    @noishpa72 ай бұрын

    Excellent information and presentation. Thank you for your work!

  • @PaulSchwarzer-ou9sw
    @PaulSchwarzer-ou9sw7 ай бұрын

    Thanks! 🎉

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    No problem!

  • @xuxiaohong888
    @xuxiaohong888Ай бұрын

    excellent information !

  • @unicorndiva1357
    @unicorndiva1357Ай бұрын

    Best video on mitochondria

  • @WaqasAbrar-tm4jy
    @WaqasAbrar-tm4jyАй бұрын

    Great video

  • @jonduringer5848
    @jonduringer58487 ай бұрын

    Super vid! Lance Hitchings is the nexus of healthspan basics and bleeding edge ;-) On on exosomes!

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Thanks, Jon. Appreciate the great comment.

  • @BradleyWHall
    @BradleyWHallАй бұрын

    Very good!

  • @alexanderilinskiy9926
    @alexanderilinskiy99267 ай бұрын

    Thank you, Lance. Great video. Though you did not mention great benefits of sunlight ar artificial IR sources for mitohondria. A lot of reaserch has been done on this issue. Sunlight, mostly IR, IS REALLY A POWERFOOL TOOL.

  • @galahadthreepwood
    @galahadthreepwoodАй бұрын

    There's also deuterium and light - especially blue light toxicity - see Jack Kruse. Or Sarah Pugh

  • @johnh7990
    @johnh7990Ай бұрын

    Thanks for the very informative review, but I was surprised you did not mention red light therapy, which is known to enhance mitochondrial function.

  • @christianvandermaas8932
    @christianvandermaas89323 ай бұрын

    Tell me about this company mittrix you mentioned. I’m very interested in following up on their research etc. Thank You !!

  • @beebennett2545
    @beebennett25452 ай бұрын

    What advice is available for someone who has had mitichondrial dysfunction and depketion for 18 years, so many mito have already died? What should I do to improve those that are left. Im disabled and nearly 80 but very keen to improve my health.

  • @VTVT1306
    @VTVT13067 ай бұрын

    Interesting and quite complicated, thank you. Is there already an update of the supplements you take?

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Not yet, but I'm planning on one in the next 2 or 3 months.

  • @benji-5796
    @benji-57963 ай бұрын

    I have fluroquinalone toxcity which is mitochondrial disfunction. Weirdly my atp levels are normal but I have high oxadative stress and low mito! Will ss31 help?

  • @sw4lyfe
    @sw4lyfe6 ай бұрын

    Just started my short ss-31 cycle… mots-c on deck too

  • @user-zs7rd2rp6b

    @user-zs7rd2rp6b

    Ай бұрын

    where did you buy it from?

  • @caryEUCNutbar
    @caryEUCNutbar7 ай бұрын

    Very great information! Just want to check with you about doing HIT workouts for regeneration of Mitochondria. From what I've been researching, it seems that Zone 2 training is even more optimal in the regeneration of Mitochondria. Both types of exercise helps in regeneration but it's more optimal exercising in Zone 2. A bonus too is that you can do this type of exercise daily because it doesn't stress the body to the higher limits. Ideally you could mix both HIT and Zone 2 in the right dosages to keep you exercising well into your golden years. If you did only HIT workouts.......this would lead to higher chances of injuries and burn out. What are your thoughts?

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    I mostly agree. I'd combine cardio with strength training, though.

  • @caryEUCNutbar

    @caryEUCNutbar

    7 ай бұрын

    @@LanceHitchings Yes i forgot to mention that too because strength training is very close in importantance along with Mitochondrial health. They go hand in hand. Just wanted to let others know they don't have to do HIT workouts for Mitochondrial health. Easier Zone 2 work outs work just as well, if not better. Plus they are alot easier on the body according to Inigo San Millan.

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    @@caryEUCNutbar Just gotta say, I'm a huge fan of HIIT. While I've sustain 2 injuries doing steady state cardio, I've never injured myself doing HIIT. At 74, I still do them 2 or 3 times a week. I love that I can get a great workout in as little as 5 or 10 minutes, as opposed to doing zome 2 workouts for an hour.

  • @caryEUCNutbar

    @caryEUCNutbar

    7 ай бұрын

    @@LanceHitchings I'm happy for you that you can still do these HIT workouts at your age. That's awesome!!! But i can tell you that if i told my older parents (81 mother and 86 father) that they have to do HIT workouts....... they would not work out at all. But when i explain to them that they can do low intensity Zone 2 walks. Then they are open to doing these because they can handle the workload. They are also doing resistance training as well. Your article was about Mitochondrial health for the aging. So that's why i had to make the folks know that lower intensity will work as well. I do agree that HIT workouts are extremely great too. I use this as icing on the cake. The Zone 2 allows anyone to build Mitochondria and the HIT workouts take it up a notch or 2. But HIT only workouts will make it harder for some to do this into their 90s or 100s agewise.

  • @grmalinda6251

    @grmalinda6251

    Ай бұрын

    ​@@caryEUCNutbarthanks for your input .

  • @donnazukadley7300
    @donnazukadley73005 ай бұрын

    Lets talk about C0vid jab damages to the mitochondria causing constant exhaustion and possibly Long C0vid

  • @kiwikim5163
    @kiwikim5163Ай бұрын

    Excercise+ real food+ Sleep+ Relaxation + Tons of supplements: nope

  • @galahadthreepwood

    @galahadthreepwood

    Ай бұрын

    There's also deuterium and light - especially blue light toxicity - see Jack Kruse. Or Sarah Pugh

  • @a.macdonald4877
    @a.macdonald48777 ай бұрын

    Lance, what do you think of the Phoenix dry fasting protocol to generate stem cells? have you looked into this?

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    No, I haven't. Haven't even heard of it. I"ll have to check it out. Thanks.

  • @a.macdonald4877

    @a.macdonald4877

    7 ай бұрын

    @@LanceHitchingsIt's been some time since I read the pdf book by A. Dunning, but I believe the research(like peptides) was originally done in Russia

  • @dolfo4765
    @dolfo47654 ай бұрын

    I am in an aging condition, I am willing to be a subject. Let me know the criteria for which you can proceed with these new discoveries.

  • @mithrandir491
    @mithrandir4917 ай бұрын

    I've seen people living past 100 without exercise. I think living long has to do with mental stress and simple diets.

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Yep, my mom lived to 98, ate crap food and never exercised a day in her life. Did nothing but watch TV the couple of decades. But had she chosen a healthier lifestyle, she'd still be with us. Exercise will absolutely lower your risks of all-cause mortality. That's been proven.

  • @forsdykemontague1017

    @forsdykemontague1017

    2 ай бұрын

    Stress hormones lead to mitochondrial dysfunction.

  • @WilliamThirteen
    @WilliamThirteen7 ай бұрын

    so SS-31 may act like a sort of facelift for the inner mitochondrial membrane - tightening up those sagging cristae curvatures…

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Yeah, sure. That's one way of looking at it.

  • @irinailyasova5366
    @irinailyasova53665 ай бұрын

    Jow much fo you takr it?

  • @eyera18901865
    @eyera189018657 ай бұрын

    The ovaries have 200,000 mitochondria per egg

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Wow! Doesn't surprise me, I would imagine that eggs would have a high demand for energy...creating life and all.

  • @rogerbritus9378

    @rogerbritus9378

    7 ай бұрын

    So should we ingest human caviar? LOL

  • @BlackMirrorDoll
    @BlackMirrorDoll7 ай бұрын

    every life on this planet = trilions of graves !!! what a " beautiful " creation

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Your point?

  • @grmalinda6251

    @grmalinda6251

    Ай бұрын

    There are billions of people who have never no not even once died. Just think.

  • @lancelaw5966
    @lancelaw59664 ай бұрын

    Health, and longevity doesn't have to be this technical. Where did his hair go?

  • @kenwin5845
    @kenwin58457 ай бұрын

    It was really nice meeting you at the gay bar in Portland. You are even more hot in person!

  • @scottk1174
    @scottk11747 ай бұрын

    Eating healthy for mitochondrial health is almost impossible for someone older on minimal disability income as extreme organic food costs do not lend itself to low income recipients.

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    While eating organic is healthier than non-organic, simply eating whole foods instead of overly refined and processed foods with lots of additives is still WAY healthier.

  • @reverseaging5387

    @reverseaging5387

    7 ай бұрын

    Costco sells Organics for less than regular veggies. Stop eating in restaurants and you’ll have better health and plenty of money for quality food

  • @starbright1256

    @starbright1256

    6 ай бұрын

    There are ways to improve no matter income. I grow some things myself. Container garden. Watch for sales. Community markets or community gardens. Whole foods.

  • @greggbambu411

    @greggbambu411

    5 ай бұрын

    Beans. Cheap and they add years to life.

  • @nisebiggs6572

    @nisebiggs6572

    4 ай бұрын

    Get enough sleep Intermittent fasting Reduce stress Eliminate processed foods and sugars Exercise - especially HIIT Get out in the sun Get some sunlight in your eyes first thing in the morning None of these cost money.

  • @BUY_YOUTUBE_VIEWS_d084
    @BUY_YOUTUBE_VIEWS_d0847 ай бұрын

    my day would be so bad without you

  • @LanceHitchings

    @LanceHitchings

    7 ай бұрын

    Wow! Thanks.

  • @ChrisGroggyCreaser
    @ChrisGroggyCreaser6 ай бұрын

    *Can U Cure "Chronic Fatigue Syndrome"/M.E. (Myalgic Encephalomyelitis)??? alanccreaserathotmaildotcodotuk

  • @carolinejackson9405

    @carolinejackson9405

    2 ай бұрын

    just wondering about methylene blue - I'm taking just about every other supplement. So tired of being tired. 😔. HIIT doesn't work for us.

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