The Role of Mitochondria in Aging and Disease - David Sinclair

Ғылым және технология

Biologist David Sinclair from Harvard Medical School on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genome are like a married couple.
Read the text version here: serious-science.org/role-of-m...
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1. Aging and Disease - David Gems: • Aging and Disease - Da...
2. Reversible Aging - David Sinclair: • Reversible Aging - Dav...
3. Molecular Cause of Aging - Vadim Gladyshev: • Molecular Cause of Agi...
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Пікірлер: 575

  • @evelynross6144
    @evelynross6144 Жыл бұрын

    Amazing how much younger he looks, 7 years later.

  • @hobbyfarmer1452
    @hobbyfarmer14522 жыл бұрын

    Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc.

  • @rockforester7908

    @rockforester7908

    Жыл бұрын

    He does. The skin is a good barometer of the health of all organs. His skin gets better every year as I observe him anyway.

  • @robynhope219

    @robynhope219

    Жыл бұрын

    ...and good genes!

  • @timothy4557

    @timothy4557

    Жыл бұрын

    @@robynhope219 botox ?

  • @jackrabbitism

    @jackrabbitism

    Жыл бұрын

    Before I read your comment I was thinking exactly the same thing. Hair, skin, eyes, colour - all look younger today, 12 years later. 😳

  • @Grikor496

    @Grikor496

    Жыл бұрын

    That’s for sure. His lab discovered some heavy stuff and didn’t published it yet. 100%

  • @kittyhooch1
    @kittyhooch14 жыл бұрын

    After this watch a recent video of him. Six years later he is visibly younger.

  • @kzkz1263

    @kzkz1263

    3 жыл бұрын

    Because he can no longer move his forehead?

  • @pramujisinggihriyanto6901
    @pramujisinggihriyanto6901 Жыл бұрын

    You are very competent and humble, Dr. Sinclair. Pls explain how we get NAD...

  • @PreetamBorahbiotech
    @PreetamBorahbiotech9 жыл бұрын

    your analogy of the broken marriage of genomes was the best part....

  • @debasishborthakur2141
    @debasishborthakur2141 Жыл бұрын

    The world is watching you Dr. David Sinclair.. You are our hope..

  • @robynhope219

    @robynhope219

    Жыл бұрын

    Indeed...and his obsession with anti aging is to all our benefit :-))

  • @orbitia662

    @orbitia662

    10 ай бұрын

    japan england & brazil r also almost figuring it out

  • @hamedshahbazi1
    @hamedshahbazi18 жыл бұрын

    Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!!

  • @Splassshhh1234
    @Splassshhh12343 жыл бұрын

    I like the joy he has

  • @manuelojeda9144
    @manuelojeda91442 жыл бұрын

    I just turned 70 and I feel great.

  • @debasishborthakur2141
    @debasishborthakur2141 Жыл бұрын

    OMG.. He is just genious.. Everyone please support Dr. David Sinclair.. He is doing a fantastic job.. God bless you..

  • @biophilia3091
    @biophilia30912 жыл бұрын

    Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India.

  • @rockforester7908

    @rockforester7908

    Жыл бұрын

    Every human should have this book.

  • @iwnunn7999
    @iwnunn79994 жыл бұрын

    I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body.

  • @tayya7371

    @tayya7371

    4 жыл бұрын

    check Jerry Tennant

  • @seths6069

    @seths6069

    4 жыл бұрын

    That’s his point exactly!! Have a healthy life.

  • @iwnunn7999

    @iwnunn7999

    4 жыл бұрын

    @@seths6069 thank you. You as well

  • @peetsnort

    @peetsnort

    4 жыл бұрын

    Stop using canola oil and margerine and use olive oil and lard for cooking

  • @terrytari1891

    @terrytari1891

    4 жыл бұрын

    Don't you want to live to be 231 years old!

  • @srtj.av.2556
    @srtj.av.25562 жыл бұрын

    I love when he smiles as is a good thing happening! 😊

  • @1Sun111
    @1Sun1115 жыл бұрын

    sleep, nutrition, movement, absence of stress, good emotions +++

  • @jonathanhadley2555

    @jonathanhadley2555

    4 жыл бұрын

    Easier said than done I think?

  • @director2345

    @director2345

    Жыл бұрын

    yes.... Sleep right Eat right Exercise right Think right

  • @williamtomkiel8215
    @williamtomkiel82154 жыл бұрын

    so glad I found this . . Been on NAD, 100 mg. /day for almost 2 1/2 years along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters and at 72 function and perform as a man many years younger but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth.

  • @williamtomkiel8215

    @williamtomkiel8215

    2 жыл бұрын

    @Joseph Williams based on cost and availability and convenience-Amazon and a typo, it was NR, not NAD, which i quit about 9 months ago just not enough good data to support a 300 mg / day dosing- influenced by Dr. Rhonda over at found my fitness . .

  • @williamtomkiel8215

    @williamtomkiel8215

    2 жыл бұрын

    @@Farhan-hs1bq shortly after "that' Dr. Rhonda Patrick. foundmy fitness iirc posted that uncompelling and speculative evidence wrt either NR or NMN didn't support enough actual chemical / medical detectable mitochondrial boosting beyond wishful thinking / antidotal evidence , tho the chemistry looks like it should, not all us of have the benefit of unlimited or even "free" sources for NR or NMN in the gram plus doses that "might' do something besides being exorbitantly expensive ROI- evidence lacking eat smarter. workout and recover smarter. reduce stress, learn to sleep better and don't watch too much of the "news"

  • @robynhope219

    @robynhope219

    Жыл бұрын

    NAD is so expensive that only the well-to-do can afford it:-(( I take Niacinamide, which is cheap... helps boost NAD. Did you know?

  • @williamtomkiel8215

    @williamtomkiel8215

    Жыл бұрын

    @@robynhope219 keep researching seems minimally effective

  • @TheDutchdiva10

    @TheDutchdiva10

    Жыл бұрын

    Life Extension products !!! Now IVs of NAD The best 🎉

  • @VEE-rd7cu
    @VEE-rd7cu2 жыл бұрын

    I volunteer for that aging research!!

  • @rockforester7908
    @rockforester7908 Жыл бұрын

    So exciting! One can try a lot of this right now, and very safely. My goal is to live heathfully for however long I do live, and this research is exactly the ticket.

  • @CalumnMcAulay
    @CalumnMcAulay9 жыл бұрын

    Incredible - now I just need to find a reason to live - lol

  • @kevinfairweather3661

    @kevinfairweather3661

    5 жыл бұрын

    Keep doing the lottery and hope for the best !

  • @jameshumphrey9939

    @jameshumphrey9939

    5 жыл бұрын

    or move up hill into a cave and meditate avoiding contact with other so called human beings - ironically this is why he doesn't want to live - a culture based on money @@kevinfairweather3661

  • @squamish4244

    @squamish4244

    5 жыл бұрын

    I know the feeling. Why the *FUCK* would I want a longer life as the headcase I am now? XD

  • @motherof3pearls

    @motherof3pearls

    5 жыл бұрын

    Why Not Now Hope you found your purpose!

  • @Krath1988

    @Krath1988

    5 жыл бұрын

    Because nothing is more satisfying than outliving your enemies ;)

  • @vicentesanchez4939
    @vicentesanchez49394 жыл бұрын

    Excellent lesson and info. Thx

  • @carloslopez9766
    @carloslopez9766 Жыл бұрын

    Wow loved this video!! Thank you David!

  • @kayhalsey
    @kayhalsey5 жыл бұрын

    Thank you for the information.

  • @commandresults1705
    @commandresults17059 жыл бұрын

    Great talk theorizing the future of mitochondrial development as related to aging and longevity,

  • @kevinfairweather3661
    @kevinfairweather36615 жыл бұрын

    Very succinct explanation !

  • @079Francvs
    @079Francvs3 күн бұрын

    Lo increíble es que su teoría sobre las mitocondrias fue reemplazada por un nuevo descubrimiento, el de la epigenética y ahí empezó el boom de los experimentos.

  • @MarkIsJustKidding
    @MarkIsJustKidding8 жыл бұрын

    Thanks it is fascinating!

  • @dchiffy
    @dchiffy5 жыл бұрын

    Great lecture, sounds like the progression of insulin resistance. Thank you

  • @holyhellal

    @holyhellal

    Жыл бұрын

    fantastic comment

  • @carrollhoagland1053
    @carrollhoagland10537 жыл бұрын

    Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ..., 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point.

  • @robynhope219

    @robynhope219

    Жыл бұрын

    Specializing in mito dysfunction? How do u help ur patients? I had a question: how do I get rid of zombie cells in the feet?

  • @Data_-xw7yw

    @Data_-xw7yw

    Жыл бұрын

    @@robynhope219 he died. That's why he didn't answer your question.

  • @tigerkills3038
    @tigerkills30384 жыл бұрын

    Every medical professionals should learn this.

  • @florinabelen7367
    @florinabelen7367 Жыл бұрын

    Amazing wow its good for me to enjoy my life with my family.

  • @joeschmo5699
    @joeschmo56997 жыл бұрын

    The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is.

  • @pikiwiki
    @pikiwiki4 жыл бұрын

    I understood everything!

  • @baljitsingh8394
    @baljitsingh83942 жыл бұрын

    Very informative information 👍🙏

  • @winstonchang777
    @winstonchang7774 жыл бұрын

    Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge. You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives.....

  • @yarramshettivydehi9311

    @yarramshettivydehi9311

    2 жыл бұрын

    Its true Mitochondria are powerhouses of cell The no. Mitochondria shows cell activity they have theit own DNA can live independently .more no. Of mitochomdria shows cell activity. They pla y imp role in cell division. produce ATP which release kinetic energy in the form of phosphate bonds.More in muscle cells named as sarcosomes.

  • @hanknelson3231
    @hanknelson32314 жыл бұрын

    The price for The NAD Treatment Center Detox Method can range between $6,000 to $17,000, depending on the specific program that is recommended for you and discussed with NAD Treatment Center staff. For reference, a typical 10-day treatment is $11,850.

  • @milkoansah-johnson8768

    @milkoansah-johnson8768

    4 жыл бұрын

    As they refer to hypothesis as theories, leave out causes of disease then jump to administering pharmaceuticals, you know they are only keen to make money instead of helping human life.

  • @jonathanhadley2555

    @jonathanhadley2555

    4 жыл бұрын

    Infrared Sauna & Oxygen Therapy might be better & cheaper alternatives

  • @elenabenjamin9980
    @elenabenjamin9980 Жыл бұрын

    Thank Dr Sinclair. Can you please talk about fisetin! ? How we can take? I understand that it help the mitochondrial function! 🙏🏼🍀

  • @robynhope219

    @robynhope219

    Жыл бұрын

    You can get fisetin from foods..look up.

  • @user-ww8tu8te3g
    @user-ww8tu8te3g7 жыл бұрын

    Thanks it is fascinating

  • @benjaminhardisty66
    @benjaminhardisty669 жыл бұрын

    I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model."

  • @donalain69

    @donalain69

    6 жыл бұрын

    Benjamin Hardisty o

  • @kathyenking2347

    @kathyenking2347

    6 жыл бұрын

    Benjamin, there is a product that offers the solution you seek, reducing oxidative stress by an average of 40% in 30 days proven in a clinical study. 22 more studies follow this. Based on ancient herbal and plant wisdom. Have you heard of nutrigenomics and the Nrf2 pathway? We are biohacking our genes now.

  • @truehope287

    @truehope287

    5 жыл бұрын

    Benjamin Hardisty. Have you looked at the peer & scientific studies on Protandum?

  • @brianconner664

    @brianconner664

    5 жыл бұрын

    Never trust anyone who says, Trust Me.

  • @PaulaGem

    @PaulaGem

    4 жыл бұрын

    The one thing that really bothers me about this discussion is that it ignores the elephant in the room. People in the U.S. have a shorter lifespan due to pharmaceuticals that cause mitochondrial dysfunction. Flouroquinolones is a biggie, but almost all CNS drugs disrupt normal sleep and actually cause premature aging of the brain.

  • @khamikos1
    @khamikos16 жыл бұрын

    excellent.thanks

  • @drdoomconvert
    @drdoomconvert Жыл бұрын

    No so Serious Science! Love it 😀

  • @ZeraYaqob
    @ZeraYaqob4 жыл бұрын

    The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons.

  • @melanievesters5473

    @melanievesters5473

    2 жыл бұрын

    That would make a lot of sense. Do you have more info besides the vit k?

  • @joshuabowman7210

    @joshuabowman7210

    2 жыл бұрын

    I believe your idea but never found a way to prove it can we chat I would enjoy talking about mitochondria and it’s motility and other cool things

  • @Splassshhh1234
    @Splassshhh12343 жыл бұрын

    INCREDIBLE

  • @greenwealth7781
    @greenwealth77812 жыл бұрын

    Thank you very much.

  • @bluejay6904
    @bluejay69044 жыл бұрын

    what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane. i know South Korea has developed a healthy mitochondria injection method. and England has their mitochondrial donor program for three parent babies. Is there a connection between mitochondrial fuction and telomere? i wonder.

  • @oibal60
    @oibal604 жыл бұрын

    Thanks for this. Reduce inflammation!

  • @ravenslair117
    @ravenslair1175 жыл бұрын

    Excellent. A very well spoken Professor. I have so many questions! Would taking NADH assist in this regeneration??

  • @incognitotorpedo42

    @incognitotorpedo42

    5 жыл бұрын

    No. Use NR. (nicotinamide riboside)

  • @florinabelen7367
    @florinabelen7367 Жыл бұрын

    Congratulations Its help a lot.to have hope in many people wants to have long happy life.

  • @margueriteoreilly2168
    @margueriteoreilly2168 Жыл бұрын

    Excellent Research Belfast Ireland 🇮🇪 😎

  • @SahanTheMighty
    @SahanTheMighty Жыл бұрын

    Such a lovely man 💫

  • @juntjoonunya9216
    @juntjoonunya92165 жыл бұрын

    So where do you find this magical "NAD" in nature? Please say donuts

  • @richardperez6700

    @richardperez6700

    4 жыл бұрын

    hahaha

  • @davidivers9295

    @davidivers9295

    4 жыл бұрын

    Milk has some in it but best to supplement with NR (nicotinamide riboside)or NMN

  • @BillGreenAZ

    @BillGreenAZ

    4 жыл бұрын

    @@davidivers9295 I did a search on "restore NAD in the body" and was given a result that said the same thing you did: "Research shows that when taken by mouth, nicotinamide riboside is highly bioavailable, and has been shown to boost NAD+ levels in the body"

  • @BillGreenAZ

    @BillGreenAZ

    4 жыл бұрын

    @@SrYuba I don't know the answer to that question. Sorry.

  • @TheVodec

    @TheVodec

    4 жыл бұрын

    If it was donuts you would already have young mitochondria

  • @lacoperon6325
    @lacoperon6325 Жыл бұрын

    I love this so much

  • @thexeesus
    @thexeesus4 жыл бұрын

    Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these.

  • @looncraz

    @looncraz

    3 жыл бұрын

    Typically in science we see results based on a false understanding of what is happening and with prolonged study realize what is actually happening. In other words, most scientific findings are essentially by mistake.

  • @ivanodriscoll5874
    @ivanodriscoll5874 Жыл бұрын

    Cool video and understandable.

  • @lazi16
    @lazi164 жыл бұрын

    This is almost 6 years ago and he looks younger now...

  • @NigraXXL

    @NigraXXL

    4 жыл бұрын

    Ikr?

  • @unlimited1652

    @unlimited1652

    4 жыл бұрын

    That's the point!

  • @Libertas_P77

    @Libertas_P77

    4 жыл бұрын

    I was just about to make the same point. Sinclair looks significantly younger now in 2020 than he did here in 2014. I'll stick with the NMN and other longevity aspects of my daily routine.

  • @tomigun6913

    @tomigun6913

    4 жыл бұрын

    He does

  • @thatguyweheard

    @thatguyweheard

    4 жыл бұрын

    I thought this was from today, but when I checked out the date, I thought the same thing. It's undeniable. Started NMN and Resveratrol today!

  • @yuanyao3963
    @yuanyao39632 жыл бұрын

    He definitely looks younger now, wow

  • @agr8trip
    @agr8trip Жыл бұрын

    Got to hand it to him. He does look younger now than he did back then.

  • @levizjaperdije8499
    @levizjaperdije84994 жыл бұрын

    Lelouch: Suzaku live. Suzak: Should i take NMN, Metformin and resveratrol like Sinclair. Code Geass

  • @Garium87
    @Garium874 жыл бұрын

    Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations?

  • @jonathanhadley2555

    @jonathanhadley2555

    4 жыл бұрын

    I concur as I think that once the Mitochondria has been damaged are they able to repaired?

  • @Kuato

    @Kuato

    Жыл бұрын

    @Alex Brilliant idea. Truly.

  • @NateHadley
    @NateHadley Жыл бұрын

    What’s the best NAD supplement on the market? I’ve done NAD IV treatments before (you feel TERRIBLE while doing them) but that goes away pretty quick when it’s finished. My primary concern is anxiety, brain fog and fatigue.

  • @ziyaonbashi5864
    @ziyaonbashi58642 жыл бұрын

    Sinclair looks younger now that he is 50

  • @Estrav.Krastvich

    @Estrav.Krastvich

    2 жыл бұрын

    Indeed.

  • @grace2u776
    @grace2u7765 жыл бұрын

    what about the supplement Ubiquinol( Co enzyme Q10) this is supposed to raise atp production?

  • @starrynight3363

    @starrynight3363

    4 жыл бұрын

    Grace 2U with PQQ.

  • @spruceguitar
    @spruceguitar3 жыл бұрын

    "I do not want to live forever in the memory of the people. I want to live forever in my apartment." Woody Allan

  • @gleaveinjapan

    @gleaveinjapan

    Жыл бұрын

    Interviewer: Mr Allan, do you want to be made immortal through your work? Woody Allan : No, I want to be made immortal through not dieing.

  • @timothy4557

    @timothy4557

    Жыл бұрын

    @@gleaveinjapan screw Allan.

  • @craxen1
    @craxen12 жыл бұрын

    His own appearance has also changed quite drastically if you look at him today, i swear, his five years younger today, five years later, so his own concoctions seems to work..

  • @termlimitscom8739
    @termlimitscom87394 жыл бұрын

    Notice his eyes.... no jaundice like 75% of other people. Also look at his knuckles no edema no tremors and no mandibular deformation from poor dental health..... I trust him. Did you know he wrote a book on this in 2019?

  • @nevillej9408
    @nevillej94085 жыл бұрын

    I am nearly 65 and have found that taking a small amount of D-Ribose and some Creatine daily has given me a massive amount of energy and strength so much so that two or three days a week, I will run a 5K followed by an hour in the gym doing a heavy workout and then do about 3/4 hour of swimming and still feel like I could do more. I suspect am as fit as I was in my twenties.

  • @dimipall1585

    @dimipall1585

    5 жыл бұрын

    Don't forget to take Potassium. You need A LOT MORE of it because of the muscle work. Look into it Potassium Sodium Pump 😉

  • @florencetown4024

    @florencetown4024

    Жыл бұрын

    What is D ribose

  • @rustycottrell7811
    @rustycottrell78114 жыл бұрын

    thanks for caring and sharing

  • @tomprovan50
    @tomprovan505 жыл бұрын

    2014 pretty old news has anyone an update? It is possible now to get all the supplements to keep the krebs cycle humming and the ETC working including adjusting the nad+/nadh ratio. I am sure lots f people have tried it. It would be interesting if they would post there results. Although the only test might be still healthy at an advancing age?

  • @GrooveDoctor77Musician
    @GrooveDoctor77Musician9 жыл бұрын

    I have tried Niagen about a week ago , Im still sceptical but, I have(had ) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair

  • @solorider305

    @solorider305

    5 жыл бұрын

    Hey man, how are you doing since you first started taking Niagen?

  • @someaussiekidd

    @someaussiekidd

    5 жыл бұрын

    I love anecdotes

  • @bobabucks1207

    @bobabucks1207

    4 жыл бұрын

    GrooveDoctor77 is niagen still working for you?

  • @florencetown4024

    @florencetown4024

    Жыл бұрын

    Where did you buy niagen also how old are yoi

  • @eckankar7756
    @eckankar77564 жыл бұрын

    One of the sexiest scientists out there.

  • @elizabethjohn577
    @elizabethjohn5772 жыл бұрын

    Amazing

  • @maryanncarrlton6878
    @maryanncarrlton68785 жыл бұрын

    Well yeah !

  • @graemegladman
    @graemegladman2 жыл бұрын

    You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both.

  • @brendlelau1048
    @brendlelau10482 жыл бұрын

    So if i have less functionality of mitochondrial DNA or i dont make enough of it when young i would die of a lack of cells with enough energy to run a marathon, when i am older, i am so glad it will happen later than earlier in life, but when is the cut off point when mitochondrial DNA start to grow less useful

  • @peznino1
    @peznino1 Жыл бұрын

    Did he say we are not living much longer than we did 10,000 years ago? How does he come to that conclusion and on based of what data?

  • @mnbdysl
    @mnbdysl2 жыл бұрын

    I thought this video was made in 2021, because he looks exactly the same today. Something's working.

  • @dralmarashi55
    @dralmarashi554 жыл бұрын

    I love anti aging science I am Amercan Board certified Endocrinlogist could you give some trading in this new science or rather do you offer fellowship in antiaging?

  • @Northstardanes

    @Northstardanes

    4 жыл бұрын

    Hello Fatma, more information on my website www.northstardanes.lifevantage.com

  • @haveaniceday7950
    @haveaniceday79507 жыл бұрын

    is it bioavailable orally? does it only restore muscles to a youthful state or all cells and that is just the example he used towards the end of the video?

  • @incognitotorpedo42

    @incognitotorpedo42

    5 жыл бұрын

    Yes, NR is orally bioavailable. I used it for a while, but it induced insomnia for me. I could take a low dose, but I suspect it was too low to make much difference. People report a variety of effects, so it probably works in more than just muscle. Your results will depend on the present condition of your mitochondria. If you're young, you may not notice much.

  • @PROCESSOR302
    @PROCESSOR3029 жыл бұрын

    You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length.

  • @truehope287

    @truehope287

    5 жыл бұрын

    Protandim does just that!

  • @JustinTyler111

    @JustinTyler111

    5 жыл бұрын

    The mitochondria also play a major role in epigenetics and maintenance of the nuclear DNA, hence the their importance... The microbiome also may control about 30 percent of gene expression

  • @ACTHdan

    @ACTHdan

    4 жыл бұрын

    PROCESSOR302 Or Exercise and calorie restriction to modulate AMPK and mTOR to extend telomeres. Or use senolytics to kill senescent cells, and prevent cytokine from inflaming nearby cells.

  • @Ghhhhhjjccvv

    @Ghhhhhjjccvv

    2 жыл бұрын

    @@ACTHdan bit late to this discussion but could someone break it down what is best to follow in layman’s terms if you don’t mind, it would be greatly apprecated

  • @Ghhhhhjjccvv

    @Ghhhhhjjccvv

    2 жыл бұрын

    @@ACTHdan bit late to this discussion but could someone break it down what is best to follow in layman’s terms if you don’t mind, it would be greatly appreciated

  • @nightmisterio
    @nightmisterio Жыл бұрын

    How do we know the nucleus makes the proteins?

  • @samuellopes1254
    @samuellopes12546 жыл бұрын

    Ketosis increases NAD+ to fight off inflammation

  • @NgonyamaShobane775

    @NgonyamaShobane775

    4 жыл бұрын

    And Fasting helps.

  • @jonathanhadley2555

    @jonathanhadley2555

    4 жыл бұрын

    And also help with Diabetis 2 diet related

  • @muhammadalieesaa3379
    @muhammadalieesaa33793 ай бұрын

    David Sinclair looked older when he was younger & now he's older 7 years later he's looking younger.

  • @saxmanchiro
    @saxmanchiro9 жыл бұрын

    It's a hypothesis, not a theory, yet. This reminds me of Dr. Dean Ornish's idea, back in the mid 80s, of reversing heart disease with diet only, quickly. Many in the medical field scoffed at him and chastised him for his foolishness. Now we know the truth. He was right. Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in. Could be a game changer for sure.

  • @greendeane1

    @greendeane1

    9 жыл бұрын

    saxmanchiro Ornish right? You apparently have not read any studies in the last 20 years.

  • @saxmanchiro

    @saxmanchiro

    9 жыл бұрын

    Green Deane Did you read my post carefully? I said in the 80s.

  • @dyllandroid

    @dyllandroid

    8 жыл бұрын

    If I told you I'm part of the company who currently has a Patton on the product and if you are interested in not just hearing how well of a theory it is. But to have a real testimony from a product that is not being rested but distribution. Contact me at DKHANDYTEST1@GMAIL.COM

  • @robinclar

    @robinclar

    8 жыл бұрын

    +saxmanchiro "Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in." Such as this theory confirmed by this evidence?: www.researchgate.net/publication/273789709_Risingfalling_mercury_pollution_causing_the_risingfalling_IQ_of_the_LynnFlynn_effect_as_predicted_by_the_antiinnatia_theory_of_autism_and_IQ

  • @saxmanchiro

    @saxmanchiro

    8 жыл бұрын

    robinclar I wasn't aware that mercury linked to Autism could be considered at a 'theory;' level yet. I have an autistic child and keep myself updated. Plus, my other son is a published scientist within healthcare and has worked with Dr. Piven from Chapel-Hill who is a world renowned researcher in Autism. I will read this over and see if I can get my hands on the full transcript instead of just the abstract. But thanks for sharing this with me.

  • @shapanl5355
    @shapanl53554 жыл бұрын

    Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available. One thing which I never understood about is free radical? According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death. Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created .... So please do make me understand about free radicals Doctor Thankyou

  • @starrynight3363

    @starrynight3363

    4 жыл бұрын

    Shapan L still need to neutralize ROS with antioxidants- such as Co-WQ10.

  • @romygime5822
    @romygime58229 ай бұрын

    We all want to live forever. I do not want ever to die I love the universe my home, my father in the havens, love animals. Love my family, love people, love to smell the flowers, hear the birds singing. Love to fall in love. God bless as all creatures big and small.❤❤❤❤❤🙏🙏🙏🙏🙏🙏🥰

  • @janeroth7
    @janeroth74 жыл бұрын

    Does NAD help people with MS?

  • @shivavl6814
    @shivavl6814 Жыл бұрын

    What are the natural ways of increasing DNA content of cell

  • @tigerkills3038
    @tigerkills30383 жыл бұрын

    L Dopa is converted to Dopaquinone and then to melanin by an Enzyme tyrosinase I think Vit k2 has something to do with it?.

  • @bhadanisandip
    @bhadanisandip Жыл бұрын

    Looks like David Sinclair's methods are working. In his latest videos he looks younger than he was 9 years back.

  • @TheDutchdiva10
    @TheDutchdiva10 Жыл бұрын

    I use every day

  • @agsjnsks4538
    @agsjnsks4538 Жыл бұрын

    Did it work out (this video is 8 years old by now)?

  • @georgestephenson4975
    @georgestephenson49753 жыл бұрын

    I really enjoyed your video. 8have life extension instruments

  • @robynhope219
    @robynhope219 Жыл бұрын

    Any of you aware that Metformin decreases mitochondrial respiration? So important to do your research. Dr. S. should mention this.

  • @nubianking2018
    @nubianking20184 жыл бұрын

    What can we do now...what really work.to slow or reverse it now....nad.plus.

  • @atimovers4453
    @atimovers44534 жыл бұрын

    Creatine supplements can increase atp production. Any correlation to this topic?

  • @Northstardanes

    @Northstardanes

    4 жыл бұрын

    Indeed, see more information here on my website www.northstardanes.Lifevantage.com

  • @jonathanhadley2555

    @jonathanhadley2555

    4 жыл бұрын

    And Co Q10

  • @nyx211
    @nyx2118 жыл бұрын

    But why do the nuclear and mitochondrial genomes stop communicating in the first place? What causes the nucleus to think that it isn't receiving enough energy?

  • @nagihangot6133

    @nagihangot6133

    4 жыл бұрын

    icecaloric Something genetic.

  • @rashidahmad9214
    @rashidahmad92144 жыл бұрын

    NMN cause elevated homocysteine. Please advise

  • @marlyncollante2237
    @marlyncollante2237 Жыл бұрын

    Quality and no quantity of life is the goal, to be able to enjoy what remains of life without getting sick

  • @mariatrimboli3467
    @mariatrimboli34677 жыл бұрын

    doed the dr take it ?

  • @drdavid62
    @drdavid628 жыл бұрын

    NAD levels can be raised naturally through caloric restriction and/or periods of intense exercise. Either of these separately or in combination create periods of negative energy balance within the body which raises NAD levels. There are some supplement companies out there such as Life Extension who market nicotine riboside as an NAD enhancer. I wonder how safe this would be for someone to take who is already engaging intermittent fasting/caloric restriction and/or a fairly demanding daily exercise regimen?

  • @vincentnapolitano952

    @vincentnapolitano952

    7 жыл бұрын

    IF...repairs our cells...right?

  • @rephaelreyes8552

    @rephaelreyes8552

    5 жыл бұрын

    NAD is just a coenzyme that helps with the production of ATP. Apparently it's also used for mitochondria to communicate with the DNA in the nucleus. I'm pretty sure high levels of NAD triggers the cell to produce a protein or chemical that makes metabolism more efficient for the cell.

  • @dorotabartczak9557

    @dorotabartczak9557

    5 жыл бұрын

    The best product for mitochondria is ASEA. Cell sygnaling suplement contains active redox molecules -- cellular messengrrs that efect genetic expression in a positive way, helping to protect, rejuvenate, and kiping cell functioning at optimals level.

  • @jlushefski

    @jlushefski

    4 жыл бұрын

    I think efficacy is more of a question than safety. Many life extending interventions work only in unhealthy animals. Add to that the fact humans already live proportionally long (for their size). You'll see much better results in mice than certain bats for instance, whose physiology already appears near-optimized for longevity.

  • @joembuchi3146

    @joembuchi3146

    4 жыл бұрын

    @@vincentnapolitano952 Yes. IF gives the body the appropriate time to deeply absorb nutrients and deplete all stored sugar in the body.. then repair mode follows... all damaged cells, harmful bacteria and worn out tissue becomes food.

  • @leonardodamico9344
    @leonardodamico9344 Жыл бұрын

    I have parkinson disease can you give me advice please

  • @NickFoxer
    @NickFoxer4 жыл бұрын

    Great video, but he failed to mention the most important molecule responsible for mitochondrial function. OXYGEN..... Two words: Ozone Therapy. Learn as much as you can about it. In my opinion it's the single greatest practice we have for restoring health. I actually think the "secret molecule" that he's hinting at toward the end of the video (10:40) is Ozone.

  • @larrygoldfarb9244

    @larrygoldfarb9244

    4 жыл бұрын

    He does mention oxygenated species. That in itself is what you are describing. But seriously, how many millions of couch potatoes are going to head out and start running peak 8s? The answer is probably 1 in 100,000 if that. Also there is NMN found in these foods and just about as many eat this in between the bacon cheeseburgers and french fries. :-) NMN is found in fruits and veggies such as avocados, broccoli, cabbage, edamame, and cucumbers.

  • @starrynight3363

    @starrynight3363

    4 жыл бұрын

    PQQ is the secret molecule. It is in the Quinone family - Co-Q10.

  • @melanievesters5473

    @melanievesters5473

    2 жыл бұрын

    Ozone helps me a lot. PQQ however did nothing.

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