Antiplatelet, Anticoagulant, Thrombolytic Agents

Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/ant...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Anticoagulants, Thrombolytics, and Antiplatelet Agents. Please be sure to use the table of contents to visit all of the chapters we have available in this detailed lecture. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Anticoagulants, Thrombolytics, Antiplatelets Introduction
1:03 Platelet Plug Formation
26:53 Coagulation Cascade
50:29 Fibrinolysis
1:00:45 Test Your Knowledge - Anticoagulants, Thrombolytics, Antiplatelets MOA
1:04:07 Neurological Events
1:10:41 Cardiac Events
1:27:34 Pulmonary Events
1:32:03 Peripheral & Central Vascular Events
1:44:29 Venous Thromboembolism Prophylaxis
1:48:59 Prevention of Circuitry/Catheter Clotting
1:53:32 Acetylsalicylic Acid (Aspirin) Adverse Effects
2:00:05 Aspirin Toxicity
2:02:57 P2Y12 Receptor Blockers Adverse Effects
2:13:15 PDE-3 Inhibitors Adverse Effects
2:15:07 Heparin (UFH + LMWH) Adverse Effects
2:26:50 Direct-Acting Oral Anticoagulants (DOACs) Adverse Effects
2:30:36 Warfarin Adverse Effects
2:39:21 Bleeding! Most Feared Adverse Effect
2:45:50 Drug Level Monitoring
2:55:10 Drug Reversal
3:02:30 Anticoagulants, Thrombolytics, Antiplatelets Practice Problems
3:10:18 Comment, Like, SUBSCRIBE!
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#ninjanerd #Anticoagulants #Thrombolytics #Antiplatelets

Пікірлер: 301

  • @collinstage97
    @collinstage97 Жыл бұрын

    This man and his team should get a Nobel Peace prize for the amount of medical education they put out for free

  • @DanielM-il4rz

    @DanielM-il4rz

    Жыл бұрын

    @Collin Stage , with over 2million subscribers, all the ad links and just the vast amount of videos uploaded to KZread, don’t worry, “Ninja Nerd” is getting paid!! I do agree, they do a great job with the wealth of knowledge that is provided by this channel. 👍❤️

  • @AlexanderHardy-hj5dy

    @AlexanderHardy-hj5dy

    Жыл бұрын

    "accurate medical education"

  • @emmanuelmukuka5049

    @emmanuelmukuka5049

    Жыл бұрын

    @@DanielM-il4rzhh hyhhhhhhhhhghhh

  • @Smtout1

    @Smtout1

    Жыл бұрын

    Agreed

  • @jenavdg
    @jenavdg Жыл бұрын

    Bro, unbelievable how you keep two hours of material in your head without notes or power point. Absolutely gifted

  • @markmurto

    @markmurto

    Жыл бұрын

    He took breaks. Had to. But you're right!

  • @jundelira7119

    @jundelira7119

    Ай бұрын

    I think , he is an A.I.

  • @Medical_life_with_John
    @Medical_life_with_John Жыл бұрын

    Ninja is Albert Einstein of the 21st century.

  • @wanahmadamsyarzafrie8080

    @wanahmadamsyarzafrie8080

    Жыл бұрын

    Nah not even Einstein has his own website to help people all over the world

  • @druutlectures

    @druutlectures

    Жыл бұрын

    Indeed

  • @enzamamahmed277

    @enzamamahmed277

    Жыл бұрын

    Indeed

  • @user-do5fn4ou3x

    @user-do5fn4ou3x

    Жыл бұрын

    😂 😂 😂 😂 😂 😂

  • @Iceblack002

    @Iceblack002

    Жыл бұрын

    True

  • @lyricsmusic4569
    @lyricsmusic456923 сағат бұрын

    I swear we have a lot of professors and professors and many who hold high academic degrees, but not everyone who holds a degree becomes a teacher in my opinion. Those who are able to simplify and communicate information are the ones who deserve to be appreciated and called professors, not those who hold a degree without being able to communicate ideas as well. Do, may God bless you, and we are always waiting for everything new from you. All the love from Syria❤

  • @user-nr8xi4we2h
    @user-nr8xi4we2h Жыл бұрын

    Protect this man at all cost! Cant thank you enough for simplifing such a complex topic, once again! Long live Professor Zach Murphy!

  • @mferso
    @mferso Жыл бұрын

    I Apreciate your tremendous effort to do these classes. I can say your class is much better than many professors!

  • @RambabuLakavath
    @RambabuLakavath Жыл бұрын

    We admire you from india. Iam a resident in internal medicine . To know any concept i will watch ninja nerd channel then i go to text books. Really we are very much in debt to you for this wonderful teaching. You have world wide fans sir

  • @nkemezekwe1382
    @nkemezekwe1382 Жыл бұрын

    I don’t think I’ll ever come across anyone that can teach like you, U take a person from stupid to genius. Thank you.

  • @garlicbread301
    @garlicbread301 Жыл бұрын

    Someone give this man a crown. He's a king!

  • @lucaspreafico7298
    @lucaspreafico72986 ай бұрын

    You are literally the substitute of my real pharmacology teacher

  • @muqtadaqutaiba2882
    @muqtadaqutaiba2882 Жыл бұрын

    Thank you so much!! This pharmacology series is the greatest of all time no doubt

  • @CaseyRoff
    @CaseyRoff Жыл бұрын

    Zac and the team... what the heck did I just watch? This was EXACTLY the lecture on antiplatelets, anticoags and thrombolytics I needed. I was always confused on why we give P2Y12 and ASA for MI and not Heparin, ASA and P2Y12 for stroke ect ect but this just made it so clear. Then you give reversal agents, drug monitoring and case examples just to remind us that you're not just a channel for pre-med but for clinical med students too. Love it so much and so happy with how far you guys have come.

  • @ayshadalieva9929
    @ayshadalieva9929 Жыл бұрын

    Huge gratitude from AZerbaijan. I don't know how I would be able to study medicine without your help.

  • @dsch522
    @dsch522 Жыл бұрын

    Zach your videos have been so incredibly helpful. My 62 Y/O wife has had Lupus since 1985. In 2015 her mitral valve was replaced due to Lippmann Sacks, in 2020 she had a massive DVT, and in October a subdural hematoma followed by bilateral PE’s, followed by an even bigger subdural. Your videos really made a difference. Whether Hematology (Platelets) or Brain anatomy. I seem to always find one of your videos that make it more understandable.

  • @ginaramnath1268
    @ginaramnath12687 ай бұрын

    This man (and the entire team) is a GOD-sent.

  • @PravinChandran1983
    @PravinChandran1983 Жыл бұрын

    this huge, beautiful video about the anti-coagulants is beyond comprehension, how you get the patience and persistence to make these marvelous medical science videos that benefits folks all over the world in medicine and paramedical /nursing etc. ? , thumbs up to all involved and take care and thanks again,

  • @sivajinidarmendra2250
    @sivajinidarmendra2250 Жыл бұрын

    Dear Professor, you're AMAZING....We all love you man.

  • @99Valem
    @99Valem Жыл бұрын

    i have a pharmacology test on monday about this, i cannot thank u enough, i feel like u read my mind haha

  • @qman1131
    @qman1131 Жыл бұрын

    This video came out in just the right time for me thank god.

  • @Drjpharmacy
    @Drjpharmacy Жыл бұрын

    Pharmacist Intern here 🤘🏽 and I approve of this video 😎 especially all of the drugs listed and the MOA. Drugs is our specialty

  • @imanmeer7041
    @imanmeer70418 ай бұрын

    Best lectures i have ever come across, bless you Zach🥰

  • @DanielM-il4rz
    @DanielM-il4rz Жыл бұрын

    Great job! Hospital Pharmacist here!! Job well done. 👍😊

  • @kxcreative6064

    @kxcreative6064

    Жыл бұрын

    how many of those drugs you know

  • @DanielM-il4rz

    @DanielM-il4rz

    Жыл бұрын

    @@kxcreative6064 I have heard of and understand all of them…although, our hospital (like most Healthcare Facilities) only keeps a selected number/type in stock. Most hospitals have a formulary of medications that are stocked and used on a regular basis.

  • @Heavyset_
    @Heavyset_29 күн бұрын

    i fell asleep and woke up to this

  • @janetombe6027
    @janetombe6027 Жыл бұрын

    I'm lucky to have you. I love your teaching. God bless you

  • @sukh6566
    @sukh6566 Жыл бұрын

    Went straight to this video, came out at the perfect time for me !

  • @eudorinaulva8123
    @eudorinaulva8123 Жыл бұрын

    You and dr najeeb are my saviors in med school.....thank you so much for doing this ❤❤

  • @Jetjetson
    @Jetjetson Жыл бұрын

    Wonderful to see u Zack. Your ability to impart knowledge is Magic. Your art is your beauty and your beauty is your art 😊 Master Diagramming

  • @LilFella67
    @LilFella67 Жыл бұрын

    Great content. One thing to remember, inpatient treatment of a confirmed clot (DVT/PE) requires heparin (or LMWH) combined with warfarin for a minimum of 5 days and INR >2 for 24 hours to prevent rebound clotting. Warfarin’s half life requires a much longer time combined with LMWH/Heparin to provide full anticoagulation. For DVT/PE prophylaxis, the overlap can be less.

  • @qman1131

    @qman1131

    Жыл бұрын

    Would you ever use tPA for a DVT/PE? I only hear about tPA for ischemic stroke events, but couldn't it help with DVT/PE as well?

  • @LilFella67

    @LilFella67

    Жыл бұрын

    @@qman1131 Zach talked about using tPA infused directly onto the clot. We employ this option at work. Typically, it’s a low dose infusion directly onto the clot as the location is identified with radiology. That’s for DVT. We don’t use it with PE. Obviously, it’s a lot harder to feed the catheter to the clot location in the lung.

  • @aurelienguitton4097
    @aurelienguitton4097 Жыл бұрын

    You king, thank you for all you've done for me chief !

  • @Lungmanvictor
    @Lungmanvictor Жыл бұрын

    I have watched this video now 3 times in my ECMO training. You have the ability to make it all very simple for me to understand. Oh, I wish the Ninja Nerd: Doctpr Classic came in a white. Bought my brother one already.

  • @cca8244
    @cca8244 Жыл бұрын

    Thank you for your hard work! I am definitely a visual learner so really appreciate this form of education which is even for free. You're doing a great job with each video. Greetings from Germany

  • @selenaserane2623
    @selenaserane2623 Жыл бұрын

    Wow i finally finished the vedio! Its not about marks anymore, its about learning new stuff everytime,huge thx to zach and the crew

  • @wwdpm
    @wwdpm7 ай бұрын

    Long live zach.. You help me a lot. Cant say anything more than thankyou. God bless you.

  • @NaveedAhmad-xb2io
    @NaveedAhmad-xb2io Жыл бұрын

    Great Work Professor Zach. You have made Pharmacology so easy.......Please make a video on CNS Pharmacology and Anti-psychotic Drugs & Epileptic drugs.......Love from Pakistan

  • @druutlectures

    @druutlectures

    Жыл бұрын

    Zalim apnay Pakistanio k lectures Nahi milay Kia ? ☺️

  • @markmurto
    @markmurto Жыл бұрын

    You were such a good teacher that I got all but one of the questions right at the end, [and that was the one where you said two choices, one was better in that case]. So I did pretty good and I'm not a medical student. I'm just a mechanical engineer type who loves this stuff.

  • @sajiruddinsk8129
    @sajiruddinsk8129 Жыл бұрын

    Don't compare with another, Ninja nerd is the best lec

  • @serahmed5346
    @serahmed53463 ай бұрын

    The effort you are providing to teach us is incredible. Thank you so much sir Zach Murphy

  • @TOMMY-xo1rq
    @TOMMY-xo1rq Жыл бұрын

    A walking work of art 🎨. Thank you sir ❤ .

  • @sureshkumar.t1300
    @sureshkumar.t1300 Жыл бұрын

    Sir we are from India no one give good content in general pathology neoplasia and all pls take general pathology also sir in your style ☺️

  • @waleedhussain9311
    @waleedhussain93112 ай бұрын

    This guy must be from another planet .Hats off. Salute 🫡 .no words can define your efforts 👌.

  • @abrahamendale2729
    @abrahamendale2729 Жыл бұрын

    I appreciate you my bro from Ethiopia

  • @BilalAhmed-if8rv
    @BilalAhmed-if8rv Жыл бұрын

    **hello zach in this lecture at 36:37 you have mentioned that gamma glutamyl transferase make proteins functional that are factor 2, 7, 9, 10, protein c and s but in another video of you on warfarin you have mentioned that it is gamma glutamyl carboxylase that make these proteins functional, the book I am studying for pharmacology is katzung and in that the enzyme mentioned for making the proteins functional is gamma glutamyl carboxylase not the transferase. So, I think it is a mistake.

  • @troykarlwena9115
    @troykarlwena9115 Жыл бұрын

    Thank you Prof. Zack Murphy, your video does help me alot. Not, only this one but all of your videos. I'm with you all the way from Papua New Guinea 🇵🇬. Please, do more videos to help us understand more. Your biggest fan.

  • @Medical_life_with_John
    @Medical_life_with_John Жыл бұрын

    Ninja is Don of medicine.

  • @SnowInHere
    @SnowInHere Жыл бұрын

    Keep up bro, your lectures are the BEST out there!

  • @MsEducatedScholar
    @MsEducatedScholar Жыл бұрын

    I love this channel. I found it this semester, my last semester of nursing school, and it’s so hopefully! I took anatomy several years ago & these videos are great at helping me remember things I thought I forgot. Zach, is an excellent teacher and it’s great to learn from someone who is excited about teaching, as it shows in his lectures. Please consider a way that students, grads, etc. can contribute to your channel to help it and your website grow. I refer classmates to your channel weekly and it’s so appreciated! ❤️

  • @queteimporta7049
    @queteimporta70493 ай бұрын

    You deserve the best

  • @atsbhah1971
    @atsbhah1971Ай бұрын

    I wish you released these videos when I was in med school, but I am making the best of them even now.

  • @mustafaahmed4091
    @mustafaahmed40918 ай бұрын

    Thank you, Amazing work!!

  • @sawantiparang6660
    @sawantiparang6660 Жыл бұрын

    Sir,,please keep all pharma lecture in one playlist,,it ll be easy to search

  • @johntom2362
    @johntom23625 ай бұрын

    Thank you very much Prof.

  • @indianasb59
    @indianasb596 ай бұрын

    You are such an amazing teacher!!!

  • @mohammadnawaz4450
    @mohammadnawaz4450 Жыл бұрын

    Love you Zack and team oh my god! You guys are doing great great job new pharmacology series love it from my heart

  • @getxited
    @getxited5 ай бұрын

    Wow listen you are one of a kind !!!! Infinite and accurate knowledge love it. Thank you sssooooooooooooooo much

  • @fas451
    @fas451 Жыл бұрын

    He is the best 💯💯💯

  • @woderyeleshkefale9791
    @woderyeleshkefale97916 ай бұрын

    Thanks a lot for your effort to share your knowledge with us

  • @salvadorhirth2919
    @salvadorhirth2919 Жыл бұрын

    You're the best!

  • @meerwasil842
    @meerwasil842 Жыл бұрын

    Thanku so much my beloved teacher you have helped me a lot....

  • @user-nf1to7bp2d
    @user-nf1to7bp2d11 ай бұрын

    Absolutely fabulous content and gripping presentation! If only every teacher could grab people's attention this well! Oh, but the ads! I was getting bombarded by 2 long ads every 5 minutes. There are also 1-2 ads to watch every time you jump back or forth to watch a particular section again. The excessive ads really destroy concentration, which is the opposite of what you want to (and do) achieve. They made me so mad, I just wanted to swat them out of the way like flies. After this, l will never, ever, ever order Lieferando! Your videos are great! Surely, there must be a less intrusive way to monetize?

  • @gib3666
    @gib36662 ай бұрын

    I agree with you 100%! Thank you very much for posting this video. I hope this topic will touch many hearts and help all to practice your suggestions and lessen their hardships and sufferings. Thank you again. ❤

  • @solsanchez5228
    @solsanchez5228 Жыл бұрын

    Wheew!!! You're the goat Prof. Much awe and respect🥰

  • @angela2366
    @angela2366 Жыл бұрын

    Fantastic information and so easy to understand! Thank you for taking the time to teach us!

  • @achalakp705
    @achalakp7053 ай бұрын

    The coolest explanation ever thanks for making me pro...and and wait...I'm not gonna get screwed up from my teacher. ❤

  • @madieingman1450
    @madieingman14508 ай бұрын

    These videos have been saving my life while in school! I absolutely love the content and find it easy to follow and so helpful in understanding difficult topics!

  • @ankitkumarsingh1998
    @ankitkumarsingh1998 Жыл бұрын

    learning just got so much easy!

  • @lananhtran9345
    @lananhtran934510 ай бұрын

    Awesome. I've learnt deeply all of knowdledge in this video. It make me clearly understand about antiplete, anticoagulation and thrombolytic mechanism. Thanks for a lot!

  • @zackbullock8198
    @zackbullock8198 Жыл бұрын

    Thank you for what you do! You have given answers to many questions I have about my condition. I have watched many of your videos.

  • @cherryblossom4178
    @cherryblossom4178 Жыл бұрын

    Thank youuu from Russia ❤️❤️❤️

  • @yhkuo870
    @yhkuo8708 ай бұрын

    thank you so much for connecting all the knowledge........ from physiology to clinical importance! Much appreciated!

  • @Usanov19
    @Usanov19 Жыл бұрын

    oh. ninja nerd best of the best in the world. thank you very much for tish best lecture👍👍👍😁

  • @gabriellukwesa7174
    @gabriellukwesa717410 ай бұрын

    i will always remain a ninja nerd supporter. my number one tutor🤩😇

  • @16parag
    @16parag10 ай бұрын

    Thanks Prof Zach for the beautiful and simplified lecture as always !! I would like to add 1. platelet transfusion is inefficient to reverse the effect of Ticagrelor, because circulating ticagrelor and its metabolite are likely to inhibit the fresh platelets. 2. Bentracimab is an antidote to Ticagrelor, it is still under trials though. It binds ticagrelor and its active metabolite with high affinity and specificity. 3. Apixaban clearance is less dependent on renal function(only 25%) compared to other DOACs and it is approved even in ESRD with reduced doses.

  • @gwynettsiriban3470
    @gwynettsiriban34709 ай бұрын

    I've been here since high school and you've helped me alot

  • @harshitagautam9414
    @harshitagautam9414 Жыл бұрын

    Thanks a lot for your hard work Your explanations are awesome Can you please cover Tuberculosis next week.

  • @vinceh1306
    @vinceh1306 Жыл бұрын

    Amazing work, job well done!

  • @dr.ss-4077
    @dr.ss-4077 Жыл бұрын

    Please cover whole pharmacology playlist my exams are near you r my hope ❤❤

  • @ninodiogenes949
    @ninodiogenes9498 ай бұрын

    Awesome, always the best! tks a lot from Brasil.

  • @zaidkhan-yc3fd
    @zaidkhan-yc3fd11 ай бұрын

    Thank you sir. I become sedative to watch your lectures . I always search ninja nerd for new topic

  • @cptnemo7626
    @cptnemo7626 Жыл бұрын

    You are a medico rockstar🎉🎉

  • @hammbaby
    @hammbaby2 ай бұрын

    god the platelet plug formation and anticoagulation was a beast just like you said, but you taught it so well, thank you ninja nerd team and once I get paid I'm going to sign up im looking forward to the notes yall have!

  • @user-ly1jx4mj8r
    @user-ly1jx4mj8r Жыл бұрын

    Than you so much for extensive explaination

  • @kelvinchan3069
    @kelvinchan30695 ай бұрын

    Thank you for all your hard work. Much appreciated.

  • @gareebameer
    @gareebameer2 ай бұрын

    Finally completed the video and made notes 😎

  • @tiagolince1262
    @tiagolince1262 Жыл бұрын

    Love this channel a lot

  • @karmakarma5932
    @karmakarma593211 ай бұрын

    Thanks for your efforts ❤

  • @drdritero
    @drdritero Жыл бұрын

    Great job. Thank you a lot for these videos.

  • @moa4950
    @moa4950 Жыл бұрын

    Hi! Could you do a vid on lower limb amputation, or just amputation at some point? Maybe some possible causes, different types, functionalities of each, and recovery or something? Please and thank you :)

  • @tigerhillsupa
    @tigerhillsupa Жыл бұрын

    It took so much time to digest! however it is the best lecture for anticoagulation

  • @kritikagarg6381
    @kritikagarg6381 Жыл бұрын

    Great work man

  • @raithneach
    @raithneach Жыл бұрын

    Very helpful. Thank you.

  • @abeermohamed2011
    @abeermohamed2011 Жыл бұрын

    I really appreciate your hard work 💕

  • @segunpeters6201
    @segunpeters6201 Жыл бұрын

    Another excellent lecture. Thank you For the activation of vitamin k dependent enzymes, I suppose you wanted to say gamma glutamyl carboxylate rather than gamma glutamyl transferase

  • @tonylee1835
    @tonylee18354 ай бұрын

    Incredible teacher

  • @DanGuz-wn9fq
    @DanGuz-wn9fq Жыл бұрын

    THANKS Dr. Finally getting the real eXplanation Of my PE I LOVE UOU NOW BY ADMINISTRATION

  • @rosemaryrodrigues306
    @rosemaryrodrigues3067 ай бұрын

    Thank you for sharing such good information

  • @EstherZuru
    @EstherZuru4 ай бұрын

    Your doing a great job Ninja❤ Thanks a lot!!

  • @sawantiparang6660
    @sawantiparang6660 Жыл бұрын

    As always amazing,,,,keep upload like thus video in all topic sir, thank you

  • @horcadanielap.4507
    @horcadanielap.45076 ай бұрын

    Thank you so much!!! youre making my life easier!! thank you thank you!!!

  • @AAUN
    @AAUN Жыл бұрын

    Among the antoplatelet drugs the commonly used drugs are Aspirin , Clopidogrel etc. Anticoagulants include rivaroxaban , abigatran and edoxaban . While prescibing these drugs proper education of patient is extremeny important.

  • @koroshizadi
    @koroshizadiАй бұрын

    thank you so much for these unique videos