PharmGKB

PharmGKB

The Pharmacogenomics Knowledgebase (PharmGKB) collects, curates and disseminates knowledge about the impact of human genetic variation on drug response (pharmacogenomics).

Please note that PharmGKB is a research organization and, as such, is unable to offer clinical advice.

How to Run PharmCAT

How to Run PharmCAT

Haplotypes and Star Alleles

Haplotypes and Star Alleles

Пікірлер

  • @appleifc
    @appleifc7 күн бұрын

    WOW!

  • @sidlee3118
    @sidlee311814 күн бұрын

    Evil eugenicists.

  • @AtanukumarDutta
    @AtanukumarDuttaАй бұрын

    Getting the following error while executing the command - python preprocessor/pharmcat_vcf_preprocessor.py -vcf pharmcat_positions_2.8.2.vcf File "preprocessor/pharmcat_vcf_preprocessor.py", line 103 script_dir: Path = Path(globals().get("__file__", "./_")).absolute().parent ^ SyntaxError: invalid syntax

  • @PharmgkbOrg
    @PharmgkbOrgАй бұрын

    For help, please open an issue at github.com/PharmGKB/PharmCAT. You will also need to provide more information. For example, version of python are you using?

  • @jaimedeleon1194
    @jaimedeleon1194Ай бұрын

    I love the information you're sharing here. Do you have any videos or good reading material on star alleles?

  • @jaimedeleon1194
    @jaimedeleon1194Ай бұрын

    Edit* found it. Thanks for the supporting video in the header!

  • @franciscotapia7219
    @franciscotapia7219Ай бұрын

    Interesting.

  • @dudeinnz
    @dudeinnz3 ай бұрын

    The bit about transparency, like you say is so critical!

  • @user-ro2ib1tz4h
    @user-ro2ib1tz4h5 ай бұрын

    Hello Thank you for the tutorial. But The pharmcat-2.8.2-all.jar file does not exist github anymore. Is there any alternative to this part of the pipeline? has something changed in Pharmact pipeline? I really appreciate if you can guide me on this matter.

  • @PharmgkbOrg
    @PharmgkbOrg5 ай бұрын

    All releases are available on GitHub. Make sure you click on the "Releases" link instead of a specific version. Here's a direct link to 2.8.2: github.com/PharmGKB/PharmCAT/releases/tag/v2.8.2

  • @MrMyfra
    @MrMyfra6 ай бұрын

    Excellent video well done

  • @FreedomBiafra
    @FreedomBiafra7 ай бұрын

    G-L660 is my Haplotype. Does this mean my actual lineage? My ancestral line?

  • @dashagudym3938
    @dashagudym39387 ай бұрын

    Thank you so much for this awesome video. Started taking clomipramine 3 days ago and developed serotonin syndrome and bunch of unpleasant side effects. My psychiatrist gave me the normal starting dose of 25 mg/day but I feel like I’m dying. This explains a lot

  • @lourraheresa8491
    @lourraheresa84919 ай бұрын

    amazinggg

  • @GudduKumar-wd2xg
    @GudduKumar-wd2xg9 ай бұрын

    Veadeo hindi me ❤

  • @iqraiftikhar100
    @iqraiftikhar10010 ай бұрын

    Amazing lecture.. 👏🏻 . But volume is low... resolve this issue.. difficult to hear 😞

  • @GudduKumar-wd2xg
    @GudduKumar-wd2xg10 ай бұрын

    Tast ka prige

  • @GudduKumar-wd2xg
    @GudduKumar-wd2xg10 ай бұрын

    Mam is sa pura pata cal jata haii gilbad haii ya nahi

  • @NasuMeji
    @NasuMeji11 ай бұрын

    WHY?! Did an insane person create this nomenclature? It seems idiotic.

  • @zulucharlie5244
    @zulucharlie524411 ай бұрын

    Outstanding information, very comprehensive and clear - thank you very much!

  • @jayeshsinha7045
    @jayeshsinha7045 Жыл бұрын

    I am normal metalbolizer and i started 50mg azoran and after 4weeks WBC reduces from 5800-3900 i stopped ,i am suffering from cronhs disease what are option available to maintain remission

  • @ramanipandurangan533
    @ramanipandurangan533 Жыл бұрын

    Great talk👍

  • @thaarapillai
    @thaarapillai Жыл бұрын

    Thank you for the wonderful talk and for sharing your experience! It was really motivating and covered mostly all aspects of academia.

  • @jasonmoore1051
    @jasonmoore1051 Жыл бұрын

    Thanks for recording and posting!

  • @kathyorrico4670
    @kathyorrico4670 Жыл бұрын

    Thank you for this truly excellent summary of the PGx resources!

  • @DhwaniPatel-vx9fq
    @DhwaniPatel-vx9fq Жыл бұрын

    Hey!!! How you have made your first slide transition? Can you please tell me,

  • @shivammestry6779
    @shivammestry67799 ай бұрын

    it is done with the help of morph transition

  • @Daniel-ii4zq
    @Daniel-ii4zq Жыл бұрын

    💥 𝕡𝕣𝕠𝕞𝕠𝕤𝕞

  • @jeremiahsegun9370
    @jeremiahsegun9370 Жыл бұрын

    Am Forever grateful to God🙏and Dr Alued on KZread He was able to cure my HIV diagnosis with the herbal medicine I order from him He can also cure so many sickness like HPV, HEPATITIS B, HIV, CANCER, DIABETES, LUPUS 👇 search him on KZread Doctor Alued

  • @samanthasantana6321
    @samanthasantana63212 жыл бұрын

    Thank you very much 🙏👏👏

  • @floschossow8596
    @floschossow85962 жыл бұрын

    👊 ρɾσɱσʂɱ

  • @sevenman9672
    @sevenman96722 жыл бұрын

    One of the same enzymes that metabolises THC

  • @sevenman9672
    @sevenman96722 жыл бұрын

    Even with cyp2d6 inhibitors like fluoxetine codeine still has some effect even if its mainly from codeine 6 glucoranide as opposed to morphine but obviously its relative potency is reduced relative to extensive and ultrarapid metabolisers.

  • @Rick_Cleland
    @Rick_Cleland8 ай бұрын

    👀

  • @sportspharmacists
    @sportspharmacists2 жыл бұрын

    Thank you for useful summaries! They are great!

  • @sangeetharamdave6274
    @sangeetharamdave62742 жыл бұрын

    I’m really looking forward to coming and working in your great lab!

  • @sportspharmacists
    @sportspharmacists3 жыл бұрын

    These are amazing free resources. Such a wealth of information. Thank you for standardizing and maintaining those data displays with consistent harmonized structure.

  • @sevenman9672
    @sevenman96723 жыл бұрын

    Ads off

  • @ashantifranklin9768
    @ashantifranklin97683 жыл бұрын

    All thanks to doctor Aba for curing me from HIV am forever grateful sir

  • @huntdaworld1053
    @huntdaworld10533 жыл бұрын

    Free Cedric Millage

  • @huntdaworld1053
    @huntdaworld10533 жыл бұрын

    What you are listening to now by Dr Hampikian

  • @huntdaworld1053
    @huntdaworld10533 жыл бұрын

    Dr Hampikian allowed his forensic science friends to talk about Y-STR standard s thay was not reliable.Free cedric millage.

  • @angelomartan7762
    @angelomartan77623 жыл бұрын

    You place everything revolves around you, stupud.

  • @angelomartan7762
    @angelomartan77623 жыл бұрын

    Why so hurry to speak, are you trying to impress us about your speed reading, dpeaking?

  • @mohammadadnan6374
    @mohammadadnan63743 жыл бұрын

    Very informative thx

  • @f1l4nn1m
    @f1l4nn1m3 жыл бұрын

    I ❤️ Carole! She rocks!

  • @sangeetharamdave6274
    @sangeetharamdave62743 жыл бұрын

    I am coming

  • @Bc-um9qx
    @Bc-um9qx3 жыл бұрын

    What's that even mean lol

  • @miramir2876
    @miramir28764 жыл бұрын

    please I need helpe i'm reading some articles concerning CYP2D6 and i found that in some cases when genotyping CYP2D6 some persons have sevral diplotype in CYP2D6 and I don't understand the process and can that exist ? for exp i find a person with this genotype ( *1/*1 - *1XN/*5 ) and I didn't understand I should considred him as an Extensive Metaboliser or Ultra rapid ?? and why he gote 2 genotype ?? the first is for the maternal chromosome and the second for the paternal chromosome ..??? please I need an answer.. thank's

  • @greghampikian2616
    @greghampikian26164 жыл бұрын

    Kerry Robinson, the prisoner mentioned in this talk was freed the day after this conference. He had spent 17 years in prison. He was freed by math and DNA.

  • @Montessori6587
    @Montessori65874 жыл бұрын

    Thank you for approaching complex issues so simply, concisely and with gentle humor. You poke holes in beliefs and allow light to flow. Lovely. You have helped me understand more clearly what to explore in what we are putting in place here in our Nature-based educational approach here at Another Way School for children - Native and nonnative.

  • @murlidharpatil8056
    @murlidharpatil80565 жыл бұрын

    Sir medicine o. UGT1A1 for normal bilirubin metabolism

  • @GudduKumar-wd2xg
    @GudduKumar-wd2xg9 ай бұрын

    aap tast karbaiya haii

  • @jimwoodgett9107
    @jimwoodgett91075 жыл бұрын

    Fantastic talk that covers a lot of ground and lives up to its title. Even ends with a question on #MeTooSTEM and the advice to NIH to make harassers ineligible for training grants (a no-brainer).

  • @KevinP32270
    @KevinP322707 жыл бұрын

    FREAKING AMAZING!!!

  • @hasanaiham9070
    @hasanaiham90709 күн бұрын

    😢😮

  • @sent4dc
    @sent4dc8 жыл бұрын

    So if I understood correctly they can cut out chunks of RNA but they cannot add them yet. Is that right?

  • @gwangwadaniel
    @gwangwadaniel8 жыл бұрын

    This technique is very awrsum scientific break thought but i have a lot of question and ethical problem with it because if its going to be authorized to human application companies which will be using it can edit human embryo to do a lot of genetic changes that get get out of control in the future.This will produce a new generation of genetic modified human which can facilitate a man made human evolution.Again who is gonna authorize which genes should be edited and on what condition and another thing is money ,only rich people will be able to edit their genes and they wont die or get sick .

  • @obaidullahkhan797
    @obaidullahkhan7978 жыл бұрын

    but still we don't know about our DNA so lts still ambitous.So we still cannot apply it to people.