I'm a medical doctor board-certified in Family Medicine and Emergency Medicine with an interest in longevity, health optimization, treatment and avoidance of chronic disease, and using medical science to optimize quality of life.
This channel is where I'll discuss health topics to improve the lives of men. The focus will be on high-intensity exercise, nutrition, hormones, healthy lifestyle choices, medications, and any other topics that pique my interest.
WWW.MANMEDICINE.COM
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RIP, James Helwig AKA “The Ultimate Warrior “. He was my favorite man ! 54 years young he passed 🙏
Ive used dapagliflozin with and without semaglutide. Cant say i noticed much besides being hungrier.
More great content Boss, thank you ! 🙏 Have you heard of the FOX04 peptide ? Seems like another one with both potential upsides and issues but I was curious about your thoughts.
Excellent, informative content once again! Since the conversation of erythrocytosis comes up often, it would be cool to see your take on Naringin and whether or not it's a viable option to mitigate the elevation in HCT/HGB sometime in the future.
Excellent content! Do you take any of these?
Do SGLT-2 inhibitors raise LDL? Saw claims that they do.
Yes, at least the studies say they do, but I can't see I've seen major changes in practice. Probably because many people on these drugs are also on statins, ezetimibe, etc.
For me, this drug was a nightmare, constant yeast infection, dehydration, and started messing with my BPH stay away. Stay away stay away.
Definitely not for everyone. Thanks for sharing the downsides.
Any video on dose frequency?
I’m 52 stage four arthritic right hip left hip looks good. Arthritic knees, lower back arthritis facet joint arthritis in the cervical spine. My doctor said my spine looks about 80-year-old man. Start a 25 mg of deca on top of my low-dose TRT my test levels are good up in the 900 range all other labs, good thyroid, good but the amount of relief that I’m getting in all my arthritic joints is amazing at only a dose of 25 mg a week. I can actually walk 100% better!
That's incredible
@@manmedicine it is. It should be in every orthopedic office as a protocol.
@@manmedicine any thoughts about how long I could keep this dose up? Not looking for medical advice.😉
No mention of berberine or dihydroberberine !
The video is about testosterone
@@manmedicine I thought the video was about the best ways to deal with type 2 diabetes - testosterone is the primary but always receptive to the best available evidence with the least amount of side effects- is there some off the shelf testosterone product that works effectively in assisting with type two diabetes ?
People with low LDL are more likley to die of sepsis as LDL is part of the immune system and removes gram negative bacteria. Dr. Paul Mason.
Even the AHA agrees that low LDL in over 50's lowers life expectancy.
Celebrity wrestlers die of cocaine induced myocardiac infarction. Rick Rude, Mr. Perfect, Roddy Piper, etc.The Ultimate Warrior died of MI but the cause was undetermined.
So what diet do you recommend? The AHA high sugar, low fat, low sodium, healthy grains and seed oils which caused everything in the first place?
Sugar causes atherosclerosis not high cholesterol. Most heart patients are pre or full diabetics. The research into familial hypercholesterolemia causing heart disease is sketchy.
Most Americans are pre-diabetic or diabetic
How about calisthenics
There's no money in it
Repatha expensive dollars a shot 350
Yeah its crazy
Coronary artery scan under 100
What about hmg ? Everybody speak about trt plus hcg or trt plus gonadorelin , but what about directly stimulation fsh with hmg ? Microdose ? Or trt with hcg plus hmg together ? I never found no data about that , hmg is much better less extrogenic , everybody complain about price but did someone ever try it ?
Very valuable video!
Congrats Andrew, you got a lot more subs since I been on your channel last. Last time I was here you were at about 1500! Awesome to see this growing. Such an important topic!
Thanks!
Thanks for the discussion about the impact on neurotransmitters and what happens in the synapses. It sounds like someone like me who can’t take SSRIs (due to a difference in biology that means drugs like that cause flooding in the synapses instead of the intended actions) probably can’t take tesofensine?
Yeah i would probably avoid it
Glad you’re on it. We definitely should not be burying our heads in the sand with these health issues. Thankfully we have individuals like you educating us. I’ve actually never heard of this calcium score test until I started a carnivore diet eleven months ago and my doctor became very concerned. Even though I lost fifteen lbs and look, feel better she’s definitely not a fan of a meat only diet. She recommended the calcium score test. Honestly I was a bit apprehensive because at 57 years old I was a raging sugar addict most of my life. It wasn’t until I started on TRT 10 years ago that I took a better approach on my health and diet. Anyways to my surprise I scored zero across the board. Do you think there is a hereditary connection to this? My great grandparents, and grandparents mainly succumbed to cancer or Alzheimer’s related conditions. But no coronary artery disease that I could find.
Yes absolutely. Genes make a big difference
How come amphetamines dont cause the same damage being a more potent stimmulant? Shouldnt it also be as likely to cause arythmias?
They do. I see meth cardiomyopathy almost every week
Hey Doc, it’s Sean from Matrix! I also tell people the same thing about calcium scores. I’m more concerned about the soft plaque that is not being tested for. I’m glad you bring this up to help others understand that calcified plaque itself is relatively safe. Of course you just don’t want a lot of it built up.
Hey Sean! Yeah you got it. A zero score is good, but doesn't mean you can slack off!
Great channel. Ex SF and also in healthcare. Keep up the good work. Thanks.
Thank you, sir.
Great video. Thank you. You were talking about 1" needles for "Fatties" and IM's. Well, I'm almost one of those "Fatties" and I was thinking of using a 1 1/4" 27 G needle. Does the extra 1/4" concern you? Thanks.
I am currently on TRT. I also have Gilbert's Syndrome ( I don't know if this plays a factor). My current levels of Hematorcrit are 0.532 L/L and my Hemoglobin levels are 177 g/L. My MCV is around 96. As a result of my Gilbert's my platelet count is 134 xE9/L. I should also mention that I have PTSD and moderate obstructive sleep apnea. ( I have difficulty using my CPAP at night , usually only getting 2-3 hours of sleep with it on and the rest of my sleep with it off) My levels of Hematocrit have slowly creeped up over the years of being on TRT. Just recently after getting my blood results my Clinic has done exactly what you are talking about. Basically scaring me, telling me I MUST go make a blood donation and if the levels don't come down they will take me off TRT altogether. Can I please have your feedback?
Using CPAP can be a difficult adjustment. Maybe consider seeing if you are a candidate for some of the surgical procedures to correct sleep apnea.
Fell into the camp where I was "feared" into donating blood every month while on therapy. I just received my new labs, my ferritin is now 8.
Sadly, I see this a lot.
Unfortunately I hit 61 this last blood panel, with a hemoglobin of 19.5....so a phlebotomy was definitely needed.
On the PLUS side, BP was GREAT (127/73), total Cholesterol was great (130), HDL/LDL great, etc. I also live at mile high elevation so my range is probably a little higher than most to begin with.
Well if you lived in La Rinconada, Peru you would have an average HCT ;)
@@manmedicine super high altitude?
What about doing only 50-60 mg of test (exo) and clomid (50 ed)?
So low doses of T with Clomid can allow LH and FSH to rise but its not a great protocol long term
@@manmedicine thank you!!! How long can it take to rise LH if I’ve been blasting and crusing on 200-500 mg for about a year now? I want to come off completely and try this method with propionate and clomid…
Great video!
As a bodybuilder who has been on lisinopril for 3 years my bp got to where I was increasing dosage so I decided to throw in 5 mg per day and it brought me back down to 119 so I would say in combination with something else it's great and this video is great because more men need to definitely keep an eye on their blood pressure
So I'm just getting to this video now and I would like to point out (as long as I'm not mistaken) that a severe burn victim's skeletal muscle doesn't necessarily "waste" away, more than it's being used to feed the body for repairs. More of reallocation than (a)typical wasting due to a caloric deficit combined with a hypermetabolic syndrome or Atrophy. Am I incorrect?
You're correct. It's post-burn hypermetabolism.
@@manmedicine Thx dude, keep up the great work! We all appreciate it👍
Thanks Andrew. Great video as always.
Great video, thank you for sharing your knowledge
The only thing that worried me was that when I started TRT, you need to watch out for breast tissue growth. I am not worried about that now, nor my estrogen/estrodial levels but I was at first because I had heard horror stories. One question for you all, why do some guys develop breast tissue that looks sort of female, fatty tissue while on TRT? Is that not estrogen related? Gynecomastia is what I am thinking about. Is that more steroid abuse related? Thanks all.
What about npp?
Fascinating, especially as I had a Heart Attack 2 weeks ago, 72 yrs old, 6.5 yrs after Dble By-Pass (100% LAD, no heart attack), HDL/LDL within parameters, 4x Week lifting, avg 4k daily Cardio .... sometimes I guess chit just happens ... if you are young watching this, ffs take note GL 🍀
Wow. Glad you made it!
@@manmedicine Thanks... 🙏
Is vision loss with Tadalafil something to be concerned about
drugs do not pay off!
💉
Does nattokinase, serrapeptidase, and garlic safely get rid of hard and soft plaques?
Aged garlic and Berberine. Vit K2 maybe.
A young male basketballer died of a heart attack. Hmm. What, in the last 3 or 4 years could have caused this?
I have a question sir, what happens to an androgen after interacting with androgen receptor? does the AR change it into something else or does it unbind from the receptor and gets disposed of or goes to another AR?
Testosterone leaves the receptor and is conjugated with glucuronic acid and sulfuric acid in the liver to form androsterone glucuronide and etiocholanolone glucuronide, respectively. The conjugated metabolites are then excreted in the urine. They are also metabolized by bacteria in the gut.
@@manmedicine amazing, thank you sir
@@manmedicine the question remains that does a testosterone molecule bind to another AR after unbinding from previous AR? or Glucuronidation or Sulfurization heppen before testosterone binds to another AR?
@@armanrasouli2779 Yes, it eventually is released and is potentially free to bind again until it is metabolized.
@@manmedicine appreciate it sir
screening options make great videos man
Hey doc, my question is can you draw and inject with the same insulin needle to do SC (perhaps dulling the needle for injection) or do you initially use a traditional syringe and needle say 21 inch to withdraw then switch out toa 27 g 1/2 inch for the SC into the stomach?
You can but it does dull the needle a little.
What is the best way to reduce LDL, diet and exercise for 6 months have lowered mine slightly but I’m still 30% above the reference range
Oméga 3, citrus bergamot, soluble fiber and if not enough ezetimibe wich is NOT a statin
Drop your body fat to 10-15% and reevaluate. Genetics do play a role and meds are sometimes needed.
Superb explanation & insight. A true reality check on men’s health & lifestyles on top of genetics. Thanks for the information
If a carotid echo showed minor plaque but the calcium score was 0, do you think that requires aggressive management if lipids, BP are normal and HbA1c under 5.5?
Most important context is your age
Well you have built some plaque so I'd take it seriously and see where you can improve
@@FS-wd3hu Early 50s