In before this channel blows up. Vigorous Steve mentioned you on his recent podcast and I've now already watched almost all your videos. I like your style, your humbleness, and dead honesty. Keep at it and have a great run.

@manmedicine

8 ай бұрын

Thank you! You made my day

@Michael_Komansky2679

5 ай бұрын

Props from Steve is a legitimate "co-sign"

Impressed with such a comprehensive review. I've used Tesofensine on and off during the past two years. First run I did was 1.5 months at 0.5mg/day, got a noticeable mood improvement after a week or so, way more active and willing to take action instead of slacking, which at times I tend to. After a month it was evident I was losing fat mass in the midriff area (I also exercise extensively, I do 2h of high intensity exercise, mostly tennis, or 1h of resistance training 5-6 days a week). I noticed after 1.5 months I started to get "overactive" mentally, sort of, as if my brain would go into overdrive, and that didnt feel too good, so I discontinued use. Took a few days for that feeling to wane down. I've since used it here and there on an as-needed basis when I feel I need an extra umph. You mentioned about anyone with a history of panic attacks, and I do have one. Not major and all quite well resolved, but I've had 3 such instances that I can recall, and teso didnt seem to trigger anything of the sort, though I can see some potential for it on people with a more severe proclivity to panic attacks...

@GalenEppley

3 ай бұрын

Source?

Most comprehensive review of tesofensine I have seen so far. Great video. Do more chemicals such as this. They would do well. First time viewer.

Im super curious about tesofensine and really appreciate at the thoroughness of this overview. Will subscribe to your channel for more of this even though I’m not a man. Edit: ps if you can recommend any channels with similar content and quality but dealing with women’s health /hormones, or just general health, I’d really appreciate it!

Incredible stuff

Phenomenal information!!🏆 Subscribed,liked,& notifications on!!!

@manmedicine

2 ай бұрын

thanks!

Hello sir, you seem very educated. I got one question, im prescribed Tramadol. Would it interact in very negative way with Tesofensine? Would really appreciate your feedback

Could share personal experience asked about but would prefer to do so in a private manner

Do people have to follow a low tyramine diet with Teso like with other MAOIs? I haven't seen anything like that so far with this, but if it's in the same class, I would assume that might still be an issue. It really would be helpful if there was a medication interaction list or warnings about diet (if there is one). The reality is that nobody is going to be able to get the green light from their doctor when it isn't FDA approved yet, and people are taking it anyway. But really, thank you for this video and going over it in depth with everything you've been able to find on it. You've been the most informative source I've found so far.

@manmedicine

6 ай бұрын

Great question. It's probably not necessary but I would be cautious since this is, as you said, a relatively new drug. Some docs are prescribing it via compounding pharmacies. I'm hopeful it will pan out, but i'm waiting before I jump on the bandwagon.

Doc! i use armodafinil low-dose sometimes.. i "feel" similar effects but of course not as much. i need to find way to sleep on time , ill try melatonin. i am getting dry mouth, but i just drink more water so thats good thing i guess. i don't think of food at all, no cravings. but my son brought a subway sandwich and i had no problem eating, unlike semaglutide where i would eat maybe half than normal. I'm on Day 2 so i'll update after a week.

@manmedicine

4 ай бұрын

Interesting! Yes please send an update down the road

Best review of this drug ! My only concerns are the blood pressure and heart rate . But I took contrave and there was no issue ( although contrave didn’t work for weight loss) . Can I extrapolate and assume I would be ok. Normally my pulse rate runs in the 50s and blood pressure is normal . Thankyou

@manmedicine

4 ай бұрын

I wouldn't assume you'd have a similar experience. We don't have enough studies on this drug.

Sounds like this would be useful for ADHD?

Great video as always. Could you do a dive on raloxifene and Tamoxifen and their potential treatment for puberty caused gyno and the benefits and side effects .

@051Jerrett

2 ай бұрын

That will just shrink the growth "possibility" the only cure is surgery

I am often reminded of Eben Byers when referencing the online “research” pharmacies. His body is still so radioactive it had to be interned in a special lead coffin.

Thanks for the discussion about the impact on neurotransmitters and what happens in the synapses. It sounds like someone like me who can’t take SSRIs (due to a difference in biology that means drugs like that cause flooding in the synapses instead of the intended actions) probably can’t take tesofensine?

@manmedicine

4 күн бұрын

Yeah i would probably avoid it

We know the many SSRI have unwanted sexual side effects. Do we know if TF also causes erection and of ejac issues?

Is this shown/speculated to mess up neurotransmitters after use or long term?

@manmedicine

3 ай бұрын

Unknown but possible

Taking low doses of amytriptylene HCL- (10mg daily) Would Tesofensine affect this in any way? Would I have to worry about serotonin syndrome?

@manmedicine

7 ай бұрын

I would not risk it without explicit permission from your doctor.

Experienced significant agitation, mania, paranoia, insomnia. Discontinued use after 11 weeks. Took 4-6 weeks for side effects to occur.

@manmedicine

4 ай бұрын

I could see it causing things like that for sure.

Meridia (Sibutramine) was fda approved but later found to cause strokes and cardiovascular problems .. they are probably being extra careful this doesn't have the same side effects. I'd wait out on trying, there could be a reason it hasn't been approved yet

@manmedicine

7 ай бұрын

I think you might be right. That would make sense.

Is the liver toxicity from this drug caused by depletion of glutathione when it is metabolized by the liver?

@manmedicine

8 ай бұрын

nope, it's just competition between multiple drugs for the same enzyme. It's a theoretical problem with tesofensine. There's not studies I could find that answered whether or not we have to worry about this.

Gonna have to somewhat disagree with you. I have experience with the drugs its compared to. And to be very honest. I cant decide if its more like C or M. That said. This is my 2nd try. The 1st attempt got nothing. In fact It made me irritable and no noticeable effect on appetite. #2 was off the charts and had me questioning if it really was teso. I couldn't sleep for almost 3 days taking a similar sized dose as the 1st attempt. Lesson learned. I decreased the dosage by 99% and its perfect. I get a boost in energy, drive, mood, and clarity of thought. Its like the fountain of youth no joke. I use it only sparingly if I need a boost. The experience while enjoyable hints that it wont get any better and probably worse if used again the next day. But I will share this. I got it from an outlet and not off the street. And I still do question if what I have really is Teso to the point I considered purchasing something to test it. I can only handle about 5 drops in a glass of water. THATS IT. Anymore and I wont be able to get any sleep. I hope this helps and you look like Randy Couture yes!

@palana8870

6 ай бұрын

Couple of questions. Was this liquid you ingested a 1mg/ml set up? Could you describe the effects in more detail? I am having difficulty finding any anecdotal accounts of user experience. Thank you.

Would this show up on a CDL drug test

@manmedicine

4 ай бұрын

Not sure. It would probably show up as a false positive for tricyclic antidepressants or possibly amphetamine. I'd have to dig up the tox data to see if anyone has looked into that.

@billhobbs9969

3 ай бұрын

Curious if there is an update to this question

That fly buzzing around in the video needs to sit down and start taking some notes

@manmedicine

6 ай бұрын

I think he was on tesofensine

I took this for 30 days, til i remembered there was an interaction with my bupropion, which ive been taking forever to try and help me quit smoking. Like...7 years. No go. 30 days of tesofensine...havent smoked since july (its new years eve at this moment). Also lost about 10 lbs, but note that if you do eat...you will have a full normal appetite. It just makes you not think about stuff if its not in your face. I did my first 24 hour fast while taking it and was never starving feeling. I'm interested in what exactly the interaction is with buproprion cause ive got another 30 day supply of it just hanging out on my bathroom counter atm.

@GalenEppley

3 ай бұрын

Source?

@davidmeloche3563

3 ай бұрын

@@GalenEppley source of what? Where I got my tesofensine? Or the "don't take it with antidepressants"? That's in the medical literature on tesofensine. WebMD. PubMed. It's called "Serotonin Syndrome" and taking anything that affects serotonin runs the risk of that, like antidepressants or triple re-uptake inhibitors.