Definitely important to mention L-carnitine metabolites considering their concerning effects. Intestinal microbiota metabolism of l-carnitine is shown to produce TMAO and to accelerate atherosclerosis, heart disease, and cancer. Gotta be responsible with the reporting and not only share the potential positive effects of supplementation

@johnmayneson9539

Жыл бұрын

This is assuming tmao is dangerous. The research is rather shaky if tmao does cause any of those effects. It’s only been shown that some people with cancer had higher tmao levels, is that causative? Who knows but considering our bodies make tmao in the gut I pose the questions why our bodies would make something that allegedly does so much damage…?

@gatesroyale

Жыл бұрын

@@johnmayneson9539 valid points hope others listen to your explanation

@scottwilliams9116

Жыл бұрын

I’ve been supplementing with 5000g of l-carnatine and mitigating the tmao issue by taking garlic extract which is a good anti microbial

@melastname2690

Жыл бұрын

Says the guy named @pathologicaldoubt

@jahongirkarim

Жыл бұрын

The connection between TMAO and atherosclerosis, kidney disease, etc. is only a correlation and correlation does not prove causation.

Love this channel so freaking much bro. My friends are constantly asking me for workout/supplement advice you’re always one of the few channels I recommend. Longtime fan; really appreciate all the work you put in to make the information as digestible yet non-biased as possible.

this guy is awesome, all vids are very informative and this dude researches the hell out of everything

Awesome review of the science on L-carnitine. You did your homework! I will be watching more of your videos.

Ray peat said that Carnitine "promoting the oxidation of unsaturated fats during stress, and increasing oxidative damage to cells". Also another website (tusolwellness) states "L-Carnitine has been found to increase the activity of AChE, the enzyme that breaks down acetycholine in the hippocampus"\

Great video man!

glad I found this channel, love the approach! subscribed. thx sir for the great job.

Excellent video!

Excellent information 👍🏽💯

Fatty acids are not broken down into ATP. The breakdown of fatty acids releases energy which is coupled to the synthesis of ATP.

Awesome as usual 👏👏keep it up bro

Great Video. Thank you very much!

Thank you very much. Great video

Its a nootropic as well, its amazing

Wow. That was a lot of good info to digest.

Love your videos!!.. would you ever do one talking about magnesium?

Great Video! Thanks for the Life Upgrading Info! Gday from down under (Australia) =)

Bravo sir yet another excellent and informative video! Would love to see a video on vitamin k2 mk4 and mk7 and it's potential to increase testosterone...

As always, thanks for the great and detailed information and research you put into your channel. I see an existing comment asking about timing and dosing. Would like to know about that too. Please keep up the great work !!

Amazing! You hit all the facts. I would say that injectable forms are so much more effective... Like way way way more effective!

In the thumbnail picture he uses Gorilla Mind's Carnitine L Tartrate, best for androgen receptor upregulating and fat loss when used at 4g+. When he speaks about cognitive performance at 10:20, it is explaining ALCAR (ALC or Acetyl L Carnitine) which crosses blood brain barrier easily, taken at 500mg-1.5g. And then plain old L-Carnitine. Make sure you know which you are getting, as they may have different benefits

@robmagz

Жыл бұрын

When is the best time to take l carnitine tartrate to maximize its performance?

@sebk174

Жыл бұрын

@@robmagz I feel positiv effects immediately after ingestion on empty stomach.

@supercal333

Жыл бұрын

Can a-l-car still upregulate androgen receptors and if so how much relative to l-car?

@mitchellmarshall7298

Жыл бұрын

@@robmagz Take about 30mins to an hour before workout

@mitchellmarshall7298

Жыл бұрын

@@supercal333 Nothing I can give you on that, but since alcar passes blood brain barrier the dosage is much less than LCLT. If you were to take as much alcar as LCLT you'd def have cognitive effects, maybe positive maybe negative

Acetyl L-Carnitine is the form needed for crossing the blood brain barrier and will also be used by the body. Regular L-Carnitine will not be the right choice to those looking for the cognitive/brain cellular benefits.

@Anthony-pq3bz

3 ай бұрын

What’s your thoughts on L-carnitine L-tartrate?

@DopeBoysofAtlanta

2 ай бұрын

Tanks for the info

@davidjanbaz7728

2 ай бұрын

EXACTLY : Those studies on brain benefits were done with ALCRN, not L- Carnitine.

@MoreTrenMoreMen69

15 күн бұрын

@@Anthony-pq3bzpretty effective for androgen receptor up regulation, so minor performance boost. potential boost in libido and testicular function (seminal volume) as well. good for cardio as it increases bodyfat utilization.

@gustavoalceudesouzacruz7354

11 күн бұрын

oral l-carnitine does nothing. you need to inject to really feel the benefits an you need to use a really big needle since its almost like a gel..

Love the energy and time you put into your videos!!! Would love for you to take a look at Vitamin D Deficiency. Traditional Hunter-gatherers Vitamin D blood levels are around 115 nmol/L while the current recommended Vitamin D blood levels is 40 - 60 nmol/L… Hope this says a lot and it is definitely worth doing some research on this :)

@sabincioflec8413

Жыл бұрын

Hey, do you have a link about this by any chance? From what i researched especially from chris masterjohn, the upper limit seems to be around 60 in the presence of enough vit A, otherwise toxicity symptoms occur and kidney stones form.

@larsnystrom6698

11 ай бұрын

@RuXueChiew You are confused about units! The recommendation is for 40 - 60 ng/ml. You have to multiply that with 2.5 to get nmol/l for vitamin D.

As usual, great video! What are the best sources . dietary that is

Okay so I've been researching fitness supplements for the past year and this is the first time ive heard of this L-carnitine supplementation for these purposes. Very interesting

@flex-jsteve540

Жыл бұрын

You’re living under a rock….watch mpmd and educate yourself

Can you make a video comparing oral VS Injectable L-Carnitine and going through the medical research about dangers in TMAO? Love you channel bro!💸

@evanpanch7143

Жыл бұрын

Ya I was hoping he would talk about the injectables cuz I thought you can't intake an ethacasius dose oraly?

@timwest7467

Жыл бұрын

​@@evanpanch7143 you can take a sufficient dose orally however you have to dose much higher. I dose at 5g during fat loss phases and I definitely notice the difference

@peterstebbins6717

Жыл бұрын

You defs need to talk about bioavailability my guy @nutrition library

@big_chungus73

Жыл бұрын

I don't think he went into the injectables conversation, because almost nobody is going to want to pin every single day for the relatively minor benefits.

@ScottMuzzaMuscles

Жыл бұрын

@moreplatesmoredates includes this in his video

easy on the eyes and very well researched and spoken

stache and hair lookin great my guy

Great videos brother! Could you make a video on L-Carnitine and TMAO? I’d be curious to get your insight and knowledge on if it’s a concern or not. And if it is not a concern maybe you could explain in depth as to why? Thank you!🤝🏼

@agentnukaz1715

Жыл бұрын

More plates more dates has a couple vids on it

@pathologicaldoubt

Жыл бұрын

It is a concern. Most definitely with oral administration

@joebartles3986

12 күн бұрын

It’s a concern. Be aware of the risks before taking it.

Excellent information, thank you ! Do you have any suggestions on dosage and when to take L-Carnitine ?

@GangdamStyle20

Жыл бұрын

Dosage -> 1-2 St (Steak)

@joebartles3986

12 күн бұрын

Dosage of zero. Don’t take it. It’s not worth the risk.

about losing fat mass you quoted reasearch that only showed reserach that showed little bit faster fat oxidation in overweight people, but other research than only imajor impactful food supplement is caffeine and green tea and still more important is diet hormones and calorie intake.

Can you make a Video about PQQ?

w video. thank you.

This is wonderful. Can you talk more about the dosages, times and cycles of how to take it please?

@jeffreymyers1761

Жыл бұрын

2 gs with some carbs if possible

@mitchellmarshall7298

Жыл бұрын

Since oral supplementation isn't very bioavailable, it is recommended to take 3-4g. I usually take it 30 mins before a workout on an empty stomach or light food. works well for extra energy and fat loss. I take Carnitine L Tartrate from gorilla mind. I have also tried ALC (Acetyl L Carnitine) and seemed to just give me brain fog since it is an acetylcholine precursor

@pathologicaldoubt

Жыл бұрын

@@mitchellmarshall7298 that’ll give you stomach cancer. Inject L-Carnotine so your gut microbiota doesn’t convert it to TMAO

@nuuttimononen5481

Жыл бұрын

L-Carnitines, similiar to creatines benefits fade away once usage is stopped and as creatine, does not require on-off cycling. Bioavailability of L-Carnitine taken orally is about 10% so its recommended to take anywhere from 2 grams up to 7 grams as it is very heavily tolerated and has no adverse effects. You can also get doctor prescribed L-Carnitine via intramusscular injection where bioavailability is 100% so the injected dose is usually anywhere from 200mgs up to 2 grams according to Dr. Kyle Gillett

@Barneyfithlawman

Жыл бұрын

@@mitchellmarshall7298 how many capsules did you take? I took a while ago didn't notice anything really. Maybe I didn't take enough each time

You didn't make a distinction in your video between L-Carnitine and Acetyl-L-Carnitine, the latter form is the one mostly responsible for cognitive benefits, while the former is the one most beneficial with regards to energy production.

Stoked to try this just started TTFD and got my life back can actually breathe now and digest but feeling a little off in other ways hopefully redox but the difference is life changing cant wait to optimise fatty acid metabolism! What's everyone's thoughts on liposomal Vs alcar?

@kittendkat5100

Жыл бұрын

TTFD - That's a type of vitamin B1, right?

@danielmclaughlin2145

Жыл бұрын

Yeah it's the best b1 the only one which crosses the BBB. ALA messed me up I have a mercury load though. ALCAR however has been amazing. Fixing what ALA did with milk thistle and charcoal lol.

What’s the best form to take and why? I see plain l-carnitine, acetyl, and fumarate. Fumarate seems the least expensive. Is this ok to take?

I am surprised that there was no mentioning of side-effects and possible dangers. Also, no mention about dosages and how much remains bioactive after digestion.

I love your videos but was hoping you would talk about the injectables cuz I thought you can't intake an ethacasius dose oraly?

Never talked about TMAO..... eat garlic alot suppliment as well

If you make a video like this touting potential benefits from studies I think it's very important to include the doses and also talk about the potential risks. You didn't mention conversion to TMAO and the potential negative effects of long term elevated levels of TMAO.

@larsnystrom6698

11 ай бұрын

@5kribbles A very short scan of research confirmed your concerns, and gave me this story: The gut microbiome converts L-Carnitine into TMAO, which causes arteriosclerosis. Berberine counteracts that effect of the gut mucrobiome. And yes, the research seems to indicate that it's not just an accociation between TMAO and arteriosclerosis. It's actually causative. The increase of TMAO with L-Carnitine was very robust. The research on Berberine was with Coline induced TMAO, not L-Carnitine. I don't know if it's the same bacteria. So if it works for L-Carnitine too is yet unknown.

@5kribbles

11 ай бұрын

Very interesting thank you! @@larsnystrom6698

@CzaristMatt

5 ай бұрын

Who eats L-Car these days. Inject it.

Both l carnation tart and acetyl is awesome

Could you do a video on hairloss?

Do we need hormone replacement therapy after taking L Carnatine?

Would it be worthwhile supplementing L-Carnitie if I'm already supplementing L-Methionine L-Lysine?

YOUR INCREDIBLE KNOWLEDGE BLOWS MY MIND. GREAT WORK. BEST WISHES FROM INDIA

You had me at ATP

Any specific brand you recommend with what dosage?

ever since i started taking it ive been more insulin sensitive idk why no one talks about that.

You forgot a very important part: the L-carnitine formulations. In the studies different formulations have been used where for example acelyl-L-carnitine can pass the brain-blood-barrier while other forms like tartrate or fumarate don't and also to enter muscle cells you need to stack it with high IG carbs (insulin needed).

Carnitine I tried a few times my strength increases were wow same day to 3 days of use. Severe headaches within 2-3 days of use like clockwork. I couldn't continue.

what is the first and second most popular? creatine and preworkout?

do you think that it is safe or will it sill be effective if i take l carnitine for about 3 months

Is acetyl carnitine effective?

Here is my question, during an extended fast how does mitochondria utilize fatty acids without dietary protein is this when muscle loss begins?

Acetyl L-Carnitine is the best variant by some way to takes

thoughts on supplementing with gaba? (heard it might increase HGH)

Generally you have to also consider its strong anti-thyroid action

@pathologicaldoubt

Жыл бұрын

Especially if you have or are prone to hypothyroidism

@Mo-yj3wf

5 ай бұрын

Only ALCAR or l- carnitine too?

@maxbergh7135

5 ай бұрын

@@Mo-yj3wf both but there is especially evidence for ALCAR regarding Hyperthyroidism, look it up (PubMed etc)

Dosage? Timing?

Well i need to try this, i am a total noob when it comes to training but i wanna change that and improve my health and general wellbeing

@agentnukaz1715

Жыл бұрын

I'd recommend protein powder and creatine, vitamins, zinc, magnisum, D3. You'll end up like us with a basket full of supplements when u make nookie gains just fine without them

@thetruth4654

Жыл бұрын

@@agentnukaz1715 I do take protein and creatine, and i am considering getting zinc and magnesium aswell as i am aware that they are very good for muscle and strength gains

@agentnukaz1715

Жыл бұрын

@@thetruth4654 that's a good idea. Zinc, mag, and D3 may increase testosterone if your deficient. Maybe consider trying gorilla minds, sigma supplement since it has all of those plus Boron and testosterone boosting herbs such as Fadogia, tomkat, and ashwaghanda.

Any thoughts on l carnitine and potential TMAO production?

I have the MTHFR gene mutation and Carnitine is the ONLY thing that gives me energy and helps me lose weight.

Hello, I have been waiting for this video for a long time. Could you tell me if Acetyl Carnitine is cholinergic? cholinergics give me symptoms of depression. The information I found about the cholinergic properties of ALCAR is confusing.

@h.sowandegray2913

Жыл бұрын

It is. Look up the channel - nootropicsexpert

One video for glycine, please.

I know it’s an amino acid along with taurine that helps with your heart. It builds your heart muscles too. I had a dog that had congestive heart failure and he was eating dog food that didn’t have them in it.. He ended up passing away.. I also know that L Carnitine helps with muscle building..

Here before he reaches a mil subscribers💯💯

Add garlic to reduce TMAO..........

Okay I'm sorry if I missed this but do you need to take it everyday?

can you make an video about ac-262?

I’ve heard that alcar is the best form to take orally, or you have to inject it. Is this correct?

So… how much is suggested to take and when?

@nutrition Library do you need to cycle off, and do you take it everyday? Great content, love your channel

I recently got L carnitine powder and it has a citrus flavor similar to lemon. I would like to know if the one you consume tastes the same.

Can a-l-car still upregulate androgen receptors and if so how much relative to l-car?

Bio-availability of oral L-Carnitine is between 14-18% according to research. This means you need to take around 3 grams (usually 6 capsules of 500mg) to have any meaningful effect.

6:20 I guess somebody did not pay for the paper hahahah

First 2 days of Oral L-Carnitine and I felt sleepy and goofy happy within an hour, almost like a weird mix of mild euphoria and sedation. Has anyone experienced this ??

Recommended dosage? Recommended time of day for supplementation? With a meal vs without?

@declineofthewest.

Жыл бұрын

Web search is helpful

Carnitine is great, but you should review beta-alanine and ALCAR. Beta-alanine is a precursor to Carnosine another promising amino acid, that might be more efficient than taking carnosine directly. ALCAR (acetyl-l-carnitine) has an easier time crossing the BBB.

@jonnull

Жыл бұрын

Citrulline is a precusor to Arginine, not Carnitine.

@charlesmarks1394

Жыл бұрын

@@jonnull You are right, editing out the Citrulline comment. I think I meant to say beta-alanine, a better precursor to "Carnosine" which is a different amino-acid with some promising health research. Citrulline and other Nitric-Oxide producers are great for a workout but have more conflicting evidence regarding long term benefits.

L-carnitine tartate vs acetyl-carnitine

Can it be taken sublingually to increase bioavailability

Wow super supplement that no one talks about 🤯 I'm missing this 👌✨ my pre or intra workouts don't have it 🦾😤🦾

you have anything on Kava?

On the Andrew Huberman podcast with Dr Gilette they say to ingest at least 3-5 grams of L carnitine to work ...

@deeptimnm

Жыл бұрын

I am taking 500 mg and it works just fine to begin with.

but how much L- carnitine should we take to receive those benefits?

Did I miss dosages? I've watched it twice now. Also, why does every L-carnatine I find have Alpha lipioc acid with it??

Please put chapter

Does it help with fat loss ?

been using ALCAR before workout. ive become a machine with no tiredness whatsoever....

@sebk174

Жыл бұрын

Alcar is more for cognitive function. L-Carnitine Tartrate is for physical performance.

@big_chungus73

Жыл бұрын

@sebastiank7287 there is plenty of crossover between the two

Did I miss the part about recommended daily dosage ?

Acetlt l carnitine or just l carnitine?

yay dr berg!

i remeber taking this and my spunk becoming yellow. it was concerning. never touching it again

Pretty sure the muscle failure you're talking about with anaerobic weight lifting is more dealing with nerve refraction rather than lactate production.

Hi do you know the product Biogen Rage Testo

I took this in liquid form, i didn't feel any difference whatsoever, however, my sweat started to stink so much, it became unbearable. I never had issues with sweating. Even the clothes after washing continued to smell. I do not recommend it at all. It took me maybe 6 months to fix my sweat smell again and if you want to be walking skunk, go ahead hahah. I gave you friendly warning

@william2062

Жыл бұрын

Yes, but i doubt it's up to the meat

@big_chungus73

Жыл бұрын

I read about this on the Amazon reviews for the liquid form, but didn't see any mention of it in pill form 🤔

@william2062

Жыл бұрын

Just take in minimal amount i guess, but I'll never do it again. And if we eat enough meat we should have enough

@ShuckyDucky09

Жыл бұрын

Didn't notice any effect on my sweat it makes my urine smell terrible though 😂😂

Injectable L carnitine is the way to go if you're concerned about TMAO. I've been using it for 6 months and don't plan to ever stop. It's amazing.

@chillnspace777

11 ай бұрын

What is TMAO

You didnt discuss dosages and LC forms

Dosage and frequency?

Dosage?