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Structural Activity Relationships(SAR) of Benzodiazepines - Lorazepam, clonazepam
Every position in the benzodiazepine ring show some relation to their pharmacological activity, so studying SAR of benzodiazepines is a good aspect to understand their relative activity. For example, drugs like Lorazepam, Oxazepam, Temazepam have hydroxyl group at 3rd position which renders the drugs relatively polar in nature thereby directly excreted in the urine without any significant phase I metabolism. That's why these drugs have short duration of action.
0:00 Introduction
0:03 Common structure of benzodiazepines
1:12 1st position
1:59 2nd position
3:43 LOT : Lorazepam, Oxazepam and Temazepam are polar
6:06 8th and 9th positions
7:53 Fused ring systems
#xanaxs
#lorazepam
#clonazepam
Пікірлер: 73
I’m a Pharmacy student in Zimbabwe. I Found this helpful
That was very helpful!!!! Thank you
Very good, learned a lot
Loved it😍🔥
very good presentation.. good lecturing.
Amazing n simple sar ❤️🔥
FANTASTIC!!! thx for the vedio~
@egpat
3 жыл бұрын
Glad you liked it! Thanks for watching.
Thats very nice ,thank u sir
Sooperb👍🏽
need more of these lectures
That's amazing lecture 🔥🥳
@basicpharma1833
4 жыл бұрын
kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html
It helped a lot🙏 thank you sir
Very informative. Thankyou 🙏
@egpat
3 жыл бұрын
Glad it was helpful! Thank you
Nice description
Simple and detail SAR 😊😊😊😊... TYSM sir... Keep it high ...👍👍👍👍👌
@basicpharma1833
4 жыл бұрын
kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html
Thank you so much 🥰
well explained ..... thank you
@egpat
4 жыл бұрын
Glad it was helpful! Thank you.
Thank you
Very nice 👍 sir
thank you ...
More helpful sir
I am from Tamil Nadu . I can easily understand ur vedios
thank you🥰
Very helpful video. Thanku so much 🙏
@egpat
Жыл бұрын
Glad to hear that, thank you. Keep watching
Superb vdo sir 😊
@basicpharma1833
4 жыл бұрын
kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html
I’ve never seen any reports or literatures of rupture of tendons and ligaments due to muscle wasting induced by benzodiazepines,but I tore many muscles,tendons and ligaments.
Really it's very helpful to me sir
@egpat
3 жыл бұрын
Glad to hear that. Keep watching.
Super sir
Fast but clear and easy
Super explanation
@egpat
4 жыл бұрын
Thank you
Ur awesome
appreciated
Super 😘
Sir olanzapine is similar with which drug I mean is it similar to nitrazepam or not Which is the most powerful benzodiazapine or thienobenzodiazapine
Thanks 😭
With SAR structures also learnt in easy way
Sir there was a mistake while explaining sar at 5th position.......lorazepam has ortho substituted phenyl ring at 5th position ....u explained it while explaining the sar at 3rd position
I, AM CHEMICAL SCIENCE LABORATORY TECHNOLOGY STUDENT; FROM ETHIOPIA.
Do more and more videos sir
Ur videos are amazing brother keep it up also upload videos on chromatography , tandem MSM etc
@egpat
9 ай бұрын
Sure I will
Thanku sir,Sir please update medicinal chemistry playlist in your channel,So that i would be helpful for all learners...thankuu
@egpat
3 жыл бұрын
Sure, I will completely update playlist. Thanks for your interest.
@shaikh3667
3 жыл бұрын
@@egpat thanku
@keendrx
Жыл бұрын
@@egpat thank you, please update faster as you can possible . Update more g pat related videos also❤
Sir,make a video on heterocyclic ring systems....creating a lot of confusion sir🙏🙏
@egpat
3 жыл бұрын
Already two videos were uploaded, you can find them here. Thank you. kzread.info/dash/bejne/m4WL25ixYbK6Zso.html kzread.info/dash/bejne/nJZmy5qKlLGyYpc.html
@tangelladurgasairam1274
3 жыл бұрын
@@egpat Thank you sir...👏👏🙏
What is the reason behind all these groups and their relationship with activity?
@egpat
4 жыл бұрын
There is no specific reason, but these benzodiazepines with optimal groups were found better in activity in various practical experiments. The possible reason may be due to more binding and interaction of these groups on the target site resulting in more activity.
@basicpharma1833
4 жыл бұрын
kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html
😍😍
Sir there is a correction needed to be done at 5:37 of video , where u have written Lorazepam instead of Oxazepam
@egpat
4 жыл бұрын
Ya..it is actually oxazepam. Thanks for informing.
@basicpharma1833
4 жыл бұрын
kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html
Where would a person start to learn how to make etizolam?
@jaydendembowski2467
2 жыл бұрын
Go to college and major in chemistry
Good lecturing 👍👍
@egpat
3 жыл бұрын
Thanks for liking
😌😌😌😇💓
I need sar of insulin help plz
@egpat
3 жыл бұрын
Sure, I will try to upload soon. Thanks for your interest.
@arturk5925
3 жыл бұрын
@@egpat thank you😊