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Structural Activity Relationships(SAR) of Benzodiazepines - Lorazepam, clonazepam

Every position in the benzodiazepine ring show some relation to their pharmacological activity, so studying SAR of benzodiazepines is a good aspect to understand their relative activity. For example, drugs like Lorazepam, Oxazepam, Temazepam have hydroxyl group at 3rd position which renders the drugs relatively polar in nature thereby directly excreted in the urine without any significant phase I metabolism. That's why these drugs have short duration of action.
0:00 Introduction
0:03 Common structure of benzodiazepines
1:12 1st position
1:59 2nd position
3:43 LOT : Lorazepam, Oxazepam and Temazepam are polar
6:06 8th and 9th positions
7:53 Fused ring systems
#xanaxs
#lorazepam
#clonazepam

Пікірлер: 73

  • @lennoxmachoko5342
    @lennoxmachoko53422 жыл бұрын

    I’m a Pharmacy student in Zimbabwe. I Found this helpful

  • @suhailaali1478
    @suhailaali14782 жыл бұрын

    That was very helpful!!!! Thank you

  • @hellbenttrent
    @hellbenttrent2 жыл бұрын

    Very good, learned a lot

  • @shubhamsharma3366
    @shubhamsharma33662 жыл бұрын

    Loved it😍🔥

  • @mee19n21
    @mee19n213 жыл бұрын

    very good presentation.. good lecturing.

  • @mondkarketkiganesh8548
    @mondkarketkiganesh85482 жыл бұрын

    Amazing n simple sar ❤️‍🔥

  • @AtomLab9823
    @AtomLab98233 жыл бұрын

    FANTASTIC!!! thx for the vedio~

  • @egpat

    @egpat

    3 жыл бұрын

    Glad you liked it! Thanks for watching.

  • @sanjeevsingh3694
    @sanjeevsingh36943 жыл бұрын

    Thats very nice ,thank u sir

  • @mubashirajerry8071
    @mubashirajerry80713 жыл бұрын

    Sooperb👍🏽

  • @windowsseven-bo4fm
    @windowsseven-bo4fm3 ай бұрын

    need more of these lectures

  • @sharanugurikar2330
    @sharanugurikar23304 жыл бұрын

    That's amazing lecture 🔥🥳

  • @basicpharma1833

    @basicpharma1833

    4 жыл бұрын

    kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html

  • @sairashaikh1730
    @sairashaikh1730 Жыл бұрын

    It helped a lot🙏 thank you sir

  • @karthikaep1598
    @karthikaep15983 жыл бұрын

    Very informative. Thankyou 🙏

  • @egpat

    @egpat

    3 жыл бұрын

    Glad it was helpful! Thank you

  • @manavisingh2641
    @manavisingh26414 жыл бұрын

    Nice description

  • @atharvachavan4848
    @atharvachavan48484 жыл бұрын

    Simple and detail SAR 😊😊😊😊... TYSM sir... Keep it high ...👍👍👍👍👌

  • @basicpharma1833

    @basicpharma1833

    4 жыл бұрын

    kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html

  • @nuwaidkhader
    @nuwaidkhader2 жыл бұрын

    Thank you so much 🥰

  • @zakirzak1494
    @zakirzak14944 жыл бұрын

    well explained ..... thank you

  • @egpat

    @egpat

    4 жыл бұрын

    Glad it was helpful! Thank you.

  • @RJ-qg3bi
    @RJ-qg3bi3 жыл бұрын

    Thank you

  • @kuljyoti3130
    @kuljyoti3130 Жыл бұрын

    Very nice 👍 sir

  • @adelalsilimi2010
    @adelalsilimi201011 ай бұрын

    thank you ...

  • @user-lc5oe3gz5z
    @user-lc5oe3gz5z6 ай бұрын

    More helpful sir

  • @sriramvishnu5483
    @sriramvishnu54832 жыл бұрын

    I am from Tamil Nadu . I can easily understand ur vedios

  • @merhawikahsay9622
    @merhawikahsay96225 ай бұрын

    thank you🥰

  • @athirapaul01
    @athirapaul01 Жыл бұрын

    Very helpful video. Thanku so much 🙏

  • @egpat

    @egpat

    Жыл бұрын

    Glad to hear that, thank you. Keep watching

  • @onemanideas524
    @onemanideas5244 жыл бұрын

    Superb vdo sir 😊

  • @basicpharma1833

    @basicpharma1833

    4 жыл бұрын

    kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html

  • @MK-pl4fr
    @MK-pl4fr Жыл бұрын

    I’ve never seen any reports or literatures of rupture of tendons and ligaments due to muscle wasting induced by benzodiazepines,but I tore many muscles,tendons and ligaments.

  • @kusumagompa2381
    @kusumagompa23813 жыл бұрын

    Really it's very helpful to me sir

  • @egpat

    @egpat

    3 жыл бұрын

    Glad to hear that. Keep watching.

  • @sandhyaranirenangi7786
    @sandhyaranirenangi7786 Жыл бұрын

    Super sir

  • @hellbenttrent
    @hellbenttrent2 жыл бұрын

    Fast but clear and easy

  • @zakirzak1494
    @zakirzak14944 жыл бұрын

    Super explanation

  • @egpat

    @egpat

    4 жыл бұрын

    Thank you

  • @sriramvishnu5483
    @sriramvishnu54832 жыл бұрын

    Ur awesome

  • @mogheezahmed7735
    @mogheezahmed77352 жыл бұрын

    appreciated

  • @jayaramasubhashpola8485
    @jayaramasubhashpola84852 жыл бұрын

    Super 😘

  • @p.sibrampatra3482
    @p.sibrampatra34823 жыл бұрын

    Sir olanzapine is similar with which drug I mean is it similar to nitrazepam or not Which is the most powerful benzodiazapine or thienobenzodiazapine

  • @teebaya
    @teebaya2 жыл бұрын

    Thanks 😭

  • @sandhyaranirenangi7786
    @sandhyaranirenangi7786 Жыл бұрын

    With SAR structures also learnt in easy way

  • @chemistchauhan
    @chemistchauhan2 жыл бұрын

    Sir there was a mistake while explaining sar at 5th position.......lorazepam has ortho substituted phenyl ring at 5th position ....u explained it while explaining the sar at 3rd position

  • @mekdesbelete8766
    @mekdesbelete87663 жыл бұрын

    I, AM CHEMICAL SCIENCE LABORATORY TECHNOLOGY STUDENT; FROM ETHIOPIA.

  • @sandhyaranirenangi7786
    @sandhyaranirenangi7786 Жыл бұрын

    Do more and more videos sir

  • @yasirmazhar2085
    @yasirmazhar20859 ай бұрын

    Ur videos are amazing brother keep it up also upload videos on chromatography , tandem MSM etc

  • @egpat

    @egpat

    9 ай бұрын

    Sure I will

  • @shaikh3667
    @shaikh36673 жыл бұрын

    Thanku sir,Sir please update medicinal chemistry playlist in your channel,So that i would be helpful for all learners...thankuu

  • @egpat

    @egpat

    3 жыл бұрын

    Sure, I will completely update playlist. Thanks for your interest.

  • @shaikh3667

    @shaikh3667

    3 жыл бұрын

    @@egpat thanku

  • @keendrx

    @keendrx

    Жыл бұрын

    ​@@egpat thank you, please update faster as you can possible . Update more g pat related videos also❤

  • @tangelladurgasairam1274
    @tangelladurgasairam12743 жыл бұрын

    Sir,make a video on heterocyclic ring systems....creating a lot of confusion sir🙏🙏

  • @egpat

    @egpat

    3 жыл бұрын

    Already two videos were uploaded, you can find them here. Thank you. kzread.info/dash/bejne/m4WL25ixYbK6Zso.html kzread.info/dash/bejne/nJZmy5qKlLGyYpc.html

  • @tangelladurgasairam1274

    @tangelladurgasairam1274

    3 жыл бұрын

    @@egpat Thank you sir...👏👏🙏

  • @alphagonist4748
    @alphagonist47484 жыл бұрын

    What is the reason behind all these groups and their relationship with activity?

  • @egpat

    @egpat

    4 жыл бұрын

    There is no specific reason, but these benzodiazepines with optimal groups were found better in activity in various practical experiments. The possible reason may be due to more binding and interaction of these groups on the target site resulting in more activity.

  • @basicpharma1833

    @basicpharma1833

    4 жыл бұрын

    kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html

  • @salonisoni4722
    @salonisoni47223 жыл бұрын

    😍😍

  • @santoshsahu1976
    @santoshsahu19764 жыл бұрын

    Sir there is a correction needed to be done at 5:37 of video , where u have written Lorazepam instead of Oxazepam

  • @egpat

    @egpat

    4 жыл бұрын

    Ya..it is actually oxazepam. Thanks for informing.

  • @basicpharma1833

    @basicpharma1833

    4 жыл бұрын

    kzread.info/dash/bejne/iIBnsqqDcbrbl9I.html

  • @mce3210
    @mce32103 жыл бұрын

    Where would a person start to learn how to make etizolam?

  • @jaydendembowski2467

    @jaydendembowski2467

    2 жыл бұрын

    Go to college and major in chemistry

  • @capmarvel3635
    @capmarvel36353 жыл бұрын

    Good lecturing 👍👍

  • @egpat

    @egpat

    3 жыл бұрын

    Thanks for liking

  • @PriyankaChauhan-kh1kr
    @PriyankaChauhan-kh1kr3 жыл бұрын

    😌😌😌😇💓

  • @arturk5925
    @arturk59253 жыл бұрын

    I need sar of insulin help plz

  • @egpat

    @egpat

    3 жыл бұрын

    Sure, I will try to upload soon. Thanks for your interest.

  • @arturk5925

    @arturk5925

    3 жыл бұрын

    @@egpat thank you😊