RNAi: Slicing, dicing and serving your cells - Alex Dainis

View full lesson: ed.ted.com/lessons/rnai-slicin...
RNA, the genetic messenger, makes sure the DNA recipe gives your cells exactly what they ordered. But sometimes that means inhibiting some other RNA that got the recipe wrong. This process is called RNA interference (RNAi), and it acts as a self-correcting system within the complicated genetic kitchen of your body. Alex Dainis explains the importance -- and exciting potential -- of RNAi.
Lesson by Alex Dainis, animation by Cinematic Sweden.

Пікірлер: 184

  • @secondjoint
    @secondjoint10 жыл бұрын

    The quality of the animation is sooo good! I'm used to seeing amateurish work in these edutainment animations. This animator actually understands stretch, correct physics, motion blur etc.

  • @KnakuanaRka

    @KnakuanaRka

    5 жыл бұрын

    secondjoint Great animations, but I do think that the metaphor shown by those animations only manages to confuse the matter instead of clarifying.

  • @toobaaaapi

    @toobaaaapi

    5 ай бұрын

    Quality of animation is good but the content was not upto mark, ended confusing the topic more than clarifying it.

  • @ichliebemeinfunt
    @ichliebemeinfunt8 жыл бұрын

    I couldn't understand RNAi well, but this lecture is very clever and help my study so much! Thanks!!! Before then, I was a little confused by technical terms of this phenomenon.

  • @kristiabondoc6681
    @kristiabondoc66819 жыл бұрын

    This is the best explanation out there. Thanks a bunch! Really appreciate it.

  • @valeriesze
    @valeriesze10 жыл бұрын

    I wish to contribute myself in creating this kind of educative videos when I grow up. This is so much meaningful.

  • @justagreekinternetuser8998

    @justagreekinternetuser8998

    Жыл бұрын

    so, did you?

  • @XENOS1010
    @XENOS10107 жыл бұрын

    Great video , best metaphor ever and I like the cute animation

  • @PeterDosRamos
    @PeterDosRamos11 жыл бұрын

    Congratulations Alex! What an accomplishment...

  • @asapelliott
    @asapelliott3 жыл бұрын

    Amazing communication of science in this video!

  • @runforestrun406
    @runforestrun4065 жыл бұрын

    This video is absolutely amazing

  • @jack171380
    @jack1713805 жыл бұрын

    Moral of the story, Chop up unsatisfied customers.

  • @judonomobic
    @judonomobic11 жыл бұрын

    wow Alex! That is way cool. You are certainly making an impact! Thank you!

  • @deanomuir
    @deanomuir11 жыл бұрын

    Loved it .....well done Alex

  • @CallieSqueakz
    @CallieSqueakz8 жыл бұрын

    Thank you for the lesson.

  • @vineethvishnu9975
    @vineethvishnu99757 жыл бұрын

    woww........difficult topic explained in very easy way.......thanks a lotttt

  • @SetsunaKai5
    @SetsunaKai58 жыл бұрын

    Best TED video, ever!

  • @phuongho-ej1zt
    @phuongho-ej1zt7 жыл бұрын

    this video is so amazing.

  • @jakeshmohapatra6956
    @jakeshmohapatra69562 жыл бұрын

    The voice has perfect timing to understanding.

  • @SciFiles
    @SciFiles11 жыл бұрын

    This video is awesome! Its so informative! Good job alex!

  • @imadnemeir9455
    @imadnemeir945511 жыл бұрын

    wonderfully done

  • @tribenisharma1879
    @tribenisharma18794 жыл бұрын

    Best video on this topic...Thanks a lot😊

  • @nopemeneither
    @nopemeneither11 жыл бұрын

    A fantastic video, thank you for this

  • @katherineguzman5752
    @katherineguzman57523 жыл бұрын

    OMG what a great explanation!

  • @omni100won
    @omni100won11 жыл бұрын

    Nice animation! I liked it a lot

  • @masonacton9868
    @masonacton98689 жыл бұрын

    The animation was awesome

  • @halcyonparade
    @halcyonparade11 жыл бұрын

    The cooking metaphor sorta makes it a bit more confusing for me

  • @Gracese0
    @Gracese08 жыл бұрын

    thank you for making wonderful video

  • @beartheburn3863
    @beartheburn38633 жыл бұрын

    Let me summarize everything in one shot ( actually this is the project that I've been assigned) So rna interference is basically used to prevent gene expression ( prevention of translation and hence production of proteins ) So to do it artificially we use vectors and introduce the desired dna . Now this dna produces both sense and anti sense strand these being complementary to each other bind together . Dicer proteins sense these and chop them and these thereby approach the m rna and slicer protein comes and chops down the m rna too So , viola ! We've successfully prevented the gene expression

  • @Sapnakolira

    @Sapnakolira

    2 жыл бұрын

    So in eukaryotes these double stranded rnas are created in response to an attack by viruses???

  • @lemonade4865

    @lemonade4865

    2 жыл бұрын

    Wait aren't you supposed to use desired Double Stranded RNA and not DNA for the vector?

  • @justagreekinternetuser8998

    @justagreekinternetuser8998

    Жыл бұрын

    @@Sapnakolira no. Sometimes, viruses have genetic material in the form of double stranded RNA, instead of DNA that we have. So, they insert it in cells and manipulate their cell functions, in order to replicate their dsRNA and move to close cells and infect them too.

  • @adthakur638
    @adthakur6385 жыл бұрын

    Perfect explanation

  • @SenapatiM96
    @SenapatiM962 жыл бұрын

    Lovely video. Thank you.

  • @veryawful861
    @veryawful8613 жыл бұрын

    That RNA decking the other RNA caught me off guard and had me bustin up!

  • @natpbs
    @natpbs11 жыл бұрын

    Congratulations alex, this is cool!

  • @linettelow
    @linettelow11 жыл бұрын

    Succinctly narrated; wonderfully illustrated :)

  • @knosis
    @knosis2 жыл бұрын

    What a classic video. I watched this video when I was studying for my MCAT and now I am in medical school, studying for USMLE Step 1 and came across an RNA question and it reminded me of this. Thank you so much for these videos!

  • @nitinnarwade4075
    @nitinnarwade40754 жыл бұрын

    what was that at 2:18, wooallaaaa....!! 🤣🤣🤣🤣🤣🤣🤣. Nice animation and correctly explained with an example of a kitchen. Pretty helpful for explaining to the students. 👍 👍 👍

  • @liwazamemon918
    @liwazamemon9185 жыл бұрын

    That video was great really love it 😍😍

  • @Suicidal_Muffin
    @Suicidal_Muffin11 жыл бұрын

    Congrats Alex!

  • @mLBB-x-HoK22savg
    @mLBB-x-HoK22savg5 ай бұрын

    Thanks I'm good at learning this way

  • @CJonesApple
    @CJonesApple11 жыл бұрын

    Aw well done Alex!

  • @atiiisa4047
    @atiiisa4047 Жыл бұрын

    such a nice video.

  • @hustletime1632
    @hustletime16327 ай бұрын

    Oh man that was impressive I understand everything. ❤thank you

  • @laylamedo
    @laylamedo Жыл бұрын

    That is stunning 😍 Thanks a lot 🙏 💓

  • @BlueyTheCheese
    @BlueyTheCheese10 жыл бұрын

    AHHH this is so addictive.

  • @davidsweeney111
    @davidsweeney11111 жыл бұрын

    superb video !

  • @robly17
    @robly1711 жыл бұрын

    Alex for the win!

  • @alz123alz
    @alz123alz8 жыл бұрын

    beautiful. thanks

  • @ThEKeeYs
    @ThEKeeYs11 жыл бұрын

    very nice and simple

  • @Emoda3004
    @Emoda300410 жыл бұрын

    This is so cool and easy to remember now XD thanks

  • @056vatsalapandey3
    @056vatsalapandey32 жыл бұрын

    thank was sooooo amazing people

  • @kirtikasaxena3097
    @kirtikasaxena30978 жыл бұрын

    too good difficult concept discussed very easily

  • @farhanahmed2508

    @farhanahmed2508

    7 жыл бұрын

    kirtika Saxena Good evening, Ma'am...

  • @Andy-km1xp

    @Andy-km1xp

    6 жыл бұрын

    Farhan Ahmed lol Creepy

  • @litojonny
    @litojonny11 жыл бұрын

    what a cute animation!

  • @ume7739
    @ume77392 жыл бұрын

    Where were you when I was looking all over KZread to understand rnai for my biology test yesterday 😭😭😭😭😭😭😭😭😭😭😭

  • @FrankyFiks
    @FrankyFiks11 жыл бұрын

    this video is 4 weeks to late. tried to understand it for an exam, but the information given was too confusing. this video sums it up perfectly :)

  • @johnizer
    @johnizer11 жыл бұрын

    Wow! So complex yet so organized and it all happened by chance?...At least that's what some people believe. This is what science must be all about. Things we can observe, study and test.

  • @MustafaAHadid
    @MustafaAHadid5 жыл бұрын

    well explained

  • @yashrewaskar2902
    @yashrewaskar29024 жыл бұрын

    Thank you

  • @archanarn3884
    @archanarn38848 жыл бұрын

    superb..........saw genetic engineering class via kitchen mechanism

  • @thetypewriterbtch8763
    @thetypewriterbtch8763Ай бұрын

    Trying to make it relatable, you guys screwed with the explanation 100 times more!

  • @aminoddindomado9963
    @aminoddindomado99637 ай бұрын

    Wow I didn't know Alex Dainis narrated a Ted-Ed video !

  • @star666moon
    @star666moon11 жыл бұрын

    cool video!

  • @icarusozkavosh6573
    @icarusozkavosh65735 жыл бұрын

    Why good videos like this has so little watches?

  • @tybiblee
    @tybiblee5 жыл бұрын

    THANKS!!!

  • @ludiwang1172
    @ludiwang11728 жыл бұрын

    I read that RNAi is also being used to deal with the varroa destructor mites that are devastating beehives.

  • @banaalani7216
    @banaalani72165 жыл бұрын

    perfect!

  • @SamuelSamuelSamuel1
    @SamuelSamuelSamuel14 жыл бұрын

    Ribosome: what can I get for you Red blood cell: S-Sugar Ribosome: so glucose? Red blood cell: S-S-Sugar Ribosome: I don’t have the full ingredients for that Red blood cell: rolls on the floor screaming

  • @Owlnuss
    @OwlnussАй бұрын

    I'm shocked when I saw that this video is 10 years old! I'm currently working as a research physician with a pharma company developing RNAi drug to treat obesity.

  • @k94koonce
    @k94koonce8 жыл бұрын

    wow! amazing video

  • @user-hx5rc7zv7m

    @user-hx5rc7zv7m

    8 жыл бұрын

    узбеккино

  • @user-hx5rc7zv7m

    @user-hx5rc7zv7m

    8 жыл бұрын

    узбеки но х узбеккино

  • @XxwoodyleexX
    @XxwoodyleexX11 жыл бұрын

    there are many kinds of rna, some sends message from dna to the ribosome to create proteins, some are attached to the ribosome used to create protein.

  • @laischristina8018
    @laischristina80187 жыл бұрын

    perfect

  • @Qermaq
    @Qermaq11 жыл бұрын

    Yay Alex! :)

  • @na-is9xb
    @na-is9xb6 жыл бұрын

    Very good:)

  • @pornessianparrapio
    @pornessianparrapio Жыл бұрын

    Thx

  • @GozerB
    @GozerB11 жыл бұрын

    Was just about to skip this on my sub list. Then I saw the name Alex Dainis. :-)

  • @berzerius
    @berzerius11 жыл бұрын

    Alexxxxx!

  • @shannonlorraine7561
    @shannonlorraine75617 жыл бұрын

    😄 great job.

  • @raniabashar7955
    @raniabashar79556 жыл бұрын

    what's the difference of rna and dna?

  • @nguyentuandangkhoi
    @nguyentuandangkhoi11 жыл бұрын

    Something along those lines, but NO, no one volunteers. Neuroscientists study patients who already had an accident or a stroke, which lead to damage in certain localities in the brain. During and after preliminary treatment by ER physicians and/or neurosurgeons, scans are done, including MRI, fMRI, CT, PET, etc. which help localize the injured parts. After doing whatever they can, the patients are assessed behaviorally and compared to before the accident, etc., as well as normal brain scans.

  • @areziqbal
    @areziqbal10 жыл бұрын

    Plz explain this topic liteally

  • @xlr1271
    @xlr127111 жыл бұрын

    nice

  • @user-us2di8go4m
    @user-us2di8go4m11 жыл бұрын

    Hello TEDed. I love your videos. All your videos very interesting but in some case I try to understand without transcript as I'm not native speaker. Can I have this transcript from somewhere. Thanks.

  • @taeyang
    @taeyang8 жыл бұрын

    wow just wow

  • @marioguts

    @marioguts

    8 жыл бұрын

    +taeyang Same!!! I think people in general need a little bit more of previous knowledge to fully understand the video but it amazing nonetheless

  • @justinspykerman
    @justinspykerman2 жыл бұрын

    How do you manipulate expression in gene expression, is this possible to do within yourself without any external help?

  • @lachlanmc2335

    @lachlanmc2335

    Жыл бұрын

    yes like if u starve yourself the genes will express differently in response to lower levels of some proteins in blood to metabolize slower

  • @Amundse42
    @Amundse426 жыл бұрын

    Muy buen video, hacen verlo muy muy fácil , pero no lo es jeje :)

  • @heivmnox
    @heivmnox3 жыл бұрын

    imagine ur body housing silent assassins. lol

  • @MrPoof15
    @MrPoof1510 жыл бұрын

    This was awesomely violent.

  • @ronmaest
    @ronmaest11 жыл бұрын

    The body is [mostly, I think] reactive not active. Enough material is floating around inside to keep the process going even though the prices don't know where they're going.

  • @DudeWhoSaysDeez
    @DudeWhoSaysDeez6 жыл бұрын

    How does our cells know which RNA is virus RNA vs our own good RNA

  • @PerseusToons
    @PerseusToons7 жыл бұрын

    The animation is hilariously violent!

  • @rhino9085
    @rhino908511 жыл бұрын

    the animation is so cute

  • @adamsodhooq4463
    @adamsodhooq446311 жыл бұрын

    I like how she said volia

  • @velstorios9473
    @velstorios94736 жыл бұрын

    You could have made the pieces of the double stranded RNA look alive like smaller living parts of it :P

  • @JG-en8bg
    @JG-en8bg8 жыл бұрын

    Wow, gruesome.

  • @siyacer

    @siyacer

    4 жыл бұрын

    Drusome

  • @Ladiduify
    @Ladiduify8 жыл бұрын

    I'm a bit depressed that the video isn't in german. It would be pretty perfect for my presentation tomorrow, but in fact its in english - most of my course wouldn't understand it directly :(

  • @tygonmaster

    @tygonmaster

    8 жыл бұрын

    +Ladiduify There are German subtitles. :)

  • @MegaMGstudios
    @MegaMGstudios7 жыл бұрын

    slice and dice

  • @Fusselwurmify
    @Fusselwurmify11 жыл бұрын

    Life is... mindboggingly complex and amazing, Also cute, as it seems.

  • @incipio8068
    @incipio80686 жыл бұрын

    중간에 나오는 푸른빛집명나방이 아니라 예쁜꼬마선충(C.elegans)이 맞는거 같은데 ... I think that Korean subtitles are wrong. lI hear as [예쁜꼬마선충 - C.elegans] , but the Koean subtitle is [푸른빛집명나방Teliphasa elegans ] 영어 고수님들 이거 보시면 제대로된 영문으로 작성좀 해주세요.....ㅋㅋㅋㅋㅋㅋ

  • @sudedeniz3840
    @sudedeniz38403 жыл бұрын

    Turkce altyazi icin tesekkurler

  • @JungleJargon
    @JungleJargon11 жыл бұрын

    Clearly many things chemicals could never do without being directed by a Maker.

  • @xsjadowolf
    @xsjadowolf11 жыл бұрын

    the RNA part was always the most complicated in genetics

  • @vincentlee78
    @vincentlee7811 жыл бұрын

    i am still confused...

  • @ehe5669
    @ehe56692 жыл бұрын

    that brutally escalated quick.

  • @dingovory
    @dingovory7 жыл бұрын

    I'm sure I'd understand it better without the metaphor lol

  • @alineangel3210

    @alineangel3210

    6 жыл бұрын

    dingovory I'm almost sure that you wouldn't. I've tried to understand this for half a hour by biology videos, this video gets the information a lot easier... ;-)

  • @LegeFles

    @LegeFles

    6 жыл бұрын

    Aline Oliveira yeah no