If 1st Rh+ child develops HDN, it may be due to: 1) Rh- mother having prior history of Rh+ blood transfusion, 2) previous abortion, 3) ruptured ectopic pregnancy Thanks for the great video!

@swap251

2 жыл бұрын

4) abruptio placenta

I really like the style of teaching, well explained, simple and not over complicated, funny and easy to follow through, THANK YOU. HAVE HELPED ME ALOT DURING MY MED SCHOOL.

Rh incompatibilty has been hunting me on exams ever since, the video gave a great overview :)

Dear Friend and Educator! I really love your lectures and I am now an avid follower! May I add one footnote difference between the underlying pathophysiology of ABO Sensitization and Rh+/D-Antigen sensitization in an Rh- female. ABO blood groups are based on polysaccharide differences, which will result or have inherent, an overwhelming IgM response which explains the Immediate Immune Hemolysis reaction in ABO mismatched blood, whilst IgM antibodies do not cross the placental barrier. The Rh+/D Antigen is a protein antigen which requires sensitization, prior exposure, and then the production of IgG "memory" antibodies by B-cell activated clonal lines. IgG does cross the placental barrier as it forms the basis of fetal and neonatal, and post-natal pre-formed humoral defense. Thus when the Rh+/D+ protein antigen is exposed in the first pregnancy via delivery with some exposure, or definitely via C-section, then the "memory" IgG antibody will be fully capable to generate and affect future pregnancies whilst preformed ABO igM antibodies against ABO mismatches will be blocked by the placenta barrier.

The answer is that she might have had a previous blood transfusion (Rh+ve) or abortion. That's why first child had HDN

It's fun, educational and free. What else could it be? Thank you so much!!!

7:44 Hydrops Fetalis 8:16 Kernicterus 10:28 Coombs test 11:31 Prevention *[RhoGAM]* 14:26 What to do if the mother is already sensitized

I love your videos !!! I'm a PA student and you present the material in a straight forward yet high yield way !!

@MedicosisPerfectionalis

Жыл бұрын

I am so delighted, Maureen! Thank you so much 😊 and good luck 🍀

It's a great course. Adorable! Thank you for the efforts.

This was very helpful and funny at the same time, keep it up. ❤️🙏🏻

I'm currently preparing for a cellular biology exam in German (which isn't my mothertongue). Although the whole blood type thing etc. has never really given me hard time, I struggled to understand this particular case. Your video solved my problem completely! And schemes as well as pics are really helpful. Thx a lot!

@MedicosisPerfectionalis

Жыл бұрын

You’re very welcome 😊 Good luck 🍀

Medicosis telling me I am stupid is the highlight of my day lol thank you for the clear explanations

I just learned yesterday that I am A-. I am thankful that I have never conceived a child since I would not have known. Thank you for explaining this process!

@hjf3022

Жыл бұрын

It's not something to be worried about. Every pregnant woman is tested during the regular antenatal screening process, and you would be given anti D Ig, even regardless of the father's rhesus genotype.

No one: Medicosis:"your testicles will be very tiny but your proffessional trainer at the gym will be proud of you" 😂

@MedicosisPerfectionalis

3 жыл бұрын

Haha 😂

@jaidenemanuel2195

2 жыл бұрын

instablaster

Since we are studying online right now you helped me a lot thanks from KSA 💚💚

@MedicosisPerfectionalis

4 жыл бұрын

Awesome 👏

You rock! Thank you for taking the time to put this video together for all of us curious minds. Best wishes!

@MedicosisPerfectionalis

5 жыл бұрын

Thanks for your encouragement!

@ajanannamalai1443

3 жыл бұрын

but i dont understand why in treatment the artificial anti-D antibodies cannot cross over placenta and cause damage to babies red blood cells

You’re a legend bro ❤️ , thumbs up from KSA 👍

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😊

Excellent video, excellent channel, I love your content!! I would like to add a correction to the video. RhoGAM is actually IgG and therefore CAN CROSS the placenta. It prevents the immune reaction in the mother, and that’s why it is helpful, but it can technically cross the placenta and therefore does pose a slight risk of causing hemolytic anemia. Keep up the good work though!!

@Baharaakbari

Жыл бұрын

Does is it really cross the placenta in where did you read that can u give me the resources, cuz I read in another that it doesn’t cross , I m confused 😐

I like your video so much 😍🖤 From Sri Lanka 🇱🇰🇱🇰

@MedicosisPerfectionalis

4 жыл бұрын

You’re welcome 😊

I actually got to see a in utero transfusion unit prepared when I was doing my blood bank rotation.

@MedicosisPerfectionalis

4 жыл бұрын

Wow 😳

@chhassnainhassnain3733

4 жыл бұрын

@@MedicosisPerfectionalis i m O rh negative girl.can i marry B postive boy.is there any problem in pregnancy.i'm scared.plz help me.i dnt want any misscarrige

@shahabali1136

3 жыл бұрын

very nice

Him: If you give mommy antibodies than can pass through the placenta and destroy the baby, you are STUPID. Me: Suscribe, now....

@MedicosisPerfectionalis

4 жыл бұрын

Haha 😂 Welcome 🙏 Thank you so much 😊

I love your vedios ,,,, I'm Med Lab Technologies your Hematology and Hemostasis vedios gave me lots of information . Thanks Alot,👌👌 keep going ❤

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇 Can you please help me by sharing?

Me a computer science graduate watching this for selecting my future wife 😶‍🌫️😶

@aps9392

8 күн бұрын

What a joke

VERY CLEARLY EXPLAINED, CONCEPT CLEARED I THINK INFO IN THIS VIDEO WILL BE STUCK IN MIND FOREVER AND EVER, THANKS ALOT MEDICOSIS PERFECTIONALIS WHY OUR MEDICAL COLLEGE PROFESSORS CAN'T EXPLAIN LIKE THIS. THIS VIDEO SHOULD BE INCLUDED IN SYLLABUS, medicosis perfectionalis is medical college lecture hall

@MedicosisPerfectionalis

Жыл бұрын

Thank you 😊

I really appreciate your works thanks for you and hoping you continue on making such useful courses

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏 I will!

I was born Dec 8 1946. Perth Western Australia.The second child to an Rh neg mother and Rh pos father. Yes, I got HDN. The doctors gave me a complete blood transfusion exchange with my mother. It was said to have been experimental at the time. I am A Rh neg. I didn't have children.

Daddy Rh -ve , mommy Rh +ve , period.end of the issue 😂😂that went smooth

@MedicosisPerfectionalis

4 жыл бұрын

😂😂

@MedicosisPerfectionalis

4 жыл бұрын

😂😂

@faiyazrain786

3 жыл бұрын

shef patel n what if baby Rh -ve...🧐

@locadiachagwiza3984

3 жыл бұрын

if she is Rh+ then she wont produce anti-Rh

@tanisharj8926

3 жыл бұрын

@@locadiachagwiza3984 if mother is rh +ve (+,-) and father is rh +ve (+,-) then baby can be rh -ve

😍 I really enjoyed the video it's amazing how you make it so simple keep the good work👍❤️

@rayyanhamid1023

4 жыл бұрын

If the mother have already anti Rh igG from blood transfusion

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much for your encouraging words!

Great video. Thanks!

This video was so helpful thank you. I have a question how does the mother become sensitized without the RhoGAM please, thank you!

Thank you for great explanation 💕❤️💕

@MedicosisPerfectionalis

4 жыл бұрын

You’re welcome

1. Rh+ fetal abortion 2. Rh+ blood transfusion 3.Rh+ ectopic pregnancy. 4. Other causes of hydrops fetalis like severe anemia, infections, heart and lung conditions, chromosomal anomalied

Very helpful lecture for pg

@MedicosisPerfectionalis

5 жыл бұрын

Great 👍

u are perfect please make more about blood banking please

@MedicosisPerfectionalis

5 жыл бұрын

I will add it to my list!

When you said "during labour" my brain automatically said "WAIT NO. The baby is facing the wrong way!" But that's beside the point. Thanks for the video :)

@MedicosisPerfectionalis

4 жыл бұрын

Hahaha! You are so sharp...Are you a medical student?

@shabazgujjar8730

3 жыл бұрын

Fjmru

Thank u it's just amazing ❤️ love you... please make more..

@MedicosisPerfectionalis

4 жыл бұрын

Sure

@ajanannamalai1443

3 жыл бұрын

but i dont understand why in treatment the artificial anti-D antibodies cannot cross over placenta and cause damage to babies red blood cells

Your diagram and drawing is well it can help in better understanding🙂

@MedicosisPerfectionalis

3 жыл бұрын

Thank you 🙏

The mother was previously synthesized using the various methods like blood transfiusion before the pregnancy

@MedicosisPerfectionalis

6 жыл бұрын

You’re absolutely correct! Thanks bro!

@DejaWeja922

5 жыл бұрын

Hi

@MedicosisPerfectionalis

5 жыл бұрын

Hello!

@nanyabus.1638

3 жыл бұрын

What if no blood transfusion?

@drbeenakumari838

3 жыл бұрын

Medicosis Perfectionalis lllll

When I am a doctor iwill watch this great video 🇮🇶🇮🇶🤲

@MedicosisPerfectionalis

4 жыл бұрын

Thank you

I appreciate your drawing skills 😂💛

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😃

Thank you so much 💛

Nice 👍 explanation,thanks

@MedicosisPerfectionalis

5 жыл бұрын

You’re always welcome 🙏

Chorionic villus sampling, amniocentesis , antepartum hemorrhage or placental trauma can cause EBF in 1st pregnency .

@MedicosisPerfectionalis

4 жыл бұрын

Excellent

@awaishasaan6290

4 жыл бұрын

Medicosis Perfectionalis 谢谢 🙏

@MedicosisPerfectionalis

4 жыл бұрын

👍

@ahmedmahmoudibrahim7855

2 жыл бұрын

Ante partum Hemorrhage occur after age of viability 20weeks so no in 1st trimester 😊

@mianaimaliqbal1788

Жыл бұрын

@@ahmedmahmoudibrahim7855 no one is talking about 1st trimester doofus

Question: Hemoglobin = globin + heme; won't heme be broken down into Fe3+ and biliverdin (via hemoxygenase) and later bilirubin? I keep seeing in some sources protoporphyrin but really don't understand the relation between protoporphyrin and biliverdin/ bilirubin...answer much appreciated! EDIT: 14:11 How does Rhogam exactly prevent formation of proper anti-D-AB? Seems to be a kind of negative feedback, do you know something else about this? EDIT: 15:58 If it is true that anti-D-AB are destroyed after a few weeks, why can't then anyone just get Rh+ blood?

Congratulation!!

Thank you

Fine lectures

@MedicosisPerfectionalis

5 жыл бұрын

Thanks 🙏

This was so good 🤓

thank you..sir. 😊👍👌

@MedicosisPerfectionalis

5 жыл бұрын

Absolutely 😃

So will the baby have polychromatic erythrocytes or microcytic erythrocytes?

thank you

Normally we use indirect coombs test in the mum's serum cause it will be consumed in the foetal blood

Thank a million!

@MedicosisPerfectionalis

2 жыл бұрын

My pleasure 😇

Thanks 😊

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇

Which blood products are used in exchange transfusion when in utero and after delivery?

💊 👨‍🏫 Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/ 💉 📜 My Notes, cases and courses www.medicosisperfectionalis.com/

@andiudo5329

5 жыл бұрын

This means that if a Rh- mother is infused with Rh+ blood, say, during an accident in her youth (before she ever became pregnant) the first pregnancy will be affected?

@nabagalasarah3032

4 жыл бұрын

My view is yes

@aliciabecto2360

4 жыл бұрын

The mother has a pregnancy not completed before or she was infused with rh + before her first pregnancy

Thanks ☁️ ☀️

@MedicosisPerfectionalis

2 жыл бұрын

My pleasure 😇

Good thanks

@MedicosisPerfectionalis

4 жыл бұрын

You’re welcome 😊

Your work is excellent and appreciated! I'm writing this comment because I have a question that I need cleared up to reduce the stress between myself and my sister and possibly reunite us as sisters. The problem is that when my mother was pregnant with her she had the amniocentesis done due to the Rh negative issue now as far as I know she didn't have that problem with me right because I'm alive and and I also know all I do know is that I'm not Rh negative. so the question is my sister and I were talking and she said that she was the one that was rh - but my mom wasn't so can it be reversed like can it be an either way they would require the Doctors Care amniocentesis and such I wear the child in the womb is Rh negative and the mother's RH positive? and due to a head injury that I had in 09 and so few little issues I have with my memory and putting my words together good these days I just want to try this one more time if you don't mind to be clear. okay the question is could it have been that my sister was the Rh negative blood and my mother was the RH positive blood or would it be my mother had to be Rh negative because that's the debate is my sister said no I have already negative blood Mama wasn't always negative and I just wasn't sure and I figured that she must be right because I'm not Rh negative and I was born first I'm actually 15 years older than my sister. my mother had a lot of lost pregnancies and I just seems like my family told us that my mom was already negative so I'm just confused and I just wanted to know at least was it possible for it to be the other way around and I do apologize for such a long message for such a clear one question it's me and my issues so sorry! Thank you so much! Much Love 😍🥰!

@llso-lovelightsoundoneness1606

3 жыл бұрын

Being 1st baby I was ok. So I was the birth that sensitized my Mother? So in between me and my sister my Mom's blood was developing sensitivity to the Rh+ blood?

@llso-lovelightsoundoneness1606

3 жыл бұрын

You answered the sensitivity que8for me I am watching for either 4th or 5th time! Still gaining understanding too your work is like magic! XO

in Kenya never heard of transfusing foetus blood indeed that's so crazy wow

@MedicosisPerfectionalis

2 жыл бұрын

Yeah! I’ve never personally seen it performed in Egypt either! Thank you so much for watching my videos! I appreciate you a lot!

@fatumafatuma4077

2 жыл бұрын

@@MedicosisPerfectionalis your videos speak for them self’s man thanks too So much it really helps

Perhaps the mother had an infection (congenital), like syphyllis or parvovirus. These conditions can lead to erythroblastic fetalis.

May be because the mother had undergone such diagnostic procedure in which there as transfer of each other's blood eq amniocentesis ..or any invasive investigation ...early membrane rupture

@MedicosisPerfectionalis

5 жыл бұрын

Yes! You got it! Superb!

@Pema604

5 жыл бұрын

Tq

@MedicosisPerfectionalis

5 жыл бұрын

Is this short for “Thank you”?

@Pema604

5 жыл бұрын

Medicosis Perfectionalis yes hehe

@MedicosisPerfectionalis

5 жыл бұрын

Haha! Sorry, I am old school 😂😂

You are awesome!

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 😊

Answer: The mother has been sensitized before she became pregnant. She was sensitized probably because of previous blood transfusion of Rh + blood.

gud lecture

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏

I’m pregnant and rh- having my second born, is it compulsory to have the anti-D injection? Even if my husband is rh+

Is the RhGAM antibody IgM? Since it will not pass placenta

What is the reason for rh negative mom got rh positive after delivery

Thank you for this great explanation. There is 1 issue that wasn’t addressed though, if you could please help me with an answer: what if, the mother had her first child, and all went well. She’s trying for a second child but was just told that she was positive for an antibody that could potentially affect any future pregnancy. Kell antibodies positive. She’s not pregnant yet, what should she do? Is in vitro her only option if her husband’s blood test result are + for that antigen, instead of negative? Thank you so much for any further explanation on this specific situation. N

@taraakins8273

2 жыл бұрын

If the mother has the anti D in her blood from other rh pos pregnancies then her body will attack a rhesus positive embryo. There's nothing I know of that she can do at this point other than have science step in and have a neg embryo if affordable and if father is( -,+) which is possible. They can also just keep trying but risk miscarriages and birth defects if the embryo is positive. . They have a medicine (Rhogam) a mother can have injected soon after birth of pos or loss of one. I think it's within 72 hours.

How IgG antibodies cause aggluntination? They are monomeric....dont they cause opsonization rather?

Wait, what if the woman is O+ and the husband is AB-? What happens?

Ty ty 😊 👍👌👌👌

@MedicosisPerfectionalis

5 жыл бұрын

You are very welcome 😃

Fetal-maternal hemorrhage (abdominal trauma)

why not to give rhogam in a sensitized mother . does it not have a capacity to neutrzalised these antibodies

Hello! I am married with one kid but I have the same issue of blood group, l am Rh A- and my husband is Rh A+ and IAM pregnant for a second born it's now 19weeks but I haven't done anything. The question is what do I have to do and when to do it?........ please inform me before anything happens.

Mother is a+ve and father is b+ve... There is any chance for - ve group child?

It is on you …this is the right

It can be due to 1. Mismatch blood transfusion 2. baby maternal grandmother was rh positive 3. Previous Abortion, ectopic pregnancy

RhoGAM is an IgG antibody, so surely it can cross to the placenta, no?

@musallamlama84

5 жыл бұрын

True, then how?

What would happen if an Rh+ mother was pregnant with an Rh- baby. Would the baby develop the anti D antibodies by the time they are born? And if so, when the baby who we assume is a female grows up and gets pregnant with their first child being Rh+ would it immediately cause Erythroblastosis fetalis for her first child?

I had numerous miscarriages. Could I have bern sensitized because as children my sister and I played a game called blood brothers where we cut ourselves and touched our blood together? I am RH-

Might be ABO sensitization

Good

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏

I'm a negative 💔

LMAOOO i now like my anatomy and physiology class because of this channel

@MedicosisPerfectionalis

2 жыл бұрын

Thank you ☺️

If uncojugated bilirubin was being converted into conjugated bilirubin as you explained in the pathogenesis then why will the baby have kernicterus?

@MedicosisPerfectionalis

5 жыл бұрын

Great question...First, define kernicterus.

@rohansonus6243

5 жыл бұрын

😂😂😂

I have an important question. If the woman is rh - and the guy is rh+ and as she is pregnant and gets the shot to prevent damaging the baby, would the shot affect the baby to make it sterile(not be able to reproduce)? I heard that this is the case but I do know if it is true, and if so, does it happen 100%of the time?

@MedicosisPerfectionalis

4 жыл бұрын

No, I’ve never heard of that. Do you have any scientific study that I can refer to? Also, please talk to your doctor.

@venkatreddythupally3797

4 жыл бұрын

Medicosis Perfectionalis : #1.Rh -ve mom gave birth to Rh +ve baby and no roGham shot during pragnency. #2. Mom gave birth to second baby and baby is rh -ve, Mom might be already sensitized,but no effect to 2nd baby as baby is Rh-ve #3Mom gave birth to 3rd baby and baby is+ve. And got effected (HDN Effect, brain effected) Now tell me whether 2nd baby has sensitized blood or not ? as mother is already sensitised??

Can it be because the mother was pregnant but had an abortion? (with an Rh +ve fetus? )

@MedicosisPerfectionalis

5 жыл бұрын

Yes, of course! You got it!

Answer: 1) Prior Rh+ blood transfusion to the mother before she got pregnant, 2) If she was an IV drug abuser, 3) The grandmother theory, 4) Previous ruptured ectopic pregnancy, 5) Previous abortion, 6) Abruptio placentae.

Can mother give her milk to baby after delivery ? When baby is Rh is positive?

Is rhogam given in the first pregnancy or the second? I’m a bit confused. The mother can’t be sensitized meaning no exposure yet so would that be on the first pregnancy?

@bolanleade6479

5 жыл бұрын

It would be given in the first pregnancy if the mum is rheus neg

@amandarios448

4 жыл бұрын

Its like contraceptives, u get the hormones so you don't produce it on your own. Just watch the video he puts it very clearly

@CrystalRicotta

4 жыл бұрын

I am O - and received the shot for my first baby. She developed jaundice first week - was this related ?

What if the mommy is an rh positve?

I'm 67 and was the second live born ... Two miscarriages in-between... My mother could never explaine to me what happened... Except I was blue and she took me back to hospital for transfusions... I'm different than other people... Maybe it's the transfusion of O negative ... Then back to a positive... I feel like an O negative! Weird...

@rumyafg3907

3 жыл бұрын

Hi hope you r doing well. My son is 9 month and I am AB negative.. it's my second child and I didnt got any injection in the 1st and 2nd pregnency nobody told me. My son was the 2 day also so blue and couldn't breath long seconds and like all the night awake without closing his eyes then after we took him to hospital they changed his blood ... my son is now 9 month and cant sit or proper crawl or talk like dada or baba can I ask you if u remember how u was at child or can I ask you if he gets better my son like normal like others or he will always delay..? Thanks

You're wrong about the first born being fine. I miscarried my first pregnancy and that's how I found out my blood type. I was given rogham but the dr told me it probably wouldn't save the baby but it would save my next. What does sensitized mean? And is rh- also the same as the golden blood?

@MedicosisPerfectionalis

4 жыл бұрын

Sensitized means exposed to the antigen before...The first pregnancy may be affected if the mother has been exposed to the antigen before (e.g. a blood transfusion,...etc). Also, I am so sorry to hear that! I wish you the best!

Rh Sensitized mom gave birth to rh negative baby. Now baby is sensitized or not?

I got rhogam 5yrs back after an evacuation following miscarriage but now having weak rbc antibodies at 28weeks.Did i get sensitized during this or previous pregnancy.

@yusrazz

2 жыл бұрын

I was also weak sensitised at my 28 weeks got two shots of rhogam and my baby delivered with severe juandice at birth. He got blood transfusion at his 4th day and caught sepsis plus multi organ damage instead. Unfortunately he passed away but I have been sensitised now and I seriously worried about the future now

"You testicle will be very tiny but your trainer will be very proud of you." HAHHAHAH

Is there a risk if daddy is O- and mommy is AB+....after an abortion

Can Rhogam work in already sensitized mums?

@shabazgujjar8730

3 жыл бұрын

Vndmjc Jdjjvmf

This was my first pregnancy being rh- and we miscarried and had to get a bio globulin shot called rogam. Why didn’t I have a safe first pregnancy?

@MedicosisPerfectionalis

3 жыл бұрын

Hey Aubri, I am sorry to hear that! Was the Rh incompatibility the cause of the miscarriage? Wish you the best!

@aubridodgen673

3 жыл бұрын

@@MedicosisPerfectionalis that’s what the dr said and it was twins. One in the uterus and one in my fallopian tube in my first pregnancy. I had rehogam shot and methotrexate to correct it I think.