My interpretation of this video: first, the vit D paradox is that vit D supplementation can be both beneficial and harmful - depending on other dietary intake, in particular vit A and K. When taking vit D there is a signal in the body to produce unactivated MGP (Matrix Gla Protein). MGP is harmful, causes calcification etc. However, when MGP is activated, it is beneficial, because it makes vit D/Calcium go into the bones and teeth and make it strong. MGP is activated by carboxylation, and vit K makes this carboxylation happen. We then get carboxylated MGP, cMGP. Vit A's role in this is that when taking vit A together with vit D, the signal to produce MGP is reduced. Chris Masterjohn suggests: 1) Taking only vit D is harmful, causes calcification etc 2) Taking only vit A is also harmful, causes bone fractures etc (a little strange, I thought vit A had to do with vision and that vit D had to do with bones) 3) Taking vit D and vit A together does not cause excessive MGP. It is even a little beneficial compared to taking no supplements at all. 4) Taking vit K together with vit D is even more beneficial, because the body produces lots of MGP, which is converted into beneficial cMGP. 5) The hypothesis in the video is that it is even better to take both vit A and vit K together with vit D. However there is no comparison between taking vit D and K, vs taking vit D, K and A. So this is not really answered. And it is not obvious that it is beneficial to also take vit A - because vit A reduces MGP, the precursor to cMGP, which is what we want.

@michaelberman3648

4 жыл бұрын

Please explain in much greater detail why MGP without vitamin D present causes calcification of soft tissues? I still do not understand how MGP or c-MGP can cause calcification in the soft tissues if it is not ”activated” by vitamin D. And please explain how does the ”deactivated” form of this protein cause or results in increased calcification in the soft tissues?

@firagabird

4 жыл бұрын

Great summary. I'm also really interested to know the results of taking DK vs. ADK, if A reduces the production of the precursor protein that brings calcium into the bones, teeth, & joints.

@ldjt6184

3 жыл бұрын

@@firagabird What about taking vitamin K2 alone seeing as my D level is already at 80 ng/dl?

@firagabird

3 жыл бұрын

@@ldjt6184 Sounds good

@ldjt6184

3 жыл бұрын

@@firagabird Thanks!

According the the American Osteopathic Association in 2018: "Vitamin D can't be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans. In addition, Vitamin D supplements can increase a person's calcium and phosphate levels even while they remain Vitamin D deficient. People may suffer from vascular calcification if their magnesium levels aren't high enough to prevent the complication." I took 10kIU/day D3 plus Super K complex for years and wound up with coronary calcium score of 1650! Didn't know about the roles of A and Mg.

@billk5061

3 жыл бұрын

Sheridan Jackson, very interesting! Do you know for a reasonable certainty that your calcium score was not already elevated before the D + K? Or, did you see a continued elevation in your score after you started taking that dose? I had been taking D( 5K to 10K), mostly without K2 and certainly with out A, but probably always with Magnesium, for a couple of years before I had my scan with a zero score. But in the last couple of years I have added K2 to mostly 10K, I would like to know if my score has changed much. But a recent scan did show an asymptomatic and non obstructing kidney stone, which was not there 6 years ago. Since then I have added some A with my D, as well as reduced the amount of D to 5K. Sure would be nice to know the correct amounts of each for best over all health. Dr. Mercola turned against any added A even with high D supplementation, a few years ago, and Weston A. Price ( or WAP, who funded this guys studies) are in complete disagreement with him on that. But of course, another variable is actual dietary vitamin A. I think Mercola's argument was that we (average American) get plenty of A already. WAP says as long as you are getting at least 1000 IU/day, it is extremely unlikely that we can get too much A, and too much D without A can be a real problem. Sigh. Who knows? Right now, I am taking all 4: A little A, but more D, K2, Mag.

@kappakd

3 жыл бұрын

@@billk5061 how much k2?

@oswaldjames6295

3 жыл бұрын

@@kappakd I don't know personally, but saw a Dr. Berg Video on YT where he recommends 100 mcg. of Vit K2-Mk-7 per 10,000 iu of Vit D3.

@johncoe6304

3 жыл бұрын

Bill k, I'm doing the exact same... 5000iu d, some k, some magn, and some a

@meggi8048

5 ай бұрын

can you update on how your A D k2 Mg story went?@@billk5061

You can start watching at 28 minutes and get the main point.

@shrek22

2 жыл бұрын

Dead wrong

This was an excellent video. This gives me encouragement to continue taking K2 MK7 100 mcg with my Vitamin D3 5000 IU.

@CoachStephen

3 жыл бұрын

Do you have an end goal to justify the regime? I'm asking as I had a CAC score of 639 and that made me cease my low-fat high carb diet. Your regime seems to the most common protocol for regression of CAC scores

@bobbylee2853

Жыл бұрын

Update would be appreciated as I use the same ratios for the last few years.

@user-fn2oy1rq5p

10 ай бұрын

Why without Vitamin A? I thought that was the point. That Vitamin D and A and K are somewhat codependent

Thank you for the info! More evidence that we need to balance our intake of vitamins and minerals.

The medical industrial complex's failure to properly research and diagnose and treat microbiome and sleep and vital nutritional deficiency issues (including those related to Vitamin D3 and Vitamin K2 and Magnesium deficiencies as well as iatrogenic prescription medication usage) is a major reason why psychiatric iatrogenesis is a primary contributor to the third leading cause of death in the U.S. (which is iatrogenesis in general). If the U.S. spent just a fraction of the over $40 billion each year it spends just on iatrogenic psychiatric drugs alone, for properly researching the issues discussed in this and related KZread presentations we would probably, Lord willing, achieve an absolute revolution in medical efficacy improvement and iatrogenesis reduction. Thomas Steven Roth, MBA, MD Christian Minister for Biblical Medical Ethics, and therefore, Scientific and Religious Refugee from the Clinical Practice of Psychiatric Standards of Care

This is so relevant to me, thank you for your research, Dr Masterjohn

Great video to get good insights into the synergy of Vitamin A/D and K. But its not clear at what ratio they work perfectly

What is the most bio available form of A and K? Many suggest beta carotene is simply not enough since our conversion pathway is limited (which is why I think you said that vegetables are supplements for vitamin A). Also, how does exogenous vitamin D affect serum lipid values? Vitamin D is supposed to be derived from UVB saturated cholesterol in the skin. Would providing an exogenous source of D affect the endogenous production pathway such that it might cause dyslipidemia since the endogenous conversion pathway is seldom used?

@ninjatoitle

2 жыл бұрын

Beef liver

What about higher level of vitamin D for immune system? 40 ng/ml is not enough.

@cosmichealth3907

3 жыл бұрын

Upto 100 is safe

@Rebelz173

2 жыл бұрын

No it isn’t enough. You want to aim for at least 60 ng

One might also conclude that those lifeguards were slapping on vast amounts of toxic suncream everyday...

@teeduck

3 жыл бұрын

There are non toxic sunscreens, why assume they slapped on only toxic sunscreen, and everyday

@no22sill

Жыл бұрын

​@@teeduck everyday because they were in the sun all day everyday.. and do care to mention which natural sunscreens you have in mind

I'm not sure if this is relevant. my vitamin d status is around 28. i believe a have a less serious form of von willebrand disease based on my experiences from childhood to adulthood of bleeding out after surgeries/childbirth. at around 38 i got anemia from heavy periods. what stops my heavy bleeding is either aleve or eating grassfed cheese and butter (kerrygold). my blood pressue is excellent. i am 49 and eat no grains. i have diabetes in both parents and usually have a morning bg of 98 - 106. just some data points that may be of interest.

@lelliateodotova5483

2 жыл бұрын

I remember long time ago, If my vitamin K was low, I would have bleedings. Now I eat every days huge portion of green salad (vitamin K1), and very often chicken thighs (they have a lot of K2). But my vitamin D is almost 100, it is very very high. The doctor was saying, when they were measuring vit D, when it was more than 40 per ml in blood, people had kidney stones and etc. So, I have more than double of Vit D per ml, but I do not have kidney stones, I believe, it is because of vit K in my diet

Phd level information for a grade 3 youtube audience 🤦‍♂️. Conclusion: take vitamin A,D, K2 together to prevent problems.

5:11 The link to CVD

somebody please help ...have factor 5 lieden ,,,can I take warafin with vitamin k2 ? thank you doctor for answering

@haveaniceday7950

8 жыл бұрын

+Chris Masterjohn are there any human or animal models that show that k2 can reverse calcification in soft tissues like cartridge? at what dose if so, and what form, mk4 or mk7? thanks for all your work!

@thekam3588

4 жыл бұрын

Wow! someone else with Factor 5 Leiden!!! I have a sibling that has it but must take heparin. Nothing else worked. Take care.

How do you explain the paradox when looking at the mouse study using 5% vit d requirements? only low vit d elicits increased calcification, not excess doses

Instead of supplementing synthetic vitamin D can I just use a sperti D lamp and get the same effects?

@ryan4896

2 жыл бұрын

Yes

@no22sill

Жыл бұрын

​@@ryan4896 and what about noon sun exposure for around 20.mins everyday

@meggi8048

5 ай бұрын

yes and no, pre forms of D in the skin need hormons to work, as D is a hormon made from cholesterol like any other hormon. so on hormonal problems, or too less cholesterol etc, or in chronic disease state, the skin D production might be not working.

16:11 Vitamin A segment begins.

@Karaveba1

3 ай бұрын

Thank you!

It's insane we are taking about vit d insufficiency...most of us are low on vit d and should look to ante the levels...rather than going after animal studies and PhDs pleade look at dr heaneys work on vit d for the last 50 years...he says vit d in any form is safe as a house....

I wonder how much of the vitamin deficiency in people with more severe COVID-19 is actually due to excess body fat. The key vitamins mentioned as deficient (D, A and K2) are all fat soluble so would be stored in adipose tissue ... basically "held hostage" by body fat. And most overweight/obese people have impaired liver/mitochondrial function so have impaired ability to utilize these vitamins. My understanding is that 90% + of COVID-19 deaths occurred in people with excess body fat. In the Spain study, they used the active form of Vitamin D (calcefidiol) which can be directly utilized without healthy liver/mitochondrial function ... this may explain why it was so effective ... the active form of D overcame the excess body fat issue. Also: (1) fat cells are high expressers of ACE2 (target for SARS-Cov2 virus entry into the body), (2) fat cells are high producers of cytokines, and (3) fat cells produce a substance which blocks our body's natural clot busting mechanism. What if body fat (adipose tissue) explains the correlation between fat-soluble vitamin deficiencies and bad COVID-19 outcomes? Clearly, small minority of people who do not appear to have excess body fat (though they could be TOFI (thin on the outside, fat on the inside)) have died due to COVID-19 and it may be due to endothelial dysfunction making lungs easy target for virus. Again, this appears to be much less common explanation.

@meggi8048

5 ай бұрын

the active form is calciTriol, not calciDiol. calcidiol is the "passive" form which is also what is used in blood tests. cholecalciferol which is the D3 supplement form needs to be converted to calciDiol. so calcidiol is more active or requires less conversion steps than cholecalciferol to convert to calcitriol.

Egg yolks also nurture the baby; they don’t BECOME the baby. It is a food sack.

Some people get insomnia when they supplement with D3. Does anyone know why?

@lloydh464

2 жыл бұрын

I've heard if take too late in the day, can disrupt melatonin production.

@lloydh464

2 жыл бұрын

I've heard if take too late in the day, can disrupt melatonin production.

@stillsearchingforsanity4332

2 жыл бұрын

I take my D3 early in the day and since I started taking some of my magnesium just before bedtime, my sleep has improved a lot.

Supplements are different outcome then when o e gets it from the Sun only!!

Magnesium is another complicating factor.

@CTPH-77

4 жыл бұрын

Can you point me in the direction of some resources on this? For a lay person. Thank you

@igaluitchannel6644

4 жыл бұрын

@@CTPH-77 Well, I'm a lay person too. You could look at Dr. Carolyn Dean's interviews on KZread and that will probably give you a handful of recommended videos that will second this view; namely, that magnesium will help dissolve calcium accumulations.

@igaluitchannel6644

4 жыл бұрын

@Gigi Devoe Seems to me it would be very hard to achieve those levels. Even at the minimum levels, my system is always sleepy and with less energy, although my muscular strength is significantly increased.

@1charlastar886

4 жыл бұрын

@@igaluitchannel6644 Add boron to help both those minerals function more. Boron controls calcium metabolism in the body through the parathyroid glands. Dr. Jorge Flechas, MD, MPH, says we need 75mg a day (30mg for women who could become pregnant). This equals about a rounded 1/4 tsp. 20 Mule Team Borax or 75mg Boro Tab from halakalabs.com

@igaluitchannel6644

4 жыл бұрын

@@1charlastar886 Borax !?

Highest d level without adequate k specifically k2 would be unuseful n dangerous

This scientist said not over vite D'ed from sun. kzread.info/dash/bejne/dJOru5axaJrFl7w.html (kidney stones ~21min.). Does it matter what part of body exposed to sun, is belly or legs make more Vite D? Also the differnet co nutrients needed, as you mentioned Vite A, read of minerals (Ca,P, B, Mg ).

I couldn't watch more than half of this video. His study is inconclusive.

@deesmith9540

8 жыл бұрын

+Franka Sensale You're a vegan aren't you?

@frankasensale6788

8 жыл бұрын

+Dee Smith ~ I am.

@ejw1234

5 жыл бұрын

Which is still worth hearing...Any time the mainstream agrees on just anything I start to wonder....

@kemchobhenchod

5 жыл бұрын

@@frankasensale6788 ​ Maybe your veganism has led to nutrient deficiencies, leading to low attention span.

omg, just received my bloodwork ... Vit D is at 400!!!!

@jamieboc491

Ай бұрын

Mine is high as well

When I supplemented D3 + k2 supplements, I got hypercalcemia and almost had a heart attack, now I'm just trying to fix the imbalance I caused

@anhkimphan514

4 жыл бұрын

Kieran Young , yes you should take D3 K2 with colorful fruit or veggie with has vitamin A, and also take magnesium as well.

@elenalepotova6623

4 жыл бұрын

What dose did you take of both vitamins and for how long?

@kappakd

3 жыл бұрын

Dosages ?

It’s odd that both low and high vitamin D can be harmful? Not really, it’s an observational study. Stopped the video right there. Sick of these observational studies which can mean this or could mean that. Show better data!

Experimental evidence... on rats and mice...not strong support. I expect more evidence on humans.

@cynho3093

7 жыл бұрын

It's my understanding that high levels of Vitamin D3 is toxic to rats & high levels of Vitamin D2 is toxic to humans, so using D3 on rats should not be used as evidence,

an egg has 30 iu of vit k three a day you wont be GUY

From a guy who's had dozens of kidney stones every year for about the last decade... After starting to take vit D AND vit K (I've taken Vit D alone before with zero noticeable effect) I have been kidney stone free for nearly 4 months, first time in my adult life. N of 1 says that Vit D and Vit K is magical. Lol

@UncleMike81

3 жыл бұрын

Curious mk4 or mk7?

@WideAwakeHuman

3 жыл бұрын

@@UncleMike81 mk7

@stillsearchingforsanity4332

2 жыл бұрын

Wow, I feel for you. How long after starting K2 was the last kidney stone?

33:31 inappropriate interaction with female scientist

@dadymadass

4 жыл бұрын

:)) some vitamin ketamine:)))

wish I could make it through but the mic or bad sound makes his very monotone voice even worse, it adds a high-pitch squeal I cannot take along with the relentless delivery.. topic is interesting but geez dude you need to edit and clarify if your target audience is the public? Were the lifeguards also checked for all the chlorine they've soaked in, maybe that is why, imo that is a toxin you cannot overlook ? You seem to maybe be addressing other researchers more than public? Frustrating to wade through blow by blow so much, can you reduce your thoughts to a more manageable talk.. exhausting imo..

@johncoe6304

3 жыл бұрын

Stfu. Dude.

too much nonsense animal studies, vs thousands and thousands of high quality human studies, which have not been used to the detriment of the quality of analysis.. vitamin A is irrelevant, deficiency is very rare. K2 is crucial and the presenter has not added with his 'hypothesis' anything of value not known before. He seems too much in love with his P-H-Deeing fishing expedition into the irrelevant stuff that he should keep in those journals 99.9% of which nobody reads. Sad. Chris demonstrated in some of his other talks to be a relatively smart guy, adding value - not in this one.

@kemchobhenchod

5 жыл бұрын

Disagree. Human studies on this subject have been based on epidemiology, which is a junk science. Animal studies are not in humans, but prospective dietary studies in humans are very rare, especially now that they're so expensive.

@nickb3250

4 жыл бұрын

kemchobhenchod Agreed. Love how people shit on animal studies when the findings are inconvenient for their current dogma.